메뉴 건너뛰기




Volumn 5, Issue MAY, 2014, Pages

The IGF hormonal network in endometrial cancer: Functions, regulation, and targeting approaches

Author keywords

Biomarkers; BRCA1; Endometrial cancer; IGF1; IGF1 receptor; Insulin like growth factors; P53; Uterine serous carcinoma

Indexed keywords

CARBOPLATIN; CP 751 871; DOCETAXEL; DUSIGITUMAB; ERLOTINIB; ESTRADIOL; FIBROBLAST GROWTH FACTOR 2; FIGITUMUMAB; GANITUMAB; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR SUBSTRATE 1; LINSITINIB; NVP AEW 541; PACLITAXEL; PROTEIN P53; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN C; VORINOSTAT; ZINC FINGER PROTEIN;

EID: 84905493633     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2014.00076     Document Type: Review
Times cited : (65)

References (75)
  • 2
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • doi:10.1016/0090-8258(83)90111-7
    • Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol (1983) 15:10-7. doi:10.1016/0090-8258(83)90111-7
    • (1983) Gynecol Oncol , vol.15 , pp. 10-17
    • Bokhman, J.V.1
  • 3
    • 1842506206 scopus 로고    scopus 로고
    • Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification
    • doi:10.1007/s00428-003-0947-3
    • Lax SF. Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch (2004) 444:213-23. doi:10.1007/s00428-003-0947-3
    • (2004) Virchows Arch , vol.444 , pp. 213-223
    • Lax, S.F.1
  • 4
    • 7644242407 scopus 로고    scopus 로고
    • Uterine serous and grade 3 endometrioid carcinomas: is there a survival difference?
    • doi:10.1002/cncr.20645
    • Boruta DM, Gehrig PA, Groben PA, Bae-Jump V, Boggess JF, Fowler WC Jr, et al. Uterine serous and grade 3 endometrioid carcinomas: is there a survival difference? Cancer (2004) 101:2214-21. doi:10.1002/cncr.20645
    • (2004) Cancer , vol.101 , pp. 2214-2221
    • Boruta, D.M.1    Gehrig, P.A.2    Groben, P.A.3    Bae-Jump, V.4    Boggess, J.F.5    Fowler Jr., W.C.6
  • 5
    • 84864330983 scopus 로고    scopus 로고
    • Markers for individualised therapy in endometrial carcinoma
    • doi:10.1016/S1470-2045(12)70213-9
    • Salvesen HB, Haldorsen IS, Trovik J. Markers for individualised therapy in endometrial carcinoma. Lancet Oncol (2012) 13:e353-61. doi:10.1016/S1470-2045(12)70213-9
    • (2012) Lancet Oncol , vol.13
    • Salvesen, H.B.1    Haldorsen, I.S.2    Trovik, J.3
  • 6
    • 84859470538 scopus 로고    scopus 로고
    • Biomarkers in endometrial cancer: possible clinical applications
    • Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, et al. Biomarkers in endometrial cancer: possible clinical applications. Oncol Lett (2012) 3:1175-80.
    • (2012) Oncol Lett , vol.3 , pp. 1175-1180
    • Banno, K.1    Kisu, I.2    Yanokura, M.3    Tsuji, K.4    Masuda, K.5    Ueki, A.6
  • 7
    • 54849432745 scopus 로고    scopus 로고
    • GATA3 expression in estrogen receptor a-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival
    • doi:10.1016/j.ajog.2008.04.043
    • Engelsen IB, Stefansson IM, Akslen LA, Salvesen HB. GATA3 expression in estrogen receptor a-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival. Am J Obstet Gynecol (2008) 199:.e1-7. doi:10.1016/j.ajog.2008.04.043
    • (2008) Am J Obstet Gynecol , vol.199
    • Engelsen, I.B.1    Stefansson, I.M.2    Akslen, L.A.3    Salvesen, H.B.4
  • 8
    • 0033979559 scopus 로고    scopus 로고
    • Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis
    • Salvesen HB, Das S, Akslen LA. Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis. Clin Cancer Res (2000) 6:153-9.
    • (2000) Clin Cancer Res , vol.6 , pp. 153-159
    • Salvesen, H.B.1    Das, S.2    Akslen, L.A.3
  • 9
    • 0032896335 scopus 로고    scopus 로고
    • Prognostic significance of angiogenesis and Ki-67, p53, and p21 expression: a population-based endometrial carcinoma study
    • Salvesen HB, Iversen OE, Akslen LA. Prognostic significance of angiogenesis and Ki-67, p53, and p21 expression: a population-based endometrial carcinoma study. J Clin Oncol (1999) 17:1382-90.
