Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Duan, Yantao ^a   Hu, Lei ^a   Liu, Bing ^a   Yu, Beiqin ^a   Li, Jianfang ^a   Yan, Min ^a   Yu, Yingyan ^a   Li, Chen ^a   Su, Liping ^a   Zhu, Zhenggang ^a   Xiang, Ming ^a   Liu, Bingya ^a   Yang, Qiumeng ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Gastric cancer; Invasion; Metastasis; miR 24; Proliferation; RegIV

Indexed keywords

DOUBLE STRANDED RNA; LENTIVIRUS VECTOR; MICRORNA 24; REGENERATING ISLET DERIVED FAMILY MEMBER 4; SINGLE STRANDED RNA; TUMOR MARKER; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; LECTIN; MICRORNA; MIRN24 MICRORNA, HUMAN; REG4 PROTEIN, HUMAN; SMALL INTERFERING RNA;

3' UNTRANSLATED REGION; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CARCINOGENICITY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS; MOUSE; NONHUMAN; STOMACH CANCER; TUMOR DIFFERENTIATION; TUMOR INVASION; ADENOCARCINOMA; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; DRUG SCREENING; GENE EXPRESSION REGULATION; GENE VECTOR; GENETIC EPIGENESIS; GENETICS; LENTIVIRINAE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; STOMACH TUMOR; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; ADENOCARCINOMA; AGED; ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HUMANS; LECTINS, C-TYPE; LENTIVIRUS; MICE; MICE, NUDE; MICRORNAS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84905665343     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-127     Document Type: Article

