Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 120 B, Issue 1, 2003, Pages 97-108

  Luo, Xingguang ^a   Kranzler, Henry R ^b   Zhao, Hongyu ^a   Gelernter, Joel ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

Allele; Haplotype; OPRM1 gene; Substance dependence; opioid receptor (MOR)

Indexed keywords

MU OPIATE RECEPTOR;

ALCOHOLISM; ARTICLE; CAUCASIAN; COCAINE DEPENDENCE; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC CODE; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MONTE CARLO METHOD; NEGRO; OPIATE ADDICTION; POPULATION RESEARCH; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; SUBSTANCE ABUSE;

EID: 0041821758     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.20034     Document Type: Article

References (50)

1. American Psychiatric Association. 1987. Diagnostic and statistical manual of mental disorders, third edition, revised. Washington, DC: American Psychiatric Press.
2. Basbaum AI, Fields HL. 1984. Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry. Ann Rev Neurosci 7:309-338.
3. Bergen AW, Kokoszka J, Peterson R, Long JC, Virkkunen M, Linnoila M, Goldman D. 1997. Mu opioid receptor gene variants: Lack of association with alcohol dependence. Mol Psychiatry 6:490-494.
4. Berrettini WH, Hoehe MR, Ferraro TN, Demaria PA, Gottheil D. 1997. Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse. Addict Biol 2:303-308.
5. Bilsky E, Montegut M, Delong C, Reid L. 1992. Opioidergic modulation of cocaine conditioned place preferences. Life Sci 50:85-90.
6. Blouin AG, Perez EL, Blouin JH. 1988. Computerized administration of the diagnostic interview schedule. Psychiatry Res 23:335-344.
7. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, et al. 1998. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction. Proc Natl Acad Sci USA 16:9608-9613.
8. Cadoret TJ, Troughton E, O'Gorman TW, Heywood E. 1986. An adoption study of genetic and environmental factors in drug abuse. Arch Gen Psychiatry 43:1131-1136.
9. Cadoret TJ, Yates WR, Troughton E, Woodworth G, Stewart MA. 1995. Adoption study demonstrating two genetic pathways to drug abuse. Arch Gen Psychiatry 52:42-52.
10. Corrigall W, Coen K. 1991. Opiate antagonists reduce cocaine but not nicotine self-administration. Psychopharmacology 104:167-170.
11. De Vry J, Donselaar I, Van Ree J. 1989. Food deprivation and acquisition of intravenous cocaine self-administration in rats: Effect of naltrexone and haloperidol. J Pharmacol Exp Ther 251:735-740.
12. De Waele JP, Kiianmaa K, Gianoulakis C. 1995. Distribution of the μ and δ opioid binding sites in the brain of the alcohol-preferring AA and alcohol-avoiding ANA lines of rats. J Pharmacol Exp Ther 275:518-527.
13. Franke P, Wang T, Nothen MM, Knapp M, Neidt H, Albrecht S, Jahnes E, Propping P, Maier W. 2001. Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence. Am J Med Genet 1:114-119.
14. Gelernter J, Kranzler HR, Cubells J. 1999. Genetics of two mu-opioid receptor gene (OPRM1) exon I polymorphisms: Population studies, and allele frequencies in alcohol- and drug-dependent subjects. Mol Psychiatry 5:476-483.
15. Goodwin FK. 1989. From the alcohol, drug abuse, and mental health administration. JAMA 19:2654.
16. Grove WM, Eckert ED, Heston L, Bouchard TJ, Segal N, Lykken DT. 1990. Heritability of substance abuse and antisocial behavior: A study of monozygotic twins reared apart. Biol Psychiatry 27:1293-1304.
17. Höllt V. 2002. A polymorphism)(A118G) in the μ-opioid receptor gene affects the response to morphine-6-glucuronide in humans. Pharmacogenetics 12:1-2.
18. Hernandez-Avila CA, Wand GS, Luo XG, Gelernter J, Kranzler HR. 2003. Association between the cortisol response to opioid blockade and alleles of the Asn40Asp polymorphism at the μ-opioid receptor locus (OPRM1). Am J Med Genet (Neuropsychiatr Genet) 118B:60-65.
19. Herz A. 1997. Endogenous opioid systems and alcohol addiction. Psychopharmacology 129:99-111.
20. Hoehe MR, Kopke K, Wendel B, Rohde K, Flachmeier C, Kidd KK, Berrettini WH, Church GM. 2000. Sequence variability and candidate gene analysis in complex disease: Association of mu opioid receptor gene variation with substance dependence. Hum Mol Genet 19:2895-2908.
21. Houdi A, Bardo M, Van Loon G. 1989. Opioid mediation of cocaine-induced hyperactivity and reinforcement. Brain Res 497:195-198.
