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Volumn 16, Issue 9, 2014, Pages 861-868

Pronounced reduction of postprandial glucagon by lixisenatide: A meta-analysis of randomized clinical trials

Author keywords

Diabetes mellitus; GLP 1; Insulin secretion

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUCAGON; INSULIN; LIXISENATIDE; METFORMIN; ORAL ANTIDIABETIC AGENT; SULFONYLUREA DERIVATIVE; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; PEPTIDE; ZP10A PEPTIDE;

EID: 84905739727     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12290     Document Type: Article
Times cited : (27)

References (40)
  • 1
    • 0024026298 scopus 로고
    • Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA. Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988; 37: 667-687.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 2
    • 0014951784 scopus 로고
    • Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion
    • Muller WA, Faloona GR, Aguilar-Parada E, Unger RH. Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N Engl J Med 1970; 283: 109-115.
    • (1970) N Engl J Med , vol.283 , pp. 109-115
    • Muller, W.A.1    Faloona, G.R.2    Aguilar-Parada, E.3    Unger, R.H.4
  • 3
    • 0034880655 scopus 로고    scopus 로고
    • Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    • Toft-Nielsen MB, Damholt MB, Madsbad S et al. Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab 2001; 86: 3717-3723.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3717-3723
    • Toft-Nielsen, M.B.1    Damholt, M.B.2    Madsbad, S.3
  • 4
    • 0015232603 scopus 로고
    • Glucagon physiology and pathophysiology
    • Unger RH. Glucagon physiology and pathophysiology. N Engl J Med 1971; 285: 443-449.
    • (1971) N Engl J Med , vol.285 , pp. 443-449
    • Unger, R.H.1
  • 5
    • 0031908153 scopus 로고    scopus 로고
    • Effects of glucagon on postprandial carbohydrate metabolism in nondiabetic humans
    • Frank JW, Camilleri M, Thomforde GM, Dinneen SF, Rizza RA. Effects of glucagon on postprandial carbohydrate metabolism in nondiabetic humans. Metabolism 1998; 47: 7-12.
    • (1998) Metabolism , vol.47 , pp. 7-12
    • Frank, J.W.1    Camilleri, M.2    Thomforde, G.M.3    Dinneen, S.F.4    Rizza, R.A.5
  • 6
    • 33745301045 scopus 로고    scopus 로고
    • Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis
    • Meier JJ, Kjems LL, Veldhuis JD, Lefebvre P, Butler PC. Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis. Diabetes 2006; 55: 1051-1056.
    • (2006) Diabetes , vol.55 , pp. 1051-1056
    • Meier, J.J.1    Kjems, L.L.2    Veldhuis, J.D.3    Lefebvre, P.4    Butler, P.C.5
  • 7
    • 0034524938 scopus 로고    scopus 로고
    • Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
    • Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 2000; 85: 4053-4059.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4053-4059
    • Shah, P.1    Vella, A.2    Basu, A.3    Basu, R.4    Schwenk, W.F.5    Rizza, R.A.6
  • 8
    • 79952291919 scopus 로고    scopus 로고
    • GLP-1 for type 2 diabetes
    • Ahren B. GLP-1 for type 2 diabetes. Exp Cell Res 2011; 317: 1239-1245.
    • (2011) Exp Cell Res , vol.317 , pp. 1239-1245
    • Ahren, B.1
  • 9
    • 0031032244 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus
    • Ahren B, Larsson H, Holst JJ. Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1997; 82: 473-478.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 473-478
    • Ahren, B.1    Larsson, H.2    Holst, J.J.3
  • 10
    • 84863331401 scopus 로고    scopus 로고
    • GLP-1 based therapies: differential effects on fasting and postprandial glucose
    • Fineman MS, Cirincione BB, Maggs D, Diamant M. GLP-1 based therapies: differential effects on fasting and postprandial glucose. Diabetes Obes Metab 2012; 14: 675-688.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 675-688
