메뉴 건너뛰기




Volumn 18, Issue 8, 1999, Pages 2218-2228

A 3'-flanking NF-κB site mediates developmental silencing of the human ζ-globin gene

Author keywords

globin gene; Embryonic expression; Gene silencing; NF B; Transcription factor

Indexed keywords

PROTEIN; SYNAPTOTAGMIN;

EID: 0033561118     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (18)

References (59)
  • 1
    • 0024380072 scopus 로고
    • θ, ζ and ε globin messenger RNAs are expressed in adults
    • Albitar, M., Peschle, C. and Liebhaber, S.A. (1989) θ, ζ and ε globin messenger RNAs are expressed in adults. Blood, 74, 629-637.
    • (1989) Blood , vol.74 , pp. 629-637
    • Albitar, M.1    Peschle, C.2    Liebhaber, S.A.3
  • 2
    • 0025822311 scopus 로고
    • Human α-globin genes demonstrate autonomous developmental regulation in transgenic mice
    • Albitar, M., Katsumata, M. and Liebhaber, S.A. (1991) Human α-globin genes demonstrate autonomous developmental regulation in transgenic mice. Mol. Cell. Biol., 11, 3786-3794.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3786-3794
    • Albitar, M.1    Katsumata, M.2    Liebhaber, S.A.3
  • 3
    • 0026652315 scopus 로고
    • Developmental switch in the relative expression of the α1-and α2-globin genes in humans and in transgenic mice
    • Albitar, M., Cash, F.E., Peschle, C. and Liebhaber, S.A. (1992) Developmental switch in the relative expression of the α1-and α2-globin genes in humans and in transgenic mice. Blood, 79, 2471-2474.
    • (1992) Blood , vol.79 , pp. 2471-2474
    • Albitar, M.1    Cash, F.E.2    Peschle, C.3    Liebhaber, S.A.4
  • 4
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: Ten years after
    • Baeuerle, P.A. and Baltimore, D. (1996) NF-κB: ten years after Cell, 87, 13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 5
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A.J. (1996) The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol., 14, 649-683.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-683
    • Baldwin, A.J.1
  • 6
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the relA component of NF-κB
    • Beg, A.A., Sha, W.C., Bronson, R.T., Ghosh, S. and Baltimore, D. (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature, 376, 167-170.
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 7
    • 0031985287 scopus 로고    scopus 로고
    • Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
    • Caamano, J.H., Rizzo, C.A., Durham, S.K., Barton, D.S., Raventos-Suarez, C., Snapper, C.M. and Bravo, R. (1998) Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J. Exp. Med., 187, 185-196.
    • (1998) J. Exp. Med. , vol.187 , pp. 185-196
    • Caamano, J.H.1    Rizzo, C.A.2    Durham, S.K.3    Barton, D.S.4    Raventos-Suarez, C.5    Snapper, C.M.6    Bravo, R.7
  • 8
    • 0024344295 scopus 로고
    • Identification of a transcriptional silencer in the 5′-flanking region of the human ε-globin gene
    • Cao, S.X., Gutman, P.D., Dave, H.P. and Schechter, A.N. (1989) Identification of a transcriptional silencer in the 5′-flanking region of the human ε-globin gene. Proc. Natl Acad. Sci. USA, 86, 5306-5309.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 5306-5309
    • Cao, S.X.1    Gutman, P.D.2    Dave, H.P.3    Schechter, A.N.4
  • 9
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 11
    • 0028885258 scopus 로고
    • Isolation of intact nuclei for nuclear extract preparation from a fragile B-lymphocyte cell line
    • Dyer, R.B. and Herzog, N.K. (1995) Isolation of intact nuclei for nuclear extract preparation from a fragile B-lymphocyte cell line. Biotechniques, 19, 192-195.
