MicroRNAs differentially present in the plasma of HIV elite controllers reduce HIV infection in vitro

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Reynoso, Rita ^a   Laufer, Natalia ^b,c,f   Hackl, Matthias ^a,d   Skalicky, Susanna ^e   Monteforte, Rossella ^a   Turk, Gabriela ^b,c   Carobene, Mauricio ^b,c   Quarleri, Jorge ^b,c   Cahn, Pedro ^f,g   Werner, Roland ^h   Stoiber, Heribert ^h   Grillari Voglauer, Regina ^a,e   Grillari, Johannes ^a,e  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b Universidad de Buenos Aires   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^d TAmiRNA GmbH   (Austria)

^e Evercyte   (Austria)

^f HOSPITAL JUAN A FERNÁNDEZ   (Argentina)

^g Huesped Foundation   (Argentina)

^h INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MIRN146 MICRORNA, HUMAN; MIRN29 MICRORNA, HUMAN; MIRN33 MICRORNA, HUMAN; TRANSCRIPTOME;

ADULT; BLOOD; CASE CONTROL STUDY; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL CULTURE; COMPARATIVE STUDY; DISEASE RESISTANCE; FEMALE; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; MALE; MIDDLE AGED; PHYSIOLOGY; VIROLOGY; VIRUS REPLICATION; YOUNG ADULT;

ADULT; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DISEASE RESISTANCE; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MICRORNAS; MIDDLE AGED; TRANSCRIPTOME; VIRUS REPLICATION; YOUNG ADULT;

EID: 84905440517     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05915     Document Type: Article

References (52)

