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Volumn 9, Issue 11, 2013, Pages 2445-2452

Dendritic cell based vaccines for HIV infection: The way ahead

Author keywords

Dendritic cells; Functional cure; HIV; T cell responses; Therapeutic vaccine

Indexed keywords

ADENOSINE DEAMINASE; DENDRITIC CELL VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOLOGICAL ADJUVANT; MESSENGER RNA;

EID: 84887445284     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.25876     Document Type: Review
Times cited : (57)

References (73)
  • 3
    • 79952113495 scopus 로고    scopus 로고
    • Newsmaker interview: Michel Sidibé. New HIV infections drop, but treatment demands rise
    • Interview by Jon Cohen PMID: 21127221
    • Sidibé M. Newsmaker interview: Michel Sidibé. New HIV infections drop, but treatment demands rise. Interview by Jon Cohen. Science 2010; 330: 1301; PMID: 21127221; http://dx.doi.org/10.1126/science.330.6009.1301
    • (2010) Science , vol.330 , pp. 1301
    • Sidibé, M.1
  • 4
    • 3042807072 scopus 로고    scopus 로고
    • Therapeutic vaccines for chronic infections
    • DOI 10.1126/science.1100600
    • Autran B, Carcelain G, Combadiere B, Debre P. Therapeutic vaccines for chronic infections. Science 2004; 305: 205-8; PMID: 15247470; http://dx.doi.org/10.112 6/science.1100 60 0 (Pubitemid 38886726)
    • (2004) Science , vol.305 , Issue.5681 , pp. 205-208
    • Autran, B.1    Carcelain, G.2    Combadiere, B.3    Debre, P.4
  • 5
    • 0034330601 scopus 로고    scopus 로고
    • Evaluation of HIV-1 immunogen an immunologic modifer administered to patients infected with HIV having 300 to 549 x 106)/L CD4 cell counts: A randomized controlled trial
    • PMID: 11056590
    • Kahn JO, Cherng DW, Mayer K, Murray H, Lagakos S. Evaluation of HIV-1 immunogen, an immunologic modifer, administered to patients infected with HIV having 300 to 549 x 10(6)/L CD4 cell counts: A randomized controlled trial. JAMA 2000; 284: 2193-202; PMID: 11056590; http://dx.doi.org/10.1001/jama.284.17.2193
    • (2000) JAMA , vol.284 , pp. 2193-2202
    • Kahn, J.O.1    Cherng, D.W.2    Mayer, K.3    Murray, H.4    Lagakos, S.5
  • 6
    • 33645118800 scopus 로고    scopus 로고
    • Cellular immune responses in asymptomatic human immunodefciency virus type 1 (HIV-1) infection and effects of vaccination with recombinant envelope glycoprotein of HIV-1
    • PMID: 16425996
    • Gorse GJ, Simionescu RE, Patel GB. Cellular immune responses in asymptomatic human immunodefciency virus type 1 (HIV-1) infection and effects of vaccination with recombinant envelope glycoprotein of HIV-1. Clin Vaccine Immunol 2006; 13: 26-32; PMID: 16425996; http://dx.doi.org/10.1128/CVI.13.1.26- 32.2006
    • (2006) Clin Vaccine Immunol , vol.13 , pp. 26-32
    • Gorse, G.J.1    Simionescu, R.E.2    Patel, G.B.3
  • 7
    • 24044438267 scopus 로고    scopus 로고
    • Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: Safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine
    • Dorrell L, Yang H, Iversen AK, Conlon C, Suttill A, Lancaster M, et al. Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine. AIDS 2005; 19: 1321-3; PMID: 16052088; http://dx.doi.org/10.1097/ 01.aids.0000180104.65640.16 (Pubitemid 41224902)
    • (2005) AIDS , vol.19 , Issue.12 , pp. 1321-1323
    • Dorrell, L.1    Yang, H.2    Iversen, A.K.N.3    Conlon, C.4    Suttill, A.5    Lancaster, M.6    Dong, T.7    Cebere, I.8    Edwards, A.9    Rowland-Jones, S.10    Hanke, T.11    McMichael, A.J.12
  • 9
    • 80051668754 scopus 로고    scopus 로고
    • Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection Workshop in dendritic cell-based vaccine clinical trials in HIV-1
    • PMID 21791232
    • Ga rcía F, R out y JP. Cha llenges in dendritic cells-based therapeutic vaccination in HIV-1 infection Workshop in dendritic cell-based vaccine clinical trials in HIV-1. Vaccine 2011; 29: 6454-63; PMID: 21791232; http://dx.doi.org/10.1016/j.vaccine.2011.07.043
    • (2011) Vaccine , vol.29 , pp. 6454-6463
    • García, F.1    Routy, J.P.2
  • 10
    • 78650311033 scopus 로고    scopus 로고
    • Comprehensive analysis of virus-specifc T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine
    • ORVACS Study Group PMID: 21076273
