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Volumn 32, Issue 40, 2014, Pages 5212-5220

Fc receptor-targeting of immunogen as a strategy for enhanced antigen loading, vaccination, and protection using intranasally administered antigen-pulsed dendritic cells

Author keywords

Cancer; Chronic infection; Dendritic cell vaccine; Fc receptor targeted vaccine; Intranasal vaccine; Vaccine platform

Indexed keywords

ANTIGEN; DENDRITIC CELL VACCINE; FC RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 6; LIVE VACCINE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; BACTERIAL ANTIGEN; BACTERIAL VACCINE; CYTOKINE; FC RECEPTOR IIB;

EID: 84906046187     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2014.07.050     Document Type: Article
Times cited : (13)

References (50)
  • 1
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 5
    • 34748886192 scopus 로고    scopus 로고
    • Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting
    • Tacken P.J., de Vries I.J., Torensma R., Figdor C.G. Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting. Nat Rev Immunol 2007, 7:790-802.
    • (2007) Nat Rev Immunol , vol.7 , pp. 790-802
    • Tacken, P.J.1    de Vries, I.J.2    Torensma, R.3    Figdor, C.G.4
  • 6
    • 77954237034 scopus 로고    scopus 로고
    • Targeting a mimotope vaccine to activating Fcgamma receptors empowers dendritic cells to prime specific CD8+ T cell responses in tumor-bearing mice
    • Gil M., Bieniasz M., Wierzbicki A., Bambach B.J., Rokita H., Kozbor D. Targeting a mimotope vaccine to activating Fcgamma receptors empowers dendritic cells to prime specific CD8+ T cell responses in tumor-bearing mice. J Immunol 2009, 183:6808-6818.
    • (2009) J Immunol , vol.183 , pp. 6808-6818
    • Gil, M.1    Bieniasz, M.2    Wierzbicki, A.3    Bambach, B.J.4    Rokita, H.5    Kozbor, D.6
  • 7
    • 45949101974 scopus 로고    scopus 로고
    • Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    • Rawool D.B., Bitsaktsis C., Li Y., Gosselin D.R., Lin Y., Kurkure N.V., et al. Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis. J Immunol 2008, 180:5548-5557.
    • (2008) J Immunol , vol.180 , pp. 5548-5557
    • Rawool, D.B.1    Bitsaktsis, C.2    Li, Y.3    Gosselin, D.R.4    Lin, Y.5    Kurkure, N.V.6
  • 8
    • 0034046181 scopus 로고    scopus 로고
    • Regulation of antibody responses via antibodies, complement, and Fc receptors
    • Heyman B. Regulation of antibody responses via antibodies, complement, and Fc receptors. Ann Rev Immunol 2000, 18:709-737.
    • (2000) Ann Rev Immunol , vol.18 , pp. 709-737
    • Heyman, B.1
  • 9
    • 0034671631 scopus 로고    scopus 로고
    • Targeting weak antigens to CD64 elicits potent humoral responses in human CD64 transgenic mice
    • Keler T., Guyre P.M., Vitale L.A., Sundarapandiyan K., van De Winkel J.G., Deo Y.M., et al. Targeting weak antigens to CD64 elicits potent humoral responses in human CD64 transgenic mice. J Immunol 2000, 165:6738-6742.
    • (2000) J Immunol , vol.165 , pp. 6738-6742
    • Keler, T.1    Guyre, P.M.2    Vitale, L.A.3    Sundarapandiyan, K.4    van De Winkel, J.G.5    Deo, Y.M.6
  • 10
    • 13344259328 scopus 로고    scopus 로고
    • Antigen targeting to myeloid-specific human Fc gamma RI/CD64 triggers enhanced antibody responses in transgenic mice
    • Heijnen I.A., van Vugt M.J., Fanger N.A., Graziano R.F., de Wit T.P., Hofhuis F.M., et al. Antigen targeting to myeloid-specific human Fc gamma RI/CD64 triggers enhanced antibody responses in transgenic mice. J Clin Invest 1996, 97:331-338.
