Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association

EMBO Reports

Volumn 15, Issue 8, 2014, Pages 871-877

  Garg, Mansi ^a   Gurung, Resham L ^a   Mansoubi, Sahar ^a   Ahmed, Jubed O ^a   Davé, Anoushka ^a   Watts, Felicity Z ^a   Bianchi, Alessandro ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

CST; Stn1; SUMO; telomeres; Tpz1

Indexed keywords

HYBRID PROTEIN; PROTEIN; STN1 PROTEIN; SUMO PROTEIN; TELOMERASE; TPZ1 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; PROTEIN BINDING; SCHIZOSACCHAROMYCES POMBE PROTEIN; STN1 PROTEIN, S POMBE; SUMO 1 PROTEIN; TELOMERE BINDING PROTEIN; TPZ1 PROTEIN, S POMBE;

ALLELE; AMINO TERMINAL SEQUENCE; ARTICLE; CELL CYCLE S PHASE; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; FUNGAL STRAIN; GENETIC CONSERVATION; HOMOLOGOUS RECOMBINATION; MOLECULAR INTERACTION; NONHUMAN; NULL ALLELE; ORTHOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; SCHIZOSACCHAROMYCES; SUMOYLATION; SYNCHRONOUS CULTURE; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; CYTOLOGY; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; CARRIER PROTEINS; EVOLUTION, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SUMO-1 PROTEIN; SUMOYLATION; TELOMERASE; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERE-BINDING PROTEINS;

EID: 84905409125     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201438919     Document Type: Article

References (33)

1. Shore D, Bianchi A, (2009) Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase. EMBO J 28: 2309-2322
2. Jain D, Cooper JP, (2010) Telomeric strategies: means to an end. Annu Rev Genet 44: 243-269
3. Palm W, de Lange T, (2008) How shelterin protects mammalian telomeres. Annu Rev Genet 42: 301-334
4. Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns RM, Lingner J, Terns MP, (2010) TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol Cell Biol 30: 2971-2982
5. Cooper JP, Nimmo ER, Allshire RC, Cech TR, (1997) Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385: 744-747
6. Miyoshi T, Kanoh J, Saito M, Ishikawa F, (2008) Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science 320: 1341-1344
7. Jun HI, Liu J, Jeong H, Kim JK, Qiao F, (2013) Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1. Genes Dev 27: 1917-1931
8. Tomita K, Cooper JP, (2008) Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller. Genes Dev 22: 3461-3474
9. Sun J, Yu EY, Yang Y, Confer LA, Sun SH, Wan K, Lue NF, Lei M, (2009) Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev 23: 2900-2914
10. Gao H, Cervantes RB, Mandell EK, Otero JH, Lundblad V, (2007) RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol 14: 208-214
11. Miyake Y, Nakamura M, Nabetani A, Shimamura S, Tamura M, Yonehara S, Saito M, Ishikawa F, (2009) RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell 36: 193-206
12. Surovtseva YV, Churikov D, Boltz KA, Song X, Lamb JC, Warrington R, Leehy K, Heacock M, Price CM, Shippen DE, (2009) Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Mol Cell 36: 207-218
13. Chandra A, Hughes TR, Nugent CI, Lundblad V, (2001) Cdc13 both positively and negatively regulates telomere replication. Genes Dev 15: 404-414
14. Qi H, Zakian VA, (2000) The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase- associated est1 protein. Genes Dev 14: 1777-1788
15. Puglisi A, Bianchi A, Lemmens L, Damay P, Shore D, (2008) Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition. EMBO J 27: 2328-2339
16. Wang F, Stewart JA, Kasbek C, Zhao Y, Wright WE, Price CM, (2012) Human CST has independent functions during telomere duplex replication and C-strand fill-in. Cell Rep 2: 1096-1103
17. Chen LY, Redon S, Lingner J, (2012) The human CST complex is a terminator of telomerase activity. Nature 488: 540-544
18. Wu P, Takai H, de Lange T, (2012) Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST. Cell 150: 39-52
19. Yamazaki H, Tarumoto Y, Ishikawa F, (2012) Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev 26: 241-246
20. Moser BA, Chang YT, Kosti J, Nakamura TM, (2011) Tel1(ATM) and Rad3(ATR) kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast. Nat Struct Mol Biol 18: 1408-1413
21. Hang LE, Liu X, Cheung I, Yang Y, Zhao X, (2011) SUMOylation regulates telomere length homeostasis by targeting Cdc13. Nat Struct Mol Biol 18: 920-926
22. Xhemalce B, Seeler JS, Thon G, Dejean A, Arcangioli B, (2004) Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance. EMBO J 23: 3844-3853
23. Xhemalce B, Riising EM, Baumann P, Dejean A, Arcangioli B, Seeler JS, (2007) Role of SUMO in the dynamics of telomere maintenance in fission yeast. Proc Natl Acad Sci U S A 104: 893-898
24. Ulrich HD, Davies AA, (2009) In vivo detection and characterization of sumoylation targets in Saccharomyces cerevisiae. Methods Mol Biol 497: 81-103
25. Ren J, Gao X, Jin C, Zhu M, Wang X, Shaw A, Wen L, Yao X, Xue Y, (2009) Systematic study of protein sumoylation: development of a site-specific predictor of SUMOsp 2.0. Proteomics 9: 3409-3412
26. Martin V, Du LL, Rozenzhak S, Russell P, (2007) Protection of telomeres by a conserved Stn1-Ten1 complex. Proc Natl Acad Sci U S A 104: 14038-14043
27. Chang Y-T, Lingner J, Moser BA, Nakamura TM, (2013) Fission yeast shelterin regulates DNA polymerases and Rad3ATR kinase to limit telomere extension. PLoS Genet 9: e1003936
28. Moser BA, Subramanian L, Chang YT, Noguchi C, Noguchi E, Nakamura TM, (2009) Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres. EMBO J 28: 810-820
29. Pitt CW, Cooper JP, (2010) Pot1 inactivation leads to rampant telomere resection and loss in one cell cycle. Nucleic Acids Res 38: 6968-6975
30. Giraud-Panis MJ, Teixeira MT, Geli V, Gilson E, (2010) CST meets shelterin to keep telomeres in check. Mol Cell 39: 665-676
31. Nakaoka H, Nishiyama A, Saito M, Ishikawa F, (2012) Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract. J Biol Chem 287: 619-627
32. Wan M, Qin J, Songyang Z, Liu D, (2009) OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. J Biol Chem 284: 26725-26731
33. Miyagawa K, Low RS, Santosa V, Tsuji H, Moser BA, Fujisawa S, Harland JL, Raguimova ON, Go A, Ueno M, et al (2014) SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1T pp1 to modulate shelterin-Stn1 interaction in fission yeast. Proc Natl Acad Sci U S A 111: 5950-5955