    • Fineman, M.S.1    Cirincione, B.B.2    Maggs, D.3    Diamant, M.4
  • 11
    • 24944577486 scopus 로고    scopus 로고
    • Alpha cell function in health and disease: influence of glucagon-like peptide-1
    • Dunning BE, Foley JE, Ahren B. Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia 2005; 48: 1700-1713.
    • (2005) Diabetologia , vol.48 , pp. 1700-1713
    • Dunning, B.E.1    Foley, J.E.2    Ahren, B.3
  • 12
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
    • Nauck MA, Niedereichholz U, Ettler R et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997; 273: E981-E988.
    • (1997) Am J Physiol , vol.273
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3
  • 13
    • 77954250537 scopus 로고    scopus 로고
    • The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action
    • Hare KJ, Vilsboll T, Asmar M, Deacon CF, Knop FK, Holst JJ. The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. Diabetes 2010; 59: 1765-1770.
    • (2010) Diabetes , vol.59 , pp. 1765-1770
    • Hare, K.J.1    Vilsboll, T.2    Asmar, M.3    Deacon, C.F.4    Knop, F.K.5    Holst, J.J.6
  • 14
    • 84870054636 scopus 로고    scopus 로고
    • GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
    • Meier JJ. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat Rev Endocrinol 2012; 8: 728-742.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 728-742
    • Meier, J.J.1
  • 15
    • 84878863716 scopus 로고    scopus 로고
    • Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin
    • Kapitza C, Forst T, Coester HV, Poitiers F, Ruus P, Hincelin-Mery A. Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin. Diabetes Obes Metab 2013; 15: 642-649.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 642-649
    • Kapitza, C.1    Forst, T.2    Coester, H.V.3    Poitiers, F.4    Ruus, P.5    Hincelin-Mery, A.6
  • 16
    • 79959404178 scopus 로고    scopus 로고
    • Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
    • Nauck MA, Kemmeries G, Holst JJ, Meier JJ. Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes 2011; 60: 1561-1565.
    • (2011) Diabetes , vol.60 , pp. 1561-1565
    • Nauck, M.A.1    Kemmeries, G.2    Holst, J.J.3    Meier, J.J.4
  • 17
    • 84861765116 scopus 로고    scopus 로고
    • Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono)
    • Fonseca VA, Alvarado-Ruiz R, Raccah D et al. Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono). Diabetes Care 2012; 35: 1225-1231.
    • (2012) Diabetes Care , vol.35 , pp. 1225-1231
    • Fonseca, V.A.1    Alvarado-Ruiz, R.2    Raccah, D.3
  • 18
    • 84878358313 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide once-daily morning or evening injections in type 2 diabetes inadequately controlled on metformin (GetGoal-M)
    • Ahren B, Leguizamo Dimas A, Miossec P, Saubadu S, Aronson R. Efficacy and safety of lixisenatide once-daily morning or evening injections in type 2 diabetes inadequately controlled on metformin (GetGoal-M). Diabetes Care 2013; 36: 2543-2550.
    • (2013) Diabetes Care , vol.36 , pp. 2543-2550
    • Ahren, B.1    Leguizamo Dimas, A.2    Miossec, P.3    Saubadu, S.4    Aronson, R.5
  • 19
    • 84885331631 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide once daily versus placebo in type 2 diabetes insufficiently controlled on pioglitazone (GetGoal-P)
    • Pinget M, Goldenberg R, Niemoeller E, Muehlen-Bartmer I, Guo H, Aronson R. Efficacy and safety of lixisenatide once daily versus placebo in type 2 diabetes insufficiently controlled on pioglitazone (GetGoal-P). Diabetes Obes Metab 2013; 15: 1000-1007.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 1000-1007
    • Pinget, M.1    Goldenberg, R.2    Niemoeller, E.3    Muehlen-Bartmer, I.4    Guo, H.5    Aronson, R.6