    • (1999) J Clin Oncol , vol.17 , pp. 1382-1390
    • Salvesen, H.B.1    Iversen, O.E.2    Akslen, L.A.3
  • 10
    • 33744828734 scopus 로고    scopus 로고
    • HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients
    • doi:10.1200/JCO.2005.03.4827
    • Morrison C, Zanagnolo V, Ramirez N, Cohn DE, Kelbick N, Copeland L, et al. HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients. J Clin Oncol (2006) 24:2376-85. doi:10.1200/JCO.2005.03.4827
    • (2006) J Clin Oncol , vol.24 , pp. 2376-2385
    • Morrison, C.1    Zanagnolo, V.2    Ramirez, N.3    Cohn, D.E.4    Kelbick, N.5    Copeland, L.6
  • 11
    • 80052010923 scopus 로고    scopus 로고
    • Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group
    • doi:10.1200/JCO.2010.34.1578
    • Oza AM, Elit L, Tsao MS, Kamel-Reid S, Biagi J, Provencher DM, et al. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol (2011) 29:3278-85. doi:10.1200/JCO.2010.34.1578
    • (2011) J Clin Oncol , vol.29 , pp. 3278-3285
    • Oza, A.M.1    Elit, L.2    Tsao, M.S.3    Kamel-Reid, S.4    Biagi, J.5    Provencher, D.M.6
  • 12
    • 33847221165 scopus 로고    scopus 로고
    • Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1
    • doi:10.1038/ncpendmet0427
    • LeRoith D, Yakar S. Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab (2007) 3:302-10. doi:10.1038/ncpendmet0427
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 302-310
    • LeRoith, D.1    Yakar, S.2
  • 13
    • 79951860072 scopus 로고    scopus 로고
    • Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer
    • doi:10.1200/JCO.2009.27.5040
    • Maki RG. Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer. J Clin Oncol (2010) 28:4985-95. doi:10.1200/JCO.2009.27.5040
    • (2010) J Clin Oncol , vol.28 , pp. 4985-4995
    • Maki, R.G.1
  • 14
    • 0346206633 scopus 로고
    • A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro
    • Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med (1957) 49:825-36.
    • (1957) J Lab Clin Med , vol.49 , pp. 825-836
    • Salmon, W.D.1    Daughaday, W.H.2
  • 15
    • 0242594016 scopus 로고    scopus 로고
    • The IGF-1 receptor in cancer biology
    • doi:10.1002/ijc.11487
    • Baserga R, Peruzzi F, Reiss K. The IGF-1 receptor in cancer biology. Int J Cancer (2003) 107:873-7. doi:10.1002/ijc.11487
    • (2003) Int J Cancer , vol.107 , pp. 873-877
    • Baserga, R.1    Peruzzi, F.2    Reiss, K.3
  • 16
    • 0035115801 scopus 로고    scopus 로고
    • The somatomedin hypothesis: 2001
    • doi:10.1210/edrv.22.1.0419
    • LeRoith D, Bondy C, Yakar S, Liu J-L, Butler A. The somatomedin hypothesis: 2001. Endocr Rev (2001) 22:53-74. doi:10.1210/edrv.22.1.0419
    • (2001) Endocr Rev , vol.22 , pp. 53-74
    • LeRoith, D.1    Bondy, C.2    Yakar, S.3    Liu, J.-L.4    Butler, A.5
  • 17
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • doi:10.1038/nrc2536
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer (2008) 8:915-28. doi:10.1038/nrc2536
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 18
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: overview and recent insights
    • doi:10.1210/er.2006-0001
    • Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev (2007) 28:20-47. doi:10.1210/er.2006-0001
    • (2007) Endocr Rev , vol.28 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    LeRoith, D.3    Brodt, P.4
  • 19
    • 68149103024 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor as an oncogene
    • doi:10.1080/13813450902783106
    • Werner H, Bruchim I. The insulin-like growth factor-I receptor as an oncogene. Arch Physiol Biochem (2009) 115:58-71. doi:10.1080/13813450902783106
    • (2009) Arch Physiol Biochem , vol.115 , pp. 58-71
    • Werner, H.1    Bruchim, I.2
  • 20
    • 1442327490 scopus 로고    scopus 로고
    • Clinical implications of insulin-like growth factors through the presence of their binding proteins and receptors expressed in gynecological cancers
    • Hirano S, Ito N, Takahashi S, Tamaya T. Clinical implications of insulin-like growth factors through the presence of their binding proteins and receptors expressed in gynecological cancers. Eur J Gynaecol Oncol (2004) 25:187-91.
