메뉴 건너뛰기




Volumn 35, Issue 8, 2014, Pages 1881-1890

Nuclear adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice

Author keywords

Adenomatous polyposis coli (APC); Colitis; Goblet cell differentiation; Mouse model; Tumorigenesis

Indexed keywords

AZOXYMETHANE; BETA CATENIN; DEXTRAN SULFATE; K RAS PROTEIN; APC PROTEIN; CARCINOGEN; CYCLOOXYGENASE 2; MESSENGER RNA; PTGS2 PROTEIN, HUMAN;

EID: 84905674529     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgu121     Document Type: Article
Times cited : (9)

References (48)
  • 1
    • 77951635438 scopus 로고    scopus 로고
    • Inflammation and colon cancer
    • Terzic, J., et al. (2010) Inflammation and colon cancer. Gastroenterology, 138, 2101-2114 e5.
    • (2010) Gastroenterology , vol.138 , pp. 2101-2114
    • Terzic, J.1
  • 2
    • 78649854163 scopus 로고    scopus 로고
    • Effect of aspirin and NSAIDs on risk and survival from colorectal cancer
    • Din, F.V., et al. (2010) Effect of aspirin and NSAIDs on risk and survival from colorectal cancer. Gut, 59, 1670-9.
    • (2010) Gut , vol.59 , pp. 1670-1679
    • Din, F.V.1
  • 3
    • 84876741426 scopus 로고    scopus 로고
    • The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis
    • Rowland, K.J., et al. (2013) The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis. Semin Pediatr Surg, 22, 101-11.
    • (2013) Semin Pediatr Surg , vol.22 , pp. 101-111
    • Rowland, K.J.1
  • 4
    • 47749101220 scopus 로고    scopus 로고
    • Inflammation and cancer: the oncogene-driven connection
    • Borrello, M.G., et al. (2008) Inflammation and cancer: the oncogene-driven connection. Cancer Lett, 267, 262-70.
    • (2008) Cancer Lett , vol.267 , pp. 262-270
    • Borrello, M.G.1
  • 5
    • 84861170097 scopus 로고    scopus 로고
    • Intestinal barrier function in health and gastrointestinal disease (vol 24, pg 503, 2012)
    • Camilleri, M., et al. (2012) Intestinal barrier function in health and gastrointestinal disease (vol 24, pg 503, 2012). Neurogastroenterology and Motility, 24, 976-976.
    • (2012) Neurogastroenterology and Motility , vol.24 , pp. 976-976
    • Camilleri, M.1
  • 6
    • 84886014303 scopus 로고    scopus 로고
    • Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics
    • Pastorelli, L., et al. (2013) Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics. Front Immunol, 4, 280.
    • (2013) Front Immunol , vol.4 , pp. 280
    • Pastorelli, L.1
  • 7
    • 84878698291 scopus 로고    scopus 로고
    • Mucosal barrier in ulcerative colitis and Crohn's disease
    • Dorofeyev, A.E., et al. (2013) Mucosal barrier in ulcerative colitis and Crohn's disease. Gastroenterol Res Pract, 2013, 431231.
    • (2013) Gastroenterol Res Pract , vol.2013 , pp. 431231
    • Dorofeyev, A.E.1
  • 8
    • 41549092745 scopus 로고    scopus 로고
    • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
    • Heazlewood, C.K., et al. (2008) Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. Plos Medicine, 5, 440-460.
    • (2008) Plos Medicine , vol.5 , pp. 440-460
    • Heazlewood, C.K.1
  • 9
    • 70449524235 scopus 로고    scopus 로고
    • Colon cancer stem cells
    • Ricci-Vitiani, L., et al. (2009) Colon cancer stem cells. J Mol Med, 87, 1097- 104.
    • (2009) J Mol Med , vol.87 , pp. 1097-1104
    • Ricci-Vitiani, L.1
  • 10
    • 0030987826 scopus 로고    scopus 로고
    • Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein
    • Neufeld, K.L., et al. (1997) Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein. Proc Natl Acad Sci U S A, 94, 3034-9.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3034-3039
    • Neufeld, K.L.1
  • 11
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis, P. (2000) Wnt signaling and cancer. Genes Dev, 14, 1837-51.
    • (2000) Genes Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 13
