CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis

Nucleic Acids Research

Volumn 42, Issue 13, 2014, Pages 8433-8448

  Cazzalini, Ornella ^a   Sommatis, Sabrina ^a   Tillhon, Micol ^b   Dutto, Ilaria ^b   Bachi, Angela ^c   Rapp, Alexander ^d   Nardo, Tiziana ^b   Scovassi, A Ivana ^b   Necchi, Daniela ^a   Cardoso, M Cristina ^d   Stivala, Lucia A ^a   Prosperi, Ennio ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b CNR   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^d DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLINE; E1A ASSOCIATED P300 PROTEIN; LYSINE; PROTEASOME;

ACETYLATION; ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; EMBRYO; EXCISION REPAIR; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RADIOSENSITIVITY; SITE DIRECTED MUTAGENESIS; ULTRAVIOLET RADIATION;

ACETYLATION; CELLS, CULTURED; CHROMATIN; CREB-BINDING PROTEIN; DNA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; HUMANS; MUTATION; P300-CBP TRANSCRIPTION FACTORS; PROLIFERATING CELL NUCLEAR ANTIGEN;

EID: 84905566865     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku533     Document Type: Article

References (69)

1. Krishna, T.S., Kong, X.P., Gary, S., Burgers, P.M., and Kuriyan, J. Krishna, T.S., Kong, X.P., Gary, S., Burgers, P.M., and Kuriyan, J. (1994) Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell, 79, 1233-1243.
2. Gulbis, J.M., Kelman, Z., Hurwitz, J., O'Donnell, M., and Kuriyan, J. Gulbis, J.M., Kelman, Z., Hurwitz, J., O'Donnell, M., and Kuriyan, J. (1996) Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell, 87, 297-306.
3. Beattie, T.R. and Bell, S.D. Beattie, T.R. and Bell, S.D. (2011) Molecular machines in archaeal DNA replication. Curr. Opin. Chem. Biol., 15, 614-619.
4. Prosperi, E. Prosperi, E. (2006) The fellowship of the rings: distinct pools of proliferating cell nuclear antigen trimer at work. FASEB J., 20, 833-837.
5. Moldovan, G.L., Pfander, B., and Jentsch, S. Moldovan, G.L., Pfander, B., and Jentsch, S. (2007) PCNA, the maestro of the replication fork. Cell, 129, 665-679.
6. Naryzhny, S.N. Naryzhny, S.N. (2008) Proliferating cell nuclear antigen: a proteomics view. Cell. Mol. Life Sci., 65, 3789-3808.
7. Witko-Sarsat, V., Mocek, J., Bouayad, D., Tamassia, N., Ribeil, J.A., Candalh, C., Davezac, N., Reuter, N., Mouthon, L., and Hermine, O. et al. Witko-Sarsat, V., Mocek, J., Bouayad, D., Tamassia, N., Ribeil, J.A., Candalh, C., Davezac, N., Reuter, N., Mouthon, L., and Hermine, O. (2010) Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. J. Exp. Med., 207, 2631-2645.
8. Stoimenov, I. and Helleday, T. Stoimenov, I. and Helleday, T. (2009) PCNA on the crossroad of cancer. Biochem. Soc. Trans., 37, 605-613.
9. Mailand, N., Gibbs-Seymour, I., and Bekker-Jensen, S. Mailand, N., Gibbs-Seymour, I., and Bekker-Jensen, S. (2013) Regulation of PCNA-protein interactions for genome stability. Nat. Rev. Mol. Cell Biol., 14, 269-282.
10. Ulrich, H.D. and Takahashi, T. Ulrich, H.D. and Takahashi, T. (2013) Readers of PCNA modifications. Chromosoma, 122, 259-274.
11. Hoege, C., Pfander, B., Moldovan, G.L., Pyrowolakis, G., and Jentsch, S. Hoege, C., Pfander, B., Moldovan, G.L., Pyrowolakis, G., and Jentsch, S. (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature, 419, 135-141.