    • (1995) Biotechniques , vol.19 , pp. 192-195
    • Dyer, R.B.1    Herzog, N.K.2
  • 12
    • 15444357762 scopus 로고    scopus 로고
    • Requirement for NF-κB in osteoclast and B-cell development
    • Franzoso, G. et al. (1997) Requirement for NF-κB in osteoclast and B-cell development. Genes Dev., 11, 3482-3496.
    • (1997) Genes Dev. , vol.11 , pp. 3482-3496
    • Franzoso, G.1
  • 13
    • 0031964855 scopus 로고    scopus 로고
    • Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions and splenic microarchitecture
    • Franzoso, G. et al. (1998) Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions and splenic microarchitecture. J. Exp. Med., 187, 147-159.
    • (1998) J. Exp. Med. , vol.187 , pp. 147-159
    • Franzoso, G.1
  • 14
    • 0015009308 scopus 로고
    • Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: Stimulation of erythroid differentiation by dimethyl sulfoxide
    • Friend, C., Scher, W., Holland, J.G. and Sato, T. (1971) Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide. Proc. Natl Acad. Sci. USA, 68, 378-382.
    • (1971) Proc. Natl Acad. Sci. USA , vol.68 , pp. 378-382
    • Friend, C.1    Scher, W.2    Holland, J.G.3    Sato, T.4
  • 15
    • 0026708394 scopus 로고
    • Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB
    • Fujita, T., Nolan, G.P., Ghosh, S. and Baltimore, D. (1992) Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev., 6, 775-787.
    • (1992) Genes Dev. , vol.6 , pp. 775-787
    • Fujita, T.1    Nolan, G.P.2    Ghosh, S.3    Baltimore, D.4
  • 16
    • 0025078530 scopus 로고
    • Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal
    • Ghosh, S., Gifford, A.M., Riviere, L.R., Tempst, P., Nolan, G.P. and Baltimore, D. (1990) Cloning of the p50 DNA binding subunit of NF-κB: homology to rel and dorsal. Cell, 62, 1019-1029.
    • (1990) Cell , vol.62 , pp. 1019-1029
    • Ghosh, S.1    Gifford, A.M.2    Riviere, L.R.3    Tempst, P.4    Nolan, G.P.5    Baltimore, D.6
  • 18
    • 0028029838 scopus 로고
    • Analysis of a 70 kb segment of DNA containing the human ζ and α-globin genes linked to their regulatory element (HS-40) in transgenic mice
    • Gourdon, G., Sharpe, J.A., Wells, D., Wood, W.G. and Higgs,D.R. (1994) Analysis of a 70 kb segment of DNA containing the human ζ and α-globin genes linked to their regulatory element (HS-40) in transgenic mice. Nucleic Acids Res., 22, 4139-4147.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4139-4147
    • Gourdon, G.1    Sharpe, J.A.2    Wells, D.3    Wood, W.G.4
  • 20
    • 0024993211 scopus 로고
    • A major positive-regulatory region located far upstream of the human α-globin gene locus
    • Higgs,D.R., Wood,W.G., Jarman.A.P., Sharpe, J., Lida, J., Pretorius, I.M. and Ayyub, H. (1990) A major positive-regulatory region located far upstream of the human α-globin gene locus. Genes Dev., 4, 1588-1601.
    • (1990) Genes Dev. , vol.4 , pp. 1588-1601
    • Sharpe, J.1    Lida, J.2    Pretorius, I.M.3    Ayyub, H.4
  • 21
    • 0029954767 scopus 로고    scopus 로고
    • Analysis of mice containing a targeted deletion of β-globin locus control region 5′ hypersensitive site 3
    • Hug, B.A., Wesselschmidt, R.L., Fiering, S., Bender, M.A., Epner, E., Groudine, M. and Ley, T.J. (1996) Analysis of mice containing a targeted deletion of β-globin locus control region 5′ hypersensitive site 3. Mol. Cell. Biol., 16, 2906-2912.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2906-2912
    • Hug, B.A.1    Wesselschmidt, R.L.2    Fiering, S.3    Bender, M.A.4    Epner, E.5    Groudine, M.6    Ley, T.J.7
  • 23
    • 0026089246 scopus 로고
    • The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila
    • Ip, Y.T., Kraut, R., Levine, M. and Rushlow, C.A. (1991) The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila. Cell, 64, 439-446.