22. Inder WJ, Livesey JH, Donald RA. 1998. Peripheral plasma levels of betaendorphin in alcoholics and highly trained athletes and the relationship to a measure of central opioid tone. Horm Metab Res 30:523-525.
23. Kosten T, Kleber H, Morgan C. 1989. Role of opioid antagonists in treating intravenous cocaine abuse. Life Sci 44:887-892.
24. Kranzler HR, Gelernter J, O'Malley S, Hernandez-Avila CA, Kaufman D. 1998. Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1). Alcohol Clin Exp Res 6:1359-1362.
25. Kreek MJ. 1996. Opiates, opioids, and addiction. Mol Psychiatry 1:232-254.
26. Langsrud Ø. 1999. Fisher's Exact Test. Modified August 3, 1999, from the World Wide Web http://www.matforsk.no/ola/fisher.htm.
27. Long JC, Williams RC, Urbanek M. 1995. An E-M algorithm and testing strategy for multiple locus haplotypes. Am J Hum Genet 56:799-810.
28. Lötsch J, Skarke C, Grösch S, Darimont J, Schmidt H, Geisslinger G. 2002. The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine. Pharmacogenetics 12:3-9.
29. McGue M, Pickens RW, Svikis DS. 1992. Sex and age effects on the inheritance of alcohol problems: A twin study. J Abnorm Psychol 101:3-17.
30. Mello N, Mendelson M, Luksa B, Lukas S. 1990. Buprenorphine and NTX effects on cocaine self-administration by Rhesus monkeys. J Pharmacol Exp Ther 254:926-939.
31. Mirin SM, Weiss RD, Sollogub A, Michael J. 1984. Substance abuse and psychopathology. Washington DC: American Psychiatry Association Press. pp 75-106.
32. North BV, Curtis D, Sham PC. 2002. A note on the calculation of empirical P values from Monte Carlo procedures. Am J Hum Genet 71:439-441.
33. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B. 1992. Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Arch Gen Psychiatry 49:881-887.
34. Pasternak GW. 1993. Pharmacological mechanisms of opioid analgesics. Clin Neuropharmacol 1:1-18.
35. Peterson R, Goldman D, Long JC. 1999. Nucleotide sequence diversity in non-coding regions of ALDH2 as revealed by restriction enzymes and SSCP. Hum Genet 104:177-187.
36. Pickens RW, Svikis DS, McGue M, Lykken DT, Heston LL, Clayton PL. 1991. Heterogeneity in the inheritance of alcoholism. Arch Gen Psychiatry 48:19-28.
37. Rounsaville BJ, Kosten TR, Weissman MM, PrusoffB, Pauls D, Anton SF, Merikangas K. 1991. Psychiatric disorders in relatives of probands with opiate addiction. Arch Gen Psychiatry 46:33-42.
38. Sander T, Gscheidel N, Wendel B, Samochowiec J, Smolka M, Rommelspacher H, Schmidt LG, Hoehe MR. 1998. Human μ opioid receptor variation and alcohol dependence. Alcohol Clin Exp Res 22:2108-2110.
39. Schinka JA, Town T, Abdullah L, Crawford FC, Ordorica PI, Francis E, Hughes P, Graves AB, Mortimer JA, Mullan M. 2002. A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. Mol Psychiatry 7:224-228.
40. Sham PC, Curtis D. 1995. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59:97-105.
41. Spitzer RL, Endicott J. 1975. Schedule for affective disorders and schizophrenia: Lifetime version. New York: New York Biometrics Research Division, New York State Psychiatric Institute.
42. Spitzer RL, Williams JBW, Gibbon M, First MB. 1992. The structured clinical interview for DSM-III-R (SCID), I: History, rationale, and description. Arch Gen Psychiatry 49:624-629.
43. Szeto CY, Tang NL, Lee DT, Stadlin A. 2001. Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts. Neuroreport 6:1103-1106.
44. Town T, Abdullah L, Crawford F, Schinka J, Ordorica PI, Francis E, Hughes P, Duara R, Mullan M. 1999. Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency. Am J Med Genet 5:458-461.
45. Uitenbroek DG. 1997. SISA Bonferroni. Southampton: D.G. Uitenbroek. Retrieved January 01, 2002, from the World Wide Web http://home.clara.net/sisa/bonfer.htm.
46. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP. 1992. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49:876-880.
47. Wand GS, Mangold D, El Deiry S, McCaul ME, Hoover D. 1998. Family history of alcoholism and hypothalamic opioidergic activity. Arch Gen Psychiatry 55:1114-1119.
48. Wand GS, McCaul M, Yang X, Reynolds J, Gotjen D, Lee S, Ali A. 2002. The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology 1:106-114.
49. Zadina JE, Hackler L, Ge LJ, Kastin AJ. 1997. A potent and selective endogenous agonist for the mu-opiate receptor. Nature 6624:499-502.
50. Zubieta JK, Gorelick DA, Stauffer R, Ravert HT, Dannals RF, Frest JJ. 1996. Increased p opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving. Nat Med 2:1225-1229.