Simultaneous quantification of Kirenol and ent-16β,17-dihydroxy-kauran-19-oic acid from Herba Siegesbeckiae in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 937, Issue , 2013, Pages 18-24

  Huo, Linan ^a   Jiang, Zhen ^a   Lei, Ming ^a   Wang, Xintao ^a   Guo, Xingjie ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Ent 16 ,17 dihydroxy kauran 19 oic acid; Herba Siegesbeckiae; Kirenol; LC ESI MS MS; Pharmacokinetics

Indexed keywords

HERBA SIEGESBECKIAE; KIRENOL; LC-ESI-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MULTIPLE-REACTION MONITORING MODES; NEGATIVE ELECTROSPRAY IONIZATIONS; ONE-STEP LIQUID-LIQUID EXTRACTIONS; RELATIVE STANDARD DEVIATIONS;

BODY FLUIDS; CHROMATOGRAPHY; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIPIDS; MASS SPECTROMETRY; PHARMACOKINETICS;

PLANT EXTRACTS;

ACETIC ACID ETHYL ESTER; DITERPENOID; ENT 16BETA,17 DIHYDROXY KAURAN 19 OIC ACID; HERBA SIEGESBECKIAE EXTRACT; KIRENOL; OSTHOLE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; FLOW RATE; HERBA SIEGESBECKIAE; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICINAL PLANT; NEGATIVE ION ELECTROSPRAY; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUALITY CONTROL; RAT; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ENT-16Β,17-DIHYDROXY-KAURAN-19-OIC ACID; HERBA SIEGESBECKIAE; KIRENOL; LC-ESI-MS/MS; PHARMACOKINETICS;

ANIMALS; ASTERACEAE; CHROMATOGRAPHY, LIQUID; COUMARINS; DITERPENES; DITERPENES, KAURANE; DRUG STABILITY; LINEAR MODELS; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84883531366     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.08.019     Document Type: Article

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