Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion

Biomaterials

Volumn 35, Issue 31, 2014, Pages 8895-8902

  Sellers, Drew L ^a,b   Kim, Tae Hee ^c,d   Mount, Christopher W ^c   Pun, Suzie H ^c   Horner, Philip J ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c University of Washington   (United States)

^d Korea Institute of Industrial Technology   (South Korea)

Author keywords

Drug release; Hydrogel; Pluronic; Poly(lactic co glycolic) acid microspheres; Spinal cord; Thrombin

Indexed keywords

ANIMALS; CELL PROLIFERATION; ENZYMES; MICROSPHERES; POLYSACCHARIDES; RECOVERY;

DRUG RELEASE; PLURONICS; POLY LACTIC-CO-GLYCOLIC ACID; SPINAL CORDS; THROMBIN;

HYDROGELS;

CHLORDANE; HIRUDIN; MICROSPHERE; NANOCARRIER; POLOXAMER; POLYGLACTIN; THROMBIN; ANTITHROMBIN; DELAYED RELEASE FORMULATION; FIBRINOLYTIC AGENT; HEPARIN; HIRUDIN DERIVATIVE; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DELAYED DRUG RELEASE; DEMYELINATING DISEASE; GLIOSIS; HYDROGEL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MICROENCAPSULATION; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; SPINAL CORD INJURY; ANIMAL; ANTICOAGULANT THERAPY; CHEMISTRY; CONVALESCENCE; DELAYED RELEASE FORMULATION; DEMYELINATING DISEASES; DRUG EFFECTS; PATHOLOGY; PATHOPHYSIOLOGY; SPINAL CORD; SPINAL CORD INJURIES;

ANIMALIA; MURINAE;

ANIMALS; ANTITHROMBINS; DELAYED-ACTION PREPARATIONS; DEMYELINATING DISEASES; FIBRINOLYTIC AGENTS; HEPARIN; HIRUDIN THERAPY; HIRUDINS; LACTIC ACID; MICE; MICROSPHERES; POLOXAMER; POLYGLYCOLIC ACID; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES;

EID: 84905437932     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.06.051     Document Type: Article

References (38)

