Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin

Journal of the American Chemical Society

Volumn 129, Issue 33, 2007, Pages 10082-10083

  Howard Jones, Annaleise R ^a   Kruger, Ryan G ^a,b   Lu, Wei ^a,c   Tao, Junhua ^d   Leimkuhler, Catherine ^e,f   Kahne, Daniel ^e   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b GLAXOSMITHKLINE   (United States)

^c Merck Research Laboratories Boston   (United States)

^d BioVerdant Inc   (United States)

^e HARVARD UNIVERSITY   (United States)

^f HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; ACYLTRANSFERASE; AGLYCONE; GLYCOPEPTIDE; GLYCOSYLTRANSFERASE; PEPTIDE SYNTHASE; POLYPEPTIDE ANTIBIOTIC AGENT; SCAFFOLD PROTEIN; TEICOPLANIN;

ACYLATION; ARTICLE; BINDING SITE; CATALYSIS; CATALYST; CHEMICAL REACTION KINETICS; CROSS LINKING; DEACETYLATION; DRUG STRUCTURE; GLYCOSYLATION; POLYMERIZATION;

ACYLATION; ACYLTRANSFERASES; CATALYSIS; GLYCOSYLATION; GLYCOSYLTRANSFERASES; KINETICS; TEICOPLANIN;

EID: 34548157165     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0735857     Document Type: Article

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