    • (1996) J Clin Invest , vol.97 , pp. 331-338
    • Heijnen, I.A.1    van Vugt, M.J.2    Fanger, N.A.3    Graziano, R.F.4    de Wit, T.P.5    Hofhuis, F.M.6
  • 11
    • 0026445735 scopus 로고
    • Enhanced antigen presentation using human Fc gamma receptor (monocyte/macrophage)-specific immunogens
    • Gosselin E.J., Wardwell K., Gosselin D.R., Alter N., Fisher J.L., Guyre P.M. Enhanced antigen presentation using human Fc gamma receptor (monocyte/macrophage)-specific immunogens. J Immunol 1992, 149:3477-3481.
    • (1992) J Immunol , vol.149 , pp. 3477-3481
    • Gosselin, E.J.1    Wardwell, K.2    Gosselin, D.R.3    Alter, N.4    Fisher, J.L.5    Guyre, P.M.6
  • 12
    • 84863275023 scopus 로고    scopus 로고
    • Mucosal immunization with an unadjuvanted vaccine that targets Streptococcus pneumoniae PspA to human Fcgamma receptor type I protects against pneumococcal infection through complement- and lactoferrin-mediated bactericidal activity
    • Bitsaktsis C., Iglesias B.V., Li Y., Colino J., Snapper C.M., Hollingshead S.K., et al. Mucosal immunization with an unadjuvanted vaccine that targets Streptococcus pneumoniae PspA to human Fcgamma receptor type I protects against pneumococcal infection through complement- and lactoferrin-mediated bactericidal activity. Infect Immun 2012, 80:1166-1180.
    • (2012) Infect Immun , vol.80 , pp. 1166-1180
    • Bitsaktsis, C.1    Iglesias, B.V.2    Li, Y.3    Colino, J.4    Snapper, C.M.5    Hollingshead, S.K.6
  • 13
    • 0037438477 scopus 로고    scopus 로고
    • A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation
    • Sedlik C., Orbach D., Veron P., Schweighoffer E., Colucci F., Gamberale R., et al. A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation. J Immunol 2003, 170:846-852.
    • (2003) J Immunol , vol.170 , pp. 846-852
    • Sedlik, C.1    Orbach, D.2    Veron, P.3    Schweighoffer, E.4    Colucci, F.5    Gamberale, R.6
  • 14
    • 84873737168 scopus 로고    scopus 로고
    • Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen
    • Iglesias B.V., Bitsaktsis C., Pham G., Drake J.R., Hazlett K.R., Porter K., et al. Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen. Immunol Cell Biol 2013, 91:139-148.
    • (2013) Immunol Cell Biol , vol.91 , pp. 139-148
    • Iglesias, B.V.1    Bitsaktsis, C.2    Pham, G.3    Drake, J.R.4    Hazlett, K.R.5    Porter, K.6
  • 16
    • 78650993712 scopus 로고    scopus 로고
    • In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine
    • Vilekar P., Awasthi V., Lagisetty P., King C., Shankar N., Awasthi S. In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine. BMC Immunol 2010, 11:60.
    • (2010) BMC Immunol , vol.11 , pp. 60
    • Vilekar, P.1    Awasthi, V.2    Lagisetty, P.3    King, C.4    Shankar, N.5    Awasthi, S.6
  • 17
    • 84884397574 scopus 로고    scopus 로고
    • Dendritic cell migration through the lymphatic vasculature to lymph nodes
    • Platt A.M., Randolph G.J. Dendritic cell migration through the lymphatic vasculature to lymph nodes. Adv Immunol 2013, 120:51-68.
    • (2013) Adv Immunol , vol.120 , pp. 51-68
    • Platt, A.M.1    Randolph, G.J.2
  • 18
    • 33845411595 scopus 로고    scopus 로고
    • Regulated expression of FcgammaR in human dendritic cells controls cross-presentation of antigen-antibody complexes
    • Liu Y., Gao X., Masuda E., Redecha P.B., Blank M.C., Pricop L. Regulated expression of FcgammaR in human dendritic cells controls cross-presentation of antigen-antibody complexes. J Immunol 2006, 177:8440-8447.
