Synthesis and evaluation of novel podophyllotoxin derivatives as potential antitumor agents

European Journal of Medicinal Chemistry

Volumn 85, Issue , 2014, Pages 498-507

  Cheng, Wei Hua ^a   Cao, Bo ^b   Shang, Hai ^a   Niu, Cong ^b   Zhang, Li Ming ^c   Zhang, Zhong Heng ^c   Tian, Dan Li ^d   Zhang, Shi ^b   Chen, Hong ^b,c   Zou, Zhong Mei ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

^d TIANJIN FIRST CENTRAL HOSPITAL   (China)

Author keywords

Apoptosis; Cytotoxicity; MDR 1; Multidrug resistance; Podophyllotoxin

Indexed keywords

ANTINEOPLASTIC AGENT; ETOPOSIDE; MULTIDRUG RESISTANCE PROTEIN 1; PODOPHYLLOTOXIN; PODOPHYLLOTOXIN DERIVATIVE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; 4B N [5 (NITROFURAN 2 YL)METHYL]AMIDO 4 DEMETHYL 4' DESOXY PODOPHYLLOTOXIN; 4B N [5 (NITROFURAN 2 YL)METHYL]AMIDO 4 DEMETHYL PODOPHYLLOTOXIN; 4BETA N [(FURAN 2 YL)METHYL]AMIDO 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [(FURAN 2 YL)METHYL]AMIDO 4' DEMETHYL 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [5 [(4 ETHYLPIPERAZIN 1 YL)METHYL)FURAN 2 YL] METHYL]AMIDO 4' DEMETHYL 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [5 [(4 ETHYLPIPERAZIN 1 YL)METHYL)FURAN 2 YL]METHYL]AMIDO 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [5 [(4 METHYLPIPERAZIN 1 YL)METHYL)FURAN 2 YL] METHYL]AMIDO 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [5 [(DIMETHYLAMINO)METHYL)FURAN 2 YL]METHYL]AMIDO 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [5 [(DIMETHYLAMINO)METHYL)FURAN 2 YL]METHYL]AMIDO 4' DEMETHYL 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [5 [(PYRROLIDIN 1 YL)METHYL)FURAN 2 YL]METHYL]AMIDO 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [5 [(PYRROLIDIN 1 YL)METHYL)FURAN 2 YL]METHYL]AMIDO 4' DEMETHYL 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [5(METHYLFURAN 2 YL)METHYL]AMIDO 4 DEMETHYL 4 DESOXY PODOPHYLLOTOXIN; 4BETA N [5(METHYLFURAN 2 YL)METHYL]AMIDO 4 DESOXY PODOPHYLLOTOXIN; GLYCOPROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; K562 CELL LINE; METABOLISM; MULTIDRUG RESISTANCE; SYNTHESIS; CANCER CELL LINE; CANCER PATIENT; CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; TREATMENT FAILURE; TUMOR CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; K562 CELLS; P-GLYCOPROTEIN; PODOPHYLLOTOXIN; RNA, MESSENGER;

EID: 84905818744     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.006     Document Type: Article

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