Interaction of p21CDKN1A with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair

Nucleic Acids Research

Volumn 36, Issue 5, 2008, Pages 1713-1722

  Cazzalini, Ornella ^a   Perucca, Paola ^a   Savio, Monica ^a   Necchi, Daniela ^a   Bianchi, Livia ^a   Stivala, Lucia A ^a   Ducommun, Bernard ^b   Scovassi, A Ivana ^c   Prosperi, Ennio ^a,c  

^a UNIVERSITY OF PAVIA   (Italy)

^b Université de Toulouse Paul Sabatier   (France)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; HISTONE ACETYLTRANSFERASE; PROTEIN P21; PROTEIN P300; RECOMBINANT PROTEIN;

ARTICLE; CELL STRAIN HEK293; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EMBRYO; ENZYME INHIBITION; ENZYME REGULATION; EXCISION REPAIR; FIBROBLAST CULTURE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; ULTRAVIOLET RADIATION;

CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA REPAIR; HUMANS; P300-CBP TRANSCRIPTION FACTORS; PROLIFERATING CELL NUCLEAR ANTIGEN;

EID: 41149125554     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn014     Document Type: Article

References (49)

1. Dotto,G.P. (2000) p21WAF1/Cip1: More than a break to the cell cycle? Biochim. Biophys. Acta, 1471, M43-M56.
2. Coqueret,O. (2003) New roles for p21 and p27 cell-cycle inhibitor: A function for each cell compartment? Trends Cell Biol., 13, 65-70.
3. Gulbis,J.M., Kelman,Z., Hurtwitz,J., O'Donnel,M. and Kuriyan,J. (1996) Structure of the C-terminal region of p21waf1/cip1 complexed with human PCNA. Cell, 87, 297-306.
4. Waga,S. and Stillman,B. (1998) Cyclin-dependent kinase inhibitor p21 modulates the DNA primer-template recognition complex. Mol. Cell. Biol., 18, 4177-4187.
5. Warbrick,E. (2000) The puzzle of PCNA's many partners. BioEssays, 22, 997-1006.
6. Cazzalini,O., Perucca,P., Riva,F., Stivala,L.A., Bianchi,L., Vannini,V., Ducommun,B. and Prosperi,E. (2003) p21CDKN1A does not interfere with loading of PCNA at DNA replication sites, but inhibits subsequent binding of DNA polymerase delta at the G1/S phase transition. Cell Cycle, 2, 596-603.
7. Cooper,M.P., Balajee,A.S. and Bohr,V.A. (1999) The C-terminal domain of p21 inhibits nucleotide excision repair in vitro and in vivo. Mol. Biol. Cell, 10, 2119-2129.
8. WAF1 to promote DNA repair. Cell, 114, 599-610.
9. -/- human cancer cells. Cancer Res., 56, 2250-2255.
10. Sheikh,M.S., Chen,Y.Q., Smith,M.L. and Fornace,A.J.Jr. (1997) Role of p21waf/cip1/sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene, 14, 1875-1882.
11. Savio,M., Stivala,L.A., Scovassi,A.I., Bianchi,L. and Prosperi,E. (1996) p21waf1/cip1 protein associates with the detergent-insoluble form of PCNA concomitantly with disassembly of PCNA at nucleotide excision repair sites. Oncogene, 13, 1591-1598.
12. CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen. J. Cell Sci., 119, 1517-1527.
13. Shivji,M.K.K., Ferrari,E., Ball,K., Hübscher,U. and Wood,R.D. (1998) Resistance of human nucleotide excision repair synthesis in vitro to p21CDKN1. Oncogene, 17, 2827-2838.
14. Stivala,L.A., Riva,F., Cazzalini,O., Savio,M. and Prosperi,E. (2001) p21waf1/cip1-null human fibroblasts are deficient in nucleotide excision repair downstream the recruitment of PCNA to DNA repair sites. Oncogene, 20, 563-570.
15. Frouin,I., Maga,G., Denegri,M., Riva,F., Savio,M., Spadari,S., Prosperi,E. and Scovassi,A.I. (2003) Human proliferating cell nuclear antigen, poly (ADP-ribose) polymerase-1, and p21waf1/cip1: A dynamic exchange of partners. J. Biol. Chem., 278, 39265-39268.
16. Avkin,S., Sevilya,Z., Toube,L., Geacintov,N., Chaney,S.G., Oren,M. and Livneh,Z. (2006) p53 and p21 regulate error-prone DNA repair to yield a lower mutation load. Mol. Cell, 22, 407-413.
17. Gregory,D.J., Garcia-Wilson,E., Poole,J.C., Snowden,A.W., Roninson,I.B. and, Perkins,N.D. (2002) Induction of transcription through the p300 CRD1 Motif by p21WAF1/CIP1 is core promoter specific and cyclin dependent kinase independent. Cell Cycle, 1, 343-350.
18. Hasan,S., Hassa,P.O., Imhof,R. and Hottiger,M.O. (2001) Transcriptional coactivator p300 binds PCNA and may have a role in DNA repair synthesis. Nature, 410, 387-391.
19. Hoeijmakers,J.H. (2001) Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-374.
20. Rubbi,C.P. and Milner,J. (2003) p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage. EMBO J., 22, 975-986.
21. Hong,R. and Chakravarti,D. (2003) The human proliferating cell nuclear antigen regulates transcriptional coactivator p300 activity and promotes transcriptional repression. J. Biol. Chem., 278, 44505-44513.
22. INK4a. Mol. Cell 14, 501-513.