12. Kannouche, P.L., Wing, J., and Lehmann, A.R. Kannouche, P.L., Wing, J., and Lehmann, A.R. (2004) Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol. Cell, 14, 491-500.
13. Garg, P. and Burgers, P.M. Garg, P. and Burgers, P.M. (2005) DNA polymerases that propagate the eukaryotic DNA replication fork. Crit. Rev. Biochem. Mol. Biol., 40, 115-128.
14. Das-Bradoo, S., Nguyen, H.D., Wood, J.L., Ricke, R.M., Haworth, J.C., and Bielinsky, A.K. Das-Bradoo, S., Nguyen, H.D., Wood, J.L., Ricke, R.M., Haworth, J.C., and Bielinsky, A.K. (2010) Defects in DNA ligase I trigger PCNA ubiquitylation at Lys 107. Nat. Cell Biol., 12, 74-79.
15. Branzei, D., Seki, M., and Enomoto, T. Branzei, D., Seki, M., and Enomoto, T. (2004) Rad18/Rad5/Mms2-mediated polyubiquitination of PCNA is implicated in replication completion during replication stress. Genes Cells, 9, 1031-1042.
16. Motegi, A., Liaw, H.J., Lee, K.Y., Roest, H.P., Maas, A., Wu, X., Moinova, H., Markowitz, S.D., Ding, H., and Hoeijmakers, J.H. et al. Motegi, A., Liaw, H.J., Lee, K.Y., Roest, H.P., Maas, A., Wu, X., Moinova, H., Markowitz, S.D., Ding, H., and Hoeijmakers, J.H. (2008) Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc. Natl. Acad. Sci. U.S.A., 105, 12411-12416.
17. Unk, I., Hajdú, I., Fátyol, K., Hurwitz, J., Yoon, J.H., Prakash, L., Prakash, S., and Haracska, L. Unk, I., Hajdú, I., Fátyol, K., Hurwitz, J., Yoon, J.H., Prakash, L., Prakash, S., and Haracska, L. (2008) Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. Proc. Natl. Acad. Sci. U.S.A., 105, 3768-3773.
18. Ciccia, A., Nimonkar, A.V., Hu, Y., Hajdu, I., Achar, Y.J., Izhar, L., Petit, S.A., Adamson, B., Yoon, J.C., and Kowalczykowski, S.C. et al. Ciccia, A., Nimonkar, A.V., Hu, Y., Hajdu, I., Achar, Y.J., Izhar, L., Petit, S.A., Adamson, B., Yoon, J.C., and Kowalczykowski, S.C. (2012) Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol. Cell, 47, 396-409.
19. Tian, F., Sharma, S., Zou, J., Lin, S.Y., Wang, B., Rezvani, K., Wang, H., Parvin, J.D., Ludwig, T., and Canman, C.E. et al. Tian, F., Sharma, S., Zou, J., Lin, S.Y., Wang, B., Rezvani, K., Wang, H., Parvin, J.D., Ludwig, T., and Canman, C.E. (2013) BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc. Natl. Acad. Sci. U.S.A., 110, 13558-13563.
20. Langerak, P., Nygren, A.O., Krijger, P.H., van den Berk, P.C., and Jacobs, H. Langerak, P., Nygren, A.O., Krijger, P.H., van den Berk, P.C., and Jacobs, H. (2007) A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification. J. Exp. Med., 204, 1989-1998.
21. Roa, S., Avdievich, E., Peled, J.U., Maccarthy, T., Werling, U., Kuang, F.L., Kan, R., Zhao, C., Bergman, A., and Cohen, P.E. et al. Roa, S., Avdievich, E., Peled, J.U., Maccarthy, T., Werling, U., Kuang, F.L., Kan, R., Zhao, C., Bergman, A., and Cohen, P.E. (2008) Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proc. Natl. Acad. Sci. U.S.A., 105, 16248-16253.