    • Papagno L, Alter G, Assoumou L, Murphy RL, Garcia F, Clotet B, et al.; ORVACS Study Group. Comprehensive analysis of virus-specifc T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine. AIDS 2011; 25: 27-36; PMID: 21076273; http://dx.doi.org/10.1097/QAD.0b013e328340fe55
    • (2011) AIDS , vol.25 , pp. 27-36
    • Papagno, L.1    Alter, G.2    Assoumou, L.3    Murphy, R.L.4    Garcia, F.5    Clotet, B.6
  • 11
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • DOI 10.1038/32588
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 1998 Mar 19;392: 245-252. (Pubitemid 28155090)
    • (1998) Nature , vol.392 , Issue.6673 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 12
    • 33750378183 scopus 로고    scopus 로고
    • Dendritic-cell interactions with HIV: Infection and viral dissemination
    • DOI 10.1038/nri1960, PII NRI1960
    • Wu L, KewalRamani VN. Dendritic-cell interactions with HIV: infection and viral dissemination. Nat Rev Immunol 2006; 6: 859-68; PMID: 17063186; http://dx.doi.org/10.1038/nri1960 (Pubitemid 44631654)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.11 , pp. 859-868
    • Wu, L.1    KewalRamani, V.N.2
  • 13
    • 63849314148 scopus 로고    scopus 로고
    • Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway
    • PMID: 18945959
    • Izquierdo-Useros N, Naranjo-Gómez M, Archer J, Hatch SC, Erkizia I, Blanco J, et al. Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway. Blood 2009; 113: 2732-41; PMID: 18945959; http://dx.doi.org/10.1182/blood-2008-05-158642
    • (2009) Blood , vol.113 , pp. 2732-2741
    • Izquierdo-Useros, N.1    Naranjo-Gómez, M.2    Archer, J.3    Hatch, S.C.4    Erkizia, I.5    Blanco, J.6
  • 15
    • 64249124659 scopus 로고    scopus 로고
    • In vitro priming recapitulates in vivo HIV-1 specifc T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection
    • PMID: 19165342
    • Lubong Sabado R, Kavanagh DG, Kaufmann DE, Fru K, Babcock E, Rosenberg E, et al. In vitro priming recapitulates in vivo HIV-1 specifc T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection. PLoS One 2009; 4:e4256; PMID: 19165342; http://dx.doi.org/10.1371/journal. pone.0004256
    • (2009) PLoS One , vol.4
    • Lubong Sabado, R.1    Kavanagh, D.G.2    Kaufmann, D.E.3    Fru, K.4    Babcock, E.5    Rosenberg, E.6
  • 16
    • 70450265488 scopus 로고    scopus 로고
    • Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV
    • PMID: 196 68260
    • Climent N, Martinez-Navio JM, Gil C, Garcia F, Rovira C, Hurtado C, et al. Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV. Immunol Cell Biol 2009; 87: 634-9; PMID: 196 68260; http://dx.doi.org/10.1038/icb.2009.53
    • (2009) Immunol Cell Biol , vol.87 , pp. 634-639
    • Climent, N.1    Martinez-Navio, J.M.2    Gil, C.3    Garcia, F.4    Rovira, C.5    Hurtado, C.6
  • 18
    • 79251561879 scopus 로고    scopus 로고
    • Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells
    • PMID: 20959412
    • Martinez-Navio JM, Casanova V, Pacheco R, Naval-Macabuhay I, Climent N, Garcia F, et al. Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells. J Leukoc Biol 2011; 89: 127-36; PMID: 20959412; http://dx.doi.org/10.1189/jlb.1009696
    • (2011) J Leukoc Biol , vol.89 , pp. 127-136
    • Martinez-Navio, J.M.1    Casanova, V.2    Pacheco, R.3    Naval-Macabuhay, I.4    Climent, N.5    Garcia, F.6
  • 19
    • 70349675871 scopus 로고    scopus 로고
    • Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation
    • PMID: 20067539
    • Martinez-Navio JM, Climent N, Pacheco R, Garcia F, Plana M, Nomdedeu M, et al. Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation. Immunology 2009; 128: 393-404; PMID: 20067539; http://d x. d oi. o r g/10.1111/j.13 65-2 5 67. 2 0 0 9. 0 31 21. x
    • (2009) Immunology , vol.128 , pp. 393-404
    • Martinez-Navio, J.M.1    Climent, N.2    Pacheco, R.3    Garcia, F.4    Plana, M.5    Nomdedeu, M.6
  • 20
    • 0038681023 scopus 로고    scopus 로고
    • Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
    • DOI 10.1038/nature01709
    • Mangeat B, Tu r e l l i P, Caron G, Friedli M, Perrin L, Trono D. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature 2003; 424: 99-103; PMID: 12808466; http://dx.doi.org/10.1038/nature01709 (Pubitemid 36834849)
    • (2003) Nature , vol.424 , Issue.6944 , pp. 99-103
    • Mangeat, B.1    Turelli, P.2    Caron, G.3    Friedli, M.4    Perrin, L.5    Trono, D.6
