Higher TNF-α, IGF-1, and leptin levels are found in tasters than non-tasters

Frontiers in Endocrinology

Volumn 5, Issue JUL, 2014, Pages

  Wang, Rui ^a   van Keeken, Nika M A ^b   Siddiqui, Sana ^a   Dijksman, Lea M ^c   Maudsley, Stuart ^a,d   Derval, Diana ^e   van Dam, P Sytze ^b   Martin, Bronwen ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b Department of Internal Medicine Onze Lieve Vrouwe Gasthuis ^*  (Netherlands)

^c Teaching Hospital   (Netherlands)

^d UNIVERSITY OF ANTWERP   (Belgium)

^e Better Immune System Foundation   (Netherlands)

Author keywords

BMI; IGF 1; Leptin; Taste; TNF

Indexed keywords

C PEPTIDE; LEPTIN; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; MALE; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; OBESITY; SALIVA ANALYSIS; SALIVA LEVEL; TASTE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84905394436     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2014.00125     Document Type: Article

References (46)

1. Yarmolinsky DA, Zuker CS, Ryba NJP. Common sense about taste: from mammals to insects. Cell (2009) 139:234-44. doi: 10.1016/j.cell.2009.10.001
2. Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, et al. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol Cell (2012) 47:851-62. doi:10.1016/j.molcel.2012.08.001
3. Kokrashvili Z, Mosinger B, Margolskee RF. T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1. Ann N Y Acad Sci (2009) 1170:91-4. doi:10.1111/j.1749-6632.2009.04485.x
4. Gerspach AC, Steinert RE, Schonenberger L, Graber-Maier A, Beglinger C. The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans. Am J Physiol Endocrinol Metab (2011) 301:E317-25. doi:10.1152/ajpendo.00077.2011
5. Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, et al. Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One (2009) 4:e5106. doi:10.1371/journal.pone.0005106
6. Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, et al. Modulation of taste sensitivity by GLP-1 signaling. J Neurochem (2008) 106:455-63. doi:10.1111/j.1471-4159.2008.05397.x
7. Martin B, Dotson CD, Shin YK, Ji SG, Drucker DJ, Maudsley S, et al. Modulation of taste sensitivity by GLP-1 signaling in taste buds. Ann N Y Acad Sci (2009) 1170:98-101. doi:10.1111/j.1749-6632.2009.03920.x
8. Elson AET, Dotson CD, Egan JM, Munger SD. Glucagon signaling modulates sweet taste responsiveness. FASEB J (2010) 24:3960-9. doi:10.1096/fj.10-158105
9. La Sala MS, Hurtado MD, Brown AR, Bohórquez DV, Liddle RA, Herzog H, et al. Modulation of taste responsiveness by the satiation hormone peptide YY. FASEB J (2013) 27:5022-33. doi:10.1096/fj.13-228064
10. Martin B, Maudsley S, White CM, Egan JM. Hormones in the naso-oropharynx: endocrine modulation of taste and smell. Trends Endocrinol Metab (2009) 20:163-70. doi:10.1016/j.tem.2009.01.006
11. Cai H, Maudsley S, Martin B. What is the role of metabolic hormones in taste buds of the tongue. Front Horm Res (2014) 42:134-46. doi:10.1159/000358322
12. Feng P, Zhao H, Chai J, Huang L, Wang H. Expression and secretion of TNF-a in mouse taste buds: a novel function of a specific subset of type II taste cells. PLoS One (2012) 7:e43140. doi:10.1371/journal.pone.0043140
13. Feng P, Chai J, Huang L, Wang H. TNF and IL-10 in a bitter-sweet battle in taste buds. Frontiers in Immunology Conference Abstract: 15th International Congress of Immunology (ICI); 2013 Aug 22-27; Milan, Italy: Italian Society of Immunology (2013). doi:10.3389/conf.fimmu.2013.3302.00081
14. Moller DE. Potential role of TNF-a in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab (2000) 11:212-7. doi:10.1016/S1043-2760(00)00272-1
15. Havel PJ. Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism. Diabetes (2004) 53:S143-51. doi:10.2337/diabetes.53.2007.S143
16. Golden E, Emiliano A, Maudsley S, Windham BG, Carlson OD, Egan JM, et al. Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging. PLoS One (2010) 5:e10099. doi:10.1371/journal.pone.0010099
17. Wittenburg H, Tennert U, Mössner J. Hormonale und metabolische Funktionen des Dünndarms. Internist (2010) 51:695-701. doi:10.1007/s00108-009-2564-y
18. Nosrat IV, Lindskog S, Seiger A, Nosrat CA. Lingual BDNF and NT-3 mRNA expression patterns and their relation to innervation in the human tongue: similarities and differences compared with rodents. JComp Neurol (2000) 417:133-52. doi:10.1002/(SICI)1096-9861(20000207)417:2<133::AID-CNE1>3.0.CO;2-I
19. Suzuki Y, Takeda M, Sakakura Y, Suzuki N. Distinct expression pattern of insulin-like growth factor family in rodent taste buds. JComp Neurol (2005) 482:74-84. doi:10.1002/cne.20379