22. Gali, H., Juhasz, S., Morocz, M., Hajdu, I., Fatyol, K., Szukacsov, V., Burkovics, P., and Haracska, L. Gali, H., Juhasz, S., Morocz, M., Hajdu, I., Fatyol, K., Szukacsov, V., Burkovics, P., and Haracska, L. (2012) Role of SUMO modification of human PCNA at stalled replication fork. Nucleic Acids Res., 40, 6049-6059.
23. Mathews, M.B., Bernstein, R.M., Franza, B.R., and Garrels, J.I. Mathews, M.B., Bernstein, R.M., Franza, B.R., and Garrels, J.I. (1984) Identity of the proliferating cell nuclear antigen and cyclin. Nature, 309, 374-376.
24. Prosperi, E., Stivala, L.A., Sala, E., Scovassi, A.I., and Bianchi, L. Prosperi, E., Stivala, L.A., Sala, E., Scovassi, A.I., and Bianchi, L. (1993) Proliferating cell nuclear antigen complex formation induced by ultraviolet irradiation in human quiescent fibroblasts as detected by immunostaining and flow cytometry. Exp. Cell Res., 205, 320-325.
25. Prosperi, E., Scovassi, A.I., Stivala, L.A., and Bianchi, L. Prosperi, E., Scovassi, A.I., Stivala, L.A., and Bianchi, L. (1994) Proliferating cell nuclear antigen bound to DNA synthesis sites: phosphorylation and association with cyclin D1 and cyclin A. Exp. Cell Res., 215, 257-262.
26. Wang, S.C., Nakajima, Y., Yu, Y.L., Xia, W., Chen, C.T., Yang, C.C., McIntush, E.W., Li, L.Y., Hawke, D.H., and Kobayashi, R. et al. Wang, S.C., Nakajima, Y., Yu, Y.L., Xia, W., Chen, C.T., Yang, C.C., McIntush, E.W., Li, L.Y., Hawke, D.H., and Kobayashi, R. (2006) Tyrosine phosphorylation controls PCNA function through protein stability. Nat. Cell Biol., 8, 1359-1368.
27. Zhao, H., Chen, M.S., Lo, Y.H., Waltz, S.E., Wang, J., Ho, P.C., Vasiliauskas, J., Plattner, R., Wang, Y.L., and Wang, S.C. Zhao, H., Chen, M.S., Lo, Y.H., Waltz, S.E., Wang, J., Ho, P.C., Vasiliauskas, J., Plattner, R., Wang, Y.L., and Wang, S.C. (2014) The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer. Oncogene, 33, 1429-1437.
28. Lo, Y.H., Ho, P.C., and Wang, S.C. Lo, Y.H., Ho, P.C., and Wang, S.C. (2012) Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis. J. Biol. Chem., 287, 27148-27157.
29. Groehler, A.L. and Lannigan, D.A. Groehler, A.L. and Lannigan, D.A. (2010) A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA. J. Cell Biol., 190, 575-586.
30. Lo, Y.H., Ho, P.C., Chen, M.S., Hugo, E., Ben-Jonathan, N., and Wang, S.C. Lo, Y.H., Ho, P.C., Chen, M.S., Hugo, E., Ben-Jonathan, N., and Wang, S.C. (2013) Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat diet. Biochem. Biophys. Res. Commun., 430, 43-48.
31. Naryzhny, S.N. and Lee, H. Naryzhny, S.N. and Lee, H. (2004) The post-translational modifications of proliferating cell nuclear antigen: acetylation, not phosphorylation, plays an important role in the regulation of its function. J. Biol. Chem., 279, 20194-20199.
32. Choudhary, C., Kumar, C., Gnad, F., Nielsen, M.L., Rehman, M., Walther, T.C., Olsen, J.V., and Mann, M. Choudhary, C., Kumar, C., Gnad, F., Nielsen, M.L., Rehman, M., Walther, T.C., Olsen, J.V., and Mann, M. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science, 325, 834-840.
