Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk

Journal of Gastroenterology

Volumn 49, Issue 7, 2014, Pages 1135-1144

  Suzuki, Ryo ^a   Yamamoto, Eiichiro ^a   Nojima, Masanori ^b   Maruyama, Reo ^a   Yamano, Hiro O ^c   Yoshikawa, Kenjiro ^c   Kimura, Tomoaki ^c   Harada, Taku ^a   Ashida, Masami ^a   Niinuma, Takeshi ^a   Sato, Akiko ^a   Nosho, Katsuhiko ^a   Yamamoto, Hiroyuki ^a   Kai, Masahiro ^a   Sugai, Tamotsu ^d   Imai, Kohzoh ^b   Suzuki, Hiromu ^a   Shinomura, Yasuhisa ^a  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c AKITA RED CROSS HOSPITAL   (Japan)

^d IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Biomarker; DNA methylation; Metachronous gastric cancer; Risk assessment

Indexed keywords

BISULFITE; DKK2 PROTEIN; DKK3 PROTEIN; MICRORNA; MICRORNA 34B; MICRORNA 34C; SECRETED FRIZZLED RELATED PROTEIN 1; SECRETED FRIZZLED RELATED PROTEIN 2; SECRETED FRIZZLED RELATED PROTEIN 5; UNCLASSIFIED DRUG; DNA; MIRN34 MICRORNA, HUMAN; RNA; TUMOR MARKER;

ADULT; AGE; AGED; ARTICLE; BISULFITE PYROSEQUENCING; CANCER RISK; CANCER SURGERY; DNA METHYLATION; ENDOSCOPIC SURGERY; ENDOSCOPY; ERADICATION THERAPY; FEMALE; FOLLOW UP; GENDER; GENETIC ASSOCIATION; GENETIC RISK; HELICOBACTER INFECTION; HUMAN; HUMAN TISSUE; INCIDENCE; MAJOR CLINICAL STUDY; MALE; METACHRONOUS GASTRIC CANCER; PRIORITY JOURNAL; PROSPECTIVE STUDY; PYROSEQUENCING; QUANTITATIVE ANALYSIS; STOMACH ANTRUM; STOMACH BIOPSY; STOMACH CANCER; STOMACH SURGERY; TUMOR BIOPSY; COMPLICATION; GASTROSCOPY; GENETIC PREDISPOSITION; GENETICS; HELICOBACTER PYLORI; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY; PROCEDURES; RISK ASSESSMENT; STOMACH NEOPLASMS; TUMOR RECURRENCE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GASTROSCOPY; GENETIC PREDISPOSITION TO DISEASE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROSPECTIVE STUDIES; RISK ASSESSMENT; RNA, NEOPLASM; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84905379289     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-013-0861-7     Document Type: Article

References (38)

