The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis

PLoS ONE

Volumn 5, Issue 6, 2010, Pages

  Markel, Gal ^a   Bar Haim, Erez ^a   Zahavy, Eran ^a   Cohen, Hila ^a   Cohen, Ofer ^a   Shafferman, Avigdor ^a   Velan, Baruch ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; LIVE VACCINE; CYTOKINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; CYTOKINE PRODUCTION; DEATH; FRANCISELLA TULARENSIS; HOST RESISTANCE; LAVAGE; LETHALITY; LYMPHOCYTE; MOUSE; NONHUMAN; TH17 CELL; TULAREMIA; ANIMAL; BIOSYNTHESIS; EXPOSURE; IMMUNOLOGY; LUNG LAVAGE; PATHOGENICITY; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); FRANCISELLA TULARENSIS; MURINAE;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; FRANCISELLA TULARENSIS; INHALATION EXPOSURE; INTERLEUKIN-17; MICE;

EID: 77955285620     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011176     Document Type: Article

References (48)

1. Ellis JP, Oyston C, Green M, Titball RW (2002) Tularemia. Clin Microbiol Rev 15: 631-646.
2. Sjostedt A (2007) Tularemia: history, epidemiology, pathogen physiology and clinical manifestations. Ann NY Acad Sci 1005: 1-29.
3. Tarvnik A (1989) Nature of protective immunity to Francisella tularensis. Rev Infect Dis 11: 440-451.
4. Dennis DT, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, et al. (2001) Tularemia as a biological weapon: medical and public health management. JAMA 285: 2763-2773.
5. Oyston PC, Sjostedt A, Titball RW (2004) Tularaemia: bioterrorism defense renews interest in Francisella tularensis. Nat Rev Microbiol 2: 967-978.
6. Elkins KL, Cowley SC, Bosio CM (2003) Innate and adaptive immune responses to an intracellular bacterium: Francisella tularensis live vaccine strain. Microbes Infect 5: 132-142.
7. Bosio CM, Dow W (2005) Francisella tularensis induces aberrant activation of pulmonary dendiritic cells. J Immunol 175: 6792-6801.
8. Hall JD, Woolard MD, Gunn BM, Craven RR, Taft-Benz S, et al. (2008) Infected-host-cell repertoire and cellular response in the lung following inhalation of Franciella tularensis Schu S4, LVS or U112. Infect Immun 76: 5843-5852.
9. Bar-Haim E, Gat O, Markel G, Cohen H, Shafferman A, et al. (2008) Interrelationship between dendritic cell trafficking and Francisella tularensis dissemination following airway infection. PLoS Pathog e1000211. Epub 2008 Nov 21.
10. Lopez MC, Duckett NS, Baron SD, Metzger DW (2004) Earley activation of NK cells after lung infection with the intracellular bacterium, Francisella tularensis LVS. Cell Immunol 232: 75-85.
11. Duckett NS, Olmos S, Durrant DM, Metzger DW (2005) Intranasal interleukin- 12 treatment for protection against respiratory infection with the Francisella tularensis Live Vaccine Strain. Infect Immun 73: 2306-2311.
12. Baron SD, Singh R, Metzger DW (2007) Inactivated Francisella tularensis Live Vaccine Strain protects against respiratory tularemia by intranasal vaccination in an immunoglobulin A-dependent fashion. Infect Immun 75: 2152-2162.
13. Elkins KL, Rhinehart-Jones TR, Culkin SJ, Yee D, Winegar RK (1996) Minimal requirements for murine resistance to infection with Francisella tularensis LVS. Infect Immun 64: 3288-3293.
14. Conlan JW, Sjöstedt A, North RJ (1994) CD4+ and CD8+ T-cell-dependent and -independent host defense mechanisms can operate to control and resolve primary and secondary Francisella tularensis LVS infection in mice. Infect Immun 62: 5603-5607.
15. Cowley SC, Hamilaton E, Frelinger JA, Su J, Forman J, et al. (2005) CD4_CD8_ T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202: 309-319.
16. Elkins KL, Cowley SC, Bosio CM (2007) Innate and adaptive immunity to Francisella. Ann NY Acad Sci 1105: 284-324.
17. Yee D, Rhinehart-Jones TR, Elkins KL (1996) Loss of either CD4+ or CD8+ T cells does not affect the magnitude of protective immunity to an intracellular pathogen, Francisella tularensis strain LVS. J Immunol 157: 5042-5048.
18. Chen W, KuoLee R, Shen H, Conlan JW (2004) Susceptibility of immunodeficient mice to aerosol and systemic infection with virulent strains of Francisella tularensis. Microb Pathog 36: 311-318.
19. Leiby DA, Fortier AH, Crawford RM, Schreiber RD, Nacy CA (1992) In vivo modulation of the murine immune response to Francisella tularensis LVS by administration of anticytokine antibodies. Infect Immun 60: 84-89.
20. Elkins KL, Rhinehart-Jones T, Nacy CA, Winegar RK, Fortier AH (1993) Tcell- independent resistance to infection and generation of immunity to Francisella tularensis. Infect Immun 61: 823-829.
21. Fortier AH, Polsinelli T, Green SJ, Nacy CA (1992) Activation of macrophages for destruction of Francisella tularensis: identification of cytokines, effector cells and effector molecules. Infect Immun 60: 817-825.
