메뉴 건너뛰기




Volumn 1837, Issue 10, 2014, Pages 1674-1683

Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans

Author keywords

C. elegans; EF4(LepA GUF1); Mitochondrial dysfunction; Retrograde pathways; Translation

Indexed keywords

CYTOCHROME C OXIDASE; ELONGATION FACTOR; ELONGATION FACTOR 4; UNCLASSIFIED DRUG;

EID: 84905771379     PISSN: 00052728     EISSN: 18792650     Source Type: Journal    
DOI: 10.1016/j.bbabio.2014.05.353     Document Type: Article
Times cited : (20)

References (63)
  • 3
    • 18844428621 scopus 로고    scopus 로고
    • Mitochondrial translation: Elongation factor Tu is essential in fission yeast and depends on an exchange factor conserved in humans but not in budding yeast
    • DOI 10.1534/genetics.104.037473
    • S. Chiron, A. Suleau, and N. Bonnefoy Mitochondrial translation: elongation factor Tu is essential in fission yeast and depends on an exchange factor conserved in humans but not in budding yeast Genetics 169 2005 1891 1901 (Pubitemid 40695606)
    • (2005) Genetics , vol.169 , Issue.4 , pp. 1891-1901
    • Chiron, S.1    Suleau, A.2    Bonnefoy, N.3
  • 4
    • 0742323538 scopus 로고    scopus 로고
    • Endosymbiotic gene transfer: Organelle genomes forge eukaryotic chromosomes
    • DOI 10.1038/nrg1271
    • J.N. Timmis, M.A. Ayliffe, C.Y. Huang, and W. Martin Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes Nat. Rev. Genet. 5 2004 123 135 (Pubitemid 38160279)
    • (2004) Nature Reviews Genetics , vol.5 , Issue.2 , pp. 123-135
    • Timmis, J.N.1    Ayliff, M.A.2    Huang, C.Y.3    Martin, W.4
  • 6
    • 33744752749 scopus 로고    scopus 로고
    • The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1
    • DOI 10.1093/hmg/ddl106
    • H. Antonicka, F. Sasarman, N.G. Kennaway, and E.A. Shoubridge The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1 Hum. Mol. Genet. 15 2006 1835 1846 (Pubitemid 43821774)
    • (2006) Human Molecular Genetics , vol.15 , Issue.11 , pp. 1835-1846
    • Antonicka, H.1    Sasarman, F.2    Kennaway, N.G.3    Shoubridge, E.A.4
  • 7
    • 67651097815 scopus 로고    scopus 로고
    • The R336Q mutation in human mitochondrial EFTu prevents the formation of an active mt-EFTu.GTP.aa-tRNA ternary complex
    • L. Valente, N. Shigi, T. Suzuki, and M. Zeviani The R336Q mutation in human mitochondrial EFTu prevents the formation of an active mt-EFTu.GTP.aa-tRNA ternary complex Biochim. Biophys. Acta Mol. Basis Dis. 1792 2009 791 795
    • (2009) Biochim. Biophys. Acta Mol. Basis Dis. , vol.1792 , pp. 791-795
    • Valente, L.1    Shigi, N.2    Suzuki, T.3    Zeviani, M.4
  • 11
    • 47749151842 scopus 로고    scopus 로고
    • The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions
    • H. Bauerschmitt, S. Funes, and J.M. Herrmann The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions J. Biol. Chem. 283 2008 17139 17146
    • (2008) J. Biol. Chem. , vol.283 , pp. 17139-17146
    • Bauerschmitt, H.1    Funes, S.2    Herrmann, J.M.3
  • 12
    • 33750799914 scopus 로고    scopus 로고
    • The Highly Conserved LepA Isa Ribosomal Elongation Factor that Back-Translocates the Ribosome
    • DOI 10.1016/j.cell.2006.09.037, PII S0092867406012980
    • Y. Qin, N. Polacek, O. Vesper, E. Staub, E. Einfeldt, D.N. Wilson, and K.H. Nierhaus The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome Cell 127 2006 721 733 (Pubitemid 44716253)
    • (2006) Cell , vol.127 , Issue.4 , pp. 721-733
    • Qin, Y.1    Polacek, N.2    Vesper, O.3    Staub, E.4    Einfeldt, E.5    Wilson, D.N.6    Nierhaus, K.H.7
  • 14
    • 73949097952 scopus 로고    scopus 로고
