메뉴 건너뛰기




Volumn 23, Issue 9, 2014, Pages 1285-1294

Atacicept as an investigated therapy for rheumatoid arthritis

Author keywords

Atacicept; B cell; B lymphocyte stimulator and a proliferation inducing ligand; Rheumatoid arthritis; Rheumatoid factor

Indexed keywords

APRIL PROTEIN; ATACICEPT; B CELL ACTIVATING FACTOR; CYTOKINE; IMMUNOGLOBULIN; METHOTREXATE; RHEUMATOID FACTOR; TUMOR NECROSIS FACTOR INHIBITOR; ANTIRHEUMATIC AGENT; HYBRID PROTEIN; TACI RECEPTOR-IGG FC FRAGMENT FUSION PROTEIN;

EID: 84906050258     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2014.943835     Document Type: Review
Times cited : (23)

References (52)
  • 1
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011;365(23):2205-19
    • (2011) N Engl J Med , vol.365 , Issue.23 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 2
    • 79953707617 scopus 로고    scopus 로고
    • The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases
    • Crowson CS, Matteson EL, Myasoedova E, et al. The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases. Arthritis Rheum 2011;63(3):633-9
    • (2011) Arthritis Rheum , vol.63 , Issue.3 , pp. 633-639
    • Crowson, C.S.1    Matteson, E.L.2    Myasoedova, E.3
  • 3
    • 84877847008 scopus 로고    scopus 로고
    • A pharmacokinetic and clinical assessment of tofacitinib for the treatment of rheumatoid arthritis
    • Bannwarth B, Kostine M, Poursac N. A pharmacokinetic and clinical assessment of tofacitinib for the treatment of rheumatoid arthritis. Expert Opin Drug Metab Toxicol 2013;9(6):753-61
    • (2013) Expert Opin Drug Metab Toxicol , vol.9 , Issue.6 , pp. 753-761
    • Bannwarth, B.1    Kostine, M.2    Poursac, N.3
  • 4
    • 80155128010 scopus 로고    scopus 로고
    • Remission of rheumatoid arthritis in clinical practice: Application of the American College of Rheumatology/European League Against Rheumatism 2011 remission criteria
    • Shahouri SH, Michaud K, Mikuls TR, et al. Remission of rheumatoid arthritis in clinical practice: Application of the American College of Rheumatology/European League Against Rheumatism 2011 remission criteria. Arthritis Rheum 2011;63(11):3204-15
    • (2011) Arthritis Rheum , vol.63 , Issue.11 , pp. 3204-3215
    • Shahouri, S.H.1    Michaud, K.2    Mikuls, T.R.3
  • 5
  • 6
    • 84895153556 scopus 로고    scopus 로고
    • Emerging cell and cytokine targets in rheumatoid arthritis
    • Burmester GR, Feist E, Dorner T. Emerging cell and cytokine targets in rheumatoid arthritis. Nat Rev Rheumatol 2014;10(2):77-88
    • (2014) Nat Rev Rheumatol , vol.10 , Issue.2 , pp. 77-88
    • Burmester, G.R.1    Feist, E.2    Dorner, T.3
  • 7
    • 0033538468 scopus 로고    scopus 로고
    • BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
    • Moore PA, Belvedere O, Orr A, et al. BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285(5425):260-3
    • (1999) Science , vol.285 , Issue.5425 , pp. 260-263
    • Moore, P.A.1    Belvedere, O.2    Orr, A.3
  • 8
    • 33644755600 scopus 로고    scopus 로고
    • An APRIL to remember: Novel TNF ligands as therapeutic targets
    • Dillon SR, Gross JA, Ansell SM, et al. An APRIL to remember: Novel TNF ligands as therapeutic targets. Nat Rev Drug Discov 2006;5(3):235-46
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.3 , pp. 235-246
    • Dillon, S.R.1    Gross, J.A.2    Ansell, S.M.3
  • 9
    • 38949206321 scopus 로고    scopus 로고
    • TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts
    • Bossen C, Cachero TG, Tardivel A, et al. TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood 2008;111(3):1004-12
    • (2008) Blood , vol.111 , Issue.3 , pp. 1004-1012