  • 21
    • 18344372631 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1038/nature03493
    • Chiu YL, Soros VB, Kreisberg JF, Stopak K, Yonemoto W, Greene WC. Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells. Nature 2005; 435: 108-14; PMID: 15829920; http://dx.doi.org/10.1038/nature03493 (Pubitemid 40655917)
    • (2005) Nature , vol.435 , Issue.7038 , pp. 108-114
    • Chiu, Y.-L.1    Soros, V.B.2    Kreisberg, J.F.3    Stopak, K.4    Yonemoto, W.5    Greene, W.C.6
  • 22
    • 33845906383 scopus 로고    scopus 로고
    • APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection
    • DOI 10.1084/jem.20061519
    • Pion M, Granelli-Piperno A, Mangeat B, Stalder R, Correa R, Steinman RM, et al. APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection. J Exp Med 2006; 203: 2887-93; PMID: 17145955; http://dx.doi.org/10.1084/jem.20061519 (Pubitemid 46026166)
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.13 , pp. 2887-2893
    • Pion, M.1    Granelli-Piperno, A.2    Mangeat, B.3    Stalder, R.4    Correa, R.5    Steinman, R.M.6    Piguet, V.7
  • 23
    • 36248962714 scopus 로고    scopus 로고
    • Human immature monocyte-derived dendritic cells produce and secrete α-defensins 1-3
    • DOI 10.1189/jlb.0507295
    • Rodríguez-García M, Oliva H, Climent N, García F, Gatell JM, Gallart T. Human immature monocyte-derived dendritic cells produce and secrete alpha-defensins 1-3. J Leukoc Biol 2007; 82: 1143-6; PMID: 17684038; http://dx.doi.org/10.1189/jlb.0507295 (Pubitemid 350133510)
    • (2007) Journal of Leukocyte Biology , vol.82 , Issue.5 , pp. 1143-1146
    • Rodriguez-Garcia, M.1    Oliva, H.2    Climent, N.3    Garcia, F.4    Gatell, J.M.5    Gallart, T.6
  • 24
    • 67349200264 scopus 로고    scopus 로고
    • Impact of alpha-defensins1-3 on the maturation and differentiation of human monocyte-derived DCs. Concentration-dependent opposite dual effects
    • PMID: 19237318
    • Rodríguez-García M, Oliva H, Climent N, Escribese MM, García F, Moran TM, et al. Impact of alpha-defensins1-3 on the maturation and differentiation of human monocyte-derived DCs. Concentration-dependent opposite dual effects. Clin Immunol 2009; 131: 374-84; PMID: 19237318; http://dx.doi.org/10.1016/j.clim.2009.01.012
    • (2009) Clin Immunol , vol.131 , pp. 374-384
    • Rodríguez-García, M.1    Oliva, H.2    Climent, N.3    Escribese, M.M.4    García, F.5    Moran, T.M.6
  • 25
    • 77949709988 scopus 로고    scopus 로고
    • Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression
    • PMID: 20195543
    • Rodríguez-García M, Climent N, Oliva H, Casanova V, Franco R, Leon A, et al. Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression. PLoS One 2010; 5:e9436; PMID: 20195543; http://dx.doi.org/10.1371/journal. pone.0009436
    • (2010) PLoS One , vol.5
    • Rodríguez-García, M.1    Climent, N.2    Oliva, H.3    Casanova, V.4    Franco, R.5    Leon, A.6
  • 26
    • 0038717548 scopus 로고    scopus 로고
    • Immunopathogenesis and immunotherapy in AIDS virus infections
    • DOI 10.1038/nm0703-861
    • Letvin NL, Wa lker BD. Immunopathogenesis and immunotherapy in AIDS virus infections. Nat Med 2003; 9: 861-6; PMID: 12835706; http://dx.doi.org/10.1038/ nm0703-861 (Pubitemid 36889927)
    • (2003) Nature Medicine , vol.9 , Issue.7 , pp. 861-866
    • Letvin, N.L.1    Walker, B.D.2
  • 27
    • 0347594006 scopus 로고    scopus 로고
    • Progress in Defining CD4 Helper Cell Responses in Chronic Viral Infections
    • DOI 10.1084/jem.20031947
    • Day CL, Wa l k e r BD. Progress in defning CD4 helper cell responses in chronic viral infections. J Exp Med 2003; 198: 1773-7; PMID: 14676292; http://dx.doi.org/10.1084/jem.20031947 (Pubitemid 38032110)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.12 , pp. 1773-1777
    • Day, C.L.1    Walker, B.D.2
  • 28
    • 0037432736 scopus 로고    scopus 로고
    • Immunology: CD8 T cells remember with a little help
    • DOI 10.1126/science.1084511
    • Kaech SM, Ahmed R. Immunology. CD8 T cells remember with a little help. Science 2003; 300: 263-5; PMID: 12690179; http://dx.doi.org/10.1126/science. 1084511 (Pubitemid 36433703)
    • (2003) Science , vol.300 , Issue.5617 , pp. 263-265
    • Kaech, S.M.1    Ahmed, R.2
  • 29
    • 0036083905 scopus 로고    scopus 로고