22. Taylor GA, Feng CG, Sher A (2007) Control of IFN-g-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). Microbes and Infection 9: 1644-1651.
23. Elkins KL, Cooper A, Colombini SM, Cowley SC, Kieffer TL (2002) In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70. Infect Immun 70: 1936-1948.
24. Collazo CM, Meierovics AI, De Pascalis R, Wu TH, Lyons CR, et al. (2009) T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria. Infect Immun 77: 2010-2021.
25. Cowley SC, Elkins KL (2003) Multiple T cell subsets control Francisella tularensis LVS intracellular growth without stimulation through macrophage interferon g receptors. J Exp Med 198: 379-389.
26. Iawkura Y, Nakae S, Saijo S, Ishigame H (2008) The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immun Rev 26: 57-79.
27. Nembrini C, Marsland BJ, Kopf M (2009) IL-17-producing T cells in lung immunity and inflammation. J Allergy Clin Immunol 123: 986-994.
28. Curtis MM, Way SS (2009) Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 126: 177-185.
29. Roark CL, Simonian PL, Fonteno AP, Born WK, O'brien RL (2008) cd T cells: an important source of IL-17. Curr Opin Immunol 20: 353-357.
30. Woolard MD, Hensley LL, Kawula TH, Frelinger JA (2008) Respiratory Francisella tularensis Live Vaccine Strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells. Infect Immun 76: 2651-2659.
31. Butchar JP, Rajaram MVS, Ganesan LP, Parsa KVL, Clay CD, et al. (2007) Francisella tularensis induces IL-23 production in human monocytes. J Immunol 178: 4445-4454.
32. Lyons R, Wu T (2007) Animal models of Francisella Tularensis infection. Ann NY Acad Sci 1105: 238-265.
33. Bosio CM, Bielefeldt-Ohmann, Belisle JT (2007) Active suppression of the pulmonary immune response by Francisella tularensis Schu4. J Immunol 178: 4538-4547.
34. Lin Y, Ritchea S, Logar A, Slight S, Messmer M, Rangel-Moreno J, Guglani L, Alcorn JF, Strawbridge H, Park SM, Onishi R, Nyugen N, Walter MJ, Pociask D, Randall TD, Gaffen SL, Iwakura Y, Kolls JK, Khader SA (2009) Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 31: 799-810.
35. Cowley SC, Meierovics AI, Frelinger JA, Iwakura Y, Elkins KL (2010) Lung CD4-CD8- Double-Negative T Cells Are Prominent Producers of IL-17A and IFN-{gamma} during Primary Respiratory Murine Infection with Francisella tularensis Live Vaccine Strain. J Immunol, 2010 Apr 14. Epub ahead of print.
36. Butchar JP, Cremer TJ, Clay CD, Gavrilin MA, Wewers MD, et al. (2008) Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion. PLoS ONE e2924.
37. Woolard MD, Wilson JE, Hensley LL, Jania LA, Kawula TH, et al. (2007) Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like response. J Immunol 178: 2065-2074.
38. Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7: 145-173.
39. Pulendran B (2004) Modulating Th1/Th2 responses with microbes, dendritic cells, and pathogen recognition receptors. Immun Res 29: 187-196.
40. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, et al. (2000) Novel p19 protein engages Il-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725.
41. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, et al. (2006) The orphan nuclear receptor RORct directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133
42. Martin B, Hirota K, Cua DJ, Stockinger B, Veldhoen M (2009) Interleukin-17- producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 31: 321-30.
43. Poquet Y, Kroca M, Halary F, Stenmark S, Peyrat MA, et al. (1998) Expansion of Vc9Vd2 T cells is triggered by Francisella tularensis-derived phosphoantigens in tularemia but not after tularemia vaccination. Infect Immun 66: 2107-2114.
44. Kroca M, Tarnvik A, Sjostedt A (2000) The proportion of circulating cd T cells increases after the first week of onset of tularaemia and remains elevated for more than a year. Clin Exp Immunol 120: 280-284.
45. Ye PF, Rodrigez FH, Kanaly S, Stocking KL, Schurr J, et al. (2001) Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony stimulating factor expression, neutrophil recruitment and host defense. J Exp Med 194: 529-527.
46. Kolls JK, Linden A (2004) Interleukin-17 family members and inflammation. Immunity 21: 467-476.
47. Cowley SC, Myltseva SV, Nano FE (1996) Phase variation in Francisella tularensis affecting intracellular growth, lipopolysaccharide antigenicity and nitric oxide production. Mol Microbiol 20: 867-874.
48. Overbergh L, Giulietti A, Valckx D, Decallonne R, Bouillon R, et al. (2003) The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J Biomol Tech 14: 33-43.