    • Translation factor LepA contributes to tellurite resistance in Escherichia coli but plays no apparent role in the fidelity of protein synthesis
    • S. Shoji, B.D. Janssen, C.S. Hayes, and K. Fredrick Translation factor LepA contributes to tellurite resistance in Escherichia coli but plays no apparent role in the fidelity of protein synthesis Biochimie 92 2010 157 163
    • (2010) Biochimie , vol.92 , pp. 157-163
    • Shoji, S.1    Janssen, B.D.2    Hayes, C.S.3    Fredrick, K.4
  • 15
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • S. Brenner The genetics of Caenorhabditis elegans Genetics 77 1974 71 94
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 17
    • 61449184625 scopus 로고    scopus 로고
    • Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
    • J.M. Van Raamsdonk, and S. Hekimi Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans PLoS Genet. 5 2009 e1000361
    • (2009) PLoS Genet. , vol.5 , pp. 1000361
    • Van Raamsdonk, J.M.1    Hekimi, S.2
  • 18
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
    • B. Langmead, C. Trapnell, M. Pop, and S.L. Salzberg Ultrafast and memory-efficient alignment of short DNA sequences to the human genome Genome Biol. 10 2009 R25
    • (2009) Genome Biol. , vol.10 , pp. 25
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4
  • 19
    • 65449136284 scopus 로고    scopus 로고
    • TopHat: Discovering splice junctions with RNA-Seq
    • C. Trapnell, L. Pachter, and S.L. Salzberg TopHat: discovering splice junctions with RNA-Seq Bioinformatics 25 2009 1105 1111
    • (2009) Bioinformatics , vol.25 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 20
  • 21
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • D.W. Huang, B.T. Sherman, and R.A. Lempicki Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat. Protoc. 4 2009 44 57
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 22
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • D.W. Huang, B.T. Sherman, and R.A. Lempicki Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists Nucleic Acids Res. 37 2009 1 13
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1-13
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 23
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • DOI 10.1111/j.1474-9726.2006.00267.x
    • M. Hansen, S. Taubert, D. Crawford, N. Libina, S.J. Lee, and C. Kenyon Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans Aging Cell 6 2007 95 110 (Pubitemid 46140143)
    • (2007) Aging Cell , vol.6 , Issue.1 , pp. 95-110
    • Hansen, M.1    Taubert, S.2    Crawford, D.3    Libina, N.4    Lee, S.-J.5    Kenyon, C.6
  • 24
    • 0025257192 scopus 로고
    • Isolation and incubation conditions to study heart mitochondrial protein synthesis
    • E.E. McKee, B.L. Grier, G.S. Thompson, and J.D. McCourt Isolation and incubation conditions to study heart mitochondrial protein synthesis Am. J. Physiol. 258 1990 E492 E502
    • (1990) Am. J. Physiol. , vol.258
    • McKee, E.E.1    Grier, B.L.2    Thompson, G.S.3    McCourt, J.D.4
  • 25
    • 65249189438 scopus 로고    scopus 로고
    • Complex i function is defective in complex IV-deficient Caenorhabditis elegans
    • W. Suthammarak, Y.Y. Yang, P.G. Morgan, and M.M. Sedensky Complex I function is defective in complex IV-deficient Caenorhabditis elegans J. Biol. Chem. 284 2009 6425 6435
    • (2009) J. Biol. Chem. , vol.284 , pp. 6425-6435
    • Suthammarak, W.1    Yang, Y.Y.2    Morgan, P.G.3    Sedensky, M.M.4
  • 28
    • 0025997389 scopus 로고
    • Cloning, sequencing, and mapping of an alpha-actinin gene from the nematode Caenorhabditis elegans
