A rapid and simple RP-HPLC method for quantification of kirenol in rat plasma after oral administration and its application to pharmacokinetic study

Biomedical Chromatography

Volumn 25, Issue 5, 2011, Pages 542-546

  Song, Xiao Li ^a   Zhang, Qing Ying ^a   Wang, Zhe Ming ^a   Fu, Hong Zheng ^a   Qian, Rui Qin ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Kirenol; Pharmacokinetic; RP HPLC; SPE

Indexed keywords

BODY FLUIDS; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHASE SEPARATION; RATS;

INTERNAL STANDARDS; ITS APPLICATIONS; KIRENOL; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; RAT PLASMA; RELATIVE STANDARDS DEVIATIONS; REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; SIMPLE++; SOLID-PHASE EXTRACTION;

PHARMACOKINETICS;

ACETONITRILE; DARUTOSIDE; KIRENOL; PHOSPHORIC ACID; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STABILITY; DRUG STRUCTURE; FLOW RATE; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICINAL PLANT; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

RATTUS;

EID: 79953717742     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1481     Document Type: Article

References (10)

1. Bi J, Xin HL, Gao ZF, Lin WH and Qian RQ. Effect of kirenol on cytokines in serum and apoptosis proteins expression in synoviocytes of adjuvant arthritis rats. Chinese Traditional and Herbal Drugs 2007; 38: 1207-1210.
2. Chou GX and Wang ZT. Study on chemical constituents of Herba Siegesbeckiae. Chinese Pharmaceutical Journal 2006; 41: 1854-1857.
3. Hu HH, Tang LX and Li XM. Experimental research of effect of crude and processed Herba Siegesbeckiae on anti-inflammation and anti-rhumatism. Jorunal of Chinese Medicinal Materials 2004; 29: 542-545.
4. Huh JE, Baek YH, Lee JD, Choi DY and Park DS. Therapeutic effect of Siegesbeckia pubescens on cartilage protection in a rabbit collagenase-induced model of osteoarthritis. Journal of Pharmacological Sciences 2008; 3: 317-328.
5. Kang BK, Lee EH and Kim HM. Inhibitory effects of Korean folk medicine 'Hi-Chum' on histamine release from mast cells in vivo and in vitro. Journal of Ethnopharmacology 1997; 57: 73-79.
6. Kim HM. Effect of Siegesbeckia pubescens on immediate hypersensitivity. American Journal of Chinese Medicine 1997; 25: 163-167.
7. Park HJ, Kim IT, Won JH, Jeong SH, Park EY and Nam JH. Anti-inflammatory activities of ent-16αH, 17-hydroxy-kauran-19-oic acid isolated from the roots of Siegesbeckia pubescens are due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-κB inactivation. European Journal of Pharmacology 2007; 558: 185-193.
8. Qian RQ, Zhang CY and Fu HZ. Study on therapeutic mechanism of anti-rheumatism action of Herba Siegesbeckiae. Chinese Journal of Integrated Traditional and Western Medicine 2000; 20: 192-195.
9. Xiang Y, Zhang H, Fan CQ and Yue JM. Novel diterpenoids and diterpenoid glycosides from Siegesbeckia orientalis. Journal of Natural Products 2004; 67: 1517-1521.
10. Xin HL, Bi J, Liu M, Lin WH and Qian RQ. Experimental study on anti- inflammatory and immuno-regulating effect of kirenol. Chinese Traditional and Herbal Drugs 2005; 36: 866-870.