23. Podust,V.N., Podust,L.M., Goubin,F., Ducommun,B. and Hubscher,U. (1995) Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21. Biochemistry, 34, 8869-8875.
24. Ríva,F., Savio,M., Cazzalini,O., Stivala,L.A., Scovassi,I.A., Cox,L.S., Ducommun,B. and Prosperi,E. (2004) Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase δ or DNA ligase I. Exp. Cell Res., 293, 357-367.
25. Scovassi,A.I. and Prosperi,E. (2006) Analysis of proliferating cell nuclear antigen (PCNA) associated with DNA excision repair sites in mammalian cells. Methods Mol. Biol., 314, 457-475.
26. Chakravarti,D., Ogryzko,V., Kao,H.Y., Nash,A., Chen,H., Nakatani,Y. and Evans,R.M. (1999) A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell, 96, 393-403.
27. Cayrol,C., Knibiehelr,M. and Ducommun,B. (1998) p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene 16, 311-320.
28. WAF1/CIP1 induction of transactivation. Mol. Cell. Biol., 20, 2676-2686.
29. Prosperi,E. (2006) The fellowship of the rings: Distinct pools of proliferating cell nuclear antigen (PCNA) trimer at work. FASEB J. 20, 833-837.
30. Moldovan,G.L., Pfander,B. and Jentsch,S. (2007) PCNA, the maestro of replication fork. Cell, 129, 665-679.
31. waf1 binds to the myc and cdc25A promoters upon DNA damage and induces transcriptional repression. J. Biol. Chem., 281, 34742-34750.
32. Vieyra,D., Loewith,R., Scott,M., Bonnefin,P., Boisvert,F.M., Cheema,P., Pastyryeva,S., Meijer,M., Johnston,R.N., Bazett-Jones,D.P. et al. (2002) Human ING1 proteins differentially regulate histone acetylation. J. Biol. Chem., 277, 29832-29839.
33. Hasan,S., Stucki,M., Hassa,P.O., Imhof,R., Gehrig,P., Hunziker,P., Hübscher,U. and Hottiger,M.O. (2001) Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Mol. Cell, 7, 1221-1231.
34. Hasan,S., El-Andaloussi,N., Hardeland,U., Hassa,P.O., Bürki,C., Imhof,R., Schär,P. and Hottiger,M.O. (2002) Acetylation regulates the DNA end-trimming activity of DNA polymerase β. Mol. Cell, 10 1213-1222.
35. Tini,M., Benecke,A., Um,S.-J., Torchia,J., Evans,R.M. and Chambon,P. (2002) Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol. Cell, 9, 265-277.
36. Bhakat,K.K., Hazra,T.K. and Mitra,S. (2004) Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity. Nucleic Acids Res. 32, 3033-3039.
37. Bhakat,K.K., Mokkapati,S.K., Boldogh,I, Hazra,T.K. and Mitra,S. (2006) Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo. Mol. Cell. Biol., 26, 1654-1665.
38. Likhite,V.S., Cass,E.I., Anderson,S.D., Yates,J.R. and Nardulli,A.M. (2004) Interaction of estrogen receptor α with 3-methyladenine DNA glycosylase modulates transcription and DNA repair. J. Biol. Chem. 279, 16875-16882.
39. Datta,A., Bagchi,S., Nag,A., Shiyanov,P., Adami,G.R., Yoon,T. and Raychaudhuri,P. (2001) The p48 subunit of the damaged-DNA binding protein DDB associates with CBP/p300 family of histone acetyltransferase. Mutat. Res., 486, 89-97.
40. Rapic-Otrin,V., McLenigan,M.P., Bisi,D.C., Gonsalez,M. and Levine,A.S. (2002) Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation. Nucleic Acids Res., 30, 2588-2599.
41. Fousteri,M., Vermeulen,W., van Zeeland,A.A. and Mullenders,L.H.F. (2006) Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodelling and repair factors of stalled RNA polymerase II in vivo. Mol. Cell, 23, 471-482.
42. Frit,P., Kwon,K., Coin,F., Auriol,J., Dubaele,S., Salles,B. and Egly,J.M. (2002) Transcriptional activators stimulate DNA repair. Mol. Cell, 10, 1391-1401.
43. Schultz-Norton,J.R., Walt,K.A., Ziegler,Y.S., McLeod,I.X., Yates,J.R., Raetzman,L.T. and Nardulli,A.M. (2007) The deoxyribonucleic acid repair protein flap endonuclease-1 modulates estrogen-responsive gene expression. Mol. Endocrinol., 21, 1569-1580.
44. WAF1/CIP1 selectively controls the transcription of estrogen receptor α. Mol. Cell. Biol., 25, 2419-2430.
45. Martin,P., Lardeaux,V. and Lefebvre,P. (2005) The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction. Nucleic Acids Res., 13, 4311-4321.
46. Schultz-Norton,J.R., Gabisi,V.A., Ziegler,Y.S., McLeod,I.X., Yates,J.R. and Nardulli,A.M. (2007) Interaction of estrogen receptor α with proliferating cell nuclear antigen. Nucleic Acids Res., 35, 5028-5038.
47. Keriel,A., Stary,A., Sarasin,A., Rochette-Egly,C. and Egly,J.M. (2002) XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha. Cell, 109, 125-135.
48. Ito,S., Kuraoka,I., Chymkowitch,P., Compe,E., Takedachi,A., Ishigami,C., Coin,F., Egly,J.M. and Tanaka,K. (2007) XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: Implications for Cockaine syndrome in XP-G/CS patients. Mol. Cell, 26, 231-243.
49. Groth,A., Rocha,W., Verreault,A. and Almouzni,G. (2007) Chromatin challenges during DNA replication and repair. Cell, 128, 721-733.