    • R.J. Barstead, L. Kleiman, and R.H. Waterston Cloning, sequencing, and mapping of an alpha-actinin gene from the nematode Caenorhabditis elegans Cell Motil. Cytoskeleton 20 1991 69 78
    • (1991) Cell Motil. Cytoskeleton , vol.20 , pp. 69-78
    • Barstead, R.J.1    Kleiman, L.2    Waterston, R.H.3
  • 29
    • 66149087761 scopus 로고    scopus 로고
    • A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans
    • D. Cristina, M. Cary, A. Lunceford, C. Clarke, and C. Kenyon A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans PLoS Genet. 5 2009 e1000450
    • (2009) PLoS Genet. , vol.5 , pp. 1000450
    • Cristina, D.1    Cary, M.2    Lunceford, A.3    Clarke, C.4    Kenyon, C.5
  • 30
    • 0028845118 scopus 로고
    • GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast
    • G.L. Kiser, and T.A. Weinert GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast Yeast 11 1995 1311 1316
    • (1995) Yeast , vol.11 , pp. 1311-1316
    • Kiser, G.L.1    Weinert, T.A.2
  • 31
    • 34248531753 scopus 로고    scopus 로고
    • Locating proteins in the cell using TargetP, SignalP and related tools
    • DOI 10.1038/nprot.2007.131, PII NPROT.2007.131
    • O. Emanuelsson, S. Brunak, G. von Heijne, and H. Nielsen Locating proteins in the cell using TargetP, SignalP and related tools Nat. Protoc. 2 2007 953 971 (Pubitemid 46745592)
    • (2007) Nature Protocols , vol.2 , Issue.4 , pp. 953-971
    • Emanuelsson, O.1    Brunak, S.2    Von Heijne, G.3    Nielsen, H.4
  • 32
    • 41349103857 scopus 로고    scopus 로고
    • An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans
    • DOI 10.1093/jb/mvm245
    • R. Ichishita, K. Tanaka, Y. Sugiura, T. Sayano, K. Mihara, and T. Oka An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans J. Biochem. 143 2008 449 454 (Pubitemid 351451767)
    • (2008) Journal of Biochemistry , vol.143 , Issue.4 , pp. 449-454
    • Ichishita, R.1    Tanaka, K.2    Sugiura, Y.3    Sayano, T.4    Mihara, K.5    Oka, T.6
  • 35
    • 77951901493 scopus 로고    scopus 로고
    • Fundamental of medical image processing with personal computer system - Development of Plugins by ImageJ
    • H. Muraishi Fundamental of medical image processing with personal computer system - development of Plugins by ImageJ Nihon Hoshasen Gijutsu Gakkai Zasshi 66 2010 260 264
    • (2010) Nihon Hoshasen Gijutsu Gakkai Zasshi , vol.66 , pp. 260-264
    • Muraishi, H.1
  • 36
    • 77949495744 scopus 로고    scopus 로고
    • Fundamental of medical image processing with personal computer system - Image processing of computed tomography with imageJ
    • S. Yamamoto Fundamental of medical image processing with personal computer system - image processing of computed tomography with imageJ Nihon Hoshasen Gijutsu Gakkai Zasshi 65 2009 1680 1682
    • (2009) Nihon Hoshasen Gijutsu Gakkai Zasshi , vol.65 , pp. 1680-1682
    • Yamamoto, S.1
  • 37
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. Elegans
    • E.L. Greer, and A. Brunet Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans Aging Cell 8 2009 113 127
    • (2009) Aging Cell , vol.8 , pp. 113-127
    • Greer, E.L.1    Brunet, A.2
  • 38
    • 34848850156 scopus 로고    scopus 로고
    • An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. Elegans
    • DOI 10.1016/j.cub.2007.08.047, PII S0960982207018647
    • E.L. Greer, D. Dowlatshahi, M.R. Banko, J. Villen, K. Hoang, D. Blanchard, S.P. Gygi, and A. Brunet An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans Curr. Biol. 17 2007 1646 1656 (Pubitemid 47503807)
    • (2007) Current Biology , vol.17 , Issue.19 , pp. 1646-1656
    • Greer, E.L.1    Dowlatshahi, D.2    Banko, M.R.3    Villen, J.4    Hoang, K.5    Blanchard, D.6    Gygi, S.P.7    Brunet, A.8
