HIV-1 induced generation of C5a attracts immature dendritic cells and promotes infection of autologous T cells

European Journal of Immunology

Volumn 37, Issue 8, 2007, Pages 2156-2163

  Soederholm, Anna ^a,b   Bánki, Zoltán ^a,b   Wilflingseder, Doris ^a,b   Gassner, Christoph ^c   Zwirner, Joerg ^d   López Trascasa, Margarita ^e   Falkensammer, Barbara ^a,b   Dierich, Manfred P ^a,b   Stoiber, Heribert ^a,b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

HIV 1; C5a; Complement; Dendritic cells; Migration

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT COMPONENT C5A;

ARTICLE; CELL MIGRATION; COCULTURE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN SITU HYBRIDIZATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; T LYMPHOCYTE;

CHEMOTAXIS, LEUKOCYTE; COCULTURE TECHNIQUES; COMPLEMENT C5A; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; T-LYMPHOCYTES; TRANSPLANTATION, AUTOLOGOUS;

EID: 34547856226     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636820     Document Type: Article

References (39)

1. Mouhoub, A., Thieblemont N., Delibrias, C., Fischer, E. and Kazatchkine, M. D., Enhancing role of complement in HIV infection. Clin. Exp. Immunol. 1994. 97: Suppl 2: 9-11.
2. Stoiber, H., Pruenster, M., Ammann, C. and Dierich, M. P., Complement-opsonized HIV: The free rider on its way to infection. Mol. Immunol. 2005. 42: 153-160.
3. Stoiber, H., Clivio, A. and Dierich, M. P., Role of complement in HIV infection. Annu. Rev. Immunol. 1997. 15: 649-674.
4. Stoiber, H., Kacani, L., Speth, C., Wurzner, R. and Dierich, M. P., The supportive role of complement in RN pathogenesis. Immunol. Rev. 2001. 180: 168-176.
5. Jarvis, J. N., Taylor, H., Iobidze, M., Dejonge, J., Chang, S. and Cohen, F., Rheumatoid factor expression and complement activation in children congenitally infected with human immunodeficiency virus. Clin. Immunol. Immunopathol. 1993. 67: 50-56.
6. Gerard, C. and Gerard, N. P., C5a anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 1994. 12: 775-808.
7. Ames, R. S., Li, Y., Sarau, H. M., Nuthulaganti, P., Foley, J.J., Ellis, C. et al., Molecular cloning and characterization of the human anaphylatoxin C3a receptor. J. Biol. Chem. 1996. 271: 20231-20234.
8. Gerard, N. P. and Gerard, C., The chemotactic receptor for human C5a anaphylatoxin. Nature 1991. 349: 614-617.
9. Crass, T., Raffetseder, U., Martin, U., Grove, M., Klos, A., Kohl, J. and Bautsch, W., Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. Eur. J. Immunol. 1996. 26: 1944-1950.
10. Guo, R. F. and Ward, P. A., Role of C5a in inflammatory responses. Annu. Rev. Immunol. 2005. 23: 821-852.
11. Zwirner, J., Fayyazi, A. and Gotze, O., Expression of the anaphylatoxin C5a receptor in non-myeloid cells. Mol. Immunol. 1999. 36:877-884.
12. Nataf, S., Stahel, P. F., Davoust, N. and Barnum, S. R., Complement anaphylatoxin receptors on neurons: New tricks for old receptors? Trends Neurosci. 1999. 22: 397-402.
13. Werfel, T., Oppermann, M., Schulze, M., Krieger, G., Weber, M. and Götze, O., Binding of fluorescein-labeled anaphylatoxin C5a to human peripheral blood, spleen, and bone marrow leukocytes. Blood 1992. 79: 152-160.
14. Monari, C., Casadevall, A., Pietrella, D., Bistoni, F. and Vecchiarelli, A., Neutrophils from patients with advanced human immunodeficiency virus infection have impaired complement receptor function and preserved Fcgamma receptor function. J. Infect. Dis. 1999. 180: 1542-1549.
15. Sozzani, S., Sallusto, F., Luini, W., Zhou, D., Piemonti, L., Allavenda, P., van Damme, J. et al., Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines. J. Immunol. 1995. 155: 3292-3295.
16. + dendritic cells derived from human skin. Immunology 2001. 103: 210-217.
17. Mellman I., Turley, S. J. and Steinman, R. M., Antigen processing for amateurs and professionals. Trends Cell. Biol. 1998. 8: 231-237.
18. Sullivan, B. L., Knopoff, E. J., Saifuddin, M., Takefman, D. M., Sarloos, N. M., Sha, B. and Spear, G. T., Susceptibility of HIV-1 plasma virus to complement-mediated lysis. Evidence for a role in clearance of virus in vivo. J. Immunol. 1996. 157: 1791-1798.
19. Döpper, S., Wilflingseder, D., Prodinger, W. M,, Stielger, G., Speth, C., Dierich, M. P. and Stoiber, H., Mechanism(s) promoting HIV-1 infection of primary unstimulated T lymphocytes in autologous B cell/T cell co-cultures. Eur. J. Immunol. 2003. 33: 2098-2107.
