Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D2-like receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3753-3756

  Salama, Ismail ^a,b   Löber, Stefan ^a   Hübner, Harald ^a   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Suez Canal University   (Egypt)

Author keywords

Binding affinity; Bivalent ligands; Dopamine; GPCR dimers

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; HALOPERIDOL; LIGAND; RADIOLIGAND;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; NONHUMAN; PHARMACOPHORE; PROTEIN TARGETING; RECEPTOR AFFINITY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; HUMANS; LIGANDS; MOLECULAR STRUCTURE; RECEPTORS, DOPAMINE D2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905907218     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.06.079     Document Type: Article

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