33. Yu, Y., Cai, J.P., Tu, B., Wu, L., Zhao, Y., Liu, X., Li, L., McNutt, M.A., Feng, J., and He, Q. et al. Yu, Y., Cai, J.P., Tu, B., Wu, L., Zhao, Y., Liu, X., Li, L., McNutt, M.A., Feng, J., and He, Q. (2009) Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. J. Biol. Chem., 284, 19310-19320.
34. Kubota, T., Nishimura, K., Kanemaki, M.T., and Donaldson, A.D. Kubota, T., Nishimura, K., Kanemaki, M.T., and Donaldson, A.D. (2013) The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication. Mol. Cell, 50, 273-280.
35. Lee, K.Y., Fu, H., Aladjem, M.I., and Myung, K. Lee, K.Y., Fu, H., Aladjem, M.I., and Myung, K. (2013) ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin. J. Cell Biol., 200, 31-44.
36. Hasan, S., Hassa, P.O., Imhof, R., and Hottiger, M.O. Hasan, S., Hassa, P.O., Imhof, R., and Hottiger, M.O. (2001) Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis. Nature, 410, 387-391.
37. Cazzalini, O., Perucca, P., Savio, M., Necchi, D., Bianchi, L., Stivala, L.A., Ducommun, B., Scovassi, A.I., and Prosperi, E. Cazzalini, O., Perucca, P., Savio, M., Necchi, D., Bianchi, L., Stivala, L.A., Ducommun, B., Scovassi, A.I., and Prosperi, E. (2008) Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair. Nucleic Acids Res., 36, 1713-1722.
38. Chan, H.M. and La Thangue, N.B. Chan, H.M. and La Thangue, N.B. (2001) p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J. Cell Sci., 114, 2363-2373.
39. Kalkhoven, E. Kalkhoven, E. (2004) CBP and p300: HATs for different occasions. Biochem. Pharmacol., 68, 1145-1155.
40. Perucca, P., Cazzalini, O., Mortusewicz, O., Necchi, D., Savio, M., Nardo, T., Stivala, L.A., Leonhardt, H., Cardoso, M.C., and Prosperi, E. Perucca, P., Cazzalini, O., Mortusewicz, O., Necchi, D., Savio, M., Nardo, T., Stivala, L.A., Leonhardt, H., Cardoso, M.C., and Prosperi, E. (2006) Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen. J. Cell Sci., 119, 1517-1527.
41. D'Orso, I. and Frankel, A.D.D'Orso, I. and Frankel, A.D. (2009) Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex. Proc. Natl. Acad. Sci. U.S.A., 106, 3101-3106.
42. Katsumi, S., Kobayashi, N., Imoto, K., Nakagawa, A., Yamashina, Y., Muramatsu, T., Shirai, T., Miyagawa, S., Sugiura, S., and Hanaoka, F. et al. Katsumi, S., Kobayashi, N., Imoto, K., Nakagawa, A., Yamashina, Y., Muramatsu, T., Shirai, T., Miyagawa, S., Sugiura, S., and Hanaoka, F. (2001) In situ visualization of ultraviolet-light-induced DNA damage repair in locally irradiated human fibroblasts. J. Invest. Dermatol., 117, 1156-1161.
43. Balasubramanyam, K., Varier, R.A., Altaf, M., Swaminathan, V., Siddappa, N.B., Ranga, U., and Kundu, T.K. Balasubramanyam, K., Varier, R.A., Altaf, M., Swaminathan, V., Siddappa, N.B., Ranga, U., and Kundu, T.K. (2004) Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J. Biol. Chem., 279, 51163-51171.
44. Gedik, C.M. and Collins, A.R. Gedik, C.M. and Collins, A.R. (1991) The mode of action of 1-beta-D-arabinofuranosylcytosine in inhibiting DNA repair; new evidence using a sensitive assay for repair DNA synthesis and ligation in permeable cells. Mutat. Res., 254, 231-237.
45. Sporbert, A., Domaing, P., Leonhardt, H., and Cardoso, M.C. Sporbert, A., Domaing, P., Leonhardt, H., and Cardoso, M.C. (2005) PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment maturation proteins. Nucleic Acids Res., 33, 3521-3528.
