Galectin-1 cross-linking of GM1 ganglioside in autoimmune suppression

ACS Symposium Series

Volumn 1115, Issue , 2012, Pages 107-121

  Ledeen, Robert W ^a   Wu, Gusheng ^a   Bleich, David ^a   Lu, Zi Hua ^a   Gabius, Hans Joachim ^b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL MEMBRANES; CHEMICAL ACTIVATION; MAMMALS;

ADAPTIVE IMMUNE SYSTEMS; AUTOIMMUNE CONDITIONS; CHANNEL ACTIVATION; GLYCOSPHINGOLIPIDS; NON-OBESE DIABETICS; REGULATORY MECHANISM; REGULATORY T CELLS; SIGNALING CASCADES;

CALCIUM;

EID: 84905253959     PISSN: 00976156     EISSN: 19475918     Source Type: Book Series    
DOI: 10.1021/bk-2012-1115.ch006     Document Type: Conference Paper

References (61)

1. Sakaguchi, S. CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004, 22, 531-562.
2. Tang, Q.; et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 2004, 199, 1455-1465.
3. Staeva-Vieira, T.; Peakman, M.; von Herrath, M Translational mini-review series on type 1 diabetes: Immune-based therapeutic approaches for type 1 diabetes. Clin. Exp. Immunol. 2007, 148, 17-31.
4. Tarbell, K.V.; et al. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J. Exp. Med. 2007, 204, 191-201.
5. Allen, S.E.; et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int. Immunol. 2007, 19, 345-354.
6. Tran, D.Q.; Ramsey, H.; Shevach, E.M. Induction of FOXP3 expression in naïve human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 2007, 110, 2983-2990.
7. Kmieciak, M.; et al. Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J. Transl. Med. 2009, 7, 89-95.
8. Garín, M.I.; Chu, C.C.; Golshayan, D.; Cernuda-Morollón, E.; Wait, R.; Lechler, R.I. Galectin-1: A key effector of regulation mediated by CD4+CD25+ T cells. Blood 2007, 109, 2058-2065.
9. Toscano, M.A.; Bianco, G.A.; Ilarregui, J.M.; et al. Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat. Immunol. 2007, 8, 825-834.
10. Wang, J.; Lu, Z.-H.; Gabius, H.-J.; Rohowsky-Kochan, C.; Ledeen, R.W.; Wu, G. Crosslinking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J. Immunol. 2009, 182, 4036-4045.
11. Kaltner, H.; Gabius, H.-J. A toolbox of lectins for translating the sugar code: the galectin network in phylogenesis and tumors. Histol. Histopathol. 2012, 27, 397-416.
12. Levi, G.; Tarrab-Hazdai, R.; Teichberg, V.I. Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbits. Eur. J. Immunol. 1983, 13, 500-507.
13. Perone, M.J.; Bertera, S.; Shufesky, W.J.; et al. Suppression of autoimmune diabetes by soluble galectin-1. J. Immunol. 2009, 182, 2641-2653.
14. Rabinovich, G.A.; Daly, G.; Dreja, H.; et al. Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J. Exp. Med. 1999, 190, 385-398.
15. Santucci, L.; Fiorucci, S.; Rubinstein, N.; et al. Galectin-1 suppresses experimental colitis in mice. Gastroenterology 2003, 124, 1381-1394.
16. Santucci, L.; Fiorucci, S.; Cammilleri, F.; Servillo, G.; Federici, B.; Morelli, A. Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice. Hepatology 2000, 31, 399-406.
17. Offner, H.; Celnik, B.; Bringman, T.S.; Casentini-Borocz, D.; Nedwin, G.E.; Vandenbark, A.A. Recombinant human beta-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 1990, 28, 177-184.
18. Cooper, D.N.W.; Barondes, S.H. Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism. J. Cell Biol. 1990, 110, 1681-1691.
19. Gabius, H.-J. Cell surface glycans: The why and how of their functionality as biochemical signals in lectin-mediated information transfer. Crit. Rev. Immunol. 2006, 26, 43-79.
20. Rappl, G.; Abken, H.; Muche, J.M.; et al. CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death. Leukemia 2002, 16, 840-845.