    • (1991) Cell , vol.64 , pp. 439-446
    • Ip, Y.T.1    Kraut, R.2    Levine, M.3    Rushlow, C.A.4
  • 24
    • 0026045994 scopus 로고
    • The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos
    • Jiang, J., Kosman, D., Ip, Y.T. and Levine, M. (1991) The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev., 5, 1881-1891.
    • (1991) Genes Dev. , vol.5 , pp. 1881-1891
    • Jiang, J.1    Kosman, D.2    Ip, Y.T.3    Levine, M.4
  • 25
    • 0025736539 scopus 로고
    • Reconstruction and analysis of human Alu genes
    • Jurka, J. and Milosavljevic, A. (1991) Reconstruction and analysis of human Alu genes. J. Mol. Evol., 32, 105-121.
    • (1991) J. Mol. Evol. , vol.32 , pp. 105-121
    • Jurka, J.1    Milosavljevic, A.2
  • 26
    • 0027454228 scopus 로고
    • Association between protooncoprotein rel and TATA-binding protein mediates transcriptional activation by NF-κB
    • Kerr, L.D., Ransone, L.J., Wamsley, P., Schmitt, M.J., Boyer, T.G., Zhou, Q., Berk, A.J. and Verma, I.M. (1993) Association between protooncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB. Nature, 365, 412-419.
    • (1993) Nature , vol.365 , pp. 412-419
    • Kerr, L.D.1    Ransone, L.J.2    Wamsley, P.3    Schmitt, M.J.4    Boyer, T.G.5    Zhou, Q.6    Berk, A.J.7    Verma, I.M.8
  • 27
    • 0025032623 scopus 로고
    • The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product
    • Kieran M. et al. (1990) The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product. Cell, 62, 1007-1018.
    • (1990) Cell , vol.62 , pp. 1007-1018
    • Kieran, M.1
  • 28
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity and interleukin-2 expression
    • Kontgen, F., Grumont, R.J., Strasser, A., Metcalf, D., Li, R., Tarlinton, D. and Gerondakis, S. (1995) Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity and interleukin-2 expression. Genes Dev., 9, 1965-1977.
    • (1995) Genes Dev. , vol.9 , pp. 1965-1977
    • Kontgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6    Gerondakis, S.7
  • 29
    • 0019496766 scopus 로고
    • Homology and concerted evolution at the α1 and α2 loci of human α-globin
    • Liebhaber, S.A., Goossens, M. and Kan, Y.W. (1981) Homology and concerted evolution at the α1 and α2 loci of human α-globin. Nature, 290, 26-29.
    • (1981) Nature , vol.290 , pp. 26-29
    • Liebhaber, S.A.1    Goossens, M.2    Kan, Y.W.3
  • 30
    • 0030003151 scopus 로고    scopus 로고
    • Developmental silencing of the embryonic ζ-globin gene: Concerted action of the promoter and the 3′-flanking region combined with stage-specific silencing by the transcribed segment
    • Liebhaber, S.A., Wang, Z., Cash, F.E., Monks, B. and Russell, J.E. (1996) Developmental silencing of the embryonic ζ-globin gene: concerted action of the promoter and the 3′-flanking region combined with stage-specific silencing by the transcribed segment. Mol. Cell. Biol., 16, 2637-2646.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2637-2646
    • Liebhaber, S.A.1    Wang, Z.2    Cash, F.E.3    Monks, B.4    Russell, J.E.5
  • 31
    • 0027618650 scopus 로고
    • Regulation of the NF-κB/rel transcription factor and IκB inhibitor system
    • Liou, H.C. and Baltimore, D. (1993) Regulation of the NF-κB/rel transcription factor and IκB inhibitor system. Curr. Opin. Cell Biol., 5, 477-487.
