Hydroxyurea exerts bi-modal dose-dependent effects on erythropoiesis in human cultured erythroid cells via distinct pathways

British Journal of Haematology

Volumn 119, Issue 4, 2002, Pages 1098-1105

  Wang, Min ^a,b   Tang, Delia C ^a   Liu, Wenli ^a   Chin, Kyung ^a   Zhu, Jianqion G ^a   Fibach, Eitan ^a   Rodgers, Griffin P ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

Death receptor; Egr 1; GATA; Human erythroid cells; Hydroxyurea

Indexed keywords

COMPLEMENTARY DNA; EARLY GROWTH RESPONSE FACTOR 1; HYDROXYUREA; MESSENGER RNA; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2;

ADULT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DNA MICROARRAY; DOSE RESPONSE; DOWN REGULATION; DRUG MEGADOSE; ERYTHROID CELL; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; UPREGULATION;

ADULT; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLONY-FORMING UNITS ASSAY; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROID PROGENITOR CELLS; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; ERYTHROPOIESIS; GATA1 TRANSCRIPTION FACTOR; GATA2 TRANSCRIPTION FACTOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLOBINS; HUMANS; HYDROXYUREA; NUCLEIC ACID SYNTHESIS INHIBITORS; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0036458850     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03958.x     Document Type: Article

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