Functional cytotoxic T lymphocytes against IGRP 206-214 predict diabetes in the non-obese diabetic mouse

Immunology and Cell Biology

Volumn 92, Issue 7, 2014, Pages 640-644

  Ko, Hyun Ja ^a,b   Chee, Jonathan ^b   Sutherland, Robyn M ^a,b   Thomas, Helen E ^b   Zhan, Yifan ^a,b   Krishnamurthy, Balasubramanian ^b   Kay, Thomas W H ^b   Lew, Andrew M ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ISLET SPECIFIC GLUCOSE 6 PHOSPHATASE CATALYTIC SUBUNIT RELATED PROTEIN; UNCLASSIFIED DRUG; EPITOPE; G6PC2 PROTEIN, MOUSE; GLUCOSE 6 PHOSPHATASE; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DIABETES MELLITUS; DISEASE MARKER; HISTORY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PREDICTION; PREDICTIVE VALUE; SPLEEN CELL; SPLENECTOMY; AGE; ANIMAL; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; IMMUNOLOGY; MALE; PROGNOSIS;

AGE FACTORS; ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; EPITOPES, T-LYMPHOCYTE; FEMALE; GLUCOSE-6-PHOSPHATASE; MALE; MICE; MICE, INBRED NOD; PEPTIDES; PROGNOSIS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84906056658     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2014.29     Document Type: Article

References (26)

1. Tisch R, McDevitt H. Insulin-dependent diabetes mellitus. Cell 1996; 85: 291-297. (Pubitemid 26160699)
2. Sibley RK, Sutherland DE, Goetz F, Michael AF. Recurrent diabetes mellitus in the pancreas iso-and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest 1985; 53: 132-144. (Pubitemid 15049005)
3. Itoh N, Hanafusa T, Miyazaki A, Miyagawa J, Yamagata K, Yamamoto K et al. Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest 1993; 92: 2313-2322. (Pubitemid 23333537)
4. Coppieters KT, Dotta F, Amirian N, Campbell PD, Kay TW, Atkinson MA et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med 2012; 209: 51-60.
5. Haskins K, Portas M, Bergman B, Lafferty K, Bradley B. Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc Natl Acad Sci USA 1989; 86: 8000-8004. (Pubitemid 19265307)
6. Christianson SW, Shultz LD, Leiter EH. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4\+ and CD8\+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 1993; 42: 44-55. (Pubitemid 23013794)
7. McDevitt HO, Unanue ER. Autoimmune diabetes mellitus-much progress, but many challenges. Adv Immunol 2008; 100: 1-12.
8. Kagi D, Odermatt B, Seiler P, Zinkernagel RM, Mak TW, Hengartner H. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J Exp Med 1997; 186: 989-997. (Pubitemid 27441144)
9. Wicker LS, Leiter EH, Todd JA, Renjilian RJ, Peterson E, Fischer PA et al. Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 1994; 43: 500-504. (Pubitemid 24064260)
10. Katz J, Benoist C, Mathis D. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur J Immunol 1993; 23: 3358-3360. (Pubitemid 23353790)
11. Yagi H, Matsumoto M, Kunimoto K, Kawaguchi J, Makino S, Harada M. Analysis of the roles of CD4\+ and CD8\+ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice. Eur J Immunol 1992; 22: 2387-2393.
12. Skowera A, Ellis RJ, Varela-Calvino R, Arif S, Huang GC, Van-Krinks C et al. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 2008; 118: 3390-3402.
13. Reijonen H, Mallone R, Heninger AK, Laughlin EM, Kochik SA, Falk B et al. GAD65-specific CD4\+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. Diabetes 2004; 53: 1987-1994. (Pubitemid 38970746)
14. Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA et al. Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8\+ T cells in autoimmune diabetes. Proc Natl Acad Sci USA 2003; 100: 8384-8388. (Pubitemid 36842554)
15. Velthuis JH, Unger WW, Abreu JR, Duinkerken G, Franken K, Peakman M et al. Simultaneous detection of circulating autoreactive CD8\+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes 2010; 59: 1721-1730.
16. Lieberman SM, Takaki T, Han B, Santamaria P, Serreze DV, DiLorenzo TP. Individual nonobese diabetic mice exhibit unique patterns of CD8\+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase. J Immunol 2004; 173: 6727-6734. (Pubitemid 39541058)
17. Verdaguer J, Schmidt D, Amrani A, Anderson B, Averill N, Santamaria P. Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J Exp Med 1997; 186: 1663-1676. (Pubitemid 27506280)
18. Taplin CE, Barker JM. Autoantibodies in type 1 diabetes. Autoimmunity 2008; 41: 11-18.
19. Trudeau JD, Kelly-Smith C, Verchere CB, Elliott JF, Dutz JP, Finegood DT et al. Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest 2003; 111: 217-223. (Pubitemid 36105920)
20. Trudeau JD, Chandler T, Soukhatcheva G, Verchere CB, Tan R. Prospective prediction of spontaneous but not recurrent autoimmune diabetes in the non-obese diabetic mouse. Diabetologia 2007; 50: 1015-1023. (Pubitemid 46559244)
21. Mannering SI, Wong FS, Durinovic-Bello I, Brooks-Worrell B, Tree TI, Cilio CM et al. Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes. Clin Exp Immunol 2010; 162: 197-209.
22. Oehen S, Brduscha-Riem K. Differentiation of naive CTL to effector and memory CTL: Correlation of effector function with phenotype and cell division. J Immunol 1998; 161: 5338-5346. (Pubitemid 28519094)
23. Prochazka M, Serreze DV, Frankel WN, Leiter EH. NOR/Lt mice: MHC-matched diabetes-resistant control strain for NOD mice. Diabetes 1992; 41: 98-106.
24. French MB, Allison J, Cram DS, Thomas HE, Dempsey-Collier M, Silva A et al. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 1997; 46: 34-39. (Pubitemid 27009946)
25. Gagnerault MC, Luan JJ, Lotton C, Lepault F. Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice. J Exp Med 2002; 196: 369-377. (Pubitemid 34875666)
26. Moon JJ, Chu HH, Hataye J, Pagan AJ, Pepper M, McLachlan JB et al. Tracking epitope-specific T cells. Nat Protoc 2009; 4: 565-581.