A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system

Circulation Research

Volumn 115, Issue 4, 2014, Pages 432-441

  Van Weerd, Jan Hendrik ^a   Badi, Ileana ^a   Van Den Boogaard, Malou ^a   Stefanovic, Sonia ^a   Van De Werken, Harmen J G ^b,c   Gomez Velazquez, Melisa ^d   Badia Careaga, Claudio ^d   Manzanares, Miguel ^d   De Laat, Wouter ^b   Barnett, Phil ^a   Christoffels, Vincent M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

anatomy histology; heart conduction system

Indexed keywords

TRANSCRIPTION FACTOR CTCF; BONE MORPHOGENETIC PROTEIN; CCCTC-BINDING FACTOR; CIRCULAR DNA; GREEN FLUORESCENT PROTEIN; REPRESSOR PROTEIN; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR 5; TBX3 PROTEIN, MOUSE;

ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; BINDING SITE; CIRCULAR CHROMOSOME CONFORMATION CAPTURE AND SEQUENCING; CTCF GENE; EMBRYO; EMBRYO DEVELOPMENT; ENHANCER REGION; GENE; GENE CLUSTER; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; HEART MUSCLE CONDUCTION SYSTEM; HOMEOSTASIS; HUMAN GENOME; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; TBX3 GENE; TBX5 GENE; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION; ANIMAL; BACTERIAL ARTIFICIAL CHROMOSOME; C57BL MOUSE; DEFICIENCY; DNA FLANKING REGION; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MORPHOGENESIS; MULTIGENE FAMILY; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

3' FLANKING REGION; ANIMALS; BINDING SITES; BONE MORPHOGENETIC PROTEINS; CHROMOSOMES, ARTIFICIAL, BACTERIAL; DNA, CIRCULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HEART CONDUCTION SYSTEM; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MORPHOGENESIS; MULTIGENE FAMILY; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84905238773     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.303591     Document Type: Article

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