BCR-ABL1-positive microvesicles transform normal hematopoietic transplants through genomic instability: Implications for donor cell leukemia

Leukemia

Volumn 28, Issue 8, 2014, Pages 1666-1675

  Zhu, X ^a   You, Y ^a   Li, Q ^a   Zeng, C ^a   Fu, F ^a   Guo, A ^a   Zhang, H ^a   Zou, P ^a   Zhong, Z ^a   Wang, H ^b   Wu, Y ^a   Kong, F ^a   Chen, Z ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Central Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; BCR ABL PROTEIN; DNA; MESSENGER RNA; METHYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL MEMBRANE; CELL TRANSFER; CONTROLLED STUDY; DNA METHYLATION; DNA RECOMBINATION; DNA STRAND BREAKAGE; DONOR; DONOR CELL LEUKEMIA; GENE OVEREXPRESSION; GENOMIC INSTABILITY; GRAFT RECIPIENT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; K562 CELL LINE; LEUKEMIA; LEUKEMOGENESIS; MALIGNANT TRANSFORMATION; MICROVESICLE; MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; UPREGULATION;

CELL TRANSFORMATION, NEOPLASTIC; CYTIDINE DEAMINASE; FUSION PROTEINS, BCR-ABL; GENE TRANSFER, HORIZONTAL; GENOMIC INSTABILITY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; REACTIVE OXYGEN SPECIES;

EID: 84905716311     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2014.51     Document Type: Article

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