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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3719-3723

Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

(8) Liu, Na a Qin, Bingjie a Sun, Lian Qi a Yu, Fei b,c Lu, Lu b Jiang, Shibo b,c Lee, Kuo Hsiung d,e Xie, Lan a

a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY (China)

b FUDAN UNIVERSITY (China)

c NEW YORK BLOOD CENTER (United States)

d UNC Hamner Institute for Drug Safety Sciences (United States)

e CHINA MEDICAL UNIVERSITY (Taiwan)

Author keywords

Anti HIV agents; Diarylaniline; NNRTIs; Physicochemical property

Indexed keywords

ANILINE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; ANTIRETROVIRUS AGENT; DIARYLANILINE DERIVATIVE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RILPIVIRINE; UNCLASSIFIED DRUG;

ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MICROBIAL SENSITIVITY TEST; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ANTIVIRAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; LIPOPHILICITY; NONHUMAN; PROCESS OPTIMIZATION; VIRUS STRAIN; WILD TYPE;

ANILINE COMPOUNDS; ANTI-HIV AGENTS; CHEMISTRY, PHYSICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV REVERSE TRANSCRIPTASE; HIV-1; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84905902705 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.07.011 Document Type: Article

Times cited : (6)

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