    • Exploiting dendritic cells to improve vaccine efficacy
    • DOI 10.1172/JCI200215962
    • Steinman RM, Pope M. Exploiting dendritic cells to improve vaccine effcacy. J Clin Invest 2002; 109: 1519-26; PMID: 12070296 (Pubitemid 34663511)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.12 , pp. 1519-1526
    • Steinman, R.M.1    Pope, M.2
  • 34
    • 0038142359 scopus 로고    scopus 로고
    • Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1
    • DOI 10.1182/blood-2002-10-3189
    • Donaghy H, Gazzard B, Gotch F, Patterson S. Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1. Blood 2003; 101: 4505-11; PMID: 12576311; http://dx.doi.org/10.1182/blood-2002-10-3189 (Pubitemid 36857821)
    • (2003) Blood , vol.101 , Issue.11 , pp. 4505-4511
    • Donaghy, H.1    Gazzard, B.2    Gotch, F.3    Patterson, S.4
  • 35
    • 0036569399 scopus 로고    scopus 로고
    • Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals
    • Chehimi J, Campbell DE, Azzoni L, Bacheller D, Papasavvas E, Jerandi G, et al. Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J Immunol 2002; 168: 4796-801; PMID: 119 7 10 31 (Pubitemid 34441389)
    • (2002) Journal of Immunology , vol.168 , Issue.9 , pp. 4796-4801
    • Chehimi, J.1    Campbell, D.E.2    Azzoni, L.3    Bacheller, D.4    Papasavvas, E.5    Jerandi, G.6    Mounzer, K.7    Kostman, J.8    Trinchieri, G.9    Montaner, L.J.10
  • 36
    • 0028289244 scopus 로고
    • Effcient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • PMID: 8145033
    • Sallusto F, Lanzavecchia A. Effcient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994; 179: 1109-18; PMID: 8145033; http://dx.doi.org/ 10.1084/jem.179.4.1109
    • (1994) J Exp Med , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 38
    • 0038407533 scopus 로고    scopus 로고
    • Cross-presentation of cell-associated antigens by dendritic cells
    • Larsson M, Fonteneau JF, Bhardwaj N. Cross-presentation of cell-associated antigens by dendritic cells. Curr Top Microbiol Immunol 2003; 276: 261-75; PMID: 12797452; http://dx.doi.org/10.1007/978-3-662-06508-2-12 (Pubitemid 36538356)
    • (2003) Current Topics in Microbiology and Immunology , vol.276 , pp. 261-275
    • Larsson, M.1    Fonteneau, J.F.2    Bhardwaj, N.3
  • 39
    • 0042662852 scopus 로고    scopus 로고
    • Potent immune response against HIV-1 and protection from virus challenge in hu-PBL-SCID mice immunized with inactivated virus-pulsed dendritic cells generated in the presence of IFN-α
    • DOI 10.1084/jem.20021924
    • Lapenta C, Santini SM, Logozzi M, Spada M, Andreotti M, Di Pucchio T, et al. Potent immune response against HIV-1 and protection from virus challenge in hu-PBL-SCID mice immunized with inactivated virus-pulsed dendritic cells generated in the presence of IFN-alpha. J Exp Med 2003; 198: 361-7; PMID: 12 8 74 2 6 6; http://dx.doi.org/10.1084/jem.20 021924 (Pubitemid 36987861)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.2 , pp. 361-367
    • Lapenta, C.1    Santini, S.M.2    Logozzi, M.3    Spada, M.4    Andreotti, M.5    Di Pucchio, T.6    Parlato, S.7    Belardelli, F.8
  • 40
    • 0042208293 scopus 로고    scopus 로고
    • + T-cell origin
    • DOI 10.1128/JVI.77.16.8719-8728.2003
    • Yoshida A, Tanaka R, Murakami T, Takahashi Y, Koyanagi Y, Nakamura M, et al. Induction of protective immune responses against R5 human immunodefciency virus type 1 (HIV-1) infection in hu-PBL-SCID mice by intrasplenic immunization with HIV-1-pulsed dendritic cells: possible involvement of a novel factor of human CD4(+) T-cell origin. J Virol 2003; 77: 8719-28; PMID: 12885891; http://dx.doi.org/10.1128/JVI.77.16.8719-8728.2003 (Pubitemid 36936083)
    • (2003) Journal of Virology , vol.77 , Issue.16 , pp. 8719-8728
    • Yoshida, A.1    Tanaka, R.2    Murakami, T.3    Takahashi, Y.4    Koyanagi, Y.5    Nakamura, M.6    Ito, M.7    Yamamoto, N.8    Tanaka, Y.9
  • 41
    • 33947355447 scopus 로고    scopus 로고
    • + dendritic cells loaded with HIV-1 viral lysate or envelope glycoproteins
    • DOI 10.1016/j.micinf.2007.01.021, PII S1286457907000536
    • Aline F, Brand D, Bout D, Pierre J, Fouquenet D, Verrier B, et al. Generation of specifc Th1 and CD8+ T-cell responses by immunization with mouse CD8+ dendritic cells loaded with HIV-1 viral lysate or envelope glycoproteins. Microbes Infect 2007; 9: 536-43; PMID: 1735 0307; http://dx.doi.org/10.1016/j. micinf.2007.01.021 (Pubitemid 46442796)
