Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 3, 2012, Pages

  Frank, Deborah U ^a   Carter, Kandis L ^a   Thomas, Kirk R ^a   Burr, R Michael ^a   Bakker, Martijn L ^b   Coetzee, William A ^c   Tristani Firouzi, Martin ^a   Bamshad, Michael J ^d   Christoffels, Vincent M ^b   Moon, Anne M ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c NEW YORK UNIVERSITY   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Embryonic electrocardiogram; Heart development; Heart rhythm; Tissue regeneration

Indexed keywords

ION CHANNEL; MUTANT PROTEIN; TBX2 PROTEIN; TBX3 PROTEIN; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR T BET; TRANSCRIPTION FACTOR TBX5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR JUNCTION ARRHYTHMIA; CARDIOVASCULAR RISK; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION; GENE SILENCING; HEART; HEART ARRHYTHMIA; HEART MUSCLE CONDUCTION SYSTEM; HEART PREEXCITATION; HOMEOSTASIS; HYPOPLASIA; IN VIVO STUDY; LETHALITY; MALE; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRENATAL PERIOD; PRIORITY JOURNAL; PROTEIN FUNCTION; SINUS BRADYCARDIA; SINUS NODE DISEASE; SUDDEN DEATH; SUPRAVENTRICULAR PREMATURE BEAT;

ALLELES; ANIMALS; ANIMALS, NEWBORN; ARRHYTHMIAS, CARDIAC; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR NODE; CONNEXIN 43; ELECTROCARDIOGRAPHY; EMBRYO, MAMMALIAN; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; HEART CONDUCTION SYSTEM; HOMEOSTASIS; HUMANS; ION CHANNELS; MICE; MUTATION; PHENOTYPE; RECOMBINATION, GENETIC; RNA, MESSENGER; SURVIVAL ANALYSIS; T-BOX DOMAIN PROTEINS;

MUS;

EID: 84856391270     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1115165109     Document Type: Article

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