Synthesis and biological evaluation of 11C-labeled β-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5117-5125

  Celen, Sofie ^a   Cleynhens, Jan ^a   Deroose, Christophe ^a   de Groot, Tjibbe ^a   Ibrahimi, Abdelilah ^a   Gijsbers, Rik ^a   Debyser, Zeger ^a   Mortelmans, Luc ^a   Verbruggen, Alfons ^a   Bormans, Guy ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Galactosidase; Galactosyl triazole; Carbon 11; Click chemistry; LacZ reporter gene; PET

Indexed keywords

1 (BETA DEXTRO GALACTOPYRANOSYL) 4 (6 METHOXYNAPHTHYL) 1,2,3 TRIAZOLE C 11; 1 (BETA GALACTOPYRANOSYL) 4 (4 METHOXYPHENYL) 1,2,3 TRIAZOLE C 11; ALKYLATING AGENT; BETA GALACTOSIDASE; BETA GALACTOSYLTRIAZOLE DERIVATIVE; CARBON 11; METHYL IODIDE; N,N DIMETHYLFORMAMIDE; O NITROPHENYL BETA DEXTRO GALACTOPYRANOSIDE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIFFUSION; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MAPPING; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LACZ GENE; LIPOPHILICITY; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PLASMA; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; REPORTER GENE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; URINE;

ANIMALS; BETA-GALACTOSIDASE; CARBON RADIOISOTOPES; CELL LINE; CELL MEMBRANE PERMEABILITY; GALACTOSE; GENE EXPRESSION; GENES, REPORTER; HUMANS; KIDNEY; LAC OPERON; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY; RADIOISOTOPES; TRIAZOLES;

MURINAE; MUS;

EID: 67650080279     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.056     Document Type: Article

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