    • 0034739023 scopus 로고    scopus 로고
    • The APC tumour suppressor has a nuclear export function
    • Rosin-Arbesfeld, R., et al. (2000) The APC tumour suppressor has a nuclear export function. Nature, 406, 1009-12.
    • (2000) Nature , vol.406 , pp. 1009-1012
    • Rosin-Arbesfeld, R.1
  • 14
    • 0037173081 scopus 로고    scopus 로고
    • Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon
    • Anderson, C.B., et al. (2002) Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc Natl Acad Sci U S A, 99, 8683- 8.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8683-8688
    • Anderson, C.B.1
  • 15
    • 0034282097 scopus 로고    scopus 로고
    • Nuclear-cytoplasmic shuttling of APC regulates betacatenin subcellular localization and turnover
    • Henderson, B.R. (2000) Nuclear-cytoplasmic shuttling of APC regulates betacatenin subcellular localization and turnover. Nat Cell Biol, 2, 653-60.
    • (2000) Nat Cell Biol , vol.2 , pp. 653-660
    • Henderson, B.R.1
  • 16
    • 57349182299 scopus 로고    scopus 로고
    • Interaction between Tumor Suppressor Adenomatous Polyposis Coli and Topoisomerase II{alpha}: Implication for the G2/M Transition
    • Wang, Y., et al. (2008) Interaction between Tumor Suppressor Adenomatous Polyposis Coli and Topoisomerase II{alpha}: Implication for the G2/M Transition. Mol. Biol. Cell, 19, 4076-4085.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4076-4085
    • Wang, Y.1
  • 17
    • 53249091946 scopus 로고    scopus 로고
    • A novel function of adenomatous polyposis coli (APC) in regulating DNA repair
    • Jaiswal, A.S., et al. (2008) A novel function of adenomatous polyposis coli (APC) in regulating DNA repair. Cancer Lett, 271, 272-80.
    • (2008) Cancer Lett , vol.271 , pp. 272-280
    • Jaiswal, A.S.1
  • 18
    • 46049085203 scopus 로고    scopus 로고
    • The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus
    • Qian, J., et al. (2008) The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. Gastroenterology, 135, 152-62.
    • (2008) Gastroenterology , vol.135 , pp. 152-162
    • Qian, J.1
  • 19
    • 84861372966 scopus 로고    scopus 로고
    • A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression
    • Zeineldin, M., et al. (2012) A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression. Oncogene, 31, 2423-37.
    • (2012) Oncogene , vol.31 , pp. 2423-2437
    • Zeineldin, M.1
  • 20
    • 3042686803 scopus 로고    scopus 로고
    • Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents
    • Takahashi, M., et al. (2004) Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci, 95, 475- 80.
    • (2004) Cancer Sci , vol.95 , pp. 475-480
    • Takahashi, M.1
  • 21
    • 84876960757 scopus 로고    scopus 로고
    • Understanding phenotypic variation in rodent models with germline apc mutations
    • Zeineldin, M., et al. (2013) Understanding phenotypic variation in rodent models with germline apc mutations. Cancer Res, 73, 2389-99.
    • (2013) Cancer Res , vol.73 , pp. 2389-2399
    • Zeineldin, M.1
  • 22
    • 84877109867 scopus 로고    scopus 로고
    • More than two decades of Apc modeling in rodents
    • Zeineldin, M., et al. (2013) More than two decades of Apc modeling in rodents. Biochim Biophys Acta, 1836, 80-89.
    • (2013) Biochim Biophys Acta , vol.1836 , pp. 80-89
    • Zeineldin, M.1
  • 23
    • 0034122380 scopus 로고    scopus 로고
    • Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane
    • Takahashi, M., et al. (2000) Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane. Carcinogenesis, 21, 1117-20.
    • (2000) Carcinogenesis , vol.21 , pp. 1117-1120
    • Takahashi, M.1
  • 24
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • Cooper, H.S., et al. (1993) Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest, 69, 238-49.
    • (1993) Lab Invest , vol.69 , pp. 238-249