    • (2007) Microbes and Infection , vol.9 , Issue.4 , pp. 536-543
    • Aline, F.1    Brand, D.2    Bout, D.3    Pierre, J.4    Fouquenet, D.5    Verrier, B.6    Dimier-Poisson, I.7
  • 42
    • 0037234103 scopus 로고    scopus 로고
    • Therapeutic dendritic-cell vaccine for simian aids
    • DOI 10.1038/nm806
    • Lu W, Wu X, Lu Y, Guo W, Andrieu JM. Therapeutic dendritic-cell vaccine for simian AIDS. Nat Med 2003; 9: 27-32; PMID: 12496959; http://dx.doi.org/10. 1038/nm806 (Pubitemid 36098256)
    • (2003) Nature Medicine , vol.9 , Issue.1 , pp. 27-32
    • Lu, W.1    Wu, X.2    Lu, Y.3    Guo, W.4    Andrieu, J.-M.5
  • 44
    • 11144283687 scopus 로고    scopus 로고
    • Therapeutic dendritic-cell vaccine for chronic HIV-1 infection
    • DOI 10.1038/nm1147
    • Lu W, Arraes LC, Ferreira W T, Andrieu JM. Therapeutic dendritic-cell vaccine for chronic HIV-1 infection. Nat Med 2004; 10: 1359-65; PMID: 15568033; http://dx.doi.org/10.1038/nm1147 (Pubitemid 40022718)
    • (2004) Nature Medicine , vol.10 , Issue.12 , pp. 1359-1365
    • Lu, W.1    Arraes, L.C.2    Ferreira, W.T.3    Andrieu, J.-M.4
  • 46
    • 33646480371 scopus 로고    scopus 로고
    • Peptide-loaded dendritic-cell vaccination followed by treatment interruption for chronic HIV-1 infection: A phase 1 trial
    • PMID: 16628588
    • Ide F, Nakamura T, To m i z a w a M, Kawana-Tachikawa A, Odawara T, Hosoya N, et al. Peptide-loaded dendritic-cell vaccination followed by treatment interruption for chronic HIV-1 infection: a phase 1 trial. J Med Virol 2006; 78: 711-8; PMID: 16628588; http://dx.doi.org/10.1002/jmv.20612
    • (2006) J Med Virol , vol.78 , pp. 711-718
    • Ide, F.1    Nakamura, T.2    Tomizawa, M.3    Kawana-Tachikawa, A.4    Odawara, T.5    Hosoya, N.6
  • 47
    • 40449119721 scopus 로고    scopus 로고
    • Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected individuals
    • DOI 10.1128/CVI.00221-07
    • Connolly NC, Whiteside TL, Wilson C, Kondragunta V, Rinaldo CR, Riddler SA. Therapeutic immunization with human immunodefciency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected individuals. Clin Vaccine Immunol 2008; 15: 284-92; PMID: 17942609; http://dx.doi.org/10.1128/CVI.00221-07 (Pubitemid 352025534)
    • (2008) Clinical and Vaccine Immunology , vol.15 , Issue.2 , pp. 284-292
    • Connolly, N.C.1    Whiteside, T.L.2    Wilson, C.3    Kondragunta, V.4    Rinaldo, C.R.5    Riddler, S.A.6
  • 48
    • 70349299844 scopus 로고    scopus 로고
    • A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. Canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy
    • AIDS Clinical Trials Group A5130 tea m PMID 19 45 0 6 47
    • Gandhi RT, O'Neill D, Bosch RJ, Chan ES, Bucy R P, Shopis J, et al.; AIDS Clinical Trials Group A5130 tea m. A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy. Vacci ne 2009; 27: 6088-94; PMID: 19 45 0 6 47; http://dx.doi.org/10.1016/j. vaccine.2009.05.016
    • (2009) Vaccine , vol.27 , pp. 6088-6094
    • Gandhi, R.T.1    O'Neill, D.2    Bosch, R.J.3    Chan, E.S.4    Bucy, R.P.5    Shopis, J.6
  • 49
    • 68449088239 scopus 로고    scopus 로고
    • Induction of novel CD8+ T-cell responses during chronic untreated HIV-1 infection by immunization with subdominant cytotoxic T-lymphocyte epitopes
    • PMID: 19528789
    • Kloverpris H, Karlsson I, Bonde J, Thorn M, Vinner L, Pedersen AE, et al. Induction of novel CD8+ T-cell responses during chronic untreated HIV-1 infection by immunization with subdominant cytotoxic T-lymphocyte epitopes. AIDS 2009; 23: 1329-40; PMID: 19528789; http://dx.doi.org/10.1097/QAD. 0b013e32832d9b00
    • (2009) AIDS , vol.23 , pp. 1329-1340
    • Kloverpris, H.1    Karlsson, I.2    Bonde, J.3    Thorn, M.4    Vinner, L.5    Pedersen, A.E.6
  • 50
    • 73549125003 scopus 로고    scopus 로고
    • Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy
    • PMID: 198 89582
    • Routy JP, Boulassel MR, Yassine-Diab B, Nicolette C, Healey D, Jain R, et al. Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy. Clin Immunol 2010; 134: 140-7; PMID: 198 895 8 2; http://dx.doi.org/10.1016/j. clim.2009.09.009
    • (2010) Clin Immunol , vol.134 , pp. 140-147