1. Donnelly D.J., Popovich P.G. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp Neurol 2008, 209:378-388.
2. Nishino A., Suzuki M., Ohtani H., Motohashi O., Umezawa K., Nagura H., et al. Thrombin may contribute to the pathophysiology of central nervous system injury. J Neurotrauma 1993, 10:167-179.
3. Gingrich M.B., Traynelis S.F. Serine proteases and brain damage - is there a link?. Trends Neurosci 2000, 23:399-407.
4. Karabiyikoglu M., Hua Y., Keep R.F., Ennis S.R., Xi G. Intracerebral hirudin injection attenuates ischemic damage and neurologic deficits without altering local cerebral blood flow. J Cereb Blood Flow Metab 2004, 24:159-166.
5. Andreu-Agulló C., Morante-Redolat J.M., Delgado A.C., Fariñas I. Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Nat Neurosci 2009, 12:1514-1523.
6. Tarzami S.T., Wang G., Li W., Green L., Singh J.P. Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells. J Thromb Haemost 2006, 4:656-663.
7. Maggio N., Shavit E., Chapman J., Segal M. Thrombin induces long-term potentiation of reactivity to afferent stimulation and facilitates epileptic seizures in rat hippocampal slices: toward understanding the functional consequences of cerebrovascular insults. J Neurosci 2008, 28:732-736.
8. Hirsh J., O'donnell M., Weitz J.I. New anticoagulants. Blood 2005, 105:453-463.
9. Rosenberg R., Damus P. The purification and mechanism of action of human antithrombin-heparin cofactor. J Biol Chem 1973, 248:6490.
10. Wallis R.B. Hirudins: from leeches to man. Semin Thromb Hemost 1996, 22:185-196.
11. Festoff B.W., Ameenuddin S., Santacruz K., Morser J., Suo Z., Arnold P.M., et al. Neuroprotective effects of recombinant thrombomodulin in controlled contusion spinal cord injury implicates thrombin signaling. J Neurotrauma 2004, 21:907-922.
12. Kempe S., Mäder K. In situ forming implants - an attractive formulation principle for parenteral depot formulations. J Control Release 2012, 161:668-679.
13. Alexander A., Ajazuddin, Khan J., Saraf S., Saraf S. Poly(ethylene glycol)-poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications. J Control Release 2013, 172:715-729.
14. Langer R. Biomaterials in drug delivery and tissue engineering: one laboratory's experience. Acc Chem Res 2000, 33:94-101.
15. Kim H.K., Chung H.J., Park T.G. Biodegradable polymeric microspheres with "open/closed" pores for sustained release of human growth hormone. J Control Release 2006, 112:167-174.
16. Kawashima Y., Yamamoto H., Takeuchi H., Hino T., Niwa T. Properties of a peptide containing dl-lactide/glycolide copolymer nanospheres prepared by novel emulsion solvent diffusion methods. Eur J Pharm Biopharm 1998, 45:41-48.
17. Barichello J.M., Morishita M., Takayama K., Nagai T. Absorption of insulin from pluronic F-127 gels following subcutaneous administration in rats. Int J Pharm 1999, 184:189-198.
18. Escobar-Chávez J.J., López-Cervantes M., Naik A., Kalia Y., Quintanar-Guerrero D., Ganem-Quintanar A. Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations. J Pharm Pharm Sci 2006, 9:339-358.
19. Sellers D.L., Maris D.O., Horner P.J. Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. J Neurosci 2009, 29:6722-6733.
20. Ng C.P., Goodman T.T., Park I.-K., Pun S.H. Bio-mimetic surface engineering of plasmid-loaded nanoparticles for active intracellular trafficking by actin comet-tail motility. Biomaterials 2009, 30:951-958.
21. Jandrot-Perrus M., Huisse M.G., Krstenansky J.L., Bezeaud A., Guillin M.C. Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets. Thromb Haemost 1991, 66:300-305.
22. Yildiz A., Okyar A., Baktir G., Araman A., Ozsoy Y. Nasal administration of heparin-loaded microspheres based on poly(lactic acid). Farmaco 2005, 60:919-924.
23. Yamamoto S., Yamamoto N., Kitamura T., Nakamura K., Nakafuku M. Proliferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord. Exp Neurol 2001, 172:115-127.
24. Horky L.L., Galimi F., Gage F.H., Horner P.J. Fate of endogenous stem/progenitor cells following spinal cord injury. J Comp Neurol 2006, 498:525-538.
25. West M.J., Slomianka L., Gundersen H.J. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 1991, 231:482-497.
26. Hagood S.K., McGinn M.J., Sun D., Colello R.J. Characterizing the mitogenic effect of basic fibroblast growth factor in the adult rat striatum. J Neurotrauma 2006, 23:205-215.
27. Fitch M.T., Doller C., Combs C.K., Landreth G.E., Silver J. Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 1999, 19:8182-8198.
28. Nicole O., Goldshmidt A., Hamill C.E., Sorensen S.D., Sastre A., Lyuboslavsky P., et al. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J Neurosci 2005, 25:4319-4329.
29. Jørgensen E.B., Hvidt S., Brown W., Schillén K. Effects of salts on the micellization and gelation of a triblock copolymer studied by rheology and light scattering. Macromolecules 1997, 30:2355-2364.
30. Kwon S.K., Kim H.-B., Song J.-J., Cho C.G., Park S.-W., Choi J.-S., et al. Vocal fold augmentation with injectable polycaprolactone microspheres/pluronic f127 hydrogel: long-term in vivo study for the treatment of glottal insufficiency. PLoS ONE 2014, 9:e85512.
31. Loy D.N., Talbott J.F., Onifer S.M., Mills M.D., Burke D.A., Dennison J.B., et al. Both dorsal and ventral spinal cord pathways contribute to overground locomotion in the adult rat. Exp Neurol 2002, 177:575-580.
32. Cantín M., Miranda P., Galadames I.S., Zavando D., Arenas P., Velásquez L., et al. In vivo biocompatibility of the PLGA microparticles in parotid gland. Int J Clin Exp Pathol 2013, 6:2412.
33. Hu P., Bembrick A.L., Keay K.A., McLachlan E.M. Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve. Brain Behav Immun 2007, 21:599-616.
34. Fleming J.C., Norenberg M.D., Ramsay D.A., Dekaban G.A., Marcillo A.E., Saenz A.D., et al. The cellular inflammatory response in human spinal cords after injury. Brain 2006, 129:3249-3269.
35. Shibata M., Kumar S.R., Amar A., Fernandez J.A., Hofman F., Griffin J.H., et al. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation 2001, 103:1799-1805.
36. Miron V.E., Boyd A., Zhao J.-W., Yuen T.J., Ruckh J.M., Shadrach J.L., et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci 2013, 16:1211-1218.
37. Hamers F.P., Lankhorst A.J., van Laar T.J., Veldhuis W.B., Gispen W.H. Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries. J Neurotrauma 2001, 18:187-201.
38. Blakemore W.F., Eames R.A., Smith K.J., McDonald W.I. Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin. J Neurol Sci 1977, 33:31-43.