Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 1958-1962

  Wang, Ji Quan ^a   Zhang, Zhaoda ^a   Kuruppu, Darshini ^a   Brownell, Anna Liisa ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Group II mGluRs; mGluR2; mGluR3; PET; Prodrug

Indexed keywords

2 (2 CARBOXYCYCLOPROPYL) 2 (3 METHOXYPHENETHYL) GLYCINE DIMETHYL ESTER CARBON 11; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 2 AMINO 3 (3,4 DICHLOROBENZYLOXY) 6 FLUOROBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; EGLUMETAD; METABOTROPIC RECEPTOR 2; MGS 0028; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HIPPOCAMPUS; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOSYNTHESIS; RAT;

AMINO ACIDS; ANIMALS; BRAIN; CORPUS STRIATUM; HIPPOCAMPUS; MALE; POSITRON-EMISSION TOMOGRAPHY; PRODRUGS; PROTEIN BINDING; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; XANTHENES;

RATTUS;

EID: 84862829586     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.039     Document Type: Article

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