    • Routy, J.P.1    Boulassel, M.R.2    Yassine-Diab, B.3    Nicolette, C.4    Healey, D.5    Jain, R.6
  • 51
    • 79751500441 scopus 로고    scopus 로고
    • A therapeutic dendritic cell-based vaccine for HIV-1 infection
    • DCV2/MANON07- AIDS Vaccine Research Objective Study Group PMID: 21233310
    • García F, Climent N, Assoumou L, Gil C, González N, Alcamí J, et al.; DCV2/MANON07- AIDS Vaccine Research Objective Study Group. A therapeutic dendritic cell-based vaccine for HIV-1 infection. J Infect Dis 2011; 203: 473-8; PMID: 21233310; http://dx.doi.org/10.1093/infdis/jiq077
    • (2011) J Infect Dis , vol.203 , pp. 473-478
    • García, F.1    Climent, N.2    Assoumou, L.3    Gil, C.4    González, N.5    Alcamí, J.6
  • 52
    • 80051670038 scopus 로고    scopus 로고
    • Final Analysis of a Phase 2 Study of an Autologous DC Immunotherapy (AGS-004) Showed Positive Outcomes in Primary Endpoint of Viral Load Control and Favorable Safety and Immunogenicity Profle in Subjects Undergoing Structured Treatment Interruption of ART (Abstract 385)
    • Boston February 27-March 2
    • Routy JP, Angel J, Ve zina S, Tremblay C, Loutfy M, Gill J, et al. Final Analysis of a Phase 2 Study of an Autologous DC Immunotherapy (AGS-004) Showed Positive Outcomes in Primary Endpoint of Viral Load Control, and Favorable Safety and Immunogenicity Profle, in Subjects Undergoing Structured Treatment Interruption of ART (Abstract 385). 18th Conference on Retroviruses and Opportunistic Infections Boston February 27-March 2 2011.
    • (2011) 18th Conference on Retroviruses and Opportunistic Infections
    • Routy, J.P.1    Angel, J.2    Vezina, S.3    Tremblay, C.4    Loutfy, M.5    Gill, J.6
  • 53
    • 84857045791 scopus 로고    scopus 로고
    • MRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients
    • PMID: 22156965
    • Va n Gu lc k E, Vlieghe E, Vekema ns M, Van Tendeloo VF, Van De Velde A, Smits E, et al. mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients. AIDS 2012; 26:F1-12; PMID: 22156965; http://dx.doi.org/10.1097/QAD.0b013e32834f33e8
    • (2012) AIDS , vol.26
    • Van Gulck, E.1    Vlieghe, E.2    Vekemans, M.3    Van Tendeloo, V.F.4    Van De Velde, A.5    Smits, E.6
  • 54
    • 84857374529 scopus 로고    scopus 로고
    • A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption
    • PMID: 22177848
    • Allard SD, De Keersmaecker B, de Goede AL, Ve r s c h u re n EJ, Koetsveld J, Reedijk ML, et al. A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption. Clin Immunol 2012; 142: 252-68; PMID: 22177848; http://dx.doi.org/10.1016/j.clim.2011.10.010
    • (2012) Clin Immunol , vol.142 , pp. 252-268
    • Allard, S.D.1    De Keersmaecker, B.2    De Goede, A.L.3    Verschuren, E.J.4    Koetsveld, J.5    Reedijk, M.L.6
  • 55
    • 84872037286 scopus 로고    scopus 로고
    • A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication
    • Garcia F, Climent N, Guardo AC, Gil C, Leon A, Autran B, et al. A Dendritic Cell-Based Vaccine Elicits T Cell Responses Associated with Control of HIV-1 Replication. Sci Transl Med 2013; 5: 166ra2.
    • (2013) Sci Transl Med , vol.5
    • Garcia, F.1    Climent, N.2    Guardo, A.C.3    Gil, C.4    Leon, A.5    Autran, B.6
  • 56
    • 73549125003 scopus 로고    scopus 로고
    • Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy
    • PMID: 19 8 89 582
    • Routy JP, Boulassel MR, Yassine-Diab B, Nicolette C, Healey D, Jain R, et al. Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy. Clin Immunol 2010; 134: 140-7; PMID: 19 8 89 582; http://dx.doi.org/10.1016/j. clim.2009.09.009
    • (2010) Clin Immunol , vol.134 , pp. 140-147
    • Routy, J.P.1    Boulassel, M.R.2    Yassine-Diab, B.3    Nicolette, C.4    Healey, D.5    Jain, R.6
  • 57
    • 84887470832 scopus 로고    scopus 로고
    • Safety and viral load changes in HIV-1 infected subjects treated with autologous dendritic immune therapy following ART discontinuation (CTN#239) Abstract OA04-05
    • Paris, France from 19 - 22 October
    • Routy JP, Boulassel MR, Mona L, Sylvie V, Cecile T, Jonathan A, et al. Safety and viral load changes in HIV-1 infected subjects treated with autologous dendritic immune therapy following ART discontinuation (CTN#239) Abstract OA04-05. AIDS Vaccine 2009 Conference Paris, France from 19 - 22 October 2009.