    • (1993) Curr. Opin. Cell Biol. , vol.5 , pp. 477-487
    • Liou, H.C.1    Baltimore, D.2
  • 32
    • 0016640079 scopus 로고
    • Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome
    • Lozzio, C.B. and Lozzio, B.B. (1975) Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood, 45, 321-334.
    • (1975) Blood , vol.45 , pp. 321-334
    • Lozzio, C.B.1    Lozzio, B.B.2
  • 33
    • 0030219342 scopus 로고    scopus 로고
    • Regulation of β-globin gene expression: Straightening out the locus
    • Martin, D.I., Fiering, S. and Groudine, M. (1996) Regulation of β-globin gene expression: straightening out the locus. Curr. Opin. Genet. Dev., 6, 488-495.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 488-495
    • Martin, D.I.1    Fiering, S.2    Groudine, M.3
  • 34
    • 0020321974 scopus 로고
    • HEL cells: A new human erythroleukemia cell line with spontaneous and induced globin expression
    • Martin, P. and Papayannopoulou, T. (1982) HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression. Science, 216, 1233-1235.
    • (1982) Science , vol.216 , pp. 1233-1235
    • Martin, P.1    Papayannopoulou, T.2
  • 35
    • 0027453552 scopus 로고
    • Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
    • Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T. and Akira, S. (1993) Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl Acad. Sci. USA, 90, 10193-10197.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 10193-10197
    • Matsusaka, T.1    Fujikawa, K.2    Nishio, Y.3    Mukaida, N.4    Matsushima, K.5    Kishimoto, T.6    Akira, S.7
  • 36
    • 0027211845 scopus 로고
    • A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins
    • Miller, I.J. and Bieker, J.J. (1993) A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol. Cell. Biol., 13, 2776-2786.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 2776-2786
    • Miller, I.J.1    Bieker, J.J.2
  • 37
    • 0024226611 scopus 로고
    • Distribution and control of some genetic disorders
    • Modell, B. and Bulyzhenkov, V. (1988) Distribution and control of some genetic disorders. World Health Stat. Q., 41, 209-218.
    • (1988) World Health Stat. Q. , vol.41 , pp. 209-218
    • Modell, B.1    Bulyzhenkov, V.2
  • 38
    • 0027209915 scopus 로고
    • A cooperative interaction between NF-κB and Sp1 is required for HIV-1 enhancer activation
    • Perkins, N.D., Edwards, N.L., Duckett, C.S., Agranoff, A.B., Schmid, R.M. and Nabel, G.J. (1993) A cooperative interaction between NF-κB and Sp1 is required for HIV-1 enhancer activation. EMBO J., 12, 3551-3558.
    • (1993) Embo J. , vol.12 , pp. 3551-3558
    • Perkins, N.D.1    Edwards, N.L.2    Duckett, C.S.3    Agranoff, A.B.4    Schmid, R.M.5    Nabel, G.J.6
  • 39
    • 0021931881 scopus 로고
    • Haemoglobin switching in human embryos: Asynchrony of ζ to α and ε to γ-globin switches in primitive and definite erythropoietic lineage
    • Peschle, C. et al. (1985) Haemoglobin switching in human embryos: asynchrony of ζ to α and ε to γ-globin switches in primitive and definite erythropoietic lineage. Nature, 313, 235-238.
    • (1985) Nature , vol.313 , pp. 235-238
    • Peschle, C.1
  • 40
    • 0026452005 scopus 로고
    • The developmental regulation of the human ζ-globin gene in transgenic mice employing β-galactosidase as a reporter gene
    • Pondel, M.D., Proudfoot, N.J., Whitelaw, C. and Whitelaw, E. (1992) The developmental regulation of the human ζ-globin gene in transgenic mice employing β-galactosidase as a reporter gene. Nucleic Acids Res., 20, 5655-5660.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 5655-5660
    • Pondel, M.D.1    Proudfoot, N.J.2    Whitelaw, C.3    Whitelaw, E.4
  • 41
    • 0042373031 scopus 로고
    • Gene deletions in α thalassemia prove that the 5′ ζ locus is functional
    • Pressley, L., Higgs, D.R., Clegg, J.B. and Weatherall, D.J. (1980) Gene deletions in α thalassemia prove that the 5′ ζ locus is functional. Proc. Natl Acad. Sci. USA, 77, 3586-3589.