    • (2004) Eur J Gynaecol Oncol , vol.25 , pp. 187-191
    • Hirano, S.1    Ito, N.2    Takahashi, S.3    Tamaya, T.4
  • 21
    • 33751278008 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium
    • doi:10.1158/1078-0432.CCR-06-0912
    • McCampbell AS, Broaddus RR, Loose DS, Davies PJA. Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium. Clin Cancer Res (2006) 12:6373-8. doi:10.1158/1078-0432.CCR-06-0912
    • (2006) Clin Cancer Res , vol.12 , pp. 6373-6378
    • McCampbell, A.S.1    Broaddus, R.R.2    Loose, D.S.3    Davies, P.J.A.4
  • 22
    • 84862026329 scopus 로고    scopus 로고
    • p53 regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy
    • doi:10.1016/j.ejca.2011.09.014
    • Attias-Geva Z, Bentov I, Kidron D, Amichay K, Sarfstein R, Fishman A, et al. p53 regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy. Eur J Cancer (2012) 48:1570-80. doi:10.1016/j.ejca.2011.09.014
    • (2012) Eur J Cancer , vol.48 , pp. 1570-1580
    • Attias-Geva, Z.1    Bentov, I.2    Kidron, D.3    Amichay, K.4    Sarfstein, R.5    Fishman, A.6
  • 23
    • 84863667602 scopus 로고    scopus 로고
    • BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines
    • doi:10.1097/IGC.0b013e318254011f
    • Amichay K, Kidron D, Attias-Geva Z, Schayek H, Sarfstein R, Fishman A, et al. BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines. Int J Gynecol Cancer (2012) 22:748-54. doi:10.1097/IGC.0b013e318254011f
    • (2012) Int J Gynecol Cancer , vol.22 , pp. 748-754
    • Amichay, K.1    Kidron, D.2    Attias-Geva, Z.3    Schayek, H.4    Sarfstein, R.5    Fishman, A.6
  • 24
    • 33646874133 scopus 로고    scopus 로고
    • Association between adiponectin, insulin resistance, and endometrial cancer
    • doi:10.1002/cncr.21866
    • Soliman PT, Wu D, Tortolero-Luna G, Schmeler KM, Slomovitz BM, Bray MS, et al. Association between adiponectin, insulin resistance, and endometrial cancer. Cancer (2006) 106:2376-81. doi:10.1002/cncr.21866
    • (2006) Cancer , vol.106 , pp. 2376-2381
    • Soliman, P.T.1    Wu, D.2    Tortolero-Luna, G.3    Schmeler, K.M.4    Slomovitz, B.M.5    Bray, M.S.6
  • 25
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
    • doi:10.1038/nrc1408
    • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer (2004) 4:579-91. doi:10.1038/nrc1408
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 26
    • 84861682298 scopus 로고    scopus 로고
    • Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer
    • doi:10.1038/onc.2011.447
    • Werner H. Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer. Oncogene (2012) 31:2703-14. doi:10.1038/onc.2011.447
    • (2012) Oncogene , vol.31 , pp. 2703-2714
    • Werner, H.1
  • 27
    • 57149142057 scopus 로고    scopus 로고
    • IGF and insulin receptor signaling in breast cancer
    • doi:10.1007/s10911-008-9099-z
    • Belfiore A, Frasca F. IGF and insulin receptor signaling in breast cancer. J Mammary Gland Biol Neoplasia (2008) 13:381-406. doi:10.1007/s10911-008-9099-z
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 381-406
    • Belfiore, A.1    Frasca, F.2
  • 28
    • 80052143150 scopus 로고    scopus 로고
    • Insulin receptor and cancer
    • doi:10.1530/ERC-11-0074
    • Belfiore A, Malaguarnera R. Insulin receptor and cancer. Endocr Relat Cancer (2011) 18:R125-47. doi:10.1530/ERC-11-0074
    • (2011) Endocr Relat Cancer , vol.18
    • Belfiore, A.1    Malaguarnera, R.2
  • 29
    • 0030843850 scopus 로고    scopus 로고
    • Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer
    • doi:10.1507/endocrj.44.419
    • Ayabe T, Tsutsumi O, Sakai H, Yoshikawa H, Yano T, Kurimoto F, et al. Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer. Endocr J (1997) 44:419-24. doi:10.1507/endocrj.44.419
    • (1997) Endocr J , vol.44 , pp. 419-424
    • Ayabe, T.1    Tsutsumi, O.2    Sakai, H.3    Yoshikawa, H.4    Yano, T.5    Kurimoto, F.6
  • 31
    • 42149124307 scopus 로고    scopus 로고
    • A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer
    • doi:10.1158/1055-9965.EPI-07-2686
    • Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Manson JE, Li J, et al. A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer. Cancer Epidemiol Biomarkers Prev (2008) 17:921-9. doi:10.1158/1055-9965.EPI-07-2686
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 921-929
    • Gunter, M.J.1    Hoover, D.R.2    Yu, H.3    Wassertheil-Smoller, S.4    Manson, J.E.5    Li, J.6
  • 32
    • 0344009727 scopus 로고    scopus 로고
    • Serum levels of insulin-like growth factor-I, IGF-binding protein 1 and 3, and insulin and endometrial cancer risk
    • doi:10.1038/sj.bjc.6601312
    • Weiderpass E, Brismar K, Bellocco R, Vainio H, Kaaks T. Serum levels of insulin-like growth factor-I, IGF-binding protein 1 and 3, and insulin and endometrial cancer risk. Br J Cancer (2003) 89:1697-704. doi:10.1038/sj.bjc.6601312
    • (2003) Br J Cancer , vol.89 , pp. 1697-1704
    • Weiderpass, E.1    Brismar, K.2    Bellocco, R.3    Vainio, H.4    Kaaks, T.5
  • 33
    • 84872589478 scopus 로고    scopus 로고
    • Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring
    • Vitale G, Brugts MP, Ogliari G, Castaldi D, Fatti LM, Varewijck AJ, et al. Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring. Aging (2012) 4:580-9.