    • Bossen, C.1    Cachero, T.G.2    Tardivel, A.3
  • 10
    • 0036732753 scopus 로고    scopus 로고
    • DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    • Litinskiy MB, Nardelli B, Hilbert DM, et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol 2002;3(9):822-9
    • (2002) Nat Immunol , vol.3 , Issue.9 , pp. 822-829
    • Litinskiy, M.B.1    Nardelli, B.2    Hilbert, D.M.3
  • 11
    • 0034601020 scopus 로고    scopus 로고
    • BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population
    • Thompson JS, Schneider P, Kalled SL, et al. BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population. J Exp Med 2000;192(1):129-35
    • (2000) J Exp Med , vol.192 , Issue.1 , pp. 129-135
    • Thompson, J.S.1    Schneider, P.2    Kalled, S.L.3
  • 12
    • 0034694088 scopus 로고    scopus 로고
    • BAFF mediates survival of peripheral immature B lymphocytes
    • Batten M, Groom J, Cachero TG, et al. BAFF mediates survival of peripheral immature B lymphocytes. J Exp Med 2000;192(10):1453-66
    • (2000) J Exp Med , vol.192 , Issue.10 , pp. 1453-1466
    • Batten, M.1    Groom, J.2    Cachero, T.G.3
  • 13
    • 0037097665 scopus 로고    scopus 로고
    • Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators
    • Hsu BL, Harless SM, Lindsley RC, et al. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol 2002;168(12):5993-6
    • (2002) J Immunol , vol.168 , Issue.12 , pp. 5993-5996
    • Hsu, B.L.1    Harless, S.M.2    Lindsley, R.C.3
  • 14
    • 0036144353 scopus 로고    scopus 로고
    • Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogrens syndrome
    • Groom J, Kalled SL, Cutler AH, et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogrens syndrome. J Clin Invest 2002;109(1):59-68
    • (2002) J Clin Invest , vol.109 , Issue.1 , pp. 59-68
    • Groom, J.1    Kalled, S.L.2    Cutler, A.H.3
  • 15
    • 0034972257 scopus 로고    scopus 로고
    • Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
    • Cheema GS, Roschke V, Hilbert DM, et al. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum 2001;44(6):1313-19
    • (2001) Arthritis Rheum , vol.44 , Issue.6 , pp. 1313-1319
    • Cheema, G.S.1    Roschke, V.2    Hilbert, D.M.3
  • 16
    • 0037108490 scopus 로고    scopus 로고
    • BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases
    • Roschke V, Sosnovtseva S, Ward CD, et al. BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. J Immunol 2002;169(8):4314-21
    • (2002) J Immunol , vol.169 , Issue.8 , pp. 4314-4321
    • Roschke, V.1    Sosnovtseva, S.2    Ward, C.D.3
  • 17
    • 84855522022 scopus 로고    scopus 로고
    • The discovery and development of belimumab: The anti-BLyS-lupus connection
    • Stohl W, Hilbert DM. The discovery and development of belimumab: The anti-BLyS-lupus connection. Nat Biotechnol 2012;30(1):69-77
    • (2012) Nat Biotechnol , vol.30 , Issue.1 , pp. 69-77
    • Stohl, W.1    Hilbert, D.M.2
  • 18
    • 38149114077 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single-And repeated-dose study
    • Tak PP, Thurlings RM, Rossier C, et al. Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single-And repeated-dose study. Arthritis Rheum 2008;58(1):61-72
    • (2008) Arthritis Rheum , vol.58 , Issue.1 , pp. 61-72
    • Tak, P.P.1    Thurlings, R.M.2    Rossier, C.3
  • 19
    • 37149032474 scopus 로고    scopus 로고
    • Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: Results of a multicenter, phase Ib, double-blind, placebocontrolled, dose-escalating trial
