메뉴 건너뛰기




Volumn 69, Issue 9, 2014, Pages 857-864

The path to personalised medicine in copd

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHIECTASIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY CALCIFICATION; DECISION SUPPORT SYSTEM; DISEASE ACTIVITY; EMPHYSEMA; FORCED EXPIRATORY VOLUME; GENETIC MARKER; HUMAN; INFLAMMATION; INTEGRATED HEALTH CARE SYSTEM; LIFESTYLE MODIFICATION; LUNG CANCER; MICROBIOME; PERSONALIZED MEDICINE; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SMOKING;

EID: 84905964581     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2014-205507     Document Type: Review
Times cited : (151)

References (80)
  • 1
    • 79955498646 scopus 로고    scopus 로고
    • Addressing the complexity of chronic obstructive pulmonary disease: From phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine
    • Agusti A, Sobradillo P, Celli B. Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine. Am J Respir Crit Care Med 2011;183:1129-37.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1129-1137
    • Agusti, A.1    Sobradillo, P.2    Celli, B.3
  • 3
    • 79551603829 scopus 로고    scopus 로고
    • Characterisation of COPD heterogeneity in the ECLIPSE cohort
    • Agusti A, Calverley P, Celli B, et al. Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res 2010;11:122-36.
    • (2010) Respir Res , vol.11 , pp. 122-136
    • Agusti, A.1    Calverley, P.2    Celli, B.3
  • 4
    • 84873956600 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease, GOLD executive summary
    • Vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease, GOLD executive summary. Am J Respir Crit Care Med 2013;187:347-65.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 347-365
    • Vestbo, J.1    Hurd, S.S.2    Agusti, A.G.3
  • 5
    • 84890467491 scopus 로고    scopus 로고
    • Phenotypes and disease characterization in chronic obstructive pulmonary disease
    • Agusti A. Phenotypes and disease characterization in chronic obstructive pulmonary disease. Toward the extinction of phenotypes? Ann Am Thorac Soc 2013;10:S125-30.
    • (2013) Toward the Extinction of Phenotypes?. Ann Am Thorac Soc , vol.10
    • Agusti, A.1
  • 6
    • 0036252278 scopus 로고    scopus 로고
    • Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD
    • DOI 10.1378/chest.121.5.1434
    • Nishimura K, Izumi T, Tsukino M, et al. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest 2002;121:1434-40. (Pubitemid 34499652)
    • (2002) Chest , vol.121 , Issue.5 , pp. 1434-1440
    • Nishimura, K.1    Izumi, T.2    Tsukino, M.3    Oga, T.4
  • 7
    • 77956689733 scopus 로고    scopus 로고
    • Susceptibility to exacerbation in chronic obstructive pulmonary disease
    • Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 2010;363:1128-38.
    • (2010) N Engl J Med , vol.363 , pp. 1128-1138
    • Hurst, J.R.1    Vestbo, J.2    Anzueto, A.3
  • 8
    • 51649091911 scopus 로고    scopus 로고
    • The many "small COPDs": COPD should be an orphan disease
    • Rennard SI, Vestbo J. The many "small COPDs": COPD should be an orphan disease. Chest 2008;134:623-7.
    • (2008) Chest , vol.134 , pp. 623-627
    • Rennard, S.I.1    Vestbo, J.2
  • 10
    • 0035035768 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease
    • Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001;163:1256-76.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1256-1276
    • Pauwels, R.A.1    Buist, A.S.2    Calverley, P.M.3
  • 14
    • 40549141427 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Beyond the forced expiratory manoeuvre
    • DOI 10.1159/000113612
    • Agusti A. Chronic obstructive pulmonary disease: beyond the forced expiratory manoeuvre. Respiration 2008;75:136-7. (Pubitemid 351363865)
    • (2008) Respiration , vol.75 , Issue.2 , pp. 136-137
    • Agusti, A.1
  • 15
    • 84877904457 scopus 로고    scopus 로고
    • What is chronic obstructive pulmonary disease anyway?: Continua, categories, cut points, and moving beyond spirometry
    • Rennard SI, Vestbo J, Agusti A. What is chronic obstructive pulmonary disease anyway?: continua, categories, cut points, and moving beyond spirometry. Am J Respir Crit Care Med 2013;187:1036-7.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 1036-1037
    • Rennard, S.I.1    Vestbo, J.2    Agusti, A.3
  • 16
    • 84887279386 scopus 로고    scopus 로고
    • Frequently asked questions (FAQs) about the GOLD 2011 assessment proposal of COPD
    • Agusti A, Hurd S, Jones P, et al. Frequently asked questions (FAQs) about the GOLD 2011 assessment proposal of COPD. Eur Respir J 2013;42:1391-401.