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 3586-3589
    • Pressley, L.1    Higgs, D.R.2    Clegg, J.B.3    Weatherall, D.J.4
  • 42
    • 0027515934 scopus 로고
    • Erythroid regulatory elements
    • Raich, N. and Romeo, P.H. (1993) Erythroid regulatory elements. Stem Cells, 11, 95-104.
    • (1993) Stem Cells , vol.11 , pp. 95-104
    • Raich, N.1    Romeo, P.H.2
  • 43
    • 0026610223 scopus 로고
    • Demonstration of a human ε-globin gene silencer with studies in transgenic mice
    • Raich, N., Papayannopoulou, T., Stamatoyannopoulos, G. and Enver, T. (1992) Demonstration of a human ε-globin gene silencer with studies in transgenic mice. Blood, 79, 861-864.
    • (1992) Blood , vol.79 , pp. 861-864
    • Raich, N.1    Papayannopoulou, T.2    Stamatoyannopoulos, G.3    Enver, T.4
  • 44
    • 0028939923 scopus 로고
    • GATA1 and YY1 are developmental repressors of the human ε-globin gene
    • Raich, N., Clegg, C.H., Grofti, J., Romeo, P.H. and Stamatoyannopoulos, G. (1995) GATA1 and YY1 are developmental repressors of the human ε-globin gene. EMBO J., 14, 801-809.
    • (1995) EMBO J. , vol.14 , pp. 801-809
    • Raich, N.1    Clegg, C.H.2    Grofti, J.3    Romeo, P.H.4    Stamatoyannopoulos, G.5
  • 45
    • 0032213386 scopus 로고    scopus 로고
    • Reversal of lethal α and β thalassemias in mice by expression of human embryonic globin
    • Russell, J.E. and Liebhaber, S.A. (1998) Reversal of lethal α and β thalassemias in mice by expression of human embryonic globin. Blood, 92, 3057-3063.
    • (1998) Blood , vol.92 , pp. 3057-3063
    • Russell, J.E.1    Liebhaber, S.A.2
  • 47
    • 0031947553 scopus 로고    scopus 로고
    • Sequence divergence in the 3′ untranslated regions of human ζ-and α-globin mrnas mediates a difference in their stabilities and contributes to efficient α-to ζ-gene developmental switching
    • Russell, J.E., Morales, J., Makeyev, A.V. and Liebhaber, S.A. (1998) Sequence divergence in the 3′ untranslated regions of human ζ-and α-globin mRNAs mediates a difference in their stabilities and contributes to efficient α-to ζ-gene developmental switching. Mol. Cell. Biol., 18, 2173-2183.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2173-2183
    • Russell, J.E.1    Morales, J.2    Makeyev, A.V.3    Liebhaber, S.A.4
  • 48
    • 0027490625 scopus 로고
    • Analysis of the human ζ-globin gene promoter in transgenic mice
    • Sabath, D.E., Spangler, E.A., Rubin, E.M. and Stamatoyannopoulos, G. (1993) Analysis of the human ζ-globin gene promoter in transgenic mice. Blood, 82, 2899-2905.
    • (1993) Blood , vol.82 , pp. 2899-2905
    • Sabath, D.E.1    Spangler, E.A.2    Rubin, E.M.3    Stamatoyannopoulos, G.4
  • 49
    • 0028903814 scopus 로고
    • Identification of a major positive regulatory element located 5′ to the human ζ-globin gene
    • Sabath, D.E., Koehler, K.M., Yang, W.Q., Patton, K. and Stamato-yannopoulos, G. (1995) Identification of a major positive regulatory element located 5′ to the human ζ-globin gene. Blood, 85, 2587-2597.