    • DallEra M, Chakravarty E, Wallace D, et al. Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: Results of a multicenter, phase Ib, double-blind, placebocontrolled, dose-escalating trial. Arthritis Rheum 2007;56(12):4142-50
    • (2007) Arthritis Rheum , vol.56 , Issue.12 , pp. 4142-4150
    • Dallera, M.1    Chakravarty, E.2    Wallace, D.3
  • 20
    • 34250365790 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of atacicept in healthy volunteers
    • Munafo A, Priestley A, Nestorov I, et al. Safety, pharmacokinetics and pharmacodynamics of atacicept in healthy volunteers. Eur J Clin Pharmacol 2007;63(7):647-56
    • (2007) Eur J Clin Pharmacol , vol.63 , Issue.7 , pp. 647-656
    • Munafo, A.1    Priestley, A.2    Nestorov, I.3
  • 21
    • 40749132997 scopus 로고    scopus 로고
    • Pharmacokinetics and biological activity of atacicept in patients with rheumatoid arthritis
    • Nestorov I, Munafo A, Papasouliotis O, et al. Pharmacokinetics and biological activity of atacicept in patients with rheumatoid arthritis. J Clin Pharmacol 2008;48(4):406-17
    • (2008) J Clin Pharmacol , vol.48 , Issue.4 , pp. 406-417
    • Nestorov, I.1    Munafo, A.2    Papasouliotis, O.3
  • 22
    • 67650388093 scopus 로고    scopus 로고
    • Atacicept, a novel B cell-Targeting biological therapy for the treatment of rheumatoid arthritis
    • Bracewell C, Isaacs JD, Emery P, et al. Atacicept, a novel B cell-Targeting biological therapy for the treatment of rheumatoid arthritis. Expert Opin Biol Ther 2009;9(7):909-19
    • (2009) Expert Opin Biol Ther , vol.9 , Issue.7 , pp. 909-919
    • Bracewell, C.1    Isaacs, J.D.2    Emery, P.3
  • 23
    • 17944375043 scopus 로고    scopus 로고
    • TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease impaired B cell maturation in mice lacking BLyS
    • Gross JA, Dillon SR, Mudri S, et al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity 2001;15(2):289-302
    • (2001) Immunity , vol.15 , Issue.2 , pp. 289-302
    • Gross, J.A.1    Dillon, S.R.2    Mudri, S.3
  • 24
    • 79959832697 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: Results of a phase II randomized placebo-controlled dose-finding trial
    • Genovese MC, Kinnman N, De La Bourdonnaye G, et al. Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: Results of a phase II, randomized, placebo-controlled, dose-finding trial. Arthritis Rheum 2011;63(7):1793-803
    • (2011) Arthritis Rheum , vol.63 , Issue.7 , pp. 1793-1803
    • Genovese, M.C.1    Kinnman, N.2    De La Bourdonnaye, G.3
  • 25
    • 79959856423 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II randomized placebo-controlled trial
    • Van Vollenhoven RF, Kinnman N, Vincent E, et al. Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II, randomized, placebo-controlled trial. Arthritis Rheum 2011;63(7):1782-92
    • (2011) Arthritis Rheum , vol.63 , Issue.7 , pp. 1782-1792
    • Van Vollenhoven, R.F.1    Kinnman, N.2    Vincent, E.3
  • 26
    • 84856795563 scopus 로고    scopus 로고
    • Atacicept in combination with MMF and corticosteroids in lupus nephritis: Results of a prematurely terminated trial
    • Ginzler EM, Wax S, Rajeswaran A, et al. Atacicept in combination with MMF and corticosteroids in lupus nephritis: Results of a prematurely terminated trial. Arthritis Res Ther 2012;14(1):R33
    • (2012) Arthritis Res Ther , vol.14 , Issue.1
    • Ginzler, E.M.1    Wax, S.2    Rajeswaran, A.3
  • 27
    • 84902548867 scopus 로고    scopus 로고
    • Efficacy and safety of atacicept for prevention of flares in subjects with moderate to severe systemic lupus erythematosus [abstract #2122
    • Suppl
