SCOPUS 정보 검색 플랫폼

Volumn 85, Issue , 2014, Pages 359-370

Design, synthesis and biological evaluation of 17-arylmethylamine-17- demethoxygeldanamycin derivatives as potent Hsp90 inhibitors

(10) Li, Zhenyu a Jia, Lejiao a Wang, Jifeng b Wu, Xingkang a Hao, Huilin a Xu, Hongjiao a Wu, Yunfei a Shi, Guowei b Lu, Chunhua a Shen, Yuemao a

a SHANDONG UNIVERSITY (China)

b FUDAN UNIVERSITY (China)

Author keywords

Antitumor activities; Geldanamycin; Hepatotoxicity; Hsp90; Molecular dynamics

Indexed keywords

17 (2 CHLOROBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (2 METHOXYBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (2 METHYLBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (2,4 DIMETHOXYBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3 AMINOBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3 CHLOROBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3 CYANOBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3 METHOXYBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3 METHYLBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3,4 DIFLUOROBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3,4 DIMETHOXYBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3,4,5 TRIMETHOXYBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3,5 DIFLUOROBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 AMINOBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 BROMOBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 CHLOROBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 CYANOBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 FLUOROBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 HYDROXY 3 METHOXYBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 HYDROXYBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 IODOBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 METHOXYBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 METHYLBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 METHYLSULFONYLBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (4 SULFAMOYLBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; ANTINEOPLASTIC AGENT; GELDANAMYCIN; HEAT SHOCK PROTEIN 90 INHIBITOR; TANESPIMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; 17 (3,5 DIFLUOROBENZYLAMINO)-17 DEMETHOXYGELDANAMYCIN; 17 ARYLMETHYLAMINE 17 DEMETHOXYGELDANAMYCIN DERIVATIVE; ALVESPIMYCIN; BENZOQUINONE DERIVATIVE; HEAT SHOCK PROTEIN 90; MACROCYCLIC LACTAM;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIVER TOXICITY; LNCAP CELL LINE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; THEORETICAL MODEL; TOXICITY TESTING; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL EXPERIMENT; ANIMAL MODEL; DRUG CYTOTOXICITY; IC50; MALE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; LIVER; PROTEIN CONFORMATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOQUINONES; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; LIVER; MALE; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 84905705083 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2014.07.101 Document Type: Article

Times cited : (21)

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