  • 20
    • 84883324640 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X)
    • Rosenstock J, Raccah D, Koranyi L et al. Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X). Diabetes Care 2013; 36: 2945-2951.
    • (2013) Diabetes Care , vol.36 , pp. 2945-2951
    • Rosenstock, J.1    Raccah, D.2    Koranyi, L.3
  • 21
    • 84878622377 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide once daily versus placebo in patients with T2DM insufficiently controlled on sulfonylurea+metformin (GetGoal-S)
    • Abstract 785).
    • Ratner R, Hanefeld M, Shamanna P et al. Efficacy and safety of lixisenatide once daily versus placebo in patients with T2DM insufficiently controlled on sulfonylurea+metformin (GetGoal-S). Diabetologia 2011; 54: 1-542(Abstract 785).
    • (2011) Diabetologia , vol.54 , pp. 1-542
    • Ratner, R.1    Hanefeld, M.2    Shamanna, P.3
  • 22
    • 84878592117 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: a 24-week, randomized, placebo-controlled comparison (GetGoal-L)
    • Riddle MC, Aronson R, Home P et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: a 24-week, randomized, placebo-controlled comparison (GetGoal-L). Diabetes Care 2013; 36: 2489-2496.
    • (2013) Diabetes Care , vol.36 , pp. 2489-2496
    • Riddle, M.C.1    Aronson, R.2    Home, P.3
  • 23
    • 84878603672 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: a 24-week, randomized, placebo-controlled study (GetGoal-Duo 1)
    • Riddle MC, Forst T, Aronson R et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: a 24-week, randomized, placebo-controlled study (GetGoal-Duo 1). Diabetes Care 2013; 36: 2497-2503.
    • (2013) Diabetes Care , vol.36 , pp. 2497-2503
    • Riddle, M.C.1    Forst, T.2    Aronson, R.3
  • 24
    • 84865979163 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)
    • Seino Y, Min KW, Niemoeller E, Takami A, Investigators EG-LAS. Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia). Diabetes Obes Metab 2012; 14: 910-917.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 910-917
    • Seino, Y.1    Min, K.W.2    Niemoeller, E.3    Takami, A.4    Investigators, E.-L.5
  • 25
    • 0016423677 scopus 로고
    • The essential role of glucagon in the pathogenesis of diabetes mellitus
    • Unger RH, Orci L. The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet 1975; 1: 14-16.
    • (1975) Lancet , vol.1 , pp. 14-16
    • Unger, R.H.1    Orci, L.2
  • 26
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 2006; 3: 153-165.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 27
    • 80052812653 scopus 로고    scopus 로고
    • Effects of GLP-1 and incretin-based therapies on gastrointestinal motor function
    • Marathe CS, Rayner CK, Jones KL, Horowitz M. Effects of GLP-1 and incretin-based therapies on gastrointestinal motor function. Exp Diabetes Res 2011; 2011: 279530.
    • (2011) Exp Diabetes Res , vol.2011 , pp. 279530
    • Marathe, C.S.1    Rayner, C.K.2    Jones, K.L.3    Horowitz, M.4
  • 28
    • 0032877316 scopus 로고    scopus 로고
    • Impact of lack of suppression of glucagon on glucose tolerance in humans
    • Shah P, Basu A, Basu R, Rizza R. Impact of lack of suppression of glucagon on glucose tolerance in humans. Am J Physiol 1999; 277: 283-290.
    • (1999) Am J Physiol , vol.277 , pp. 283-290
    • Shah, P.1    Basu, A.2    Basu, R.3    Rizza, R.4
  • 29
    • 84878549237 scopus 로고    scopus 로고
    • Effects of lixisenatide once daily on gastric emptying in type 2 diabetes - relationship to postprandial glycemia
    • 185C:
    • Lorenz M, Pfeiffer C, Steinstrasser A et al. Effects of lixisenatide once daily on gastric emptying in type 2 diabetes - relationship to postprandial glycemia. Regul Pept 2013; 185C: 1-8.