46. Riva, F., Savio, M., Cazzalini, O., Stivala, L.A., Scovassi, I.A., Cox, L.S., Ducommun, B., and Prosperi, E. Riva, F., Savio, M., Cazzalini, O., Stivala, L.A., Scovassi, I.A., Cox, L.S., Ducommun, B., and Prosperi, E. (2004) Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I. Exp. Cell Res., 293, 357-367.
47. Olsen, J.V., de Godoy, L.M., Li, G., Macek, B., Mortensen, P., Pesch, R., Makarov, A., Lange, O., Horning, S., and Mann, M. Olsen, J.V., de Godoy, L.M., Li, G., Macek, B., Mortensen, P., Pesch, R., Makarov, A., Lange, O., Horning, S., and Mann, M. (2005) Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol. Cell. Proteomics, 4, 2010-2021.
48. Scovassi, A.I. and Prosperi, E. Scovassi, A.I. and Prosperi, E. (2006) Analysis of proliferating cell nuclear antigen (PCNA) associated with DNA. Methods Mol. Biol., 314, 457-475.
49. Cazzalini, O., Perucca, P., Riva, F., Stivala, L.A., Bianchi, L., Vannini, V., Ducommun, B., and Prosperi, E. Cazzalini, O., Perucca, P., Riva, F., Stivala, L.A., Bianchi, L., Vannini, V., Ducommun, B., and Prosperi, E. (2003) p21CDKN1A does not interfere with loading of PCNA at DNA replication sites, but inhibits subsequent binding of DNA polymerase delta at the G1/S phase transition. Cell Cycle, 2, 596-603.
50. Krude, T. Krude, T. (1999) Mimosine arrests proliferating human cells before onset of DNA replication in a dose-dependent manner. Exp. Cell Res., 247, 148-159.
51. Krude, T., Jackman, M., Pines, J., and Laskey, R.A. Krude, T., Jackman, M., Pines, J., and Laskey, R.A. (1997) Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system. Cell, 88, 109-119.
52. Bravo, R. and Macdonald-Bravo, H. Bravo, R. and Macdonald-Bravo, H. (1987) Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J. Cell Biol., 105, 1549-1554.
53. Knibiehler, M., Goubin, F., Escalas, N., Jónsson, Z.O., Mazarguil, H., Hübscher, U., and Ducommun, B. Knibiehler, M., Goubin, F., Escalas, N., Jónsson, Z.O., Mazarguil, H., Hübscher, U., and Ducommun, B. (1996) Interaction studies between the p21Cip1/Waf1 cyclin-dependent kinase inhibitor and proliferating cell nuclear antigen (PCNA) by surface plasmon resonance. FEBS Lett., 391, 66-70.
54. Hong, R. and Chakravarti, D. Hong, R. and Chakravarti, D. (2003) The human proliferating cell nuclear antigen regulates transcriptional coactivator p300 activity and promotes transcriptional repression. J. Biol. Chem., 278, 44505-44513.
55. Ivanov, I., Chapados, B.R., McCammon, J.A., and Tainer, J.A. Ivanov, I., Chapados, B.R., McCammon, J.A., and Tainer, J.A. (2006) Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications. Nucleic Acids Res., 34, 6023-6033.
56. Sporbert, A., Gahl, A., Ankerhold, R., Leonhardt, H., and Cardoso, M.C. Sporbert, A., Gahl, A., Ankerhold, R., Leonhardt, H., and Cardoso, M.C. (2002) DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters. Mol. Cell, 10, 1355-1365.
57. McNally, R., Bowman, G.D., Goedken, E.R., O'Donnell, M., and Kuriyan, J. McNally, R., Bowman, G.D., Goedken, E.R., O'Donnell, M., and Kuriyan, J. (2010) Analysis of the role of PCNA-DNA contacts during clamp loading. BMC Struct. Biol., 10, 3.