    • Cooper, H.S.1
  • 25
    • 84905710630 scopus 로고    scopus 로고
    • Isolation of Epithelial Cells from Mouse Gastrointestinal Tract for Western Blot or RNA analysis solation of Epithelial Cells from Mouse Gastrointestinal Tract for Western Blot or RNA analysis
    • Zeineldin, M., et al. (2012) Isolation of Epithelial Cells from Mouse Gastrointestinal Tract for Western Blot or RNA analysis solation of Epithelial Cells from Mouse Gastrointestinal Tract for Western Blot or RNA analysis
    • (2012)
    • Zeineldin, M.1
  • 26
    • 0034052970 scopus 로고    scopus 로고
    • Dysplasia and cancer in the dextran sulfate sodium mouse colitis model Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation.
    • Cooper, H.S., et al. (2000) Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation. Carcinogenesis, 21, 757-68.
    • (2000) Carcinogenesis , vol.21 , pp. 757-768
    • Cooper, H.S.1
  • 28
    • 84886938281 scopus 로고    scopus 로고
    • Colon cryptogenesis: asymmetric budding
    • Tan, C.W., et al. (2013) Colon cryptogenesis: asymmetric budding. PLoS One, 8, e78519.
    • (2013) PLoS One , vol.8
    • Tan, C.W.1
  • 29
    • 69749121859 scopus 로고    scopus 로고
    • Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice
    • Dekaney, C.M., et al. (2009) Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice. Am J Physiol Gastrointest Liver Physiol, 297, G461-70.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297
    • Dekaney, C.M.1
  • 30
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker, N., et al. (2009) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature, 457, 608-11.
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1
  • 31
    • 84868613705 scopus 로고    scopus 로고
    • Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
    • Grivennikov, S.I., et al. (2012) Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature, 491, 254-8.
    • (2012) Nature , vol.491 , pp. 254-258
    • Grivennikov, S.I.1
  • 32
    • 2442649255 scopus 로고    scopus 로고
    • Alteration of gene expression in normal-appearing colon mucosa of APC(min) mice and human cancer patients
    • Chen, L.C., et al. (2004) Alteration of gene expression in normal-appearing colon mucosa of APC(min) mice and human cancer patients. Cancer Res, 64, 3694-700.
    • (2004) Cancer Res , vol.64 , pp. 3694-3700
    • Chen, L.C.1
  • 33
    • 34548379030 scopus 로고    scopus 로고
    • Dextran sulfate sodium-induced colitis-associated neoplasia: a promising model for the development of chemopreventive interventions
    • Clapper, M.L., et al. (2007) Dextran sulfate sodium-induced colitis-associated neoplasia: a promising model for the development of chemopreventive interventions. Acta Pharmacol Sin, 28, 1450-9.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1450-1459
    • Clapper, M.L.1
  • 34
    • 84885064968 scopus 로고    scopus 로고
    • Adenomatous Polyps Are Driven by Microbe- Instigated Focal Inflammation and Are Controlled by IL-10-Producing T Cells
    • Dennis, K.L., et al. (2013) Adenomatous Polyps Are Driven by Microbe- Instigated Focal Inflammation and Are Controlled by IL-10-Producing T Cells. Cancer Res, 73, 5905-13.
    • (2013) Cancer Res , vol.73 , pp. 5905-5913
    • Dennis, K.L.1
  • 35
    • 0034644705 scopus 로고    scopus 로고
    • Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells
    • Haertel-Wiesmann, M., et al. (2000) Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells. J Biol Chem, 275, 32046-51.
    • (2000) J Biol Chem , vol.275 , pp. 32046-32051
    • Haertel-Wiesmann, M.1
  • 36
    • 0033119190 scopus 로고    scopus 로고
    • Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells
    • Howe, L.R., et al. (1999) Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells. Cancer Res, 59, 1572-7.
    • (1999) Cancer Res , vol.59 , pp. 1572-1577