    • (2012) Aging , vol.4 , pp. 580-589
    • Vitale, G.1    Brugts, M.P.2    Ogliari, G.3    Castaldi, D.4    Fatti, L.M.5    Varewijck, A.J.6
  • 34
    • 34248389804 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 and its receptors (IGF 1R and IGF 2R/mannose 6-phosphate) in endometrial adenocarcinoma
    • doi:10.1016/j.ygyno.2007.02.012
    • Pavelic J, Radakovic B, Pavelic K. Insulin-like growth factor 2 and its receptors (IGF 1R and IGF 2R/mannose 6-phosphate) in endometrial adenocarcinoma. Gynecol Oncol (2007) 105:727-35. doi:10.1016/j.ygyno.2007.02.012
    • (2007) Gynecol Oncol , vol.105 , pp. 727-735
    • Pavelic, J.1    Radakovic, B.2    Pavelic, K.3
  • 35
    • 0033305004 scopus 로고    scopus 로고
    • Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
    • doi:10.1210/me.13.5.787
    • Lee AV, Jackson JG, Gooch JL, Hilsenbeck SG, Coronado-Heinsohn E, Osborne CK, et al. Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. Mol Endocrinol (1999) 13:787-96. doi:10.1210/me.13.5.787
    • (1999) Mol Endocrinol , vol.13 , pp. 787-796
    • Lee, A.V.1    Jackson, J.G.2    Gooch, J.L.3    Hilsenbeck, S.G.4    Coronado-Heinsohn, E.5    Osborne, C.K.6
  • 36
    • 0025635904 scopus 로고
    • Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells
    • Stewart AJ, Johnson MD, May FE, Westley BR. Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells. J Biol Chem (1990) 265:21172-8.
    • (1990) J Biol Chem , vol.265 , pp. 21172-21178
    • Stewart, A.J.1    Johnson, M.D.2    May, F.E.3    Westley, B.R.4
  • 37
    • 0024369203 scopus 로고
    • Insulin-like growth factor-II (IGF-II): a potential autocrine/paracrine growth factor for human breast cancer acting via the IGF-I receptor
    • doi:10.1210/mend-3-11-1701
    • Osborne CK, Coronado EB, Kitten LJ, Arteaga CI, Fuqua SA, Ramasharma K, et al. Insulin-like growth factor-II (IGF-II): a potential autocrine/paracrine growth factor for human breast cancer acting via the IGF-I receptor. Mol Endocrinol (1989) 3:1701-9. doi:10.1210/mend-3-11-1701
    • (1989) Mol Endocrinol , vol.3 , pp. 1701-1709
    • Osborne, C.K.1    Coronado, E.B.2    Kitten, L.J.3    Arteaga, C.I.4    Fuqua, S.A.5    Ramasharma, K.6
  • 38
    • 35649014346 scopus 로고    scopus 로고
    • Estradiol-17ß regulates mouse uterine epithelial cell proliferation through insulin-like growth factor 1 signaling
    • doi:10.1073/pnas.0705749104
    • Zhu L, Pollard JW. Estradiol-17ß regulates mouse uterine epithelial cell proliferation through insulin-like growth factor 1 signaling. Proc Natl Acad Sci U S A (2007) 104:15847-51. doi:10.1073/pnas.0705749104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15847-15851
    • Zhu, L.1    Pollard, J.W.2
  • 39
    • 33748927940 scopus 로고    scopus 로고
    • Interaction of IGF signaling and the androgen receptor in prostate cancer progression
    • doi:10.1002/jcb.20929
    • Wu JD, Haugk K, Woodke L, Nelson P, Coleman I, Plymate SR. Interaction of IGF signaling and the androgen receptor in prostate cancer progression. J Cell Biochem (2006) 99:392-401. doi:10.1002/jcb.20929
    • (2006) J Cell Biochem , vol.99 , pp. 392-401
    • Wu, J.D.1    Haugk, K.2    Woodke, L.3    Nelson, P.4    Coleman, I.5    Plymate, S.R.6
  • 40
    • 0037092971 scopus 로고    scopus 로고
    • Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease
    • Hellawell GO, Turner GD, Davies DR, Poulsom R, Brewster SF, Macaulay VM. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res (2002) 62:2942-50.
