Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as α-glucosidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7185-7192

  Liu, Yan ^a   Ke, Zhuofeng ^a   Cui, Jianfang ^a   Chen, Wen Hua ^a   Ma, Lin ^a   Wang, Bo ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Glucosidase; Inhibitory activity; QSAR; Xanthone derivatives

Indexed keywords

1,3 DIHYDROXY 2 NITRO 12H BENZO[B]XANTHEN 12 ONE; 1,3 DIHYDROXY 4 NITRO 9H XANTHEN 9 ONE; 2 AMINO 1,3 DIHYDROXY 12H BENZO[B]XANTHEN 12 ONE; 3 (3 BROMOPROPOXY) 1 HYDROXY 12H BENZO[B]XANTHEN 12 ONE; 3 (3 BROMOPROPOXY) 1 HYDROXY 9H XANTHEN 9 ONE; 4 AMINO 1,3 DIHYDROXY 12H BENZO[B]XANTHEN 12 ONE; 4 AMINO 1,3 DIHYDROXY 9H XANTHEN 9 ONE; 6 HYDROXY 2,3 DIHYDRO 1H PYRANO[2,3 C]XANTHEN 7 ONE; 6 HYDROXY 2,3 DIHYDRO 1H,7H BENZO[B]PYRANO[3,2 H]XANTHEN 7 ONE; ALPHA GLUCOSIDASE INHIBITOR; HYDROGEN; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ACCURACY; ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; MULTIPLE LINEAR REGRESSION ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGULATORY MECHANISM; VALIDATION STUDY;

ALPHA-GLUCOSIDASES; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHONES;

EID: 48449092937     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.043     Document Type: Article

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