    • Howe, L.R.1
  • 37
    • 0037064055 scopus 로고    scopus 로고
    • Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors
    • Longo, K.A., et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem, 277, 38239-44.
    • (2002) J Biol Chem , vol.277 , pp. 38239-38244
    • Longo, K.A.1
  • 38
    • 64049109107 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung
    • Harris, R.E. (2009) Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung. Inflammopharmacology, 17, 55-67.
    • (2009) Inflammopharmacology , vol.17 , pp. 55-67
    • Harris, R.E.1
  • 39
    • 84875152003 scopus 로고    scopus 로고
    • Tumor suppressor APC protein is essential in mucosal repair from colonic inflammation through angiogenesis
    • Yoshimi, K., et al. (2013) Tumor suppressor APC protein is essential in mucosal repair from colonic inflammation through angiogenesis. Am J Pathol, 182, 1263-74.
    • (2013) Am J Pathol , vol.182 , pp. 1263-1274
    • Yoshimi, K.1
  • 40
    • 0034710914 scopus 로고    scopus 로고
    • Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm
    • Neufeld, K.L., et al. (2000) Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A, 97, 12085-90.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12085-12090
    • Neufeld, K.L.1
  • 41
    • 32244446448 scopus 로고    scopus 로고
    • A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma
    • Leow, C.C., et al. (2005) A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma. Ann N Y Acad Sci, 1059, 174-83.
    • (2005) Ann N Y Acad Sci , vol.1059 , pp. 174-183
    • Leow, C.C.1
  • 42
    • 33746000105 scopus 로고    scopus 로고
    • The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid
    • Eisinger, A.L., et al. (2006) The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. J Biol Chem, 281, 20474-82.
    • (2006) J Biol Chem , vol.281 , pp. 20474-20482
    • Eisinger, A.L.1
  • 43
    • 28544444039 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis
    • Castellone, M.D., et al. (2005) Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science, 310, 1504-10.
    • (2005) Science , vol.310 , pp. 1504-1510
    • Castellone, M.D.1
  • 44
    • 33746864818 scopus 로고    scopus 로고
    • Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling
    • Du, Q., et al. (2006) Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling. Cancer Res, 66, 7024-31.
    • (2006) Cancer Res , vol.66 , pp. 7024-7031
    • Du, Q.1
  • 45
    • 65649106947 scopus 로고    scopus 로고
    • Colon cancer: preventive agents and the present status of chemoprevention
    • Half, E., et al. (2009) Colon cancer: preventive agents and the present status of chemoprevention. Expert Opin Pharmacother, 10, 211-9.
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 211-219
    • Half, E.1
  • 46
    • 85047690934 scopus 로고    scopus 로고
    • Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation
    • Tessner, T.G., et al. (2004) Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest, 114, 1676-85.
    • (2004) J Clin Invest , vol.114 , pp. 1676-1685
    • Tessner, T.G.1
  • 47
    • 0032750920 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by nonsteroidal antiinflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing
    • Jones, M.K., et al. (1999) Inhibition of angiogenesis by nonsteroidal antiinflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med, 5, 1418-23.
    • (1999) Nat Med , vol.5 , pp. 1418-1423
    • Jones, M.K.1
  • 48
    • 47949122478 scopus 로고    scopus 로고
    • In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells
    • Khayrullina, T., et al. (2008) In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells. J Immunol, 181, 721-35.
    • (2008) J Immunol , vol.181 , pp. 721-735
    • Khayrullina, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.