    • (2013) Eur Respir J , vol.42 , pp. 1391-1401
    • Agusti, A.1    Hurd, S.2    Jones, P.3
  • 17
    • 84905980740 scopus 로고    scopus 로고
    • (accessed 9 March 2014)
    • Bohr N. https://www.goodreads.com/author/quotes/821936.Niels-Bohr (accessed 9 March 2014).
    • Bohr, N.1
  • 18
    • 51249109930 scopus 로고    scopus 로고
    • Proportional classifications of COPD phenotypes
    • Marsh SE, Travers J, Weatherall M, et al. Proportional classifications of COPD phenotypes. Thorax 2008;63:761-7.
    • (2008) Thorax , vol.63 , pp. 761-767
    • Marsh, S.E.1    Travers, J.2    Weatherall, M.3
  • 20
    • 33745209743 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease, inflammation and co-morbidity: A common inflammatory phenotype?
    • Sevenoaks MJ, Stockley RA. Chronic obstructive pulmonary disease, inflammation and co-morbidity: a common inflammatory phenotype? Respir Res 2006;7:70.
    • (2006) Respir Res , vol.7 , pp. 70
    • Sevenoaks, M.J.1    Stockley, R.A.2
  • 21
    • 0038670579 scopus 로고    scopus 로고
    • The human phenome project
    • DOI 10.1038/ng0503-15
    • Freimer N, Sabatti C. The human phenome project. Nat Genet 2003;34:15-21. (Pubitemid 36548781)
    • (2003) Nature Genetics , vol.34 , Issue.1 , pp. 15-21
    • Freimer, N.1    Sabatti, C.2
  • 22
    • 77957705828 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease phenotypes: The future of COPD
    • Han MK, Agusti A, Calverley PM, et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med 2010;182:598-604.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 598-604
    • Han, M.K.1    Agusti, A.2    Calverley, P.M.3
  • 23
    • 84905974827 scopus 로고    scopus 로고
    • Bohr N. (accessed 9 March 2014)
    • Bohr N. http://quoteinvestigator.com/2013/10/20/no-predict/(accessed 9 March 2014).
  • 24
    • 69249106988 scopus 로고    scopus 로고
    • Systems biology and emerging technologies will catalyze the transition from reactive medicine to predictive, personalized, preventive and participatory (P4) medicine
    • Galas DJ, Hood L. Systems biology and emerging technologies will catalyze the transition from reactive medicine to predictive, personalized, preventive and participatory (P4) medicine. IBC 2009;1:1-4.
    • (2009) IBC , vol.1 , pp. 1-4
    • Galas, D.J.1    Hood, L.2
  • 25
    • 84879409324 scopus 로고    scopus 로고
    • The COPD control panel: Towards personalised medicine in COPD
    • Agusti A, MacNee W. The COPD control panel: towards personalised medicine in COPD. Thorax 2013;68:687-90.
    • (2013) Thorax , vol.68 , pp. 687-690
    • Agusti, A.1    Macnee, W.2
  • 26
    • 84905973604 scopus 로고    scopus 로고
    • Kotter JP. (accessed 10 March 2014)
    • Kotter JP. http://www.goodreads.com/quotes/708508-transformation-is-a- process-not-an-event (accessed 10 March 2014).
  • 27
    • 84883053051 scopus 로고    scopus 로고
    • Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort
    • Miller J, Edwards LD, Agusti A, et al. Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort. Respir Med 2013;107:1376-84.
    • (2013) Respir Med , vol.107 , pp. 1376-1384
    • Miller, J.1    Edwards, L.D.2    Agusti, A.3
  • 29
    • 34548277025 scopus 로고    scopus 로고
    • From COPD to chronic systemic inflammatory syndrome?
    • DOI 10.1016/S0140-6736(07)61383-X, PII S014067360761383X
    • Fabbri LM, Rabe KF. From COPD to chronic systemic inflammatory syndrome? Lancet 2007;370:797-9. (Pubitemid 47320803)
    • (2007) Lancet , vol.370 , Issue.9589 , pp. 797-799
    • Fabbri, L.M.1    Rabe, K.F.2
  • 30
    • 84862100999 scopus 로고    scopus 로고
    • Persistent systemic inflammation is associated with poor clinical outcomes in COPD: A novel phenotype
    • Agusti A, Edwards LD, Rennard SI, et al. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS ONE 2012;7:e37483.
