Effectiveness of intravenous levetiracetam as an adjunctive treatment in pediatric refractory status epilepticus

Pediatric Emergency Care

Volumn 30, Issue 8, 2014, Pages 525-528

  Kim, Jon Soo ^a   Lee, Jeong Ho ^b   Ryu, Hye Won ^b   Lim, Byung Chan ^b   Hwang, Hee ^a   Chae, Jong Hee ^b   Choi, Jieun ^c   Kim, Ki Joong ^b   Hwang, Yong Seung ^b   Kim, Hunmin ^a  

^a Seoul National University Bundang Hospital   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University Boramae Hospital   (South Korea)

Author keywords

effectiveness; intravenous; refractory status epilepticus

Indexed keywords

BENZODIAZEPINE; ETIRACETAM; LORAZEPAM; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID; ANTICONVULSIVE AGENT; PIRACETAM;

ADOLESCENT; ANTICONVULSANT THERAPY; ARTICLE; BRADYCARDIA; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EPILEPTIC STATE; FEMALE; HUMAN; HYPERTENSION; HYPOTENSION; LOADING DRUG DOSE; MALE; MEDICAL RECORD REVIEW; NEUROLOGIC DISEASE; NEWBORN; OUTCOME ASSESSMENT; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; SEIZURE; TACHYCARDIA; TREATMENT RESPONSE; ANALOGS AND DERIVATIVES; INFANT; PRESCHOOL CHILD; STATUS EPILEPTICUS; TREATMENT OUTCOME;

ADOLESCENT; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; PIRACETAM; STATUS EPILEPTICUS; TREATMENT OUTCOME;

EID: 84905968294     PISSN: 07495161     EISSN: 15351815     Source Type: Journal    
DOI: 10.1097/PEC.0000000000000183     Document Type: Article

References (25)

1. Chin RF, Neville BG, Scott RC. A systematic review of the epidemiology of status epilepticus. Eur J Neurol. 2004;11:800-810. (Pubitemid 39665056)
2. DeLorenzo RJ, Hauser WA, Towne AR, et al. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology. 1996;46:1029-1035. (Pubitemid 26134646)
3. Sahin M, Menache CC, Holmes GL, et al. Outcome of severe refractory status epilepticus in children. Epilepsia. 2001;42:1461-1467. (Pubitemid 33140623)
4. Sasidaran K, Singhi S, Singhi P. Management of acute seizures and status epilepticus in pediatric emergency. Indian J Pediatr. 2012;79:510-517.
5. Kalviainen R, Eriksson K, Parviainen I. Refractory generalised convulsive status epilepticus: a guide to treatment. CNS Drugs. 2005;19:759-768. (Pubitemid 41324063)
6. Gallentine WB, Hunnicutt AS, Husain AM. Levetiracetam in children with refractory status epilepticus. Epilepsy Behav. 2009;14:215-218.
7. Glauser TA, Mitchell WG, Weinstock A, et al. Pharmacokinetics of levetiracetam in infants and young children with epilepsy. Epilepsia. 2007; 48:1117-1122. (Pubitemid 46854880)
8. Vigevano F. Levetiracetam in pediatrics. J Child Neurol. 2005;20:87-93. (Pubitemid 40484845)
9. Zelano J, Kumlien E. Levetiracetam as alternative stage two antiepileptic drug in status epilepticus: a systematic review. Seizure. 2012;21:233-236.
10. Aiguabella M, Falip M, Villanueva V, et al. Efficacy of intravenous levetiracetam as an add-on treatment in status epilepticus: a multicentric observational study. Seizure. 2011;20:60-64.
11. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30:389-399.
12. McTague A, Kneen R, Kumar R, et al. Intravenous levetiracetam in acute repetitive seizures and status epilepticus in children: experience from a children's hospital. Seizure. 2012;21:529-534.
13. Young G, Jordan K, Doig G. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology. 1996;47:83-89. (Pubitemid 26243864)
14. Abend NS, Dlugos DJ. Treatment of refractory status epilepticus: literature review and a proposed protocol. Pediatr Neurol. 2008;38:377-390. (Pubitemid 351671983)
15. Metsaranta P, Koivikko M, Peltola J, et al. Outcome after prolonged convulsive seizures in 186 children: low morbidity, no mortality. Dev Med Child Neurol. 2004;46:4-8. (Pubitemid 38120444)
16. Gilbert DL, Gartside PS, Glauser TA. Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis. J Child Neurol. 1999;14:602-609. (Pubitemid 29431765)
17. Kowalski RG, Ziai WC, Rees RN, et al. Third-line antiepileptic therapy and outcome in status epilepticus: the impact of vasopressor use and prolonged mechanical ventilation. Crit Care Med. 2012;40:2677-2684.
18. Knake S, Gruener J, Hattemer K, et al. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J Neurol Neurosurg Psychiatry. 2008;79:588-589. (Pubitemid 351571881)
19. Trinka E. What is the evidence to use new intravenous AEDs in status epilepticus? Epilepsia. 2011;52:35-38.
20. Goraya JS, Khurana DS, Valencia I, et al. Intravenous levetiracetam in children with epilepsy. Pediatr Neurol. 2008;38:177-180. (Pubitemid 351221234)
21. Kirmani BF, Crisp ED, Kayani S, et al. Role of intravenous levetiracetam in acute seizure management of children. Pediatr Neurol. 2009;41:37-39.
22. Reiter P, Huff A, Knupp K, et al. Intravenous levetiracetam in the management of acute seizures in children. Pediatr Neurol. 2010;43:117-121.
23. Gillard M, Chatelain P, Fuks B. Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SVA2) in human brain and in CHO cells expressing the human recombinant protein. Eur J Pharmacol. 2006;536: 102-108.
24. Ng Y, Hastriter E, Cardenas J, et al. Intravenous levetiracetam in children with seizures: a prospective safety study. J Child Neurol. 2010;25:551-555.
25. Ramantani G, Ikonomidou C, Walter B, et al. Levetiracetam: safety and efficacy in neonatal seizures. Eur J Paediatr Neurol. 2011;15:1-7.