Self-consistent synthesis of the squalene synthase inhibitor zaragozic acid C via controlled oligomerization

Journal of the American Chemical Society

Volumn 130, Issue 51, 2008, Pages 17281-17283

  Nicewicz, David A ^a   Satterfield, Andrew D ^a   Schmitt, Daniel C ^a   Johnson, Jeffrey S ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON SKELETON; EFFICIENT CONSTRUCTION; GLYCOLIC ACIDS; NATURAL PRODUCTS; OXIDATION STATE; PROTECTING GROUP; SYNTHASE INHIBITOR; SYNTHONS;

ENZYMES; FUNCTIONAL GROUPS; OLIGOMERIZATION; SILANES;

ACIDS;

SQUALENE SYNTHASE INHIBITOR; ZARAGOZIC ACID C; CARBON; FUSED HETEROCYCLIC RINGS; GLYCOLIC ACID; GLYCOLIC ACID DERIVATIVE; GLYOXYLIC ACID DERIVATIVE; SQUALENE SYNTHASE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; EPIMERIZATION; OLIGOMERIZATION; OXIDATION; STEREOCHEMISTRY; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; KINETICS; METHODOLOGY; ORGANIC CHEMISTRY; STEREOISOMERISM; SYNTHESIS;

BICYCLO COMPOUNDS, HETEROCYCLIC; CARBON; CHEMISTRY, ORGANIC; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; GLYCOLATES; GLYOXYLATES; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 67749111694     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja808347q     Document Type: Article

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