    • (2012) PLoS ONE , vol.7
    • Agusti, A.1    Edwards, L.D.2    Rennard, S.I.3
  • 31
    • 84878867004 scopus 로고    scopus 로고
    • Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease
    • Thomsen M, Ingebrigtsen TS, Marott JL, et al. Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA 2013;309:2353-61.
    • (2013) JAMA , vol.309 , pp. 2353-2361
    • Thomsen, M.1    Ingebrigtsen, T.S.2    Marott, J.L.3
  • 33
    • 84879411561 scopus 로고    scopus 로고
    • Multidimensional assessment and tailored interventions for COPD: Respiratory utopia or common sense?
    • McDonald VM, Higgins I, Wood LG, et al. Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense? Thorax 2013;68:691-4.
    • (2013) Thorax , vol.68 , pp. 691-694
    • McDonald, V.M.1    Higgins, I.2    Wood, L.G.3
  • 34
    • 0032717535 scopus 로고    scopus 로고
    • Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease
    • Soler N, Ewig S, Torres A, et al. Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. Eur Respir J 1999;14:1015-22.
    • (1999) Eur Respir J , vol.14 , pp. 1015-1022
    • Soler, N.1    Ewig, S.2    Torres, A.3
  • 37
    • 33646244263 scopus 로고    scopus 로고
    • Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease
    • Sethi S, Maloney J, Grove L, et al. Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006;173:991-8.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 991-998
    • Sethi, S.1    Maloney, J.2    Grove, L.3
  • 38
    • 84898726592 scopus 로고    scopus 로고
    • Bacterial colonization increases daily symptoms in patients with chronic obstructive pulmonary disease
    • Desai H, Eschberger K, Wrona C, et al. Bacterial colonization increases daily symptoms in patients with chronic obstructive pulmonary disease. Ann Am Thorac Soc 2014;11:303-9.
    • (2014) Ann Am Thorac Soc , vol.11 , pp. 303-309
    • Desai, H.1    Eschberger, K.2    Wrona, C.3
  • 41
  • 42
    • 84867563577 scopus 로고    scopus 로고
    • Microbiome diversity in the bronchial tracts of patients with chronic obstructive pulmonary disease
    • Cabrera-Rubio R, Garcia-Nunez M, Seto L, et al. Microbiome diversity in the bronchial tracts of patients with chronic obstructive pulmonary disease. J Clin Microbiol 2012;50:3562-8.
    • (2012) J Clin Microbiol , vol.50 , pp. 3562-3568
    • Cabrera-Rubio, R.1    Garcia-Nunez, M.2    Seto, L.3
  • 43
    • 84887874141 scopus 로고    scopus 로고
    • Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease
    • Molyneaux PL, Mallia P, Cox MJ, et al. Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013;188:1224-31.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 1224-1231
    • Molyneaux, P.L.1    Mallia, P.2    Cox, M.J.3
  • 44
    • 84892528346 scopus 로고    scopus 로고
    • Significance of the microbiome in chronic obstructive pulmonary disease
    • Martinez FJ, Erb-Downward JR, Huffnagle GB. Significance of the microbiome in chronic obstructive pulmonary disease. Ann Am Thorac Soc 2013;10(Suppl): S170-9.
    • (2013) Ann Am Thorac Soc , vol.10 , Issue.SUPPL.
    • Martinez, F.J.1    Erb-Downward, J.R.2    Huffnagle, G.B.3
  • 45
    • 84862800379 scopus 로고    scopus 로고
    • Significance of the microbiome in obstructive lung disease
    • Han MK, Huang YJ, Lipuma JJ, et al. Significance of the microbiome in obstructive lung disease. Thorax 2012;67:456-63.
    • (2012) Thorax , vol.67 , pp. 456-463
    • Han, M.K.1    Huang, Y.J.2    Lipuma, J.J.3
  • 46
    • 84887872142 scopus 로고    scopus 로고
    • The lung microbiome and viral-induced exacerbations of chronic obstructive pulmonary disease: New observations, novel approaches
    • Dickson RP, Huang YJ, Martinez FJ, et al. The lung microbiome and viral-induced exacerbations of chronic obstructive pulmonary disease: new observations, novel approaches. Am J Respir Crit Care Med 2013;188:1185-6.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 1185-1186
    • Dickson, R.P.1    Huang, Y.J.2    Martinez, F.J.3
  • 47
    • 84867427320 scopus 로고    scopus 로고
    • The lung microbiome in moderate and severe chronic obstructive pulmonary disease
    • Pragman AA, Kim HB, Reilly CS, et al. The lung microbiome in moderate and severe chronic obstructive pulmonary disease. PLoS ONE 2012;7:e47305.
