Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation

Free Radical Biology and Medicine

Volumn 75, Issue , 2014, Pages 48-59

  Dias, Irundika H K ^a   Mistry, Jayna ^a   Fell, Shaun ^a   Reis, Ana ^a   Spickett, Corinne M ^a   Polidori, Maria C ^b   Lip, Gregory Y H ^c   Griffiths, Helen R ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF COLOGNE   (Germany)

^c CITY HOSPITAL   (United Kingdom)

Author keywords

Aging; BACE1; Cholesterol; Free radicals; GSH; Lipid oxidation; Lipid raft; Low density lipoprotein; OxLDL; Redox

Indexed keywords

26 HYDROXYCHOLESTEROL; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; DESIPRAMINE; FREE RADICAL; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIPID; LOW DENSITY LIPOPROTEIN; MEMBRANE LIPID; OXIDIZED LOW DENSITY LIPOPROTEIN; SPHINGOMYELIN PHOSPHODIESTERASE; ACETYLCYSTEINE; 27-HYDROXYCHOLESTEROL; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; CHOLESTEROL DERIVATIVE; ENZYME INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SCAVENGER; SECRETASE;

AGED; ARTICLE; CELL VIABILITY; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEMENTIA; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; LIPID OXIDATION; LIPID RAFT; MASS SPECTROMETRY; NEUROBLASTOMA CELL LINE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SECRETION; PROTEIN SYNTHESIS; WESTERN BLOTTING; ALZHEIMER DISEASE; CELL ACTIVATION; CHOLESTEROL BLOOD LEVEL; ENZYME ACTIVATION; ENZYME REGULATION; IN VITRO STUDY; NERVE CELL; PROTEIN CLEAVAGE; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BLOOD; CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; SECRETION (PROCESS); TUMOR CELL LINE; VERY ELDERLY;

ACETYLCYSTEINE; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE, TUMOR; CELL SURVIVAL; CHOLESTEROL, LDL; DESIPRAMINE; ENZYME ACTIVATION; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; HYDROXYCHOLESTEROLS; LIPID METABOLISM; LIPOPROTEINS, LDL; MEMBRANE MICRODOMAINS; OXIDATION-REDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84905855338     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.07.012     Document Type: Article

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