    • Wofsy D, Isenberg D, Licu D, et al. Efficacy and safety of atacicept for prevention of flares in subjects with moderate to severe systemic lupus erythematosus [abstract #2122]. Arthritis Rheum 2013;65(9 Suppl):S675
    • (2013) Arthritis Rheum , vol.65 , Issue.9
    • Wofsy, D.1    Isenberg, D.2    Licu, D.3
  • 28
    • 39749174407 scopus 로고    scopus 로고
    • Phase i clinical study of atacicept in patients with relapsed and refractory Bcell non-Hodgkins lymphoma
    • Ansell SM, Witzig TE, Inwards DJ, et al. Phase I clinical study of atacicept in patients with relapsed and refractory Bcell non-Hodgkins lymphoma. Clin cancer Res 2008;14(4):1105-10
    • (2008) Clin Cancer Res , vol.14 , Issue.4 , pp. 1105-1110
    • Ansell, S.M.1    Witzig, T.E.2    Inwards, D.J.3
  • 29
    • 70349675652 scopus 로고    scopus 로고
    • Atacicept in relapsed/refractory multiple myeloma or active Waldenstroms macroglobulinemia: A phase i study
    • Rossi JF, Moreaux J, Hose D, et al. Atacicept in relapsed/refractory multiple myeloma or active Waldenstroms macroglobulinemia: A phase I study. Br J cancer 2009;101(7):1051-8
    • (2009) Br J Cancer , vol.101 , Issue.7 , pp. 1051-1058
    • Rossi, J.F.1    Moreaux, J.2    Hose, D.3
  • 30
    • 84859642220 scopus 로고    scopus 로고
    • Phase 1b trial of atacicept a recombinant protein binding BLyS and APRIL in patients with chronic lymphocytic leukemia
    • Kofler DM, Gawlik BB, Elter T, et al. Phase 1b trial of atacicept, a recombinant protein binding BLyS and APRIL, in patients with chronic lymphocytic leukemia. Leukemia 2012;26(4):841-4
    • (2012) Leukemia , vol.26 , Issue.4 , pp. 841-844
    • Kofler, D.M.1    Gawlik, B.B.2    Elter, T.3
  • 31
  • 32
    • 72449136292 scopus 로고    scopus 로고
    • Insights into the heterogeneity of human B cells: Diverse functions, roles in autoimmunity, and use as therapeutic targets
    • Anolik JH, Looney RJ, Lund FE, et al. Insights into the heterogeneity of human B cells: Diverse functions, roles in autoimmunity, and use as therapeutic targets. Immunol Res 2009;45(2-3):144-58
    • (2009) Immunol Res , vol.45 , Issue.2-3 , pp. 144-158
    • Anolik, J.H.1    Looney, R.J.2    Lund, F.E.3
  • 33
    • 84875873134 scopus 로고    scopus 로고
    • B-cell targeted therapeutics in clinical development
    • Bluml S, McKeever K, Ettinger R, et al. B-cell targeted therapeutics in clinical development. Arthritis Res Ther 2013;15(Suppl 1):S4
    • (2013) Arthritis Res Ther , vol.15 , Issue.SUPPL. 1
    • Bluml, S.1    McKeever, K.2    Ettinger, R.3
  • 34
    • 33646483031 scopus 로고    scopus 로고
    • The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial
    • Emery P, Fleischmann R, Filipowicz-Sosnowska A, et al. The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial. Arthritis Rheum 2006;54(5):1390-400
    • (2006) Arthritis Rheum , vol.54 , Issue.5 , pp. 1390-1400
    • Emery, P.1    Fleischmann, R.2    Filipowicz-Sosnowska, A.3
  • 35
    • 33746961890 scopus 로고    scopus 로고
    • Rituximab for rheumatoid arthritis refractory to anti-Tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    • Cohen SB, Emery P, Greenwald MW, et al. Rituximab for rheumatoid arthritis refractory to anti-Tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006;54(9):2793-806
    • (2006) Arthritis Rheum , vol.54 , Issue.9 , pp. 2793-2806
    • Cohen, S.B.1    Emery, P.2    Greenwald, M.W.3
  • 36
    • 84856388514 scopus 로고    scopus 로고
    • Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a forty-eight-week randomized double-blind placebo-controlled parallel-group phase III trial
    • Rigby W, Tony HP, Oelke K, et al. Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial. Arthritis Rheum 2012;64(2):350-9