    • (2009) AIDS Vaccine 2009 Conference
    • Routy, J.P.1    Boulassel, M.R.2    Mona, L.3    Sylvie, V.4    Cecile, T.5    Jonathan, A.6
  • 58
    • 79956200639 scopus 로고    scopus 로고
    • Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specifc CD8(+) T cell responses in HIV-1-infected individuals
    • PMID: 21625608
    • Climent N, Guerra S, García F, Rovira C, Miralles L, Gómez CE, et al. Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specifc CD8(+) T cell responses in HIV-1-infected individuals. PLoS One 2011; 6:e19644; PMID: 21625608; http://dx.doi.org/10.1371/journal. pone.0019644
    • (2011) PLoS One , vol.6
    • Climent, N.1    Guerra, S.2    García, F.3    Rovira, C.4    Miralles, L.5    Gómez, C.E.6
  • 59
    • 77957311408 scopus 로고    scopus 로고
    • Phenotype and functional analysis of human monocytes-derived dendritic cells loaded with a carbosilane dendrimer
    • PMID 20832111
    • Pion M, Serramia MJ, Diaz L, Bryszewska M, Gallart T, García F, et al. Phenotype and functional analysis of human monocytes-derived dendritic cells loaded with a carbosilane dendrimer. Biomaterials 2010; 31: 8749-58; PMID: 2 0832111; http://dx.doi.org/10.1016/j.biomaterials.2010.07.093
    • (2010) Biomaterials , vol.31 , pp. 8749-8758
    • Pion, M.1    Serramia, M.J.2    Diaz, L.3    Bryszewska, M.4    Gallart, T.5    García, F.6
  • 60
    • 84887418508 scopus 로고    scopus 로고
    • Loading dendritic cells from HIV-1 infected patients with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specifc T cell response
    • Boston, USA September 9-12
    • Climent N, Munier S, Piqué N, García F, Pavot V, Leon A, et al. Loading dendritic cells from HIV-1 infected patients with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specifc T cell response. AIDS Vaccine 2012 Conference Boston, USA September 9-12, 2012.
    • (2012) AIDS Vaccine 2012 Conference
    • Climent, N.1    Munier, S.2    Piqué, N.3    García, F.4    Pavot, V.5    Leon, A.6
  • 61
    • 67749142116 scopus 로고    scopus 로고
    • Dendritic cells loaded with HIV-1 p24 proteins adsorbed on surfactant-free anionic PLA nanoparticles induce enhanced cellular immune responses against HIV-1 after vaccination
    • PMID: 19450633
    • Aline F, Brand D, Pierre J, Roingeard P, Séverine M, Verrier B, et al. Dendritic cells loaded with HIV-1 p24 proteins adsorbed on surfactant-free anionic PLA nanoparticles induce enhanced cellular immune responses against HIV-1 after vaccination. Vaccine 2009; 27: 5284-91; PMID: 19450633; http://dx.doi.org/10.1016/j.vaccine.2009.05.028
    • (2009) Vaccine , vol.27 , pp. 5284-5291
    • Aline, F.1    Brand, D.2    Pierre, J.3    Roingeard, P.4    Séverine, M.5    Verrier, B.6
  • 62
    • 34948892906 scopus 로고    scopus 로고
    • Formulation of HIV-1 Tat and p24 antigens by PLA nanoparticles or MF59 impacts the breadth, but not the magnitude, of serum and faecal antibody responses in rabbits
    • DOI 10.1016/j.vaccine.2007.08.060, PII S0264410X07009905
    • Guillon C, Mayol K, Terrat C, Compagnon C, Primard C, Charles MH, et al. Formulation of HIV-1 Tat and p24 antigens by PLA nanoparticles or MF59 impacts the breadth, but not the magnitude, of serum and faecal antibody responses in rabbits. Vaccine 2007; 25: 7491-501; PMID: 17904700; http://dx.doi.org/10.1016/ j.vaccine.2007.08.060 (Pubitemid 47516619)
    • (2007) Vaccine , vol.25 , Issue.43 , pp. 7491-7501
    • Guillon, C.1    Mayol, K.2    Terrat, C.3    Compagnon, C.4    Primard, C.5    Charles, M.-H.6    Delair, T.7    Munier, S.8    Verrier, B.9
  • 63
    • 84871120939 scopus 로고    scopus 로고
    • Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals
    • PMID: 23240012
    • Casanova V, Naval-Macabuhay I, Massanella M, Rodríguez- García M, Blanco J, Gatell JM, et al. Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals. PLoS One 2012; 7:e51287; PMID: 23240012; http://dx.doi.org/10.1371/ journal.pone.0051287
    • (2012) PLoS One , vol.7
    • Casanova, V.1    Naval-Macabuhay, I.2    Massanella, M.3    Rodríguez- García, M.4    Blanco, J.5    Gatell, J.M.6
  • 64
    • 0034648026 scopus 로고    scopus 로고
    • The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression
    • DOI 10.1016/S0014-5793(00)01751-8, PII S0014579300017518
    • Blanco J, Va lenzuela A, Herrera C, Lluís C, Hovanessian AG, Franco R. The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression. FEBS Lett 2000; 477: 123-8; PMID: 10899322; http://dx.doi.org/10.1016/S0014-5793(00)01751-8 (Pubitemid 30438869)
    • (2000) FEBS Letters , vol.477 , Issue.1-2 , pp. 123-128
    • Blanco, J.1    Valenzuela, A.2    Herrera, C.3    Lluis, C.4    Hovanessian, A.G.5    Franco, R.6