    • (2002) Cancer Res , vol.62 , pp. 2942-2950
    • Hellawell, G.O.1    Turner, G.D.2    Davies, D.R.3    Poulsom, R.4    Brewster, S.F.5    Macaulay, V.M.6
  • 41
    • 77952951956 scopus 로고    scopus 로고
    • Differential regulation of IGF1-R gene transcription by wild type and mutant androgen receptor in prostate cancer cells
    • doi:10.1016/j.mce.2010.04.017
    • Schayek H, Seti H, Greenberg NM, Werner H, Plymate SR. Differential regulation of IGF1-R gene transcription by wild type and mutant androgen receptor in prostate cancer cells. Mol Cell Endocrinol (2010) 323:239-45. doi:10.1016/j.mce.2010.04.017
    • (2010) Mol Cell Endocrinol , vol.323 , pp. 239-245
    • Schayek, H.1    Seti, H.2    Greenberg, N.M.3    Werner, H.4    Plymate, S.R.5
  • 42
    • 16444367879 scopus 로고    scopus 로고
    • Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells
    • doi:10.1158/0008-5472.CAN-04-1837
    • Pandini G, Mineo R, Frasca F, Roberts CT Jr, Marcelli M, Vigneri R, et al. Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells. Cancer Res (2005) 65:1849-57. doi:10.1158/0008-5472.CAN-04-1837
    • (2005) Cancer Res , vol.65 , pp. 1849-1857
    • Pandini, G.1    Mineo, R.2    Frasca, F.3    Roberts Jr., C.T.4    Marcelli, M.5    Vigneri, R.6
  • 43
    • 84855511518 scopus 로고    scopus 로고
    • Expression of IGF-1R, VEGF-C and D2-40 and their correlation with lymph node metastasis in endometrial adenocarcinoma
    • Pengchong H, Tao H. Expression of IGF-1R, VEGF-C and D2-40 and their correlation with lymph node metastasis in endometrial adenocarcinoma. Eur J Gynaecol Oncol (2011) 32:660-4.
    • (2011) Eur J Gynaecol Oncol , vol.32 , pp. 660-664
    • Pengchong, H.1    Tao, H.2
  • 44
    • 37049027678 scopus 로고    scopus 로고
    • FGF2 transcript levels are positively correlated with EGF and IGF-1 in the malignant endometrium
    • doi:10.1016/j.canlet.2007.10.002
    • Soufla G, Sifakis S, Spandidos DA. FGF2 transcript levels are positively correlated with EGF and IGF-1 in the malignant endometrium. Cancer Lett (2008) 259:146-55. doi:10.1016/j.canlet.2007.10.002
    • (2008) Cancer Lett , vol.259 , pp. 146-155
    • Soufla, G.1    Sifakis, S.2    Spandidos, D.A.3
  • 45
    • 0029757120 scopus 로고    scopus 로고
    • Wild type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene
    • doi:10.1073/pnas.93.16.8318
    • Werner H, Karnieli E, Rauscher FJ III, LeRoith D. Wild type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc Natl Acad Sci U S A (1996) 93:8318-23. doi:10.1073/pnas.93.16.8318
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 8318-8323
    • Werner, H.1    Karnieli, E.2    Rauscher F.J, I.I.I.3    LeRoith, D.4
  • 46
    • 84870202214 scopus 로고    scopus 로고
    • IGF-1 and BRCA1 signaling pathways in familial cancer
    • doi:10.1016/S1470-2045(12)70362-5
    • Werner H, Bruchim I. IGF-1 and BRCA1 signaling pathways in familial cancer. Lancet Oncol (2012) 13:537-44. doi:10.1016/S1470-2045(12)70362-5
    • (2012) Lancet Oncol , vol.13 , pp. 537-544
    • Werner, H.1    Bruchim, I.2
  • 47
    • 0034033970 scopus 로고    scopus 로고
    • BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1
    • doi:10.1006/mgme.1999.2958
    • Maor SB, Abramovitch S, Erdos MR, Brody LC, Werner H. BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1. Mol Genet Metab (2000) 69:130-6. doi:10.1006/mgme.1999.2958
    • (2000) Mol Genet Metab , vol.69 , pp. 130-136
    • Maor, S.B.1    Abramovitch, S.2    Erdos, M.R.3    Brody, L.C.4    Werner, H.5
  • 48
    • 0037464450 scopus 로고    scopus 로고
    • BRCA1-Sp1 interactions in transcriptional regulation of the IGF-IR gene
    • doi:10.1016/S0014-5793(03)00315-6
    • Abramovitch S, Glaser T, Ouchi T, Werner H. BRCA1-Sp1 interactions in transcriptional regulation of the IGF-IR gene. FEBS Lett (2003) 541:149-54. doi:10.1016/S0014-5793(03)00315-6
    • (2003) FEBS Lett , vol.541 , pp. 149-154
    • Abramovitch, S.1    Glaser, T.2    Ouchi, T.3    Werner, H.4
  • 49
    • 0347986569 scopus 로고    scopus 로고
    • Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene
    • doi:10.1055/s-2004-814154
    • Abramovitch S, Werner H. Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene. Horm Metab Res (2003) 35:758-62. doi:10.1055/s-2004-814154
