Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Yin, Jun xiang ^a   Tu, Jiang long ^a   Lin, Hao jie ^a   Shi, Fu dong ^a   Liu, Ru lan ^a   Zhao, Chong bo ^a   Coons, Stephen W ^a   Kuniyoshi, Sandra ^a   Shi, Jiong ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOTOXIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PERTUSSIS TOXIN; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL LOSS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATION; DISEASE SEVERITY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; FEMALE; FRONTAL LOBE; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; MACROPHAGE MIGRATION INHIBITION; MEMBRANE DAMAGE; MICROGLIA; MOTOR DYSFUNCTION; MOUSE; NERVE FIBER MEMBRANE; NONHUMAN; SPINAL CORD NERVE CELL; T LYMPHOCYTE SUBPOPULATION; TH17 CELL; THORACOLUMBAR SPINE; AMINO ACID SEQUENCE; ANIMAL; CELL MOTION; DEMYELINATING DISEASE; DOSE RESPONSE; DRUG ADMINISTRATION ROUTE; HELPER CELL; IMMUNOLOGY; LEUKOCYTE; METABOLISM; MOLECULAR GENETICS; MOTOR ACTIVITY; MYELIN SHEATH; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; SPINAL CORD;

MUS;

AMINO ACID SEQUENCE; ANIMALS; BLOOD-BRAIN BARRIER; CELL MOVEMENT; DEMYELINATING DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; LEUKOCYTES; MICE; MICROGLIA; MOLECULAR SEQUENCE DATA; MOTOR ACTIVITY; MYELIN SHEATH; PERMEABILITY; PERTUSSIS TOXIN; SPINAL CORD; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 77957878988     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012400     Document Type: Article

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