References (42)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011, 61:69-90.
2. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
3. Qin W, Shi Y, Zhao B, Yao C, Jin L, Ma J, Jin Y: miR-24 regulates apoptosis by targeting the open reading frame (ORF) region of FAF1 in cancer cells. PLoS One 2010, 5:e9429.
4. Bullock MD, Sayan AE, Packham GK, Mirnezami AH: microRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression. Biol Cell 2012, 104:3-12.
5. Tzur G, Levy A, Meiri E, Barad O, Spector Y, Bentwich Z, Mizrahi L, Katzenellenbogen M, Ben-Shushan E, Reubinoff BE, Galun E: microRNA expression patterns and function in endodermal differentiation of human embryonic stem cells. PLoS One 2008, 3:e3726.
6. Ambros V: The functions of animal microRNAs. Nature 2004, 431:350-355.
7. Esquela-Kerscher A, Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006, 6:259-269.
8. Zheng YS, Zhang H, Zhang XJ, Feng DD, Luo XQ, Zeng CW, Lin KY, Zhou H, Qu LH, Zhang P, Chen YQ: miR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Oncogene 2012, 31:80-92.
9. Mattiske S, Suetani RJ, Neilsen PM, Callen DF: The oncogenic role of miR-155 in breast cancer. Cancer Epidemiol Biomarkers Prev 2012, 21:1236-1243.
10. Malleter M, Jacquot C, Rousseau B, Tomasoni C, Juge M, Pineau A, Sakanian V, Roussakis C: miRNAs, a potential target in the treatment of non-small-cell lung carcinomas. Gene 2012, 506:355-359.
11. Hou YY, Cao WW, Li L, Li SP, Liu T, Wan HY, Liu M, Li X, Tang H: microRNA-519d targets MKi67 and suppresses cell growth in the hepatocellular carcinoma cell line QGY-7703. Cancer Lett 2011, 307:182-190.
12. Li Z, Gu X, Fang Y, Xiang J, Chen Z: microRNA expression profiles in human colorectal cancers with brain metastases. Oncol Lett 2012, 3:346-350.
13. Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, Hijiya N, Matsuura K, Fujioka T, Seto M, Moriyama M: microRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res 2010, 70:2339-2349.
14. Lu Z, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR: microRNA expression profiles classify human cancers. Nature 2005, 435:834-838.
15. Mendell JT, Olson EN: microRNAs in stress signaling and human disease. Cell 2012, 148:1172-1187.
16. Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu CG, Oue N, Yasui W, Yoshida K, Sasaki H, Nomura S, Seto Y, Kaminishi M, Calin GA, Croce CM: Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol 2010, 11:136-146.
17. Wu WK, Lee CW, Cho CH, Fan D, Wu K, Yu J, Yu JJ, Sung JJ: microRNA dysregulation in gastric cancer: a new player enters the game. Oncogene 2010, 29:5761-5771.
18. Li X, Zhang Y, Zhang Y, Ding J, Wu K, Fan D: Survival prediction of gastric cancer by a seven-microRNA signature. Gut 2010, 59:579-585.
19. Mishra PJ, Song B, Mishra PJ, Wang Y, Humeniuk R, Banerjee D, Merlino G, Ju J, Bertino JR: miR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism. PLoS One 2009, 4:e8445.
20. Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J: miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell 2009, 35:610-625.
21. Xu Y, Zhao F, Wang Z, Song Y, Luo Y, Zhang X, Jiang L, Sun Z, Miao Z, Xu H: microRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1. Oncogene 2012, 31:1398-1407.
22. Tie J, Pan Y, Zhao L, Wu K, Liu J, Sun S, Guo X, Wang B, Gang Y, Zhang Y, Li Q, Qiao T, Zhao Q, Nie Y, Fan D: miR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet 2010, 6:e1000879.
23. Li Z, Cao Y, Jie Z, Liu Y, Li Y, Li J, Zhu G, Liu Z, Tu Y, Peng G, Lee DW, Park SS: miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3. Cancer Lett 2012, 323:41-47.
24. Bader AG, Brown D, Stoudemire J, Lammers P: Developing therapeutic microRNAs for cancer. Gene Ther 2011, 18:1121-1126.
25. Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT: Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009, 137:1005-1017.
26. Xie L, Wang T, Yu S, Chen X, Wang L, Qian X, Yu L, Ding Y, Zhang C, Liu B: Cell-free miR-24 and miR-30d, potential diagnostic biomarkers in malignant effusions. Clin Biochem 2011, 44:216-220.
27. Lin SC, Liu CJ, Lin JA, Chian WF, Hung PS, Chang KW: miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis. Oral Oncol 2010, 46:204-208.
28. Liu X, Wang A, Heidbreder CE, Jiang L, Yu J, Kolokythas A, Huang L, Dai Y, Zhou X: microRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma. FEBS Lett 2010, 584:4115-4120.
29. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Zhang Y, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J, Zhang CY: Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008, 18:997-1006.
30. Cao M, Seike M, Soeno C, Mizutani H, Kitamura K, Minegishi Y, Noro R, Yoshimura A, Cai L, Genma A: miR-23a regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells. Int J Oncol 2012, 41:869-875.
31. To KH, Pajovic S, Gallie BL, Thériault BL: Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development. BMC Cancer 2012, 12:69.
32. Wu J, Zhang YC, Suo WH, Liu XB, Shen WW, Tian H, Fu GH: Induction of anion exchanger-1 translation and its opposite roles in the carcinogenesis of gastric cancer cells and differentiation of K562 cells. Oncogene 2010, 29:1987-1996.
33. Lewis BP, Burge CB, Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
34. Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK: Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: RegIV. Biochim Biophys Acta 2001, 1518:287-293.
35. Oue N, Hamai Y, Mitani Y, Matsumura S, Oshimo Y, Aung PP, Kuraoka K, Nakayama H, Yasui W: Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res 2004, 64:2397-2405.
36. Zheng HC, Xu XY, Yu M, Takahashi H, Masuda S, Takano Y: The role of RegIV gene and its encoding product in gastric carcinogenesis. Hum Pathol 2010, 41:59-69.
37. Kuniyasu H, Oue N, Sasahira T, Yi L, Moriwaka Y, Shimomoto T, Fujii K, Ohmori H, Yasui W: RegIV enhances peritoneal metastasis in gastric carcinomas. Cell Prolif 2009, 42:110-121.
38. Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Fukuda K, Kin S, Nakase Y, Shimomura K, Oue N, Yasui W, Hayasizaki H, Okazaki Y, Yamagishi H, Hagiwara A, Otsuji E: Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as a novel marker for the detection of peritoneal micrometastasis. Anticancer Res 2008, 28:1169-1179.
39. Moon JH, Fujiwara Y, Nakamura Y, Okada K, Hanada H, Sakakura C, Takiguchi S, Nakajima K, Miyata H, Yamasaki M, Kurokawa Y, Mori M, Doki Y: RegIV as a potential biomarker for peritoneal dissemination in gastric adenocarcinoma. J Surg Oncol 2012, 105:189-194.
40. Mitani Y, Oue N, Matsumura S, Yoshida K, Noguchi T, Ito M, Tanaka S, Kuniyasu H, Kamata N, Yasui W: RegIV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene 2007, 26:4383-4393.
41. Klein CA: Cancer. The metastasis cascade. Science 2008, 321:1785-1787.
42. Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA: microRNAs-the micro steering wheel of tumour metastases. Nat Rev Cancer 2009, 9:293-302.