Optical imaging of molecular signatures in pulmonary inflammation

Proceedings of the American Thoracic Society

Volumn 6, Issue 5, 2009, Pages 416-418

  Ntziachristos, Vasilis ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Fluorescence; In vivo; Inflammation; Lung; Proteases; Tomography

Indexed keywords

PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DIAGNOSTIC IMAGING; FEMALE; FLUORESCENCE MOLECULAR TOMOGRAPHY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PNEUMONIA;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENCE; LUMINESCENT MEASUREMENTS; LUNG DISEASES; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED BALB C; MOLECULAR IMAGING; PEPTIDE HYDROLASES; TOMOGRAPHY; TRANSILLUMINATION;

EID: 69249231134     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200901-003AW     Document Type: Conference Paper

References (14)

1. Jones H, Marino P, Shakur B, Morrell N. In vivo assessment of lung inflammatory cell activity in patients with COPD and asthma. Eur Respir J 2003;21:567-573.
2. Cataldo D, Gueders M, Rocks N, Sounni N, Evrard B, Bartsch P, Louis R, Noel A, Foidart J. Pathogenic role of matrix metalloproteases and their inhibitors in asthma and chronic obstructive pulmonary disease and therapeutic relevance of matrix metalloproteases inhibitors. Cell Mol Biol 2003;49:875-884.
3. Barnes PJ. Molecular basis for corticosteroid action in asthma. Chem Immunol 2000;78:72-80. (Pubitemid 30736169)
4. Ntziachristos V, Tung C, Bremer C, Weissleder R. Fluorescence-mediated tomography resolves protease activity in vivo. Nat Med 2002;8:757-760. (Pubitemid 34778731)
5. Ntziachristos V, Ripoll J, Wang LHV, Weissleder R. Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol 2005;23:313-320. (Pubitemid 41094419)
6. Sosnovik D, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation 2007;115:1384-1391. (Pubitemid 46661480)
7. Haller J, Hyde D, Deliolanis N, de Kleine R, Niedre M, Ntziachristos V. Visualization of pulmonary inflammation using noninvasive fluorescence molecular imaging. J Appl Physiol 2008;104:795-802.
8. Schultz R, Ripoll J, Ntziachristos V. Fluorescence tomography of tissues with non-contact measurements. IEEE Trans Med Imaging 2004;23: 492-500.
9. Graves E, Culver J, Ripoll J, Weissleder R, Ntziachristos V. Singular value analysis and optimization of experimental parameters in fluorescence molecular tomography. J Opt Soc Am A Opt Image Sci Vis 2004;21:231-241.
10. Graves E, Ripoll J, Weissleder R, Ntziachristos V. A sub-millimeter resolution fluorescence molecular imaging system for small animal imaging. Med Phys 2003;30:901-911. (Pubitemid 36578694)
11. Soubret A, Ripoll J, Ntziachristos V. Accuracy of fluorescent tomography in the presence of heterogeneities: study of the normalized Born ratio. IEEE Trans Med Imaging 2005;24:1377-1386. (Pubitemid 41463574)
12. Ntziachristos V, Weissleder R. Experimental three-dimensional fluorescence reconstruction of diffuse media using a normalized Born approximation. Opt Lett 2001;26:893-895. (Pubitemid 33693607)
13. Ripoll J, Ntziachristos V. From finite to infinite volumes: removal of boundaries in diffuse wave imaging. Phys Rev Letters 2006;96(17): 173909 (and references therein).
14. Niedre MJ, Turner GM, Ntziachristos V. Time-resolved imaging of optical coefficients through murine chest cavities. Biomed Optics 2006;11(6):064017-1-7. (Pubitemid 46323020)