21. André, S.; Sanchez-Ruderisch, H.; Nakagawa, H; et al. Tumor suppressor p16INK4a: Modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells. FEBS J. 2007, 274, 3233-3256.
22. Kopitz, J. Glycolipids. In The Sugar Code: Fundamentals of Glycosciences; Gabius, H.-J., Ed.; Wiley-VCH: Weinheim, Germany, 2009; pp 177-198.
23. Ledeen, R.W.; Wu, G. Neurobiology Meets Glycosciences. In The Sugar Code: Fundamentals of Glycosciences; Gabius, H.-J., Ed.; Wiley-VCH: Weinheim, Germany, 2009; pp 495-516.
24. Kopitz, J.; von Reitzenstein, C.; Burchert, M.; Cantz, M.; Gabius, H.-J. Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture. J. Biol. Chem. 1998, 273, 11205-11211.
25. Schengrund, C.L.; Repman, M.A. Density-dependent changes in gangliosides and sialidase activity of murine neuroblastoma cells. J. Neurochem. 1982, 39, 940-947.
26. Wang, P.; Zhang, J.; Bian, H.; et al. Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor. Biochem. J. 2004, 380, 425-433.
27. Tuosto, L.; Parolini, I.; Schröder, S.; Sargiacomo, M.; Lanzavecchia, A.; Viola, A. Organization of plasma membrane functional rafts upon T cell activation. Eur. J. Immunol. 2001, 31, 345-349.
28. Brumeanu, T.-D.; Preda-Pais, A.; Stoica, C.; Bona, C.; Casares, S. Differential partitioning and trafficking of GM gangliosides and cholesterol-rich lipid rafts in thymic and splenic CD4 T cells. Mol. Immunol. 2007, 44, 530-540.
29. Kopitz, J.; von Reitzenstein, C.; André, S.; Kaltner, H.; Uhl, J.; Ehemann, V.; Cantz, M.; Gabius, H.-J. Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3. J. Biol. Chem. 2001, 276, 35917-35923.
30. Kopitz, J.; Bergmann, M.; Gabius, H.-J. How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane. IUBMB Life 2010, 62, 624-628.
31. Shimada, K.; Koh, C.S.; Uemura, K.; Yanagisawa, N. Suppression of experimental allergic encephalomyelitis in Lewis rats by administration of gangliosides. Cell. Immunol. 1994, 154, 231-239.
32. Sekiguchi, Y.; Ichikawa, M.; Inoue, A.; Itoh, M.; Koh, C.S. Brain-derived gangliosides suppress the chronic relapsing-remitting experimental autoimmune encephalomyelitis in NOD mice induced with myelin oligodendrocyte glycoprotein peptide. J. Neuroimmunol. 2001, 116, 196-205.
33. Monteiro de Castro, G.; Eduarda, Z.M.; Ventura-Oliveira, D.; Aparecida, V.C.; Ashimine, R.; de Lima Zollner, R. Th1 and Th2 cytokine immunomodulation by gangliosides in experimental autoimmune encephalomyelitis. Cytokine 2004, 26, 155-163.
34. Ledeen, R.W.; Oderfeld-Nowak, B.; Brosnan, C.F.; Cervone, A. Gangliosides offer partial protection in experimantal allergic neuritis. Ann. Neurol. 1990, 27, S69-S74.
35. Ponzin, D.; Menegus, A.M.; Kirschner, G.; Nunzi, M.G.; Fiori, M.G.; Raine, C.S. Effects of gangliosides on the expression of autoimmune demyelination in the peripheral nervous system. Ann. Neurol. 1991, 30, 678-685.
36. Vieira, K.P.; de Almeida e Silva Lima Zollner, A.R.; Malaguti, C.; Vilella, C.A.; de Lima Zollner, R. Ganglioside GM1 effects on the expression of nerve growth factor (NGF), Trk-A receptor, proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic (NOD) mice. Cytokine 2008, 42, 92-104.
37. Fishman, P.H. Role of membrane gangliosides in the binding and action of bacterial toxins. J. Membr. Biol. 1982, 69, 85-97.
38. Siebert, H.C.; André, S.; Lu, SY; et al. Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins. Biochemistry 2003, 42, 14762-14773.
39. Williams, N. A.; Stasiuk, L.M.; Nashar, T.O.; Richards, C.M.; Lang, A.K.; Day, M.J.; Hirst, T.R. Prevention of autoimmune disease due to lymphocyte modulation by the B-subunit of Escherichia coli heat-labile enterotoxin. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 5290-5295.