    • (2012) PLoS ONE , vol.7
    • Pragman, A.A.1    Kim, H.B.2    Reilly, C.S.3
  • 48
    • 84905979564 scopus 로고    scopus 로고
    • The lung microbiome in moderate and severe chronic obstructive pulmonary disease
    • Pragman AA, Kim HB, Reilly CS, et al. The lung microbiome in moderate and severe chronic obstructive pulmonary disease. Ann Am Thorac Soc 2014;11(Suppl 1): S77-8.
    • (2014) Ann Am Thorac Soc , vol.11 , Issue.SUPPL. 1
    • Pragman, A.A.1    Kim, H.B.2    Reilly, C.S.3
  • 49
    • 84861399683 scopus 로고    scopus 로고
    • The lung tissue microbiome in chronic obstructive pulmonary disease
    • Sze MA, Dimitriu PA, Hayashi S, et al. The lung tissue microbiome in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012;185:1073-80.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 1073-1080
    • Sze, M.A.1    Dimitriu, P.A.2    Hayashi, S.3
  • 50
    • 77958159129 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease biomarker(s) for disease activity needed-urgently
    • Vestbo J, Rennard S. Chronic obstructive pulmonary disease biomarker(s) for disease activity needed-urgently. Am J Respir Crit Care Med 2010;182:863-4.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 863-864
    • Vestbo, J.1    Rennard, S.2
  • 51
    • 80053534329 scopus 로고    scopus 로고
    • Avoiding confusion in COPD: From risk factors to phenotypes to measures of disease characterisation
    • Agusti A, Celli B. Avoiding confusion in COPD: from risk factors to phenotypes to measures of disease characterisation. Eur Respir J 2011;38:749-51.
    • (2011) Eur Respir J , vol.38 , pp. 749-751
    • Agusti, A.1    Celli, B.2
  • 52
    • 0034727453 scopus 로고    scopus 로고
    • Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: A randomised controlled trial
    • Brightling CE, Monteiro W, Ward R, et al. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2000;356:1480-5.
    • (2000) Lancet , vol.356 , pp. 1480-1485
    • Brightling, C.E.1    Monteiro, W.2    Ward, R.3
  • 54
    • 80052936263 scopus 로고    scopus 로고
    • Acute exacerbations of COPD: Identification of biological clusters and their biomarkers
    • Bafadhel M, McKenna S, Terry S, et al. Acute exacerbations of COPD: identification of biological clusters and their biomarkers. Am J Respir Crit Care Med 2011;184:662-71.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 662-671
    • Bafadhel, M.1    McKenna, S.2    Terry, S.3
  • 55
    • 84863447204 scopus 로고    scopus 로고
    • Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease
    • Bafadhel M, McKenna S, Terry S, et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012;186:48-55.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 48-55
    • Bafadhel, M.1    McKenna, S.2    Terry, S.3
  • 56
    • 0017402583 scopus 로고
    • The natural history of chronic airflow obstruction
    • Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977;1:1645-8. (Pubitemid 8124466)
    • (1977) British Medical Journal , vol.1 , Issue.6077 , pp. 1645-1648
    • Fletcher, C.1    Peto, R.2
  • 57
    • 80053350305 scopus 로고    scopus 로고
    • Changes in forced expiratory volume in 1 second over time in COPD
    • Vestbo J, Edwards LD, Scanlon PD, et al. Changes in forced expiratory volume in 1 second over time in COPD. N Eng J Med 2011;365:1184-92.
