Design, synthesis and biological evaluation of novel 1-hydroxyl-3- aminoalkoxy xanthone derivatives as potent anticancer agents

European Journal of Medicinal Chemistry

Volumn 85, Issue , 2014, Pages 487-497

  Yang, Zheng Min ^a   Huang, Jun ^a   Qin, Jiang Ke ^a   Dai, Zhi Kai ^b   Lan, Wen Li ^a   Su, Gui Fa ^a   Tang, Huang ^a   Yang, Feng ^a  

^a GUANGXI NORMAL UNIVERSITY   (China)

^b GUILIN MEDICAL UNIVERSITY   (China)

Author keywords

Anticancer activity; Apoptosis; Intracellular calcium; Mitochondrial membrane potential; Structure activity relationships; Synthesis; Xanthone

Indexed keywords

1 HYDROXYL 3 AMINOALKOXY XANTHONE DERIVATIVE; ANTINEOPLASTIC AGENT; PSOROSPERMIN; UNCLASSIFIED DRUG; VADIMEZAN; XANTHONE DERIVATIVE; 1 (2 (1 HYDROXY 9 OXO 9H XANTHEN 3 YLOXY)ETHYL) 1 METHYLPYRROLIDINIUM IODIDE; 1 (3 (1 HYDROXY 9 OXO 9H XANTHEN 3 YLOXY)PROPYL) 1 METHYLPYRROLIDINIUM IODIDE; 1 (4 (1 HYDROXY 9 OXO 9H XANTHEN 3 YLOXY)BUTYL) 1 METHYLPIPERIDINIUM IODIDE; 1 (4 (1 HYDROXY 9 OXO 9H XANTHEN 3 YLOXY)BUTYL) 1 METHYLPYRROLIDINIUM IODIDE; 1 (5 (1 HYDROXY 9 OXO 9H XANTHEN 3 YLOXY)PENTYL) 1 METHYLPYRROLIDINIUM IODIDE; 1 (6 (1 HYDROXY 9 OXO 9H XANTHEN 3 YLOXY)HEXYL) 1 METHYLPYRROLIDINIUM IODIDE; 1 HYDROXY 3 (2 (PYRROLIDIN 1 YL)ETHOXY) 9H XANTHEN 9 ONE; 1 HYDROXY 3 (3 (PYRROLIDIN 1 YL)PROPOXY) 9H XANTHEN 9 ONE; 1 HYDROXY 3 (4 (PIPERIDIN 1 YL)BUTOXY) 9H XANTHEN 9 ONE; 1 HYDROXY 3 (4 (PYRROLIDIN 1 YL)BUTOXY) 9H XANTHEN 9 ONE; 1 HYDROXY 3 (4 MORPHOLINOBUTOXY) 9H XANTHEN 9 ONE; 1 HYDROXY 3 (5 (PYRROLIDIN 1 YL)PENTYLOXY) 9H XANTHEN 9 ONE; 1 HYDROXY 3 (6 (PYRROLIDIN 1 YL)HEXYLOXY) 9H XANTHEN 9 ONE; 3 (2 BROMOETHOXY) 1 HYDROXY 9H XANTHEN 9 ONE; 3 (3 BROMOPROPOXY) 1 HYDROXY 9H XANTHEN 9 ONE; 3 (4 (DIETHYLAMINO)BUTOXY) 1 HYDROXY 9H XANTHEN 9 ONE; 3 (4 (DIMETHYLAMINO)BUTOXY) 1 HYDROXY 9H XANTHEN 9 ONE; 3 (4 BROMOBUTOXY) 1 HYDROXY 9H XANTHEN 9 ONE; 3 (5 BROMOPENTYLOXY) 1 HYDROXY 9H XANTHEN 9 ONE; 3 (6 BROMOHEXYLOXY) 1 HYDROXY 9H XANTHEN 9 ONE; 4 (1 HYDROXY 9 OXO 9H XANTHEN 3 YLOXY) N,N,N TRIMETHYLBUTAN 1 METHYLPYRROLIDINIUM IODIDE; 4-(4 (1 HYDROXY 9 OXO 9H XANTHEN 3 YLOXY)BUTYL) 4 METHYLMORPHOLIN 4 IUM IODIDE; N,N DIETHYL 4 (1 HYDROXY 9 OXO 9H XANTHEN 3 YLOXY) N METHYLBUTAN 1 A MINIUM IODIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CARCINOMA CELL LINE; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; NASOPHARYNX TUMOR; STOMACH CANCER; STOMACH CARCINOMA; STRUCTURE ACTIVITY RELATION; APOPTOSIS; CANCER CELL LINE; DRUG STRUCTURE; HUMAN CELL CULTURE; IC50; LUNG ADENOCARCINOMA; NASOPHARYNX CANCER; CHEMISTRY; DRUG EFFECTS; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHONES;

EID: 84905827430     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.076     Document Type: Article

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