    • (2003) Horm Metab Res , vol.35 , pp. 758-762
    • Abramovitch, S.1    Werner, H.2
  • 50
    • 35148841175 scopus 로고    scopus 로고
    • Elevated insulin-like growth factor-I receptor levels in primary breast tumors associated with BRCA1 mutations
    • doi:10.1016/j.canlet.2007.07.019
    • Maor S, Yosepovich A, Papa MZ, Yarden RI, Mayer D, Friedman E, et al. Elevated insulin-like growth factor-I receptor levels in primary breast tumors associated with BRCA1 mutations. Cancer Lett (2007) 257:236-43. doi:10.1016/j.canlet.2007.07.019
    • (2007) Cancer Lett , vol.257 , pp. 236-243
    • Maor, S.1    Yosepovich, A.2    Papa, M.Z.3    Yarden, R.I.4    Mayer, D.5    Friedman, E.6
  • 51
    • 79960672556 scopus 로고    scopus 로고
    • BRCA-1/2 germline mutations in Jewish patients with uterine serous carcinoma
    • doi:10.1111/IGC.0b013e3181ef622d
    • Bruchim I, Amichay K, Kidron D, Attias Z, Biron-Shental T, Drucker L, et al. BRCA-1/2 germline mutations in Jewish patients with uterine serous carcinoma. Int J Gynecol Cancer (2010) 20:1148-53. doi:10.1111/IGC.0b013e3181ef622d
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 1148-1153
    • Bruchim, I.1    Amichay, K.2    Kidron, D.3    Attias, Z.4    Biron-Shental, T.5    Drucker, L.6
  • 52
    • 84901778615 scopus 로고    scopus 로고
    • Ganitumab (AMG 479) inhibits IGF2-dependent ovarian cancer growth and potentiates platinum-based chemotherapy
    • doi:10.1158/1078-0432.CCR-13-3448
    • Beltran PJ, Calzone FJ, Mitchell P, Chung YA, Cajulis E, Moody B, et al. Ganitumab (AMG 479) inhibits IGF2-dependent ovarian cancer growth and potentiates platinum-based chemotherapy. Clin Cancer Res (2014). doi:10.1158/1078-0432.CCR-13-3448
    • (2014) Clin Cancer Res
    • Beltran, P.J.1    Calzone, F.J.2    Mitchell, P.3    Chung, Y.A.4    Cajulis, E.5    Moody, B.6
  • 53
    • 77955049754 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib dose-escalation, open-label study
    • doi:10.1038/sj.bjc.6605767
    • Molife LR, Fong PC, Paccagnella L, Reid AH, Shaw HM, Vidal L, et al. The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib dose-escalation, open-label study. Br J Cancer (2010) 103:332-9. doi:10.1038/sj.bjc.6605767
    • (2010) Br J Cancer , vol.103 , pp. 332-339
    • Molife, L.R.1    Fong, P.C.2    Paccagnella, L.3    Reid, A.H.4    Shaw, H.M.5    Vidal, L.6
  • 54
    • 84855398829 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncology
    • doi:10.1158/0008-5472.CAN-11-0550
    • Gao J, Chang YS, Jallal B, Viner J. Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncology. Cancer Res (2012) 72:3-12. doi:10.1158/0008-5472.CAN-11-0550
    • (2012) Cancer Res , vol.72 , pp. 3-12
    • Gao, J.1    Chang, Y.S.2    Jallal, B.3    Viner, J.4
  • 55
    • 23044493251 scopus 로고    scopus 로고
    • Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
    • doi:10.1016/S1359-6446(05)03512-9
    • Hofmann F, Garcia-Echeverria C. Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov Today (2005) 10:1041-7. doi:10.1016/S1359-6446(05)03512-9
    • (2005) Drug Discov Today , vol.10 , pp. 1041-1047
    • Hofmann, F.1    Garcia-Echeverria, C.2
  • 56
    • 57149127369 scopus 로고    scopus 로고
    • IGF-1 receptor inhibitors in clinical trials - early lessons
    • doi:10.1007/s10911-008-9104-6
    • Weroha SJ, Haluska P. IGF-1 receptor inhibitors in clinical trials - early lessons. J Mammary Gland Biol Neoplasia (2008) 13:471-83. doi:10.1007/s10911-008-9104-6
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 471-483
    • Weroha, S.J.1    Haluska, P.2
  • 57
    • 12144285705 scopus 로고    scopus 로고
    • In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase
    • doi:10.1016/S1535-6108(04)00051-0
    • Garcia-Echeverria C, Pearson MA, Marti A, Meyer T, Mestan J, Zimmermann J, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell (2004) 5:231-9. doi:10.1016/S1535-6108(04)00051-0
    • (2004) Cancer Cell , vol.5 , pp. 231-239
    • Garcia-Echeverria, C.1    Pearson, M.A.2    Marti, A.3    Meyer, T.4    Mestan, J.5    Zimmermann, J.6
  • 58
    • 79551547098 scopus 로고    scopus 로고
    • Dual IGF-I/II-neutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth
    • doi:10.1158/0008-5472.CAN-10-2274