1. Mikhail M.,Wang B.& Saksena N. K. Mechanisms involved in non-progressive HIV disease. AIDS Rev 5 230-244 (2003 (Pubitemid 38258386)
2. Rodes B. et al. Differences in disease progression in a cohort of long-term nonprogressors after more than 16 years of HIV-1 infection. AIDS 18 1109-1116 (2004 (Pubitemid 38738510)
3. Blankson J. N. Control of HIV-1 replication in elite suppressors. Discov Med 9 261-266 (2010
4. Blankson J. N. Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses? Antiviral Res 85 295-302 (2010
5. Calugi G. Montella F. Favalli C.& Benedetto A. Entire genome of a strain of human immunodeficiency virus type 1 with a deletion of nef that was recovered 20 years after primary infection: large pool of proviruses with deletions of env. J Virol 80 11892-11896 (2006 (Pubitemid 44788901)
6. Alexander L. et al. Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection. J Virol 74 4361-4376 (2000 (Pubitemid 30214444)
7. Miura T. et al. Impaired replication capacity of acute/early viruses in persons who become HIV controllers. J Virol 84 7581-7591 (2010
8. O'Connell K. A. Bailey J. R.& Blankson J. N. Elucidating the elite: mechanisms of control in HIV-1 infection. Trends Pharmacol Sci 30 631-637 (2009
9. Blankson J. N. et al. Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors. J Virol 81 2508-2518 (2007
10. Lamine A. et al. Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study). AIDS 21 1043-1045 (2007 (Pubitemid 46684337)
11. Migueles S. A. et al. HLA B5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc Natl Acad Sci U S A 97 2709-2714 (2000 (Pubitemid 30159236)
12. Lopez M. et al. The expansion ability but not the quality of HIV-specific CD8(1) T cells is associated with protective human leucocyte antigen class I alleles in longterm non-progressors. Immunology 134 305-313 (2011
13. Pastori C. et al. Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression. Blood 107 4825-4833 (2006 (Pubitemid 43882634)
14. Witwer K. W. Watson A. K. Blankson J. N.& Clements J. E. Relationships of PBMC microRNA expression plasma viral load and CD41T-cell count in HIV-1-infected elite suppressors and viremic patients. Retrovirology 9 5 (2012
15. Becker J. et al. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. J Biotechnol 156 227-235 (2011
16. Lecellier C. H. et al. A cellular microRNA mediates antiviral defense in human cells. Science 308 557-560 (2005
17. Weilner S. Schraml E. Redl H. Grillari-Voglauer R.& Grillari J. Secretion of microvesicular miRNAs in cellular and organismal aging. Exp Gerontol (2012
18. Jones C. I. et al. Identification of circulatingmicroRNAs as diagnostic biomarkers for use in multiple myeloma. Br J Cancer 107 1987-1996 (2012
19. Li L. M. et al. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res 70 9798-9807 (2010
20. Tanaka Y. et al. Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma. Cancer 119 1159-1167 (2013
21. Wang W. T. Zhao Y. N. Han B. W. Hong S. J.& Chen Y. Q. Circulating microRNAs identified in a genome-wide serum microRNA expression analysis as noninvasive biomarkers for endometriosis. J Clin Endocrinol Metab 98 281-289 (2013
22. Wang X. et al. Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection. Blood 113 671-674 (2009
23. Huang J. et al. Cellular microRNAs contribute to HIV-1 latency in resting primary CD41 T lymphocytes. Nat Med 13 1241-1247 (2007 (Pubitemid 47530631)
24. Ji F. et al. Circulating microRNAs in hepatitis B virus-infected patients. J Viral Hepat 18 e242-251 (2011
25. Farid W. R. et al.Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation. Liver Transpl 18 290-297 (2012
26. Cobos Jimenez V. et al. Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons. Sci Rep 2 763 (2012
27. Li Q. J. et al.miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129 147-161 (2007
28. Xie W. et al. MiR-181a regulates inflammation responses in monocytes and macrophages. PLoS One 8 e58639 (2013
29. Duskova K. et al. MicroRNA regulation and its effects on cellular transcriptome in human immunodeficiency virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts. BMC Infect Dis 13 250 (2013
30. Gupta A. et al. Comparative expression profile of miRNA and mRNA in primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1). PLoS One 6 e22730 (2011
31. Houzet L. et al. MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals. Retrovirology 5 118 (2008
32. Bignami F. et al. Stable changes in CD41T lymphocyte miRNA expression after exposure to HIV-1. Blood 119 6259-6267 (2012
33. Pegtel D. M. et al. Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci U S A 107 6328-6333 (2010
34. Zhang Y. et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell 39 133-144 (2010
35. Mittelbrunn M. et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun 2 282 (2011
36. Witwer K. W.& Clements J. E. Evidence for miRNA expression differences of HIV-1-positive treatment-naive patients and elite suppressors: a re-analysis. Blood 119 6395-6396 (2012
37. Ahluwalia J. K. et al.Human cellular microRNAhsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology 5 117 (2008
38. Sun G. et al. Interplay between HIV-1 infection and host microRNAs. Nucleic Acids Res 40 2181-2196 (2012
39. Hariharan M. Scaria V. Pillai B.& Brahmachari S. K. Targets for human encoded microRNAs in HIV genes. Biochem Biophys Res Commun 337 1214-1218 (2005 (Pubitemid 41505253)
40. Cruz N. V. Amorim R. Oliveira F. E. Speranza F. A.& Costa L. J.Mutations in the nef and vif genes associated with progression to AIDS in elite controller and slow-progressor patients. J Med Virol 85 563-574 (2013
41. Mwimanzi P. et al. Attenuation of multiple Nef functions in HIV-1 elite controllers. Retrovirology 10 1 (2013
42. Spinello I. et al. MicroRNA-146a and AMD3100 two ways to control CXCR4 expression in acute myeloid leukemias. Blood Cancer J 1 e26 (2011
43. Montecalvo A. et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 119 756-766 (2012
44. Vergoulis T. et al. TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support. Nucleic Acids Res 40 D222-229 (2012
45. Manganaro L. et al. Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD41 T lymphocytes. Nat Med 16 329-333 (2010
46. Kirschner M. B. et al. Haemolysis during sample preparation alters microRNA content of plasma. PLoS One 6 e24145 (2011
47. Blondal T. et al. Assessing sample and miRNA profile quality in serum and plasma or other biofluids. Methods 59 S1-6 (2013
48. Mestdagh P. et al. A novel and universal method for microRNA RT-qPCR data normalization. Genome Biol 10 R64 (2009
49. Andersen C. L. Jensen J. L.& Orntoft T. F. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization applied to bladder and colon cancer data sets. Cancer Res 64 5245-5250 (2004 (Pubitemid 39006544)
50. Soederholm A. et al. HIV-1 induced generation of C5a attracts immature dendriticcells and promotes infection of autologous T cells. Eur J Immunol 37 2156-2163 (2007 (Pubitemid 47250208)
51. Sturn A. Quackenbush J.& Trajanoski Z. Genesis: cluster analysis of microarray data. Bioinformatics 18 207-208 (2002 (Pubitemid 34145055)
52. Hochberg Y.& Benjamini Y. More powerful procedures for multiple significance testing. Stat Med 9 811-818 (1990). (Pubitemid 20343989) Técnicas