    • (2006) J Immunol , vol.177 , pp. 8440-8447
    • Liu, Y.1    Gao, X.2    Masuda, E.3    Redecha, P.B.4    Blank, M.C.5    Pricop, L.6
  • 19
    • 65249101473 scopus 로고    scopus 로고
    • Differential requirements for protection against mucosal challenge with Francisella tularensis in the presence versus absence of cholera toxin B and inactivated F. tularensis
    • Bitsaktsis C., Rawool D.B., Li Y., Kurkure N.V., Iglesias B., Gosselin E.J. Differential requirements for protection against mucosal challenge with Francisella tularensis in the presence versus absence of cholera toxin B and inactivated F. tularensis. J Immunol 2009, 182:4899-4909.
    • (2009) J Immunol , vol.182 , pp. 4899-4909
    • Bitsaktsis, C.1    Rawool, D.B.2    Li, Y.3    Kurkure, N.V.4    Iglesias, B.5    Gosselin, E.J.6
  • 20
    • 80052358761 scopus 로고    scopus 로고
    • Development of tolerogenic dendritic cells and regulatory T cells favors exponential bacterial growth and survival during early respiratory tularemia
    • Periasamy S., Singh A., Sahay B., Rahman T., Feustel P.J., Pham G.H., et al. Development of tolerogenic dendritic cells and regulatory T cells favors exponential bacterial growth and survival during early respiratory tularemia. J Leuk Biol 2011, 90:493-507.
    • (2011) J Leuk Biol , vol.90 , pp. 493-507
    • Periasamy, S.1    Singh, A.2    Sahay, B.3    Rahman, T.4    Feustel, P.J.5    Pham, G.H.6
  • 21
    • 28444494729 scopus 로고    scopus 로고
    • Essential role for humoral immunity during Ehrlichia infection in immunocompetent mice
    • Yager E., Bitsaktsis C., Nandi B., McBride J.W., Winslow G. Essential role for humoral immunity during Ehrlichia infection in immunocompetent mice. Infect Immun 2005, 73:8009-8016.
    • (2005) Infect Immun , vol.73 , pp. 8009-8016
    • Yager, E.1    Bitsaktsis, C.2    Nandi, B.3    McBride, J.W.4    Winslow, G.5
  • 22
    • 1842431587 scopus 로고    scopus 로고
    • Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection
    • Feng H.M., Whitworth T., Olano J.P., Popov V.L., Walker D.H. Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection. Infect Immun 2004, 72:2222-2228.
    • (2004) Infect Immun , vol.72 , pp. 2222-2228
    • Feng, H.M.1    Whitworth, T.2    Olano, J.P.3    Popov, V.L.4    Walker, D.H.5
  • 23
    • 0035003647 scopus 로고    scopus 로고
    • Intracellular antibody neutralizes Listeria growth
    • Edelson B.T., Unanue E.R. Intracellular antibody neutralizes Listeria growth. Immunity 2001, 14:503-512.
    • (2001) Immunity , vol.14 , pp. 503-512
    • Edelson, B.T.1    Unanue, E.R.2
  • 24
    • 0031916168 scopus 로고    scopus 로고
    • Antibody-mediated protection against intracellular pathogens
    • Casadevall A. Antibody-mediated protection against intracellular pathogens. Trends Microbiol 1998, 6:102-107.
    • (1998) Trends Microbiol , vol.6 , pp. 102-107
    • Casadevall, A.1
  • 25
    • 56649117447 scopus 로고    scopus 로고
    • Levofloxacin rescues mice from lethal intra-nasal infections with virulent Francisella tularensis and induces immunity and production of protective antibody
    • Klimpel G.R., Eaves-Pyles T., Moen S.T., Taormina J., Peterson J.W., Chopra A.K., et al. Levofloxacin rescues mice from lethal intra-nasal infections with virulent Francisella tularensis and induces immunity and production of protective antibody. Vaccine 2008, 26:6874-6882.