    • Gao J, Chesebrough JW, Cartlidge SA, Ricketts SA, Incognito L, Veldman-Jones M, et al. Dual IGF-I/II-neutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth. Cancer Res (2011) 71:1029-40. doi:10.1158/0008-5472.CAN-10-2274
    • (2011) Cancer Res , vol.71 , pp. 1029-1040
    • Gao, J.1    Chesebrough, J.W.2    Cartlidge, S.A.3    Ricketts, S.A.4    Incognito, L.5    Veldman-Jones, M.6
  • 59
    • 84873884157 scopus 로고    scopus 로고
    • Targeting IGF-1 signaling pathways in gynecologic malignancies
    • doi:10.1517/14728222.2013.749863
    • Bruchim I, Werner H. Targeting IGF-1 signaling pathways in gynecologic malignancies. Expert Opin Ther Targets (2013) 17:307-20. doi:10.1517/14728222.2013.749863
    • (2013) Expert Opin Ther Targets , vol.17 , pp. 307-320
    • Bruchim, I.1    Werner, H.2
  • 60
    • 84855467975 scopus 로고    scopus 로고
    • The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology
    • doi:10.1158/1078-0432.CCR-11-0998
    • Pollak M. The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology. Clin Cancer Res (2012) 18:40-50. doi:10.1158/1078-0432.CCR-11-0998
    • (2012) Clin Cancer Res , vol.18 , pp. 40-50
    • Pollak, M.1
  • 61
    • 79959207505 scopus 로고    scopus 로고
    • Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth
    • doi:10.1158/1078-0432.CCR-10-2243
    • Rocha GZ, Dias MM, Ropelle ER, Osorio-Costa F, Rossato FA, Vercesi AE, et al. Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. Clin Cancer Res (2011) 17:3993-4005. doi:10.1158/1078-0432.CCR-10-2243
    • (2011) Clin Cancer Res , vol.17 , pp. 3993-4005
    • Rocha, G.Z.1    Dias, M.M.2    Ropelle, E.R.3    Osorio-Costa, F.4    Rossato, F.A.5    Vercesi, A.E.6
  • 62
    • 65349175605 scopus 로고    scopus 로고
    • Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
    • doi:10.4161/cc.8.6.7933
    • Alimova IN, Liu B, Fan Z, Edgerton SM, Dillon T, Lind SE, et al. Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle (2009) 8:909-15. doi:10.4161/cc.8.6.7933
    • (2009) Cell Cycle , vol.8 , pp. 909-915
    • Alimova, I.N.1    Liu, B.2    Fan, Z.3    Edgerton, S.M.4    Dillon, T.5    Lind, S.E.6
  • 63
    • 70749106139 scopus 로고    scopus 로고
    • Metformin is a potent inhibitor of endometrial cancer cell proliferation - implications for a novel treatment strategy
    • doi:10.1016/j.ygyno.2009.09.024
    • Cantrell LA, Zhou C, Mendivil A, Malloy KM, Gehrig PA, Bae-Jump VL. Metformin is a potent inhibitor of endometrial cancer cell proliferation - implications for a novel treatment strategy. Gynecol Oncol (2010) 116:92-8. doi:10.1016/j.ygyno.2009.09.024
    • (2010) Gynecol Oncol , vol.116 , pp. 92-98
    • Cantrell, L.A.1    Zhou, C.2    Mendivil, A.3    Malloy, K.M.4    Gehrig, P.A.5    Bae-Jump, V.L.6
  • 64
    • 84864619407 scopus 로고    scopus 로고
    • Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expres- sion
    • doi:10.1111/j.1447-0756.2011.01839.x
    • Dong L, Zhou Q, Zhang Z, Zhu Y, Duan T, Feng Y. Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expres- sion. J Obstet Gynaecol Res (2012) 38:1077-85. doi:10.1111/j.1447-0756.2011.01839.x
    • (2012) J Obstet Gynaecol Res , vol.38 , pp. 1077-1085
    • Dong, L.1    Zhou, Q.2    Zhang, Z.3    Zhu, Y.4    Duan, T.5    Feng, Y.6
  • 65
    • 84858745832 scopus 로고    scopus 로고
    • Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway
    • doi:10.1016/j.ygyno.2012.01.009
    • Hanna RK, Zhou C, Malloy KM, Sun L, Zhong Y, Gehrig PA, et al. Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. Gynecol Oncol (2012) 125:458-69. doi:10.1016/j.ygyno.2012.01.009
    • (2012) Gynecol Oncol , vol.125 , pp. 458-469
    • Hanna, R.K.1    Zhou, C.2    Malloy, K.M.3    Sun, L.4    Zhong, Y.5    Gehrig, P.A.6
  • 66
    • 84876423635 scopus 로고    scopus 로고
    • Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners
    • doi:10.1371/journal.pone.0061537
    • Sarfstein R, Friedman Y, Attias-Geva Z, Fishman A, Bruchim I, Werner H. Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners. PLoS One (2013) 8:e61537. doi:10.1371/journal.pone.0061537
    • (2013) PLoS One , vol.8
    • Sarfstein, R.1    Friedman, Y.2    Attias-Geva, Z.3    Fishman, A.4    Bruchim, I.5    Werner, H.6
  • 67
