Tyrosine phosphoproteomics identifies both codrivers and cotargeting strategies for T790M-related EGFR-TKI resistance in non-small cell lung cancer

Clinical Cancer Research

Volumn 20, Issue 15, 2014, Pages 4059-4074

  Yoshida, Takeshi ^a,b   Zhang, Guolin ^a   Smith, Matthew A ^a   Lopez, Alex S ^a   Bai, Yun ^a   Li, Jiannong ^a   Fang, Bin ^a   Koomen, John ^a   Rawal, Bhupendra ^a   Fisher, Kate J ^a   Chen, Ann Y ^a   Kitano, Michiko ^b   Morita, Yume ^b   Yamaguchi, Haruka ^b   Shibata, Kiyoko ^b   Okabe, Takafumi ^b   Okamoto, Isamu ^b   Nakagawa, Kazuhiko ^b   Haura, Eric B ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL] 2 BUTYNAMIDE; PHOSPHOPEPTIDE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; PROTEOME; TYROSINE PHOSPHOPROTEOME; UNCLASSIFIED DRUG; WZ 4002; WZ 4006; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHOPROTEIN; PROTEIN KINASE INHIBITOR; TUMOR MARKER; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS ASSAY; ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GATEKEEPER MUTATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER CELL LINE; LUNG NON SMALL CELL CANCER; MASS SPECTROMETRY; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEOMICS; SIGNAL TRANSDUCTION; TUMOR REGRESSION; TUMOR XENOGRAFT; TYROSINE PHOSPHOPROTEOMICS; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENETICS; LIQUID CHROMATOGRAPHY; LUNG NEOPLASMS; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; MUTATION; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; PROCEDURES; PROTEIN MICROARRAY; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BIOMARKERS, TUMOR; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; CHROMATOGRAPHY, LIQUID; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN ARRAY ANALYSIS; PROTEIN KINASE INHIBITORS; PROTEOMICS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TUMOR CELLS, CULTURED; TYROSINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84905498876     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-1559     Document Type: Article

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