  • 40
    • 33751203889 scopus 로고    scopus 로고
    • Dietary deprivation extends lifespan in Caenorhabditis elegans
    • DOI 10.1111/j.1474-9726.2006.00241.x
    • G.D. Lee, M.A. Wilson, M. Zhu, C.A. Wolkow, R. de Cabo, D.K. Ingram, and S. Zou Dietary deprivation extends lifespan in Caenorhabditis elegans Aging Cell 5 2006 515 524 (Pubitemid 44782620)
    • (2006) Aging Cell , vol.5 , Issue.6 , pp. 515-524
    • Lee, G.D.1    Wilson, M.A.2    Zhu, M.3    Wolkow, C.A.4    De Cabo, R.5    Ingram, D.K.6    Zou, S.7
  • 41
    • 78650455712 scopus 로고    scopus 로고
    • A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
    • W. Yang, and S. Hekimi A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans PLoS Biol. 8 2010 e1000556
    • (2010) PLoS Biol. , vol.8 , pp. 1000556
    • Yang, W.1    Hekimi, S.2
  • 43
    • 0032947552 scopus 로고    scopus 로고
    • Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
    • P.A. Kirchman, S. Kim, C.Y. Lai, and S.M. Jazwinski Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae Genetics 152 1999 179 190 (Pubitemid 29222525)
    • (1999) Genetics , vol.152 , Issue.1 , pp. 179-190
    • Kirchman, P.A.1    Kim, S.2    Lai, C.-Y.3    Michal Jazwinski, S.4
  • 45
    • 0035830867 scopus 로고    scopus 로고
    • Interorganellar communication. Altered nuclear gene expression profiles in a yeast mitochondrial DNA mutant
    • A. Traven, J.M. Wong, D. Xu, M. Sopta, and C.J. Ingles Interorganellar communication. Altered nuclear gene expression profiles in a yeast mitochondrial DNA mutant J. Biol. Chem. 276 2001 4020 4027
    • (2001) J. Biol. Chem. , vol.276 , pp. 4020-4027
    • Traven, A.1    Wong, J.M.2    Xu, D.3    Sopta, M.4    Ingles, C.J.5
  • 46
    • 1842665662 scopus 로고    scopus 로고
    • Mitochondrial signaling: The retrograde response
    • DOI 10.1016/S1097-2765(04)00179-0, PII S1097276504001790
    • R.A. Butow, and N.G. Avadhani Mitochondrial signaling: the retrograde response Mol. Cell 14 2004 1 15 (Pubitemid 38469905)
    • (2004) Molecular Cell , vol.14 , Issue.1 , pp. 1-15
    • Butow, R.A.1    Avadhani, N.G.2
  • 47
    • 78650177082 scopus 로고    scopus 로고
    • Inhibition of respiration extends C. Elegans life span via reactive oxygen species that increase HIF-1 activity
    • S.J. Lee, A.B. Hwang, and C. Kenyon Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity Curr. Biol. 20 2010 2131 2136
    • (2010) Curr. Biol. , vol.20 , pp. 2131-2136
    • Lee, S.J.1    Hwang, A.B.2    Kenyon, C.3
  • 48
    • 79959791906 scopus 로고    scopus 로고
    • The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. Elegans
    • L. Walter, A. Baruah, H.W. Chang, H.M. Pace, and S.S. Lee The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans PLoS Biol. 9 2011 e1001084
    • (2011) PLoS Biol. , vol.9 , pp. 1001084
    • Walter, L.1    Baruah, A.2    Chang, H.W.3    Pace, H.M.4    Lee, S.S.5
  • 50
    • 84864065342 scopus 로고    scopus 로고
    • Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2
    • B.M. Baker, A.M. Nargund, T. Sun, and C.M. Haynes Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2 PLoS Genet. 8 2012 e1002760
    • (2012) PLoS Genet. , vol.8 , pp. 1002760
    • Baker, B.M.1    Nargund, A.M.2    Sun, T.3    Haynes, C.M.4
  • 51
    • 51049094187 scopus 로고    scopus 로고
    • Reduced cytosolic protein synthesis suppresses mitochondrial degeneration
    • X. Wang, X. Zuo, B. Kucejova, and X.J. Chen Reduced cytosolic protein synthesis suppresses mitochondrial degeneration Nat. Cell Biol. 10 2008 1090 1097
    • (2008) Nat. Cell Biol. , vol.10 , pp. 1090-1097
    • Wang, X.1    Zuo, X.2    Kucejova, B.3    Chen, X.J.4