    • (2011) N Eng J Med , vol.365 , pp. 1184-1192
    • Vestbo, J.1    Edwards, L.D.2    Scanlon, P.D.3
  • 58
    • 69249231134 scopus 로고    scopus 로고
    • Optical imaging of molecular signatures in pulmonary inflammation
    • Ntziachristos V. Optical imaging of molecular signatures in pulmonary inflammation. Proc Am Thorac Soc 2009;6:416-18.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 416-418
    • Ntziachristos, V.1
  • 60
    • 34250849756 scopus 로고    scopus 로고
    • Molecular imaging: The vision and opportunity for radiology in the future
    • DOI 10.1148/radiol.2441060773
    • Hoffman JM, Gambhir SS. Molecular imaging: the vision and opportunity for radiology in the future. Radiology 2007;244:39-47. (Pubitemid 46981957)
    • (2007) Radiology , vol.244 , Issue.1 , pp. 39-47
    • Hoffman, J.M.1    Gambhir, S.S.2
  • 61
    • 84878642324 scopus 로고    scopus 로고
    • Change in lung density measured using computed tomography in chronic obstructive pulmonary disease
    • Coxson HO, Dirksen A, Edwards L, et al. Change in lung density measured using computed tomography in chronic obstructive pulmonary disease. Lancet Respir Med 2013;1:129-36.
    • (2013) Lancet Respir Med , vol.1 , pp. 129-136
    • Coxson, H.O.1    Dirksen, A.2    Edwards, L.3
  • 62
    • 84878029438 scopus 로고    scopus 로고
    • Diagnosis of chronic obstructive pulmonary disease in lung cancer screening computed tomography scans: Independent contribution of emphysema, air trapping and bronchial wall thickening
    • Mets O, Schmidt M, Buckens C, et al. Diagnosis of chronic obstructive pulmonary disease in lung cancer screening computed tomography scans: independent contribution of emphysema, air trapping and bronchial wall thickening. Respir Res 2013;14:59.
    • (2013) Respir Res , vol.14 , pp. 59
    • Mets, O.1    Schmidt, M.2    Buckens, C.3
  • 63
    • 84876869179 scopus 로고    scopus 로고
    • Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease
    • Martinez-Garcia MA, de la Rosa D, Soler-Cataluna JJ, et al. Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013;187:823-31.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 823-831
    • Martinez-Garcia, M.A.1    De La Rosa, D.2    Soler-Cataluna, J.J.3
  • 64
    • 84904065630 scopus 로고    scopus 로고
    • Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality
    • Williams MC, Murchison JT, Edwards LD, et al. Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality. Thorax 2014;69:718-23.
    • (2014) Thorax , vol.69 , pp. 718-723
    • Williams, M.C.1    Murchison, J.T.2    Edwards, L.D.3
  • 65
    • 80054690890 scopus 로고    scopus 로고
    • Lung cancer in patients with chronic obstructive pulmonary disease: Incidence and predicting factors
    • de Torres JP, Marin JM, Casanova C, et al. Lung cancer in patients with chronic obstructive pulmonary disease: incidence and predicting factors. Am J Respir Crit Care Med 2011;184:913-19.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 913-919
    • De Torres, J.P.1    Marin, J.M.2    Casanova, C.3
  • 66
    • 84877961632 scopus 로고    scopus 로고
    • Results of initial low-dose computed tomographic screening for lung cancer
    • National Lung Screening Trial Research Team
    • Church TR, Black WC, Aberle DR, et al.; National Lung Screening Trial Research Team. Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med 2013;368:1980-91.
    • (2013) N Engl J Med , vol.368 , pp. 1980-1991
    • Church, T.R.1    Black, W.C.2    Aberle, D.R.3
  • 67
    • 84876032083 scopus 로고    scopus 로고
    • Exploring the impact of screening with low-dose CT on lung cancer mortality in mild to moderate COPD patients: A pilot study
    • de-Torres JP, Casanova C, Marin JM, et al. Exploring the impact of screening with low-dose CT on lung cancer mortality in mild to moderate COPD patients: a pilot study. Respir Med 2013;107:702-7.
    • (2013) Respir Med , vol.107 , pp. 702-707
    • De-Torres, J.P.1    Casanova, C.2    Marin, J.M.3
  • 68
    • 0033925717 scopus 로고    scopus 로고
    • Physiological and radiological characterisation of patients diagnosed with chronic obstructive pulmonary disease in primary care
    • DOI 10.1136/thorax.55.8.635
    • O'Brien C, Guest PJ, Hill SL, et al. Physiological and radiological characterisation of patients diagnosed with chronic obstructive pulmonary disease in primary care. Thorax 2000;55:635-42. (Pubitemid 30468217)
    • (2000) Thorax , vol.55 , Issue.8 , pp. 635-642
    • O'Brien, C.1    Guest, P.J.2    Hill, S.L.3    Stockley, R.A.4
  • 70
    • 81055130028 scopus 로고    scopus 로고
    • Factors associated with bronchiectasis in patients with COPD
    • Martinez-Garcia MA, Soler-Cataluna JJ, Donat SY, et al. Factors associated with bronchiectasis in patients with COPD. Chest 2011;140:1130-7.
