Kirenol stimulates osteoblast differentiation through activation of the BMP and Wnt/β-catenin signaling pathways in MC3T3-E1 cells

Fitoterapia

Volumn 98, Issue , 2014, Pages 59-65

  Kim, Mi Bo ^a   Song, Youngwoo ^a   Hwang, Jae Kwan ^a  

^a Yonsei University   (South Korea)

Author keywords

BMP; Kirenol; Osteoblast differentiation; Wnt catenin

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; CYCLIN D1; DISHEVELED 2; DITERPENOID; GLYCOGEN SYNTHASE KINASE 3BETA; KIRENOL; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; CTNNB1 PROTEIN, MOUSE; DITERPENE;

ARTICLE; BONE REMODELING; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; MC3T3 E1 CELL LINE; MESENCHYME CELL; MINERALIZATION; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; WNT SIGNALING PATHWAY; 3T3 CELL LINE; ANIMAL; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; MOUSE;

3T3 CELLS; ANIMALS; BETA CATENIN; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; DITERPENES; GENE KNOCKDOWN TECHNIQUES; MICE; OSTEOBLASTS; WNT SIGNALING PATHWAY;

EID: 84905384247     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.07.013     Document Type: Article

References (22)

1. E.M. Lewiecki New targets for intervention in the treatment of postmenopausal osteoporosis Nat Rev Rheumatol 7 2011 631 638
2. Y.B. Niu, Y.H. Li, X.H. Kong, R. Zhang, Y. Sun, and Q. Li et al. The beneficial effect of Radix dipsaci total saponins on bone metabolism in vitro and in vivo and the possible mechanisms of action Osteoporos Int 23 2012 2649 2660
3. M. Kamon, R. Zhao, and K. Sakamoto Green tea polyphenol (-)-epigallocatechin gallate suppressed the differentiation of murine osteoblastic MC3T3-E1 cells Cell Biol Int 34 2010 109 116
4. Y.C. Lo, Y.H. Chang, B.L. Wei, Y.L. Huang, and W.F. Chiou Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and β-catenin signals J Agric Food Chem 58 2010 6643 6649
5. H.J. Yoon, C.R. Seo, M. Kim, Y.J. Kim, N.J. Song, and W.S. Jang et al. Dichloromethane extracts of Sophora japonica L. stimulate osteoblast differentiation in mesenchymal stem cells Nutr Res 33 2013 1053 1062
6. R. Zhang, B.O. Oyajobi, S.E. Harris, D. Chen, C. Tsao, and H.W. Deng et al. Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts Bone 52 2013 145 156
7. J.F. Zhang, G. Li, C.Y. Chan, C.L. Meng, M.C. Lin, and Y.C. Chen et al. Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/β-catenin signaling pathway Mol Cell Endocrinol 314 2010 70 74
8. K.H. Park, J.W. Kang, E.M. Lee, J.S. Kim, Y.H. Rhee, and M. Kim et al. Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways J Pineal Res 51 2011 187 194
9. Y. Xiang, H. Zhang, C.Q. Fan, and J.M. Yue Novel diterpenoids and diterpenoid glycosides from Siegesbeckia orientalis J Nat Prod 67 2004 1517 1521 (Pubitemid 39298620)
10. Z. Jiang, Q.H. Yu, Y. Cheng, and X.J. Guo Simultaneous quantification of eight major constituents in Herba Siegesbeckiae by liquid chromatography coupled with electrospray ionization time-of-flight tandem mass spectrometry J Pharm Biomed Anal 55 2011 452 457
11. S.Y. Mun Anti-photoaging effects of Siegesbeckia orientalis L. extract on UVB-induced skin damage in human skin fibroblasts and hairless mice [MS thesis] 2012 Yonsei University Korea
12. L. Huo, Z. Jiang, M. Lei, X. Wang, and X. Guo Simultaneous quantification of kirenol and ent-16β,17-dihydroxy-kauran-19-oic acid from Herba Siegesbeckiae in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies J Chromatogr B Analyt Technol Biomed Life Sci 937 2013 18 24
13. M.B. Kim, Y. Song, C. Kim, and J.K. Hwang Kirenol inhibits adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3 T3-L1 adipocytes Biochem Biophys Res Commun 445 2014 433 438
14. H. Lee, S. Bae, and Y. Yoon The anti-adipogenic effects of (-)epigallocatechin gallate are dependent on the WNT/β-catenin pathway J Nutr Biochem 24 2013 1232 1240
15. H.S. Lee, E.Y. Jung, S.H. Bae, K.H. Kwon, J.M. Kim, and H.J. Suh Stimulation of osteoblastic differentiation and mineralization in MC3T3-E1 cells by yeast hydrolysate Phytother Res 25 2011 716 723
16. F. Li, Y. Yang, P. Zhu, W. Chen, D. Qi, and X. Shi et al. Echinacoside promotes bone regeneration by increasing OPG/RANKL ratio in MC3T3-E1 cells Fitoterapia 83 2012 1443 1450
17. W.P. Cawthorn, A.J. Bree, Y. Yao, B. Du, N. Hemati, and G. Martinez-Santibañez et al. Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism Bone 50 2012 477 489
18. D.D. Klumpers, X. Zhao, D.J. Mooney, and T.H. Smit Cell mediated contraction in 3D cell-matrix constructs leads to spatially regulated osteogenic differentiation Integr Biol (Camb) 5 2013 1174 1183
19. M.J. Don, L.C. Lin, and W.F. Chiou Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells Phytomedicine 19 2012 551 561
20. R. Baron, and M. Kneissel WNT signaling in bone homeostasis and disease: from human mutations to treatments Nat Med 19 2013 179 192
21. Y. Tian, Y. Xu, Q. Fu, and M. He Parathyroid hormone regulates osteoblast differentiation in a Wnt/β-catenin-dependent manner Mol Cell Biochem 355 2011 211 216
22. X.L. Song, Q.Y. Zhang, Z.M. Wang, H.Z. Fu, and R.Q. Qian A rapid and simple RP-HPLC method for quantification of kirenol in rat plasma after oral administration and its application to pharmacokinetic study Biomed Chromatogr 25 2011 542 546