Angiopoietin-1 ameliorates inflammation-induced vascular leakage and improves functional impairment in a rat model of acute experimental autoimmune encephalomyelitis

Experimental Neurology

Volumn 261, Issue , 2014, Pages 245-257

  Jiang, Hong ^b   Zhang, Fan ^a   Yang, Jing ^a   Han, Shu ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Angiopoietin 1; Experimental autoimmune encephalomyelitis; Inflammation induced blood vessel leakage; Microenvironment; Multiple sclerosis

Indexed keywords

ANGIOPOIETIN 1; EVANS BLUE; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; ENDOTHELIAL CELL GROWTH FACTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN TISSUE; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DEMYELINATION; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; EVOKED SOMATOSENSORY RESPONSE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FUNCTIONAL DISEASE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION INDUCED BLOOD VESSEL LEAKAGE; INFLAMMATION INDUCED VASCULAR LEAKAGE; INFLAMMATORY INFILTRATE; LOW DRUG DOSE; LUCIFERASE ASSAY; MALE; MULTIPLE SCLEROSIS; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RAT MODEL; SPINAL CORD; TREATMENT DURATION; WESTERN BLOTTING; WHITE MATTER; ANIMAL CELL; BRAIN; CELL INFILTRATION; DEMYELINATING DISEASE; DOSE RESPONSE; INFLAMMATORY CELL; MOUSE; NERVE FIBER DEGENERATION; PROTEIN FUNCTION; VASCULAR DISEASE; ANIMAL; BLOOD VESSEL; CAPILLARY PERMEABILITY; COMPLICATION; DEMYELINATING DISEASES; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; LEWIS RAT; METABOLISM; NEUTROPHIL CHEMOTAXIS; REACTION TIME; SILVER STAINING; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANGIOPOIETIN-1; ANIMALS; BLOOD VESSELS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CYTOKINES; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOTHELIAL GROWTH FACTORS; EVOKED POTENTIALS, SOMATOSENSORY; INFLAMMATION; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NEUTROPHIL INFILTRATION; RATS; RATS, INBRED LEW; REACTION TIME; SILVER STAINING;

EID: 84905450577     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.05.013     Document Type: Article

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