20. Soruri, A., Kiafard, Z., Dettmer, C., Riggert, J., Köhl J. and Zwirner, J., IL-4 down-regulates anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migration in vivo. J. Immunol. 2003;. 70: 3306-3314.
21. Delgado-Cervino, E., Fontán, G. and López-Trascasa, M., CS complement deficiency in a Spanish family. Molecular characterization of the double mutation responsible for the defect. Mol. Immunol. 2004. 42: 105-111.
22. Weinmann, O., Gutzmer, R., Zwirner, J., Wittmann, M., Langer, K., Lisewski, M. and Mommert, S., Up-regulation of C5a receptor expression and function on human monocyte derived dendritic cells by prostaglandin E2. Immunology 2003. 110: 458-465.
23. Soruri, A., Riggert, J., Schlott, T., Kiafard, Z., Dettmer, C. and Zwirner, J., Anaphylatoxin C5a induces monocyte recruitment and differentiation into dendritic cells by TNF-alpha and prostaglandin E2-dependent mechanisms. J. Immunol. 2003. 171: 2631-2636.
24. Granelli-Piperno, A., Golebiowska, A., Trumpfheller, C., Siegal, F. P. and Steinman, R. M., HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc. Natl. Acad. Sci. USA 2004. 101: 7669-7674.
25. Wilflingseder, D., Mullauer, B., Schramek, H., Banki, Z., Dierich, M.P. and Stoiber H., HIV-1-induced migration of monocyte-derived dendritic cells is associated with differential activation of MAPK pathways. J. Immunol. 2004. 173: 7497-7505.
26. Fantuzzi, L., Purificato, C., Donato, K., Belardelli, F. and Gessani, S., Human immunodeficiency virus type 1 gp120 induces abnormal maturation and functional alterations of dendritic cells: A novel mechanism for AIDS pathogenesis. J. Virol. 2000. 78: 9763-772.
27. Romani, N., Reider, D., Heuer, M., Ebner, S., Kampgen, E., Eibel, B., Niederwieser, D. and Schuler, G., Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J. Immunol Methods 1996. 196: 137-151.
28. Wahl, S. M., Allen, J. B., Gartner, S., Orenstein, J. B., Popovic, M., Chenoweth, D. E., Athur, L.O. et al., HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes. J. Immunol. 1989. 42: 3553-3559.
29. Pellis, V,, De Seta, F., Crovella, S., Bossi, F., Bulla, R., Guaschino, S., Radillo, O. et al., Mannose binding lectin and C3 act as recognition molecules for infectious agents in the vagina. Clin. Exp. Immunol. 2005. 139: 120-126.
30. Speth, C., Stoiber, H. and Dierich, M. P., Complement in different stages of HIV infection and pathogenesis. Int. Arc. Allergy Immunol. 2003. 130: 247-257
31. Bajtay, Z., Speth, C., Erdei, A. and Dierich, M. P., Cutting edge: productive HIV-1 infection of dendritic cells via complement receptor type 3 (CR3, CD11b/CD18). J. Immunol. 2004. 173: 4775-4778.
32. Pruenster, M., Wilflingseder, D., Bánki, Z., Ammann, C. G., Mullauer B, Meyer, M., Speth, C. et al., C-type lectin independent interaction of complement opsonized HIV with monocyte-derived dendritic cells. Eur. J. Immunol. 2005. 35: 2691-2698.
33. Kacani L, Bánki Z, Zwirner J, Schennach, H., Bajtay, Z., Erdei, A., Stoiber, H. and Dierich, M. P., C5a and C5a(desArg) enhance the susceptibility of monocyte-derived macrophages to HIV infection. J. Immunol. 2001. 166: 3410-3415.
34. Gasque, P., Complement: A unique innate immune sensor for danger signals. Mol. Immunol. 2004. 41: 1089-1098.
35. Steinman R M, Granelli-Piperno A, Pope M, Trumpfheller, C., Igantius, R., Arrode, G., Racz, P. and Tenner-Racz, K., The interaction of immunodeficiency viruses with dendritic cells. Curr. Top. Microbiol. Immunol. 2003. 276: 1-30.
36. Wilflingseder, D., Banki, Z., Dierich, M. P. and Stoiber, H., Mechanisms promoting dendritic cell-mediated transmission of HIV. Mol. Immunol. 2005. 42: 229-237.
37. Banki, Z., Kacani, L., Müllauer, B., Wilflingseder, D., Obermoser, G., Niederegger, H., Schenach, H. et al., Cross-linking of CD32 induces maturation of human monocyte-derived dendritic cells via NF-kappa B signaling pathway. J. Immunol. 2003. 170: 3963-3970
38. Rothermel, E., Rolf, O., Götze, O. and Zwirner, J., Nucleotide and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a. Biochim. Biophys. Acta 1997. 1351: 9-12.
39. Scandella, E., Men, Y., Legler, D. F., Gillessen, S., Prikler, L., Ludewig, B. and Gruettrup, M., CCL19/CC121-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood 2004. 103: 1595-1601.