    • (2008) Vaccine , vol.26 , pp. 6874-6882
    • Klimpel, G.R.1    Eaves-Pyles, T.2    Moen, S.T.3    Taormina, J.4    Peterson, J.W.5    Chopra, A.K.6
  • 26
    • 79953037633 scopus 로고    scopus 로고
    • Antibodies contribute to effective vaccination against respiratory infection by type A Francisella tularensis strains
    • Mara-Koosham G., Hutt J.A., Lyons C.R., Wu T.H. Antibodies contribute to effective vaccination against respiratory infection by type A Francisella tularensis strains. Infect Immun 2011, 79:1770-1778.
    • (2011) Infect Immun , vol.79 , pp. 1770-1778
    • Mara-Koosham, G.1    Hutt, J.A.2    Lyons, C.R.3    Wu, T.H.4
  • 27
    • 34748903561 scopus 로고    scopus 로고
    • Innate and adaptive immunity to Francisella
    • Elkins K.L., Cowley S.C., Bosio C.M. Innate and adaptive immunity to Francisella. Ann NY Acad Sci 2007, 1105:284-324.
    • (2007) Ann NY Acad Sci , vol.1105 , pp. 284-324
    • Elkins, K.L.1    Cowley, S.C.2    Bosio, C.M.3
  • 28
    • 84869879671 scopus 로고    scopus 로고
    • Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria
    • Ryden P., Twine S., Shen H., Harris G., Chen W., Sjostedt A., et al. Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria. Mol Immunol 2013, 54:58-67.
    • (2013) Mol Immunol , vol.54 , pp. 58-67
    • Ryden, P.1    Twine, S.2    Shen, H.3    Harris, G.4    Chen, W.5    Sjostedt, A.6
  • 29
    • 70449501815 scopus 로고    scopus 로고
    • Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis
    • Lin Y., Ritchea S., Logar A., Slight S., Messmer M., Rangel-Moreno J., et al. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 2009, 31:799-810.
    • (2009) Immunity , vol.31 , pp. 799-810
    • Lin, Y.1    Ritchea, S.2    Logar, A.3    Slight, S.4    Messmer, M.5    Rangel-Moreno, J.6
  • 30
    • 77955285620 scopus 로고    scopus 로고
    • The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis
    • Markel G., Bar-Haim E., Zahavy E., Cohen H., Cohen O., Shafferman A., et al. The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis. PLoS ONE 2010, 5:e11176.
    • (2010) PLoS ONE , vol.5
    • Markel, G.1    Bar-Haim, E.2    Zahavy, E.3    Cohen, H.4    Cohen, O.5    Shafferman, A.6
  • 31
    • 84884216378 scopus 로고    scopus 로고
    • Interleukin-17 protects against the francisella tularensis live vaccine strain but not against a virulent F. tularensis type A strain
    • Skyberg J.A., Rollins M.F., Samuel J.W., Sutherland M.D., Belisle J.T., Pascual D.W. Interleukin-17 protects against the francisella tularensis live vaccine strain but not against a virulent F. tularensis type A strain. Infect Immun 2013, 81:3099-3105.
    • (2013) Infect Immun , vol.81 , pp. 3099-3105
    • Skyberg, J.A.1    Rollins, M.F.2    Samuel, J.W.3    Sutherland, M.D.4    Belisle, J.T.5    Pascual, D.W.6
  • 32
    • 0027511113 scopus 로고
    • Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from l-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice
    • Green S.J., Nacy C.A., Schreiber R.D., Granger D.L., Crawford R.M., Meltzer M.S., et al. Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from l-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice. Infect Immun 1993, 61:689-698.
    • (1993) Infect Immun , vol.61 , pp. 689-698
    • Green, S.J.1    Nacy, C.A.2    Schreiber, R.D.3    Granger, D.L.4    Crawford, R.M.5    Meltzer, M.S.6
  • 33
    • 0030031886 scopus 로고    scopus 로고
    • Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice
    • Takai T., Ono M., Hikida M., Ohmori H., Ravetch J.V. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 1996, 379:346-349.