58. Fukuda, K., Morioka, H., Imajou, S., Ikeda, S., Ohtsuka, E., and Tsurimoto, T. Fukuda, K., Morioka, H., Imajou, S., Ikeda, S., Ohtsuka, E., and Tsurimoto, T. (1995) Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen. J. Biol. Chem., 270, 22527-22534.
59. Sankar, N., Kadeppagari, R.K., and Thimmapaya, B. Sankar, N., Kadeppagari, R.K., and Thimmapaya, B. (2009) c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells. J. Biol. Chem., 284, 15193-15205.
60. Tillhon, M., Cazzalini, O., Nardo, T., Necchi, D., Sommatis, S., Stivala, L.A., Scovassi, A.I., and Prosperi, E. Tillhon, M., Cazzalini, O., Nardo, T., Necchi, D., Sommatis, S., Stivala, L.A., Scovassi, A.I., and Prosperi, E. (2012) p300/CBP acetyl transferases interact with and acetylate the nucleotide excision repair factor XPG. DNA Repair (Amst.), 11, 844-852.
61. Wang, Q.E., Han, C., Zhao, R., Wani, G., Zhu, Q., Gong, L., Battu, A., Racoma, I., Sharma, N., and Wani, A.A. Wang, Q.E., Han, C., Zhao, R., Wani, G., Zhu, Q., Gong, L., Battu, A., Racoma, I., Sharma, N., and Wani, A.A. (2013) p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair. Nucleic Acids Res., 41, 1722-1733.
62. Stivala, L.A. and Prosperi, E. Stivala, L.A. and Prosperi, E. (2004) Analysis of p21CDKN1A recruitment to DNA excision repair foci in the UV-induced DNA damage response. Methods Mol. Biol., 281, 73-89.
63. Mocquet, V., Lainé, J.P., Riedl, T., Yajin, Z., Lee, M.Y., and Egly, J.M. Mocquet, V., Lainé, J.P., Riedl, T., Yajin, Z., Lee, M.Y., and Egly, J.M. (2008) Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step. EMBO J., 27, 155-167.
64. Dimitrova, D.S. and Gilbert, D.M. Dimitrova, D.S. and Gilbert, D.M. (2000) Stability and nuclear distribution of mammalian replication protein A heterotrimeric complex. Exp. Cell Res., 254, 321-327.
65. Miura, M., Domon, M., Sasaki, T., and Takasaki, Y. Miura, M., Domon, M., Sasaki, T., and Takasaki, Y. (1992) Induction of proliferating cell nuclear antigen (PCNA) complex formation in quiescent fibroblasts from a xeroderma pigmentosum patient. J. Cell Physiol., 150, 370-376.
66. Aboussekhra, A. and Wood, R.D. Aboussekhra, A. and Wood, R.D. (1995) Detection of nucleotide excision repair incisions in human fibroblasts by immunostaining for PCNA. Exp. Cell Res., 221, 326-332.
67. Georgescu, R.E., Kim, S.S., Yurieva, O., Kuriyan, J., Kong, X.P., and O'Donnell, M. Georgescu, R.E., Kim, S.S., Yurieva, O., Kuriyan, J., Kong, X.P., and O'Donnell, M. (2008) Structure of a sliding clamp on DNA. Cell, 132, 43-54.
68. Zhou, Y. and Hingorani, M.M. Zhou, Y. and Hingorani, M.M. (2012) Impact of individual proliferating cell nuclear antigen-DNA contacts on clamp loading and function on DNA. J. Biol. Chem., 287, 35370-35381.
69. Yao, T.P., Oh, S.P., Fuchs, M., Zhou, N.D., Ch'ng, L.E., Newsome, D., Bronson, R.T., Li, E., Livingston, D.M., and Eckner, R. Yao, T.P., Oh, S.P., Fuchs, M., Zhou, N.D., Ch'ng, L.E., Newsome, D., Bronson, R.T., Li, E., Livingston, D.M., and Eckner, R. (1998) Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell, 93, 361-372.