40. Sobel, D.O.; Yankelevich, B.; Goyal, D.; Nelson, D.; Mazumder, A. The B-subunit of cholera toxin induces immunoregulatory cells and prevents diabetes in the NOD mouse. Diabetes 1998, 47, 186-191.
41. Salmond, R.J.; Luross, J.A.; Williams, N.A. Immune modulation by the cholera-like enterotoxins. Expert Rev. Mol. Med. 2002, 2002, 1-16.
42. Dixon, S.J.; Stewart, D.; Grinstein, S.; Spiegel, S. Transmembrane signaling by the B subunit of cholera toxin: increased cytoplasmic free calcium in rat lymphocytes. J. Cell. Biol. 1987, 105, 1153-1161.
43. Guoy, H.; Detterre, P.; Debre, P.; Bismuth, G. Cell calcium signaling via GM1 cell surface gangliosides in the human Jurkat T cell line. J. Immunol. 1994, 152, 3271-3281.
44. Walzel, H.; Blach, M.; Hirabayashi, J.; Kasai, K.I.; Brock, J. Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T cells. Glycobiology 2000, 10, 131-140.
45. Fang, Y.; Xie, X.; Ledeen, R.W.; Wu, G. Characterization of cholera toxin B subunit-induced Ca2+ influx in neuroblastoma cells: evidence for a voltage independent GM1-associated Ca2+ channel. J. Neurosci. Res. 2002, 57, 1-10.
46. Wu, G.; Lu, Z.-H.; Obukhov, A.G.; Nowycky, M.C.; Ledeen, R.W. Induction of calcium influx through TRPC5 channels by cross-linking of GM1 ganglioside associated with α5β1 integrin initiates neurite outgrowth. J. Neurosci. 2007, 27, 7447-7458.
47. Clapham, D.E.; Runnels, L.W.; Strübing, C. The TRP ion channel family. Nat. Rev. Neurosci. 2001, 2, 387-396.
48. Wu, G.; Lu, Z.-H.; Gabius, H.-J.; Ledeen, R.W.; Bleich, D. Ganglioside deficiency in effector T cells from NOD mice induces resistance to regulatory T cell suppression. Diabetes 2011, 60, 2341-2349.
49. Quattrini, A.; Lorenzetti, I.; Sciorati, C.; Corbo, M.; Previtali, S.C.; Feltri, M.L.; Canal, N.; Wrabetz, L.; Nemni, R.; Clementi, E. Human IgM anti-GM1 autoantibodies modulate intracellular calcium homeostasis in neuroblastoma cells. J. Neuroimmunol. 2001, 114, 213-219.
50. Crawford, M.P.; et al. High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood 2004, 103, 4222-4231.
51. Lassmann, H.; Ransohoff, R.M. The CD4-Th1 model for multiple sclerosis: a critical [correction of crucial] re-appraisal. Trends Immunol. 2004, 25, 132-137.
52. Walter, U.; Santamaria, P. CD8+ T cells in autoimmunity. Curr. Opin. Immunol. 2005, 17, 624-631.
53. Coppieters, K.T.; Dotta, F.; Amiran, N.; Campbell, P.D.; Kay, T.W.; Atkinson, M.A.; Roep, B.O.; von Herrath, M.G. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J. Exp. Med. 2012, 209, 51-60.
54. de Mello Coelho, V.D.; Nguyen, B.; Giri; et al. Quantitative differences in lipid raft components between murine CD4+ and CD8+ T cells. BMC Immunol. 2004, 5, 2.
55. Nashar, T.O.; Williams, N.A.; Hirst, T.R. Cross-linking of cell surface ganglioside GM1 induces the selective apoptosis of mature CD8+ T lymphocytes. Int. Immunol. 1996, 15, 731-736.
56. Anderson, M.S.; Bluestone, J.A. The NOD mouse: A model of immune dysregulation. Annu. Rev. Immunol. 2005, 23, 447-485.
57. D'Alise, A.M.; et al. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 19857-19862.
58. Schneider, A.; Rieck, M.; Sanda, S.; Pihoker, C.; Greenbaum, C.; Buckner, J.H. The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J. Immunol. 2008, 181, 7350-7355.
59. Wu, G.; Ledeen, R.W. Gangliosides as modulators of neuronal calcium. Prog. Brain Res. 1994, 101, 101-112.
60. Gabius, H.-J., Ed.; The Sugar Code: Fundamentals of Glycosciences; Wiley- VCH: Weinheim, Germany, 2009.
61. Gabius, H.-J.; André, S.; Jiménez-Barbero, J.; Romero, A.; Solís, D. From lectin structure to functional glycomics: Principles of the sugar code. Trends Biochem. Sci. 2011, 36, 298-313.