20. Uchida N, Kanazawa M, Suzuki Y, Takeda M. Expression of BDNF and TrkB in mouse taste buds after denervation and in circumvallate papillae during development. Arch Histol Cytol (2003) 66:17-25. doi:10.1679/aohc.66.17
21. Jeon TI, Zhu B, Larson JL, Osborne TF. SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. J Clin Invest (2008) 118:3693-700. doi:10.1172/JCI36461
22. Depoortere I. Taste receptors of the gut: emerging roles in health and disease. Gut (2014) 63:179-90. doi:10.1136/gutjnl-2013-305112
23. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A (2007) 104:15069-74. doi:10.1073/pnas.0706890104
24. Young RL, Chia B, Isaacs NJ, Ma J, Khoo J, Wu TZ, et al. Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes (2013) 62:3532-41. doi:10.2337/db13-0581
25. Bartoshuk LM, Duffy VB, Miller IJ. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav (1994) 56:1165-71. doi:10.1016/0031-9384(94)90361-1
26. Wang R, Ross CA, Cai H, Cong W-N, Daimon CM, Carlson OD, et al. Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients. Front Physiol (2014) 5:231. doi:10.3389/fphys.2014.00231
27. Bartoshuk LM. Bitter taste of saccharin related to the genetic ability to taste the bitter substance 6-n-propylthiouracil. Science (1979) 205:934-5. doi:10.1126/science.472717
28. Tepper BJ. 6-n-propylthiouracil: a genetic marker for taste, with implications for food preference and dietary habits. Am J Hum Genet (1998) 63:1271-6. doi:10.1086/302124
29. Hong J-H, Chung J-W, Kim Y-K, Chung S-C, Lee S-W, Kho H-S. The relationship between PTC taster status and taste thresholds in young adults. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2005) 99:711-5. doi:10.1016/j.tripleo.2004.08.004
30. Gent JF, Bartoshuk LM. Sweetness of sucrose, neohesperidin dihydrochalcone, and saccharin is related to genetic ability to taste the bitter substance 6-N-propylthiouracil. Chem Senses (1983) 7:265-72. doi:10.1093/chemse/7.3-4.265
31. Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction. J Biol Chem (2002) 277:1-4. doi:10.1074/jbc.R100054200
32. Martin B, Shin YK, White CM, Ji S, Kim W, Carlson OD, et al. Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression. Diabetes (2010) 59:1143-52. doi:10.2337/db09-0807
33. Shin YK, Martin B, Kim W, White CM, Ji SG, Sun YX, et al. Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PLoS One (2010) 5:e12729. doi:10.1371/journal.pone.0012729
34. Cai H, Cong WN, Daimon CM, Wang R, Tschop MH, Sevigny J, et al. Altered lipid and salt taste responsivity in ghrelin and GOAT null mice. PLoS One (2013) 8:e76553. doi:10.1371/journal.pone.0076553
35. Zhang YY, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homolog. Nature (1994) 372:425-32. doi:10.1038/372425a0
36. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, et al. Effects of the obese gene-product on body-weight regulation in ob/ob mice. Science (1995) 269:540-3. doi:10.1126/science.7624776
37. Gao S, Kinzig KP, Aja S, Scott KA, Keung W, Kelly S, et al. Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A (2007) 104:17358-63. doi:10.1073/pnas.0708385104
38. Kawai K, Sugimoto K, Nakashima K, Miura H, Ninomiya Y. Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci U S A (2000) 97:11044-9. doi:10.1073/pnas.190066697
39. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor-necrosis-factor-alpha - direct role in obesity-linked insulin resistance. Science (1993) 259:87-91. doi:10.1126/science.7678183
40. Sewter CP, Digby JE, Blows F, Prins J, O'Rahilly S. Regulation of tumour necrosis factor-alpha release from human adipose tissue in vitro. J Endocrinol (1999) 163:33-8. doi:10.1677/joe.0.1630033
41. Sethi JK, Hotamisligil GS. The role of TNFa in adipocyte metabolism. Semin Cell Dev Biol (1999) 10:19-29. doi:10.1006/scdb.1998.0273
42. Yamamura M, Yamada Y, Momita S, Kamihira S, Tomonaga M. Circulating interleukin-6 levels are elevated in adult T-cell leukaemia/lymphoma patients and correlate with adverse clinical features and survival. Br J Haematol (1998) 100:129-34. doi:10.1046/j.1365-2141.1998.00538.x
43. Feng P, Yee KK, Rawson NE, Feldman LM, Feldman RS, Breslin PAS. Immune cells of the human peripheral taste system: dominant dendritic cells and CD4 T cells. Brain Behav Immun (2009) 23:760-6. doi:10.1016/j.bbi.2009.02.016
44. Liu M, Ramos-Castañeda J, Arvan P. Role of the connecting peptide in insulin biosynthesis. J Biol Chem (2003) 278:14798-805. doi:10.1074/jbc.M212070200
45. Steiner DF. The proinsulin C-peptide - a multirole model. Exp Diabesity Res (2004) 5:7-14. doi:10.1080/15438600490424389
46. Schneider HJ, Friedrich N, Klotsche J, Schipf S, Nauck M, Volzke H, et al. Prediction of incident diabetes mellitus by baseline IGF1 levels. Eur J Endocrinol (2011) 164:223-9. doi:10.1530/EJE-10-0963