Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 30, 2013, Pages 12414-12419

  Kim, Jae Young ^a   Welsh, Eric A ^a   Oguz, Umut ^a   Fang, Bin ^a   Bai, Yun ^a   Kinose, Fumi ^a   Bronk, Crystina ^a   Rix, Lily L Remsing ^a   Beg, Amer A ^a   Rix, Uwe ^a   Eschrich, Steven A ^a   Koomen, John M ^a   Haura, Eric B ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Astrocyte elevated gene 1 (AEG 1); Non canonical I?B kinase; Stable isotope labeling by amino acids (SILAC)

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEIN; PHOSPHOTRANSFERASE; POLO LIKE KINASE 1; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; S6 KINASE; SCATTER FACTOR RECEPTOR; TANK BINDING KINASE 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; MASS SPECTROMETRY; MITOSIS; MUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; RNA INTERFERENCE; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

ASTROCYTE ELEVATED GENE-1 (AEG-1); NON-CANONICAL IΚB KINASE; STABLE ISOTOPE LABELING BY AMINO ACIDS (SILAC);

AMINO ACID SEQUENCE; GENES, RAS; HUMANS; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEOMICS; SIGNAL TRANSDUCTION;

EID: 84880653259     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220674110     Document Type: Article

References (36)

1. Tojima Y, et al. (2000) NAK is an IkappaB kinase-activating kinase. Nature 404(6779): 778-782.
2. Shen RR, Hahn WC (2011) Emerging roles for the non-canonical IKKs in cancer. Oncogene 30(6):631-641.
3. Chau TL, et al. (2008) Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? Trends Biochem Sci 33(4):171-180.
4. Boehm JS, et al. (2007) Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 129(6):1065-1079.
5. Guo JP, et al. (2009) Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. Am J Pathol 175(1):324-333.
6. Guan H, et al. (2011) IKBKE is over-expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-kB. J Pathol 223(3):436-445.
7. Guo J, et al. (2013) IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer. Oncogene 32(2):151-159.
8. Chien Y, et al. (2006) RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell 127(1):157-170.
9. Barbie DA, et al. (2009) Systematic RNA interference reveals that oncogenic KRASdriven cancers require TBK1. Nature 462(7269):108-112.
10. Ou YH, et al. (2011) TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell 41(4):458-470.
11. Xie X, et al. (2011) IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci USA 108(16):6474-6479.
12. Luo J, et al. (2009) A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137(5):835-848.
13. Lee SG, Su ZZ, Emdad L, Sarkar D, Fisher PB (2006) Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci USA 103(46):17390-17395.
14. Wang J, et al. (2010) NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication. J Immunol 185(3):1720-1729.
15. Zheng Y, Vig M, Lyons J, Van Parijs L, Beg AA (2003) Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function. J Exp Med 197(7):861-874.
16. Dix MM, et al. (2012) Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome. Cell 150(2):426-440.
17. Ong SE, et al. (2002) Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 1(5): 376-386.
18. Schwartz D, Gygi SP (2005) An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets. Nat Biotechnol 23(11): 1391-1398.
19. Jang YJ, Ma S, Terada Y, Erikson RL (2002) Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase. J Biol Chem 277(46):44115-44120.
20. Krause A, Hoffmann I (2010) Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. PLoS ONE 5(3):e9849.
21. Dammermann A, Merdes A (2002) Assembly of centrosomal proteins and microtubule organization depends on PCM-1. J Cell Biol 159(2):255-266.
22. Hames RS, et al. (2005) Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. Mol Biol Cell 16(4):1711-1724.
23. Budde PP, Kumagai A, Dunphy WG, Heald R (2001) Regulation of Op18 during spindle assembly in Xenopus egg extracts. J Cell Biol 153(1):149-158.
24. Adachi Y, Luke M, Laemmli UK (1991) Chromosome assembly in vitro: Topoisomerase II is required for condensation. Cell 64(1):137-148.
25. Uemura T, et al. (1987) DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe. Cell 50(6):917-925.
26. Lee SH, Sterling H, Burlingame A, McCormick F (2008) Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. Genes Dev 22(21):2926-2931.
27. Kueng S, et al. (2006) Wapl controls the dynamic association of cohesin with chromatin. Cell 127(5):955-967.
28. Gandhi R, Gillespie PJ, Hirano T (2006) Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr Biol 16(24):2406-2417.
29. Lin CY, et al. (2000) Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2. Proc Natl Acad Sci USA 97(23):12589-12594.
30. Brown DM, Ruoslahti E (2004) Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5(4):365-374.
31. Kikuno N, et al. (2007) Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 26(55): 7647-7655.
32. Archambault V, Glover DM (2009) Polo-like kinases: Conservation and divergence in their functions and regulation. Nat Rev Mol Cell Biol 10(4):265-275.
33. Goncalves A, et al. (2011) Functional dissection of the TBK1 molecular network. PLoS ONE 6(9):e23971.
34. Duncan JS, et al. (2012) Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell 149(2):307-321.
35. Nazarian R, et al. (2010) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468(7326):973-977.
36. Sun T, et al. (2011) Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell 144(5):703-718.