    • 84897879220 scopus 로고    scopus 로고
    • Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling
    • doi:10.1210/en.2013-1925
    • Malaguanera R, Sacco A, Morcavallo A, Squatrito S, Migliaccio A, Morrione A, et al. Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling. Endocrinology (2014) 155:1207-21. doi:10.1210/en.2013-1925
    • (2014) Endocrinology , vol.155 , pp. 1207-1221
    • Malaguanera, R.1    Sacco, A.2    Morcavallo, A.3    Squatrito, S.4    Migliaccio, A.5    Morrione, A.6
  • 69
    • 84895419209 scopus 로고    scopus 로고
    • Vorinostat in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma
    • doi:10.1038/bcj.2014.1
    • Siegel DS, Richardson P, Dimopoulos M, Moreau P, Mitsiades C, Weber D, et al. Vorinostat in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma. Blood Cancer J (2014) 4:e182. doi:10.1038/bcj.2014.1
    • (2014) Blood Cancer J , vol.4
    • Siegel, D.S.1    Richardson, P.2    Dimopoulos, M.3    Moreau, P.4    Mitsiades, C.5    Weber, D.6
  • 70
    • 84880704905 scopus 로고    scopus 로고
    • Combination of Vorinostat and caspase-8 inhibition exhibits high anti-tumoral activity on endometrial cancer cells
    • doi:10.1016/j.molonc.2013.03.003
    • Bergada L, Sorolla A, Yeramian A, Eritja N, Mirantes C, Matias-Guiu X, et al. Combination of Vorinostat and caspase-8 inhibition exhibits high anti-tumoral activity on endometrial cancer cells. Mol Oncol (2013) 7:763-75. doi:10.1016/j.molonc.2013.03.003
    • (2013) Mol Oncol , vol.7 , pp. 763-775
    • Bergada, L.1    Sorolla, A.2    Yeramian, A.3    Eritja, N.4    Mirantes, C.5    Matias-Guiu, X.6
  • 71
    • 80052527908 scopus 로고    scopus 로고
    • The mechanism of action of the histone deacetylase inhibitor vorinostat involves interactions with the insulin-like growth factor signaling pathway
    • doi:10.1371/journal.pone.0024468
    • Sarfstein R, Bruchim I, Fishman A, Werner H. The mechanism of action of the histone deacetylase inhibitor vorinostat involves interactions with the insulin-like growth factor signaling pathway. PLoS One (2011) 6(9):e24468. doi:10.1371/journal.pone.0024468
    • (2011) PLoS One , vol.6 , Issue.9
    • Sarfstein, R.1    Bruchim, I.2    Fishman, A.3    Werner, H.4
  • 72
    • 79959265311 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor 1 receptor in Ewing's sarcoma: reality and expectations
    • doi:10.1155/2011/402508
    • Olmos D, Martins AS, Jones RL, Alam S, Scurr M, Judson IR. Targeting the insulin-like growth factor 1 receptor in Ewing's sarcoma: reality and expectations. Sarcoma (2011) 2011(2011):402508. doi:10.1155/2011/402508
    • (2011) Sarcoma , vol.2011 , Issue.2011 , pp. 402508
    • Olmos, D.1    Martins, A.S.2    Jones, R.L.3    Alam, S.4    Scurr, M.5    Judson, I.R.6
  • 73
    • 78650858388 scopus 로고    scopus 로고
    • Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab
    • doi:10.1038/sj.bjc.6605972
    • Gualberto A, Hixon ML, Karp DD, Li D, Green S, Dolled-Filhart M, et al. Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab. Br J Cancer (2011) 104:68-74. doi:10.1038/sj.bjc.6605972
    • (2011) Br J Cancer , vol.104 , pp. 68-74
    • Gualberto, A.1    Hixon, M.L.2    Karp, D.D.3    Li, D.4    Green, S.5    Dolled-Filhart, M.6
  • 74
    • 84867574623 scopus 로고    scopus 로고
    • Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas
    • doi:10.1016/j.ejca.2012.05.009
    • Asmane I, Watkin E, Alberti L, Duc A, Marec-Berard P, Ray-Coquard I, et al. Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. Eur J Cancer (2012) 48:3027-35. doi:10.1016/j.ejca.2012.05.009
    • (2012) Eur J Cancer , vol.48 , pp. 3027-3035
    • Asmane, I.1    Watkin, E.2    Alberti, L.3    Duc, A.4    Marec-Berard, P.5    Ray-Coquard, I.6
  • 75
    • 28044468153 scopus 로고    scopus 로고
    • The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells
    • doi:10.1016/j.ghir.2005.07.005
    • Nahor I, Abramovitch S, Engeland K, Werner H. The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells. Growth Horm IGF Res (2005) 15:388-96. doi:10.1016/j.ghir.2005.07.005
    • (2005) Growth Horm IGF Res , vol.15 , pp. 388-396
    • Nahor, I.1    Abramovitch, S.2    Engeland, K.3    Werner, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.