    • (1996) Nature , vol.379 , pp. 346-349
    • Takai, T.1    Ono, M.2    Hikida, M.3    Ohmori, H.4    Ravetch, J.V.5
  • 34
    • 84857038613 scopus 로고    scopus 로고
    • Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone
    • Sharp P.E., Martin-Ramirez J., Boross P., Mangsbo S.M., Reynolds J., Moss J., et al. Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone. Mol Immunol 2012, 50:49-56.
    • (2012) Mol Immunol , vol.50 , pp. 49-56
    • Sharp, P.E.1    Martin-Ramirez, J.2    Boross, P.3    Mangsbo, S.M.4    Reynolds, J.5    Moss, J.6
  • 35
    • 84885453544 scopus 로고    scopus 로고
    • Immunotherapy targeting inhibitory Fcgamma receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization
    • Williams E.L., Tutt A.L., Beers S.A., French R.R., Chan C.H., Cox K.L., et al. Immunotherapy targeting inhibitory Fcgamma receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization. J Immunol 2013, 191:4130-4140.
    • (2013) J Immunol , vol.191 , pp. 4130-4140
    • Williams, E.L.1    Tutt, A.L.2    Beers, S.A.3    French, R.R.4    Chan, C.H.5    Cox, K.L.6
  • 36
    • 80051866221 scopus 로고    scopus 로고
    • Immunology. The adjuvant effects of antibodies
    • Smyth M.J., Kershaw M.H. Immunology. The adjuvant effects of antibodies. Science 2011, 333:944-945.
    • (2011) Science , vol.333 , pp. 944-945
    • Smyth, M.J.1    Kershaw, M.H.2
  • 37
    • 0037124367 scopus 로고    scopus 로고
    • Inducing tumor immunity through the selective engagement of activating Fcgamma receptors on dendritic cells
    • Kalergis A.M., Ravetch J.V. Inducing tumor immunity through the selective engagement of activating Fcgamma receptors on dendritic cells. J Exp Med 2002, 195:1653-1659.
    • (2002) J Exp Med , vol.195 , pp. 1653-1659
    • Kalergis, A.M.1    Ravetch, J.V.2
  • 38
    • 15244360555 scopus 로고    scopus 로고
    • Current vaccine adjuvants: an overview of a diverse class
    • Kensil C.R., Mo A.X., Truneh A. Current vaccine adjuvants: an overview of a diverse class. Front Biosci 2004, 9:2972-2988.
    • (2004) Front Biosci , vol.9 , pp. 2972-2988
    • Kensil, C.R.1    Mo, A.X.2    Truneh, A.3
  • 39
    • 0036499205 scopus 로고    scopus 로고
    • Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8+ CTL responses in vivo
    • Schuurhuis D.H., Ioan-Facsinay A., Nagelkerken B., van Schip J.J., Sedlik C., Melief C.J., et al. Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8+ CTL responses in vivo. J Immunol 2002, 168:2240-2246.
    • (2002) J Immunol , vol.168 , pp. 2240-2246
    • Schuurhuis, D.H.1    Ioan-Facsinay, A.2    Nagelkerken, B.3    van Schip, J.J.4    Sedlik, C.5    Melief, C.J.6
  • 40
    • 36248992389 scopus 로고    scopus 로고
    • Immunization with heat-killed Francisella tularensis LVS elicits protective antibody-mediated immunity
    • Lavine C.L., Clinton S.R., Angelova-Fischer I., Marion T.N., Bina X.R., Bina J.E., et al. Immunization with heat-killed Francisella tularensis LVS elicits protective antibody-mediated immunity. Eur J Immunol 2007, 37:3007-3020.
    • (2007) Eur J Immunol , vol.37 , pp. 3007-3020
    • Lavine, C.L.1    Clinton, S.R.2    Angelova-Fischer, I.3    Marion, T.N.4    Bina, X.R.5    Bina, J.E.6
  • 41
    • 0034020889 scopus 로고    scopus 로고
    • Purified lipopolysaccharide from Francisella tularensis live vaccine strain (LVS) induces protective immunity against LVS infection that requires B cells and gamma interferon
    • Dreisbach V.C., Cowley S., Elkins K.L. Purified lipopolysaccharide from Francisella tularensis live vaccine strain (LVS) induces protective immunity against LVS infection that requires B cells and gamma interferon. Infect Immun 2000, 68:1988-1996.