1. Ono H, Kondo H, Gotoda T, Shirao K, Yamaguchi H, Saito D, et al. Endoscopic mucosal resection for treatment of early gastric cancer. Gut. 2001;48:225-9. (Pubitemid 32141848)
2. Soetikno R, Kaltenbach T, Yeh R, Gotoda T. Endoscopic mucosal resection for early cancers of the upper gastrointestinal tract. J Clin Oncol. 2005;23:4490-8. (Pubitemid 46196578)
3. Oka S, Tanaka S, Kaneko I, Mouri R, Hirata M, Kawamura T, et al. Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer. Gastrointest Endosc. 2006;64:877-83. (Pubitemid 44829827)
4. Isomoto H, Shikuwa S, Yamaguchi N, Fukuda E, Ikeda K, Nishiyama H, et al. Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study. Gut. 2009;58:331-6.
5. Nakajima T, Oda I, Gotoda T, Hamanaka H, Eguchi T, Yokoi C, et al. Metachronous gastric cancers after endoscopic resection: how effective is annual endoscopic surveillance? Gastric Cancer. 2006;9:93-8. (Pubitemid 43885767)
6. Maehata Y, Nakamura S, Fujisawa K, Esaki M, Moriyama T, Asano K, et al. Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer. Gastrointest Endosc. 2012;75:39-46.
7. Kato M, Nishida T, Yamamoto K, Hayashi S, Kitamura S, Yabuta T, et al. Scheduled endoscopic surveillance controls secondary cancer after curative endoscopic resection for early gastric cancer: a multicentre retrospective cohort study by Osaka University ESD study group. Gut. 2012.
8. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784-9.
9. Fukase K, Kato M, Kikuchi S, Inoue K, Uemura N, Okamoto S, et al. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet. 2008;372:392-7.
10. Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M. DNA methylation and cancer pathways in gastrointestinal tumors. Pharmacogenomics. 2008;9:1917-28.
11. Yamamoto E, Suzuki H, Takamaru H, Yamamoto H, Toyota M, Shinomura Y. Role of DNA methylation in the development of diffuse-type gastric cancer. Digestion. 2011;83:241-9.
12. Jones P, Baylin S. The epigenomics of cancer. Cell. 2007;128:683-92. (Pubitemid 46273572)
13. Maekita T, Nakazawa K, Mihara M, Nakajima T, Yanaoka K, Iguchi M, et al. High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res. 2006;12:989-95. (Pubitemid 43259882)
14. Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, et al. LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis. Cancer Epidemiol Biomarkers Prev. 2008;17:2555-64.
15. Nakajima T, Maekita T, Oda I, Gotoda T, Yamamoto S, Umemura S, et al. Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev. 2006;15:2317-21. (Pubitemid 44877064)
16. Ushijima T, Hattori N. Molecular pathways: involvement of Helicobacter pylori-triggered inflammation in the formation of an epigenetic field defect, and its usefulness as cancer risk and exposure markers. Clin Cancer Res. 2012;18:923-9.
17. Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano H, Yoshikawa K, et al. Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis. 2010;31:2066-73.
18. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney system. In: International workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol. 1996;20:1161.
19. Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, et al. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 2008;68:4123-32.
20. Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, et al. Frequent epigenetic inactivation of SFRP genes and constitutive activation of wnt signaling in gastric cancer. Oncogene. 2007;26:4699-713. (Pubitemid 47067406)
21. Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, et al. Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. Carcinogenesis. 2007;28:2459-66. (Pubitemid 350238947)
22. Chan AO, Lam S, Wong BC, Yuen M, Yeung Y, Hui W, et al. Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut. 2003;52:502-6. (Pubitemid 36363400)
23. Cheng ASL, Li M, Kang W, Cheng V, Chou J, Lau S, et al. Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. Gastroenterology. 2013;144:122, 133.e9.
24. Hayashi Y, Tsujii M, Wang J, Kondo J, Akasaka T, Jin Y, et al. CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis. Gut. 2012.
25. Ando T, Yoshida T, Enomoto S, Asada K, Tatematsu M, Ichinose M, et al. DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect. Int J Cancer. 2009;124:2367-74.
26. Nanjo S, Asada K, Yamashita S, Nakajima T, Nakazawa K, Maekita T, et al. Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection. Gastric Cancer. 2012;15:382-8.
27. Takamaru H, Yamamoto E, Suzuki H, Nojima M, Maruyama R, Yamano HO, et al. Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer. Cancer Prev Res (Phila). 2012;5:1203-12.
28. Suzuki H, Maruyama R, Yamamoto E, Kai M. DNA methylation and microRNA dysregulation in cancer. Mol Oncol. 2012;6:567-78.
29. Niwa T, Tsukamoto T, Toyoda T, Mori A, Tanaka H, Maekita T, et al. Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res. 2010;70:1430-40.
30. Chiba T, Marusawa H, Ushijima T. Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology. 2012;143:550-63.
31. Ikeno T, Ota H, Sugiyama A, Ishida K, Katsuyama T, Genta RM, et al. Helicobacter pylori-induced chronic active gastritis, intestinal metaplasia, and gastric ulcer in Mongolian gerbils. Am J Pathol. 1999;154:951-60. (Pubitemid 29122615)
32. Naylor GM, Gotoda T, Dixon M, Shimoda T, Gatta L, Owen R, et al. Why does Japan have a high incidence of gastric cancer? Comparison of gastritis between UK and Japanese patients. Gut. 2006;55:1545-52. (Pubitemid 44629199)
33. Wong B, Lam S, Wong W, Chen J, Zheng T, Feng R, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA (Chicago, IL). 2004;291:187-94. (Pubitemid 38082812)
34. Wu CY, Kuo KN, Wu MS, Chen YJ, Wang CB, Lin JT. Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease. Gastroenterology. 2009;137:1641, 8.e1-2.
35. Chan AO, Peng JZ, Lam SK, Lai KC, Yuen MF, Cheung HK, et al. Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation. Gut. 2006;55:463-8.
36. Nakajima T, Enomoto S, Yamashita S, Ando T, Nakanishi Y, Nakazawa K, et al. Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication. J Gastroenterol. 2010;45:37-44.
37. Perri F, Cotugno R, Piepoli A, Merla A, Quitadamo M, Gentile A, et al. Aberrant DNA methylation in non-neoplastic gastric mucosa of H. pylori infected patients and effect of eradication. Am J Gastroenterol. 2007;102:1361-71. (Pubitemid 46976302)
38. Sepulveda A, Yao Y, Yan W, Park D, Kim J, Gooding W, et al. CpG methylation and reduced expression of O6-methylguanine DNA methyltransferase is associated with Helicobacter pylori infection. Gastroenterology. 2010;138:1836-44.