Mimosine arrests proliferating human cells before onset of DNA replication in a dose-dependent manner

Experimental Cell Research

Volumn 247, Issue 1, 1999, Pages 148-159

  Krude, Torsten ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MIMOSINE;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SYNCHRONIZATION; DNA REPLICATION; DNA REPLICATION ORIGIN; EUKARYOTIC CELL; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EUKARYOTA;

EID: 0033602015     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4342     Document Type: Article

References (30)

1. Johnson R. T., Downes C. S., Meyn R. E. The Synchronization of Mammalian Cells. 1993;Oxford Univ. Press, Oxford. p. 1-24.
2. Lalande M. A reversible arrest point in the late G1 phase of the mammalian cell cycle. Exp. Cell Res. 186:1990;332-339.
3. Hoffman B. D., Hanauske-Abel H. M., Flint A., Lalande M. A new class of reversible cell cycle inhibitors. Cytometry. 12:1991;26-32.
4. Watson P. A., Hanauske-Abel H. H., Flint A., Lalande M. Mimosine reversibly arrests cell cycle progression at the G1-S phase border. Cytometry. 12:1991;242-246.
5. Dijkwel P. A., Hamlin J. L. Initiation of DNA replication in the dihydrofolate reductase locus is confined to the early S period in CHO cells synchronized with the plant amino acid mimosine. Mol. Cell. Biol. 12:1992;3715-3722.
6. Mosca P. J., Dijkwel P. A., Hamlin J. L. The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells. Mol. Cell. Biol. 12:1992;4375-4383.
7. Levenson V., Hamlin J. L. A general protocol for evaluating the specific effects of DNA replication inhibitors. Nucleic Acids Res. 21:1993;3997-4004.
8. Hughes T. A., Cook P. R. Mimosine arrests the cell cycle after cells enter S-phase. Exp. Cell Res. 222:1996;275-280.
9. Gilbert D. M., Neilson A., Miyazawa H., DePamphilis M. L., Burhans W. C. Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism. J. Biol. Chem. 270:1995;9597-9606.
10. Dai Y., Gold B., Vishwanatha J. K., Rhode S. L. Mimosine inhibits viral DNA synthesis through ribonucleotide reductase. Virology. 205:1994;210-216.
11. Kalejta R. F., Hamlin J. L. The dual effect of mimosine on DNA replication. Exp. Cell Res. 231:1997;173-183.
12. Reichard P. From RNA to DNA, why so many ribonucleotide reductases. Science. 260:1993;1773-1777.
13. Tsai W. C., Ling K. H. Toxic action of mimosine. I. Inhibition of mitosis and DNA synthesis of H.Ep-2 cell by mimosine and 3,4-dihydroxypyridine. Toxicon. 9:1971;241-247.
14. Wang Y., Zhao J., Clapper J., Martin L. D., Du C., DeVore E. R., Harkins K., Dobbs D. L., Benbow R. M. Mimosine differentially inhibits DNA replication and cell cycle progression in somatic cells compared to embryonic cells of Xenopus laevis. Exp. Cell Res. 217:1995;84-91.
15. Tsvetkov L. M., Russev G. C., Anachkova B. B. Effect of mimosine on DNA synthesis in mammalian cells. Cancer Res. 57:1997;2252-2255.
16. Krude T., Jackman M., Pines J., Laskey R. A. Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system. Cell. 88:1997;109-119.
17. Gurdon J. B. Injected nuclei in frog oocytes: fate, enlargement, and chromatin dispersal. J. Embryol. Exp. Morphol. 36:1976;523-540.
18. Krude T. Chromatin assembly factor 1 (CAF-1) colocalizes with replication foci in HeLa cell nuclei. Exp. Cell Res. 220:1995;304-311.
19. Vogt G., Bohm R., Segner H. Mimosine, a naturally occurring drug interfering primarily with the cell nucleus. J. Submicrosc. Cytol. Pathol. 25:1993;247-256.
20. Vogt G., Bohm R., Segner H. Mimosine-induced cell death and related chromatin changes. J. Submicrosc. Cytol. Pathol. 26:1994;319-330.
21. Jackson D. A., Cook P. R. Replication occurs at a nucleoskeleton. EMBO J. 5:1986;1403-1410.
22. Jackson D. A., Cook P. R. A cell-cycle-dependent DNA polymerase activity that replicates intact DNA in chromatin. J. Mol. Biol. 192:1986;65-76.
23. Hassan A. B., Cook P. R. Visualization of replication sites in unfixed human cells. J. Cell Sci. 105:1993;541-550.
24. Hozak P., Hassan A. B., Jackson D. A., Cook P. R. Visualization of replication factories attached to nucleoskeleton. Cell. 73:1993;361-373.
25. Hand R. Eukaryotic DNA: Organization of the genome for replication. Cell. 15:1978;317-325.
26. Jha A. N., Hande P. M., Mullenders L. H., Natarajan A. T. Mimosine is a potent clastogen in primary and transformed hamster fibroblasts but not in primary or transformed human lymphocytes. Mutagenesis. 10:1995;385-391.
27. Mosca P. J., Lin H. B., Hamlin J. L. Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells. Nucleic Acids Res. 23:1995;261-268.
28. Lin H. B., Falchetto R., Mosca P. J., Shabanowitz J., Hunt D. F., Hamlin J. L. Mimosine targets serine hydroxymethyltransferase. J. Biol. Chem. 271:1996;2548-2556.
29. Pasero P., Gasser S. M. New systems for replicating DNA in vitro. Curr. Opin. Cell. Biol. 10:1998;304-310.
30. Pasero P., Braguglia D., Gasser S. M. ORC-dependent and origin-specific initiation of DNA replication at defined foci in isolated yeast nuclei. Genes Dev. 11:1997;1504-1518.