    • (2011) Chest , vol.140 , pp. 1130-1137
    • Martinez-Garcia, M.A.1    Soler-Cataluna, J.J.2    Donat, S.Y.3
  • 71
    • 84885109944 scopus 로고    scopus 로고
    • Cardiovascular comorbidity in chronic obstructive pulmonary disease: Systematic literature review
    • Mullerova H, Agusti A, Erqou S, et al. Cardiovascular comorbidity in chronic obstructive pulmonary disease: systematic literature review. Chest 2013;144:1163-78.
    • (2013) Chest , vol.144 , pp. 1163-1178
    • Mullerova, H.1    Agusti, A.2    Erqou, S.3
  • 72
    • 80052435472 scopus 로고    scopus 로고
    • Current controversies and future perspectives in chronic obstructive pulmonary disease
    • Agusti A, Vestbo J. Current controversies and future perspectives in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011;184:507-13.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 507-513
    • Agusti, A.1    Vestbo, J.2
  • 73
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • Barabasi AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet 2011;12:56-68.
    • (2011) Nat Rev Genet , vol.12 , pp. 56-68
    • Barabasi, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 74
    • 34547146985 scopus 로고    scopus 로고
    • Network medicine-from obesity to the "diseasome"
    • Barabasi AL. Network medicine-from obesity to the "diseasome". N Engl J Med 2007;357:404-7.
    • (2007) N Engl J Med , vol.357 , pp. 404-407
    • Barabasi, A.L.1
  • 75
    • 79959973314 scopus 로고    scopus 로고
    • Systems medicine and integrated care to combat chronic noncommunicable diseases
    • Bousquet J, Anto J, Sterk P, et al. Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med 2011;3:43.
    • (2011) Genome Med , vol.3 , pp. 43
    • Bousquet, J.1    Anto, J.2    Sterk, P.3
  • 76
    • 84874730103 scopus 로고    scopus 로고
    • GOLD COPD categories are not fit for purpose in primary care
    • Jones R, Price D, Chavannes N, et al. GOLD COPD categories are not fit for purpose in primary care. Lancet Respir Med 2013;1:e17.
    • (2013) Lancet Respir Med , vol.1
    • Jones, R.1    Price, D.2    Chavannes, N.3
  • 77
    • 79953166862 scopus 로고    scopus 로고
    • Tiotropium versus salmeterol for the prevention of exacerbations of COPD
    • Vogelmeier C, Hederer B, Glaab T, et al. Tiotropium versus salmeterol for the prevention of exacerbations of COPD. N Eng J Med 2011;364:1093-103.
    • (2011) N Eng J Med , vol.364 , pp. 1093-1103
    • Vogelmeier, C.1    Hederer, B.2    Glaab, T.3
  • 78
    • 84891372240 scopus 로고    scopus 로고
    • Effect of ADRB2 polymorphisms on the efficacy of salmeterol and tiotropium in preventing COPD exacerbations: A prespecified substudy of the POET-COPD trial
    • Rabe KF, Fabbri LM, Israel E, et al. Effect of ADRB2 polymorphisms on the efficacy of salmeterol and tiotropium in preventing COPD exacerbations: a prespecified substudy of the POET-COPD trial. Lancet Respir Med 2014;2:44-53.
    • (2014) Lancet Respir Med , vol.2 , pp. 44-53
    • Rabe, K.F.1    Fabbri, L.M.2    Israel, E.3
  • 79
    • 84855204475 scopus 로고    scopus 로고
    • I have taken my umbrella, so of course it does not rain
    • Postma DS, Brusselle G, Bush A, et al. I have taken my umbrella, so of course it does not rain. Thorax 2012;67:88-9.
    • (2012) Thorax , vol.67 , pp. 88-89
    • Postma, D.S.1    Brusselle, G.2    Bush, A.3
  • 80
    • 84890316396 scopus 로고    scopus 로고
    • Moving from the Oslerian paradigm to the post-genomic era: Are asthma and COPD outdated terms?
    • Vanfleteren LE, Kocks JW, Stone IS, et al. Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms? Thorax 2014;69:72-9.
    • (2014) Thorax , vol.69 , pp. 72-79
    • Vanfleteren, L.E.1    Kocks, J.W.2    Stone, I.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.