    • (1995) Blood , vol.85 , pp. 2587-2597
    • Sabath, D.E.1    Koehler, K.M.2    Yang, W.Q.3    Patton, K.4    Stamato-Yannopoulos, G.5
  • 50
    • 0025738076 scopus 로고
    • Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65
    • Schmid, R.M., Perkins, N.D., Duckett, C.S., Andrews, P.C. and Nabel, G.J. (1991) Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65. Nature, 352, 733-736.
    • (1991) Nature , vol.352 , pp. 733-736
    • Schmid, R.M.1    Perkins, N.D.2    Duckett, C.S.3    Andrews, P.C.4    Nabel, G.J.5
  • 51
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • Sen, R. and Baltimore, D. (1986) Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell, 46, 705-716.
    • (1986) Cell , vol.46 , pp. 705-716
    • Sen, R.1    Baltimore, D.2
  • 52
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • Sha, W.C., Liou, H.C., Tuomanen, E.I. and Baltimore, D. (1995) Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell, 80, 321-330.
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha, W.C.1    Liou, H.C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 55
    • 0027224017 scopus 로고
    • Cross-coupling of the NF-κB p65 and Fos/ jun transcription factors produces potentiated biological function
    • Stein, B., Baldwin, A.J., Ballard, D.W., Greene, W.C., Angel, P. and Herrlich, P. (1993a) Cross-coupling of the NF-κB p65 and Fos/ Jun transcription factors produces potentiated biological function. EMBO J., 12, 3879-3891.
    • (1993) EMBO J. , vol.12 , pp. 3879-3891
    • Stein, B.1    Baldwin, A.J.2    Ballard, D.W.3    Greene, W.C.4    Angel, P.5    Herrlich, P.6
  • 56
    • 0027316201 scopus 로고
    • Functional and physical associations between NF-κB and C/EBP family members: A rel domain-bZIP interaction
    • Stein, B., Cogswell, P.C. and Baldwin, A.J. (1993b) Functional and physical associations between NF-κB and C/EBP family members: a Rel domain-bZIP interaction. Mol. Cell. Biol., 13, 3964-3974.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3964-3974
    • Stein, B.1    Cogswell, P.C.2    Baldwin, A.J.3
  • 57
    • 0024506821 scopus 로고
    • A dominant control region from the human β-globin locus conferring integration site-independent gene expression
    • Talbot, D., Collis, P., Antoniou, M., Vidal, M., Grosveld, F. and Greaves, D.R. (1989) A dominant control region from the human β-globin locus conferring integration site-independent gene expression. Nature, 338, 352-355.
    • (1989) Nature , vol.338 , pp. 352-355
    • Talbot, D.1    Collis, P.2    Antoniou, M.3    Vidal, M.4    Grosveld, F.5    Greaves, D.R.6
  • 58
    • 0029655902 scopus 로고    scopus 로고
    • Intronic and flanking sequences are required to silence enhancement of an embryonic β-type globin gene
    • Wandersee, N.J., Ferris, R.C. and Ginder, G.D. (1996) Intronic and flanking sequences are required to silence enhancement of an embryonic β-type globin gene. Mol. Cell. Biol., 16, 236-246.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 236-246
    • Wandersee, N.J.1    Ferris, R.C.2    Ginder, G.D.3
  • 59
    • 0028817585 scopus 로고
    • Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of relB, a member of the NF-κB/rel family
    • Weih, F., Carrasco, D., Durham, S.K., Barton, D.S., Rizzo, C.A., Ryseck, R.P., Lira, S.A. and Bravo, R. (1995) Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell, 80, 331-340.
    • (1995) Cell , vol.80 , pp. 331-340
    • Weih, F.1    Carrasco, D.2    Durham, S.K.3    Barton, D.S.4    Rizzo, C.A.5    Ryseck, R.P.6    Lira, S.A.7    Bravo, R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.