    • (2000) Infect Immun , vol.68 , pp. 1988-1996
    • Dreisbach, V.C.1    Cowley, S.2    Elkins, K.L.3
  • 42
    • 0027931231 scopus 로고
    • Transfer of immunity against lethal murine Francisella infection by specific antibody depends on host gamma interferon and T cells
    • Rhinehart-Jones T.R., Fortier A.H., Elkins K.L. Transfer of immunity against lethal murine Francisella infection by specific antibody depends on host gamma interferon and T cells. Infect Immun 1994, 62:3129-3137.
    • (1994) Infect Immun , vol.62 , pp. 3129-3137
    • Rhinehart-Jones, T.R.1    Fortier, A.H.2    Elkins, K.L.3
  • 43
    • 27744578295 scopus 로고    scopus 로고
    • Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma-dependent mechanism
    • Conlan W., Shen H., Kuolee R., Zhao X., Chen W. Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma-dependent mechanism. Vaccine 2005, 23:2477-2485.
    • (2005) Vaccine , vol.23 , pp. 2477-2485
    • Conlan, W.1    Shen, H.2    Kuolee, R.3    Zhao, X.4    Chen, W.5
  • 44
    • 77954731553 scopus 로고    scopus 로고
    • Lung CD4-CD8-double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain
    • Cowley S.C., Meierovics A.I., Frelinger J.A., Iwakura Y., Elkins K.L. Lung CD4-CD8-double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain. J Immunol 2010, 184:5791-5801.
    • (2010) J Immunol , vol.184 , pp. 5791-5801
    • Cowley, S.C.1    Meierovics, A.I.2    Frelinger, J.A.3    Iwakura, Y.4    Elkins, K.L.5
  • 46
    • 27744576801 scopus 로고    scopus 로고
    • Cell surface recycling of internalized antigen permits dendritic cell priming of B cells
    • Bergtold A., Desai D.D., Gavhane A., Clynes R. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 2005, 23:503-514.
    • (2005) Immunity , vol.23 , pp. 503-514
    • Bergtold, A.1    Desai, D.D.2    Gavhane, A.3    Clynes, R.4
  • 47
    • 0345414168 scopus 로고    scopus 로고
    • Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake
    • Yada A., Ebihara S., Matsumura K., Endo S., Maeda T., Nakamura A., et al. Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol 2003, 225:21-32.
    • (2003) Cell Immunol , vol.225 , pp. 21-32
    • Yada, A.1    Ebihara, S.2    Matsumura, K.3    Endo, S.4    Maeda, T.5    Nakamura, A.6
  • 48
    • 77955261234 scopus 로고    scopus 로고
    • CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells
    • Yewdall A.W., Drutman S.B., Jinwala F., Bahjat K.S., Bhardwaj N. CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells. PLoS ONE 2010, 5:e11144.
    • (2010) PLoS ONE , vol.5
    • Yewdall, A.W.1    Drutman, S.B.2    Jinwala, F.3    Bahjat, K.S.4    Bhardwaj, N.5
  • 49
    • 0035801333 scopus 로고    scopus 로고
    • Killing of dendritic cells: a life cut short or a purposeful death?
    • Ronchese F., Hermans I.F. Killing of dendritic cells: a life cut short or a purposeful death?. J Exp Med 2001, 194:F23-F26.
    • (2001) J Exp Med , vol.194
    • Ronchese, F.1    Hermans, I.F.2
  • 50
    • 36749045921 scopus 로고    scopus 로고
    • Mechanisms of dendritic cell-based vaccination against infection
    • Fajardo-Moser M., Berzel S., Moll H. Mechanisms of dendritic cell-based vaccination against infection. Int J Med Microbiol 2008, 298:11-20.
    • (2008) Int J Med Microbiol , vol.298 , pp. 11-20
    • Fajardo-Moser, M.1    Berzel, S.2    Moll, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.