Biased signaling through G-protein-coupled PROKR2 receptors harboring missense mutations

FASEB Journal

Volumn 28, Issue 8, 2014, Pages 3734-3744

  Sbai, Oualid ^a,b,c   Monnier, Carine ^a,b,c   Dodé, Catherine ^d   Pin, Jean Philippe ^a,b,c   Hardelin, Jean Pierre ^e   Rondard, Philippe ^a,b,c  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b INSERM   (France)

^c UNIV MONTPELLIER   (France)

^d FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

^e Institut Pasteur   (France)

Author keywords

Kallmann syndrome; Prokineticin; arrestin

Indexed keywords

BETA ARRESTIN; CALCIUM; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROKINETICIN RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CALCIUM CELL LEVEL; CELL SURFACE; HEK293 CELL LINE; HUMAN; HUMAN CELL; KALLMANN SYNDROME; LIGAND BINDING; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE;

KALLMANN SYNDROME; PROKINETICIN; Β-ARRESTIN;

ARRESTINS; CALCIUM SIGNALING; GASTROINTESTINAL HORMONES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HEK293 CELLS; HUMANS; KALLMANN SYNDROME; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; NEUROPEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84905227323     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-243402     Document Type: Article

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