Topotecan-tamoxifen duple PLGA polymeric nanoparticles: Investigation of in vitro, in vivo and cellular uptake potential

International Journal of Pharmaceutics

Volumn 473, Issue 1-2, 2014, Pages 384-394

  Khuroo, Tahir ^a,b,c   Verma, Devina ^a   Talegaonkar, Sushama ^a   Padhi, Santwana ^a   Panda, Amulya K ^b   Iqbal, Zeenat ^a  

^a HAMDARD UNIVERSITY   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^c RANBAXY LABORATORIES LTD   (India)

Author keywords

Bioavailability; MCF 7; Nanoparticles; P glycoprotein; Tamoxifen; Topotecan

Indexed keywords

POLYGLACTIN; TAMOXIFEN CITRATE; TOPOTECAN; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; DNA TOPOISOMERASE INHIBITOR; DRUG CARRIER; LACTIC ACID; NANOPARTICLE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; TAMOXIFEN;

ARTICLE; BREAST CANCER; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG RELEASE; ENCAPSULATION; EX VIVO STUDY; IN VITRO STUDY; IN VIVO STUDY; MCF 7 CELL LINE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; CHEMISTRY; FEMALE; HUMAN; INTESTINE ABSORPTION; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BIOLOGICAL TRANSPORT; DRUG CARRIERS; FEMALE; HUMANS; INTESTINAL ABSORPTION; LACTIC ACID; MCF-7 CELLS; NANOPARTICLES; POLYGLYCOLIC ACID; RATS, WISTAR; TAMOXIFEN; TOPOISOMERASE I INHIBITORS; TOPOTECAN;

EID: 84905454936     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.07.022     Document Type: Article

References (23)

1. International Agency for Research on Cancer, 2014. Global battle against cancer won't be won with treatment alone. Effective prevention measures urgently needed to prevent cancer crisis (Press Release No. 224), (Lyon/London 3 February).
2. S. Acharya, and S.K. Sahoo PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect Adv. Drug Deliv. 63 3 2011 170 183
3. T. Bao, and M.A. Rudek The clinical pharmacology of anastrozole Eur. Oncol. Haematol. 2 2011 106 108
4. U. Bilati, E. Allémann, and E. Doelker Poly(d,l-lactide-co- glycolide) protein-loaded nanoparticles prepared by the double emulsion method-processing and formulation issues for enhanced entrapment efficiency J. Microencapsul. 22 2 2005 205 214 (Pubitemid 40775308)
5. A. Budhian, S.J. Siegel, and K.I. Winey Haloperidol-loaded nanoparticles: systematic study of particle size and drug content Int. J. Pharm. 336 2007 367 375 (Pubitemid 46670649)
6. F. Danhier, E. Ansorena, J.M. Silva, R. Coco, B.A. Le, and V. Préat PLGA-based nanoparticles: an overview of biomedical applications J. Control. Release 161 2 2012 505 522
7. M. Fernanda, B. Stephanie, and M. Franco A pharmacokinetic evaluation of topotecan as a cervical cancer therapy Expert Opin. 9 2 2013 215 224
8. E. Ghasemian, A. Vatanara, A.R. Najafabadi, M.R. Rouini, K. Gilani, and M. Darabi Preparation, characterization and optimization of sildenafil citrate loaded PLGA nanoparticles by statistical factorial design DARU J. Pharm. Sci. 21 1 2013 1 10
9. A. Honig, L. Rieger, A. Sutterlin, M. Kapp, J. Dietl, and M.W. Sutterlin Brain metastases in breast cancer - an in vitro study to evaluate new systemic chemotherapeutic options Anticancer Res. 25 2005 1531 1538
10. A.K. Jain, N.K. Swarnakar, C. Godugu, R.P. Singh, and S. Jain The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen Biomaterials 32 2 2011 503
11. G.K. Jain, S.A. Pathan, S. Akhter, N. Ahmad, N. Jain, and S. Talegaonkar Mechanistic study of hydrolytic erosion and drug release behaviour of PLGA nanoparticles: influence of chitosan Polym. Degrad. Stab. 95 12 2010 2360 2366
12. A. Kumari, K.Y. Sudesh, and C.Y. Subhash Biodegradable polymeric nanoparticles based drug delivery systems Colloids Surf. B Biointerfaces 75 1 2010 1 18
13. N. Nafee, S. Taetz, M. Schneider, U.F. Schaefer, and C.M. Lehr Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides Nanomedicine 3 3 2007 173 183 (Pubitemid 47332344)
14. L. Ning, H. Xiaohong, Y. Jianliang, G. Lin, S. Yuanyuan, and D. Ping Absolute bioavailability studies of a new oral topotecan formulation in Chinese patients using UHPLC-MS/MS J. Pharm. Biomed. Anal. 76 2013 252 256
15. E. Park, S. Kum, C. Wang, S.Y. Park, B.S. Kim, and G. Schuller-Levis Anti-inflammatory activity of herbal medicines: inhibition of nitric oxide production and tumor necrosis-a secreation in an activated macrophage-like cell line Am. J. Chin. Med. 33 2005 415
16. Y. Pommier, E. Leo, H. Zhang, and C. Marchand DNA topoisomerases and their poisoning by anticancer and antibacterial drugs Chem. Biol. 17 5 2010 421 433
17. K.S. Saini, C. Taylor, A.J. Ramirez, C. Palmieri, U. Gunnarsson, and H.J. Schmoll Role of the multidisciplinary team in breast cancer management: results from a large international survey involving 39 countries Ann. Oncol. 23 4 2011 853 859
18. J. Sariego Breast cancer in the young patient Am. Surg. 76 12 2010 1397 1401
19. B. Semete, L.I.J. Booysen, L. Kalombo, J.D. Venter, L. Katata, and B. Ramalapa et al. In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles Toxicol. Appl. Pharmacol. 249 2 2010 158 165
20. X.R. Song, Z. Cai, Y. Zheng, G. He, F.Y. Cui, and D. Gong Reversion of multidrug resistance by co-encapsulation of vincristine and verapamil in PLGA nanoparticles Eur. J. Pharm. Sci. 37 3 2009 300 305
21. B.L. Staker, K. Hjerrild, M.D. Feese, C.A. Behnke, A.B. Burgin, and L. Stewart The mechanism of topoisomerase I poisoning by a camptothecin analog PNAS 99 24 2002 15387 15392 (Pubitemid 35403944)
22. K.S. Yadav, and K.K. Sawant Formulation optimization of etoposide loaded PLGA nanoparticles by double factorial design and their evaluation Curr. Drug Deliv. 7 2010 51 64
23. Y. Yeo, and K. Park Control of encapsulation efficiency and initial burst in polymeric microparticle systems Arch. Pharm. Res. 27 1 2004 1 12 (Pubitemid 43158226)