  • 52
    • 78650694150 scopus 로고    scopus 로고
    • Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster
    • S. Liu, and B. Lu Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster PLoS Genet. 6 2010 e1001237
    • (2010) PLoS Genet. , vol.6 , pp. 1001237
    • Liu, S.1    Lu, B.2
  • 53
    • 84863045210 scopus 로고    scopus 로고
    • Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis
    • V. Iadevaia, Y.L. Huo, Z. Zhang, L.J. Foster, and C.G. Proud Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis Biochem. Soc. Trans. 40 2012 168 172
    • (2012) Biochem. Soc. Trans. , vol.40 , pp. 168-172
    • Iadevaia, V.1    Huo, Y.L.2    Zhang, Z.3    Foster, L.J.4    Proud, C.G.5
  • 54
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • DOI 10.1016/S0092-8674(02)00808-5
    • D.H. Kim, D.D. Sarbassov, S.M. Ali, J.E. King, R.R. Latek, H. Erdjument-Bromage, P. Tempst, and D.M. Sabatini mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery Cell 110 2002 163 175 (Pubitemid 34876545)
    • (2002) Cell , vol.110 , Issue.2 , pp. 163-175
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 56
    • 0032915417 scopus 로고    scopus 로고
    • Regulation of ribosome biogenesis by the rapamycin-sensitive TOR- signaling pathway in Saccharomyces cerevisiae
    • T. Powers, and P. Walter Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae Mol. Biol. Cell 10 1999 987 1000 (Pubitemid 29193726)
    • (1999) Molecular Biology of the Cell , vol.10 , Issue.4 , pp. 987-1000
    • Powers, T.1    Walter, P.2
  • 57
    • 0038682500 scopus 로고    scopus 로고
    • Amino acid transporters: Roles in amino acid sensing and signalling in animal cells
    • DOI 10.1042/BJ20030405
    • R. Hyde, P.M. Taylor, and H.S. Hundal Amino acid transporters: roles in amino acid sensing and signalling in animal cells Biochem. J. 373 2003 1 18 (Pubitemid 36819495)
    • (2003) Biochemical Journal , vol.373 , Issue.1 , pp. 1-18
    • Hyde, R.1    Taylor, P.M.2    Hundal, H.S.3
  • 59
    • 84865188660 scopus 로고    scopus 로고
    • Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut
    • S. Chakrabarti, P. Liehl, N. Buchon, and B. Lemaitre Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut Cell Host Microbe 12 2012 60 70
    • (2012) Cell Host Microbe , vol.12 , pp. 60-70
    • Chakrabarti, S.1    Liehl, P.2    Buchon, N.3    Lemaitre, B.4
  • 60
    • 84897493440 scopus 로고    scopus 로고
    • Rheb and mammalian target of rapamycin in mitochondrial homoeostasis
    • M.J. Groenewoud, and F.J. Zwartkruis Rheb and mammalian target of rapamycin in mitochondrial homoeostasis Open Biol. 3 2013 130185
    • (2013) Open Biol. , vol.3 , pp. 130185
    • Groenewoud, M.J.1    Zwartkruis, F.J.2
  • 62
    • 84883817838 scopus 로고    scopus 로고
    • The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans
    • A. Rousakis, A. Vlassis, A. Vlanti, S. Patera, G. Thireos, and P. Syntichaki The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans Aging Cell 12 2013 742 751
    • (2013) Aging Cell , vol.12 , pp. 742-751
    • Rousakis, A.1    Vlassis, A.2    Vlanti, A.3    Patera, S.4    Thireos, G.5    Syntichaki, P.6
  • 63
    • 84874065131 scopus 로고    scopus 로고
    • A genetic program promotes C. Elegans longevity at cold temperatures via a thermosensitive TRP channel
    • R. Xiao, B. Zhang, Y. Dong, J. Gong, T. Xu, J. Liu, and X.Z. Xu A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel Cell 152 2013 806 817
    • (2013) Cell , vol.152 , pp. 806-817
    • Xiao, R.1    Zhang, B.2    Dong, Y.3    Gong, J.4    Xu, T.5    Liu, J.6    Xu, X.Z.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.