    • (2012) Arthritis Rheum , vol.64 , Issue.2 , pp. 350-359
    • Rigby, W.1    Tony, H.P.2    Oelke, K.3
  • 37
    • 84863841745 scopus 로고    scopus 로고
    • Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: The phase III FILM trial
    • Stohl W, Gomez-Reino J, Olech E, et al. Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: The phase III FILM trial. Ann Rheum Dis 2012;71(8):1289-96
    • (2012) Ann Rheum Dis , vol.71 , Issue.8 , pp. 1289-1296
    • Stohl, W.1    Gomez-Reino, J.2    Olech, E.3
  • 38
    • 84863012323 scopus 로고    scopus 로고
    • Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a forty-eight-week randomized doubleblind placebo-controlled parallel-group phase III trial
    • Tak PP, Mease PJ, Genovese MC, et al. Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a forty-eight-week randomized, doubleblind, placebo-controlled, parallel-group phase III trial. Arthritis Rheum 2012;64(2):360-70
    • (2012) Arthritis Rheum , vol.64 , Issue.2 , pp. 360-370
    • Tak, P.P.1    Mease, P.J.2    Genovese, M.C.3
  • 39
    • 84876889502 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with rheumatoid arthritis: A phase II, randomized, double-blind, placebo-controlled, dose-ranging Study
    • Stohl W, Merrill JT, McKay JD, et al. Efficacy and safety of belimumab in patients with rheumatoid arthritis: A phase II, randomized, double-blind, placebo-controlled, dose-ranging Study. J Rheumatol 2013;40(5):579-89
    • (2013) J Rheumatol , vol.40 , Issue.5 , pp. 579-589
    • Stohl, W.1    Merrill, J.T.2    McKay, J.D.3
  • 40
    • 84881480292 scopus 로고    scopus 로고
    • Tabalumab an anti-BAFF monoclonal antibody in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors
    • Genovese MC, Fleischmann RM, Greenwald M, et al. Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors. Ann Rheum Dis 2013;72(9):1461-8
    • (2013) Ann Rheum Dis , vol.72 , Issue.9 , pp. 1461-1468
    • Genovese, M.C.1    Fleischmann, R.M.2    Greenwald, M.3
  • 41
    • 84875715149 scopus 로고    scopus 로고
    • Tabalumab in rheumatoid arthritis patients with an inadequate response to methotrexate and naive to biologic therapy: A phase II randomized placebo-controlled trial
    • Genovese MC, Bojin S, Biagini IM, et al. Tabalumab in rheumatoid arthritis patients with an inadequate response to methotrexate and naive to biologic therapy: A phase II, randomized, placebo-controlled trial. Arthritis Rheum 2013;65(4):880-9
    • (2013) Arthritis Rheum , vol.65 , Issue.4 , pp. 880-889
    • Genovese, M.C.1    Bojin, S.2    Biagini, I.M.3
  • 42
    • 33845592936 scopus 로고    scopus 로고
    • Rituximab: Novel B-cell depletion therapy for the treatment of rheumatoid arthritis
    • Dass S, Vital EM, Emery P. Rituximab: Novel B-cell depletion therapy for the treatment of rheumatoid arthritis. Expert Opin Pharmacother 2006;7(18):2559-70
    • (2006) Expert Opin Pharmacother , vol.7 , Issue.18 , pp. 2559-2570
    • Dass, S.1    Vital, E.M.2    Emery, P.3
  • 43
    • 44849097480 scopus 로고    scopus 로고
    • Cutting edge: The dependence of plasma cells and independence of memory B cells on BAFF and APRIL
    • Benson MJ, Dillon SR, Castigli E, et al. Cutting edge: The dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol 2008;180(6):3655-9
    • (2008) J Immunol , vol.180 , Issue.6 , pp. 3655-3659
    • Benson, M.J.1    Dillon, S.R.2    Castigli, E.3
  • 44
    • 84880133587 scopus 로고    scopus 로고
    • The TNF family member APRIL dampens collagen-induced arthritis