    • (2013) Regul Pept , pp. 1-8
    • Lorenz, M.1    Pfeiffer, C.2    Steinstrasser, A.3
  • 30
    • 79961187183 scopus 로고    scopus 로고
    • The role of dysregulated glucagon secretion in type 2 diabetes
    • D'Alessio D. The role of dysregulated glucagon secretion in type 2 diabetes. Diabetes Obes Metab 2011; 13(Suppl. 1): 126-132.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.SUPPL. 1 , pp. 126-132
    • D'Alessio, D.1
  • 32
    • 77954980506 scopus 로고    scopus 로고
    • Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice
    • Hancock AS, Du A, Liu J, Miller M, May CL. Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice. Mol Endocrinol 2010; 24: 1605-1614.
    • (2010) Mol Endocrinol , vol.24 , pp. 1605-1614
    • Hancock, A.S.1    Du, A.2    Liu, J.3    Miller, M.4    May, C.L.5
  • 33
    • 84870704490 scopus 로고    scopus 로고
    • Human monoclonal antibodies against glucagon receptor improve glucose homeostasis by suppression of hepatic glucose output in diet-induced obese mice
    • Kim WD, Lee YH, Kim MH et al. Human monoclonal antibodies against glucagon receptor improve glucose homeostasis by suppression of hepatic glucose output in diet-induced obese mice. PLoS One 2012; 7: e50954.
    • (2012) PLoS One , vol.7
    • Kim, W.D.1    Lee, Y.H.2    Kim, M.H.3
  • 34
    • 0017346571 scopus 로고
    • Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man
    • Liljenquist JE, Mueller GL, Cherrington AD et al. Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man. J Clin Invest 1977; 59: 369-374.
    • (1977) J Clin Invest , vol.59 , pp. 369-374
    • Liljenquist, J.E.1    Mueller, G.L.2    Cherrington, A.D.3
  • 35
    • 34247237309 scopus 로고    scopus 로고
    • A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog
    • Rivera N, Everett-Grueter CA, Edgerton DS et al. A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J Pharmacol Exp Ther 2007; 321: 743-752.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 743-752
    • Rivera, N.1    Everett-Grueter, C.A.2    Edgerton, D.S.3
  • 36
    • 33750877987 scopus 로고    scopus 로고
    • Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice
    • Sorensen H, Brand CL, Neschen S et al. Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice. Diabetes 2006; 55: 2843-2848.
    • (2006) Diabetes , vol.55 , pp. 2843-2848
    • Sorensen, H.1    Brand, C.L.2    Neschen, S.3
  • 37
    • 0030975613 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas
    • Heller RS, Kieffer TJ, Habener JF. Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas. Diabetes 1997; 46: 785-791.
    • (1997) Diabetes , vol.46 , pp. 785-791
    • Heller, R.S.1    Kieffer, T.J.2    Habener, J.F.3
  • 38
    • 84879189059 scopus 로고    scopus 로고
    • The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty
    • Plamboeck A, Veedfald S, Deacon CF et al. The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty. Am J Physiol Gastrointest Liver Physiol 2013; 304: G1117-G1127.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.304
    • Plamboeck, A.1    Veedfald, S.2    Deacon, C.F.3
  • 39
    • 0344357096 scopus 로고
    • Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
    • Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A 1987; 84: 3434-3438.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 3434-3438
    • Drucker, D.J.1    Philippe, J.2    Mojsov, S.3    Chick, W.L.4    Habener, J.F.5
  • 40
    • 0026034765 scopus 로고
    • Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line
    • Fehmann HC, Habener JF. Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line. FEBS Lett 1991; 279: 335-340.
    • (1991) FEBS Lett , vol.279 , pp. 335-340
    • Fehmann, H.C.1    Habener, J.F.2


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