  • 65
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • PMID: 22658128
    • Brahmer JR, Ty k o d i SS, Chow LQ, Hwu WJ, To p a l i a n SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012; 366: 2455-65; PMID: 22658128; http://dx.doi.org/10.1056/ NEJMoa1200694
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3    Hwu, W.J.4    Topalian, S.L.5    Hwu, P.6
  • 66
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • PMID: 22658127
    • To p a l i a n SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366: 2443-54; PMID: 22658127; http://dx.doi.org/10. 1056/NEJMoa1200690
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3    Gettinger, S.N.4    Smith, D.C.5    McDermott, D.F.6
  • 67
    • 62249172189 scopus 로고    scopus 로고
    • Enhancing SIV-specifc immunity in vivo by PD-1 blockade
    • PMID: 19078956
    • Velu V, Titanji K, Zhu B, Husain S, Pladevega A, Lai L, et al. Enhancing SIV-specifc immunity in vivo by PD-1 blockade. Nature 2009; 458: 206-10; PMID: 19078956; http://dx.doi.org/10.1038/nature07662
    • (2009) Nature , vol.458 , pp. 206-210
    • Velu, V.1    Titanji, K.2    Zhu, B.3    Husain, S.4    Pladevega, A.5    Lai, L.6
  • 68
    • 84859417996 scopus 로고    scopus 로고
    • Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy
    • PMID: 22337996
    • Va n Lint S, Goyvaerts C, Maenhout S, Goethals L, Disy A, Benteyn D, et al. Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy. Cancer Res 2012; 72: 1661-71; PMID: 22337996; http://dx.doi.org/10.1158/0008- 5472.CAN-11-2957
    • (2012) Cancer Res , vol.72 , pp. 1661-1671
    • Van Lint, S.1    Goyvaerts, C.2    Maenhout, S.3    Goethals, L.4    Disy, A.5    Benteyn, D.6
  • 69
    • 84876005284 scopus 로고    scopus 로고
    • CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
    • PMID 2 3515 0 8 0
    • Brentjens RJ, Davila ML, Riviere I, Park J, Wa ng X, Cowell LG, et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med 2013; 5: 77ra 38; PMID: 2 3515 0 8 0; http://dx.doi.org/10.1126/scitranslmed.3005930
    • (2013) Sci Transl Med , vol.5 , pp. 77-38
    • Brentjens, R.J.1    Davila, M.L.2    Riviere, I.3    Park, J.4    Wang, X.5    Cowell, L.G.6
  • 70
    • 73349094086 scopus 로고    scopus 로고
    • Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
    • MOPH-TAVEG Investigators PMID 19843557
    • Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Chiu J, Paris R, et al.; MOPH-TAVEG Investigators. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 2009; 361: 2209-20; PMID: 19843557; http://dx.doi.org/10.1056/NEJMoa0908492
    • (2009) N Engl J Med , vol.361 , pp. 2209-2220
    • Rerks-Ngarm, S.1    Pitisuttithum, P.2    Nitayaphan, S.3    Kaewkungwal, J.4    Chiu, J.5    Paris, R.6
  • 71
    • 54949106244 scopus 로고    scopus 로고
    • Broad immunogenicity of a multigene multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modifed vaccinia virus Ankara
    • HIV Immunogenicity Study 01/02 Team. PMID: 18808335
    • Sandström E, Nilsson C, Hejdeman B, Bråve A, Bratt G, Robb M, et al.; HIV Immunogenicity Study 01/02 Team. Broad immunogenicity of a multigene, multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modifed vaccinia virus Ankara. J Infect Dis 2008; 198: 1482-90; PMID: 18808335; http://dx.doi.org/10.1086/592507
    • (2008) J Infect Dis , vol.198 , pp. 1482-1490
    • Sandström, E.1    Nilsson, C.2    Hejdeman, B.3    Bråve, A.4    Bratt, G.5    Robb, M.6
  • 72
    • 84887424840 scopus 로고    scopus 로고
    • Targeting HIV gag p24 to DICR on dendritic cells induces T cell and potent and long-lasting antibody responses in non-human primates
    • Boston, USA September 9-12
    • Flamar A, Le Grand R, Contreras V, Zurawski S, Dereudre-Bosquet N. M, et al. Targeting HIV Gag p24 To DICR On Dendritic Cells Induces T Cell And Potent And Long-Lasting Antibody Responses In Non-Human Primates. AIDS Vaccine Conference Boston, USA September 9-12, 2012.
    • (2012) AIDS Vaccine Conference
    • Flamar, A.1    Le Grand, R.2    Contreras, V.3    Zurawski, S.4    Dereudre-Bosquet, N.M.5
  • 73
    • 79955551576 scopus 로고    scopus 로고
    • Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
    • PMID: 21467219
    • Flynn BJ, Kastenmüller K, Wille-Reece U, Tomaras GD, Alam M, Lindsay RW, et al. Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates. Proc Natl Acad Sci U S A 2 011; 108: 7131-6; PMID: 21467219; http://dx.doi.org/10.1073/pnas.1103869108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 7131-7136
    • Flynn, B.J.1    Kastenmüller, K.2    Wille-Reece, U.3    Tomaras, G.D.4    Alam, M.5    Lindsay, R.W.6


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