    • Fernandez L, Salinas GF, Rocha C, et al. The TNF family member APRIL dampens collagen-induced arthritis. Ann Rheum Dis 2013;72(8):1367-74
    • (2013) Ann Rheum Dis , vol.72 , Issue.8 , pp. 1367-1374
    • Fernandez, L.1    Salinas, G.F.2    Rocha, C.3
  • 45
    • 84860390375 scopus 로고    scopus 로고
    • Ofatumumab a fully human anti-CD20 monoclonal antibody in biological-naive rheumatoid arthritis patients with an inadequate response to methotrexate: A randomised doubleblind placebo-controlled clinical trial
    • Taylor PC, Quattrocchi E, Mallett S, et al. Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: A randomised, doubleblind, placebo-controlled clinical trial. Ann Rheum Dis 2011;70(12):2119-25
    • (2011) Ann Rheum Dis , vol.70 , Issue.12 , pp. 2119-2125
    • Taylor, P.C.1    Quattrocchi, E.2    Mallett, S.3
  • 46
    • 0029875268 scopus 로고    scopus 로고
    • CAMPATH-1H in rheumatoid arthritis-An intravenous dose-ranging study
    • Isaacs JD, Manna VK, Rapson N, et al. CAMPATH-1H in rheumatoid arthritis-An intravenous dose-ranging study. Br J Rheumatol 1996;35(3):231-40
    • (1996) Br J Rheumatol , vol.35 , Issue.3 , pp. 231-240
    • Isaacs, J.D.1    Manna, V.K.2    Rapson, N.3
  • 47
    • 39749114393 scopus 로고    scopus 로고
    • Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: Twelve-year outcomes
    • Lorenzi AR, Clarke AM, Wooldridge T, et al. Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: Twelve-year outcomes. Arthritis Rheum 2008;58(2):370-5
    • (2008) Arthritis Rheum , vol.58 , Issue.2 , pp. 370-375
    • Lorenzi, A.R.1    Clarke, A.M.2    Wooldridge, T.3
  • 48
    • 79955569760 scopus 로고    scopus 로고
    • In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment
    • Roll P, Muhammad K, Schumann M, et al. In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment. Arthritis Rheum 2011;63(5):1255-64
    • (2011) Arthritis Rheum , vol.63 , Issue.5 , pp. 1255-1264
    • Roll, P.1    Muhammad, K.2    Schumann, M.3
  • 49
    • 79959807954 scopus 로고    scopus 로고
    • Impact of IL-6 receptor inhibition on human memory B cells in vivo: Impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells
    • Muhammad K, Roll P, Seibold T, et al. Impact of IL-6 receptor inhibition on human memory B cells in vivo: Impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells. Ann Rheum Dis 2011;70(8):1507-10
    • (2011) Ann Rheum Dis , vol.70 , Issue.8 , pp. 1507-1510
    • Muhammad, K.1    Roll, P.2    Seibold, T.3
  • 50
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-Tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
    • Emery P, Keystone E, Tony HP, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-Tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis 2008;67(11):1516-23
    • (2008) Ann Rheum Dis , vol.67 , Issue.11 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3
  • 51
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional diseasemodifying antirheumatic drug therapy study
    • Genovese MC, McKay JD, Nasonov EL, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional diseasemodifying antirheumatic drug therapy study. Arthritis Rheum 2008;58(10):2968-80
    • (2008) Arthritis Rheum , vol.58 , Issue.10 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3
  • 52
    • 78650464387 scopus 로고    scopus 로고
    • Clinical safety of tocilizumab in rheumatoid arthritis
    • Bannwarth B, Richez C. Clinical safety of tocilizumab in rheumatoid arthritis. Expert Opin Drug Saf 2011;10(1):123-31.
    • (2011) Expert Opin Drug Saf , vol.10 , Issue.1 , pp. 123-131
    • Bannwarth, B.1    Richez, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.