Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression

Blood

Volumn 124, Issue 7, 2014, Pages 1146-1156

  Zhu, Jianqiong ^a   Chin, Kyung ^a   Aerbajinai, Wulin ^a   Kumkhaek, Chutima ^a   Li, Hongzhen ^a   Rodgers, Griffin P ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CELL PROTEIN; GI ALPHA 2 PROTEIN; GI ALPHA 3 PROTEIN; HEMOGLOBIN F; HEMOGLOBIN GAMMA CHAIN; HYDROXYUREA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN; PROTEIN C JUN; PROTEIN P50; SECRETION ASSOCIATED AND RAS RELATED PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; SAR1A PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG BINDING SITE; ENZYME ACTIVATION; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PHARMACOGENETICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; S PHASE CELL CYCLE CHECKPOINT; TRANSCRIPTION REGULATION; BINDING SITE; CELL CULTURE; CELL CYCLE CHECKPOINT; DRUG EFFECTS; GENETICS; K562 CELL LINE; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELLS, CULTURED; ETS-DOMAIN PROTEIN ELK-1; FETAL HEMOGLOBIN; GAMMA-GLOBINS; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; HYDROXYUREA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; K562 CELLS; MONOMERIC GTP-BINDING PROTEINS; NF-KAPPA B; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-JUN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84905990759     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-10-534842     Document Type: Article

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